Title:
USE OF LONG-CHAIN NON-CODING RNA-NEAT1, AND ADENO-ASSOCIATED VIRUS OVEREXPRESSING RNA-NEAT1 AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/253162
Kind Code:
A1
Abstract:
Provided are the use of long-chain non-coding RNA-NEAT1, and sgRNA and an adeno-associated virus overexpressing RNA-NEAT1 and the use thereof, which belong to the technical field of medicines. Provided is the use of the long-chain non-coding RNA-NEAT1 in the preparation of a drug for treating Fuchs' endothelial corneal dystrophy. The overexpression of the long-chain non-coding RNA-NEAT1 can effectively reduce corneal endothelial injury and relieve corneal edema symptoms, and the long-chain non-coding RNA-NEAT1 can be used for treating Fuchs' endothelial corneal dystrophy.
Inventors:
SHI WEIYUN (CN)
WANG QUN (CN)
ZHOU QINGJUN (CN)
DOU SHENGQIAN (CN)
JIANG HUI (CN)
ZHANG BIN (CN)
WANG QUN (CN)
ZHOU QINGJUN (CN)
DOU SHENGQIAN (CN)
JIANG HUI (CN)
ZHANG BIN (CN)
Application Number:
PCT/CN2022/095885
Publication Date:
December 08, 2022
Filing Date:
May 30, 2022
Export Citation:
Assignee:
EYE INSTITUTE OF SHANDONG FIRST MEDICAL UNIV (CN)
International Classes:
A61K31/7088; A61K9/00; A61K47/46; A61P27/02; C12N15/113; C12N15/864
Foreign References:
| CN113350367A | 2021-09-07 | |||
| US20200158716A1 | 2020-05-21 |
Other References:
BAI, YANHUI ET AL: "LncRNA NEAT1 Promotes Inflammatory Response and Induces Corneal Neovascularization", JOURNAL OF MOLECULAR ENDOCRINOLOGY, vol. 61, no. 4, 15 October 2018 (2018-10-15), XP009541786
ZHENG, JIUSHENG ET AL.: "RNA (Research Progress of Long Non-coding RNA in Eye Diseases", INTERNATIONAL JOURNAL OF OPHTHALMOLOGY, vol. 20, no. 10, 31 October 2020 (2020-10-31), pages 1740 - 1742, XP093013840
" Clinical Guideline for Eye Diseases", 30 June 2017, CHANGCHUN: JILIN SCIENCE AND TECHNOLOGY PRESS,, CN, ISBN: 978-7-5578-1139-6, article YAN, XIANWEI ET AL: "Section Five. Corneal Neovascularization", pages: 79 - 81, XP009543061
JIANG YANYUN; GONG YINGYING: "Fuchs' Endothelial Corneal Dystrophy", JOURNAL OF CLINICAL OPHTHALMOLOGY, CN, vol. 25, no. 2, 30 April 2017 (2017-04-30), CN, pages 177 - 182, XP009542094, ISSN: 1006-8422
ZHENG, JIUSHENG ET AL.: "RNA (Research Progress of Long Non-coding RNA in Eye Diseases", INTERNATIONAL JOURNAL OF OPHTHALMOLOGY, vol. 20, no. 10, 31 October 2020 (2020-10-31), pages 1740 - 1742, XP093013840
" Clinical Guideline for Eye Diseases", 30 June 2017, CHANGCHUN: JILIN SCIENCE AND TECHNOLOGY PRESS,, CN, ISBN: 978-7-5578-1139-6, article YAN, XIANWEI ET AL: "Section Five. Corneal Neovascularization", pages: 79 - 81, XP009543061
JIANG YANYUN; GONG YINGYING: "Fuchs' Endothelial Corneal Dystrophy", JOURNAL OF CLINICAL OPHTHALMOLOGY, CN, vol. 25, no. 2, 30 April 2017 (2017-04-30), CN, pages 177 - 182, XP009542094, ISSN: 1006-8422
Attorney, Agent or Firm:
BEIJING YICHUANMING INTELLECTUAL PROPERTY AGENCY (SPECIAL GENERAL PARTNERSHIP) (CN)
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