Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
N1-(1,2-CIS-2-HALOGENOCYCLOPROPYL) SUBSTITUTED PYRIDOCARBOXYLIC ACID DERIVATIVE
Document Type and Number:
Japanese Patent JPH11124367
Kind Code:
A
Abstract:

To obtain a new compound useful as a producing intermediate of a quinolone derivative useful as a medicine, a therapeutic agent for an animal, chemicals for aquaculture, antibacterial preservatives, etc.

This compound, e.g. 5-amino-6,7,8-trifluoro-1-(1,2-cis-2-fluoro-1- cyclopropyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, is expressed by formula I {R1 is (methyl)amino, OH, thiol or H; A is N or C-X3 (X3 is a halogen, a 1-6C alkyl, H, etc.); X, X1 and X2 are each a halogen; Z is H, a 1-6C (alkoxy) alkyl, a phenyl alkyl of a 1-6C alkyl chain, a phenyl, etc.; when R1 is H, X3 us not a halogen or H}. The compound of the formula I is obtained by, e.g. using a compound of formula III as a starting substance and obtaining a compound of formula V through a compound of formula III, a compound of formula IV, etc.


Inventors:
HAYAKAWA ISAO
KIMURA YOICHI
Application Number:
JP23376398A
Publication Date:
May 11, 1999
Filing Date:
August 20, 1998
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
DAIICHI SEIYAKU CO
International Classes:
A61K31/00; A61K31/435; A61K31/4375; A61K31/44; A61K31/455; C07D471/04; A61K31/47; A61K31/4709; A61K31/495; A61K31/55; A61P31/00; A61P31/04; C07D213/61; C07D215/233; C07D215/56; C07D401/04; C07D405/14; C07D519/00; C07D; (IPC1-7): C07D215/56; C07D471/04
Attorney, Agent or Firm:
Miyuki Ariga (3 outside)