Title:
USE OF LY2922470 IN PREPARING MEDICAMENT FOR PREVENTING OR TREATING CEREBROVASCULAR DISEASES OR TISSUE ISCHEMIA-REPERFUSION INJURY
Document Type and Number:
WIPO Patent Application WO/2024/041330
Kind Code:
A1
Abstract:
Disclosed is use of LY2922470 in preparing a medicament for preventing or treating cerebrovascular diseases or tissue ischemia-reperfusion injury. The treatment effect of LY2922470 and TAK875 on ischemic stroke is evaluated by using an MCAO cerebral ischemia reperfusion injury animal model. Experimental results show that LY2922470 has the effect of treating ischemic stroke, and the treatment effect is not directly related to a GPR40 target. The present invention proves the significant potential of LY2922470 as a medicament for cerebrovascular diseases and ischemia-reperfusion injury and discloses for the first time that LY2922470 can effectively ameliorate the infarction focus. An effective novel potential alternative medicament for treating related cerebrovascular diseases and reperfusion injury is provided, the indication of LY2922470 is expanded, and the application potential and market prospect of LY2922470 are greatly improved.
More Like This:
Inventors:
CUI QINGHUA (CN)
ZHOU WANLU (CN)
ZHOU WANLU (CN)
Application Number:
PCT/CN2023/110548
Publication Date:
February 29, 2024
Filing Date:
August 01, 2023
Export Citation:
Assignee:
CO LTD OF JEAMOON TECH (CN)
International Classes:
A61K31/4709; A61P9/10
Foreign References:
| CN115317484A | 2022-11-11 | |||
| CN109666027A | 2019-04-23 | |||
| US20130045990A1 | 2013-02-21 |
Other References:
HAMDOUCHI CHAFIQ, KAHL STEVEN D., PATEL LEWIS ANJANA, CARDONA GUEMALLI R., ZINK RICHARD W., CHEN KEYUE, EESSALU THOMAS E., FICORIL: "The Discovery, Preclinical, and Early Clinical Development of Potent and Selective GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus (LY2881835, LY2922083, and LY2922470)", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 59, no. 24, 22 December 2016 (2016-12-22), US , pages 10891 - 10916, XP055972684, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.6b00892
HAMDOUCHI CHAFIQ, MAITI PRANAB, WARSHAWSKY ALAN M., DEBAILLIE AMY C., OTTO KEITH A., WILBUR KELLY L., KAHL STEVEN D., PATEL LEWIS : "Discovery of LY3104607: A Potent and Selective G Protein-Coupled Receptor 40 (GPR40) Agonist with Optimized Pharmacokinetic Properties to Support Once Daily Oral Treatment in Patients with Type 2 Diabetes Mellitus", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 61, no. 3, 8 February 2018 (2018-02-08), US , pages 934 - 945, XP093144613, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.7b01411
HAMDOUCHI CHAFIQ, MAITI PRANAB, WARSHAWSKY ALAN M., DEBAILLIE AMY C., OTTO KEITH A., WILBUR KELLY L., KAHL STEVEN D., PATEL LEWIS : "Discovery of LY3104607: A Potent and Selective G Protein-Coupled Receptor 40 (GPR40) Agonist with Optimized Pharmacokinetic Properties to Support Once Daily Oral Treatment in Patients with Type 2 Diabetes Mellitus", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 61, no. 3, 8 February 2018 (2018-02-08), US , pages 934 - 945, XP093144613, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.7b01411
Attorney, Agent or Firm:
CHENGDU FANGYU UNION PATENT AGENCY (GENERAL PARTNERSHIP) (CN)
Download PDF:
Previous Patent: MUFFLER AND REFRIGERATING SYSTEM COMPRISING MUFFLER
Next Patent: CHARGING SYSTEM OF ELECTRIC VEHICLE, AND ELECTRIC VEHICLE
Next Patent: CHARGING SYSTEM OF ELECTRIC VEHICLE, AND ELECTRIC VEHICLE