Title:
USE OF MEGANUCLEASES FOR INDUCING HOMOLOGOUS RECOMBINATION EX VIVO AND IN TOTO IN VERTEBRATE SOMATIC TISSUES AND APPLICATION THEREOF.
Document Type and Number:
WIPO Patent Application WO2004067753
Kind Code:
A3
Abstract:
Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and to its application for genome engineering and gene therapy.
Inventors:
ARNOULD SYLVAIN (FR)
BRUNEAU SYLVIA (FR)
CABANIOLS JEAN-PIERRE (FR)
CHAMES PATRICK (FR)
CHOULIKA ANDRE (FR)
DUCHATEAU PHILIPPE (FR)
EPINAT JEAN-CHARLES (FR)
GOUBLE AGNES (FR)
LACROIX EMMANUEL (FR)
PAQUES FREDERIC (FR)
PEREZ-MICHAUT CHRISTOPHE (FR)
SMITH JULIANNE (FR)
SOURDIVE DAVID (FR)
BRUNEAU SYLVIA (FR)
CABANIOLS JEAN-PIERRE (FR)
CHAMES PATRICK (FR)
CHOULIKA ANDRE (FR)
DUCHATEAU PHILIPPE (FR)
EPINAT JEAN-CHARLES (FR)
GOUBLE AGNES (FR)
LACROIX EMMANUEL (FR)
PAQUES FREDERIC (FR)
PEREZ-MICHAUT CHRISTOPHE (FR)
SMITH JULIANNE (FR)
SOURDIVE DAVID (FR)
Application Number:
PCT/IB2004/000848
Publication Date:
September 16, 2004
Filing Date:
January 28, 2004
Export Citation:
Assignee:
CELLECTIS (FR)
ARNOULD SYLVAIN (FR)
BRUNEAU SYLVIA (FR)
CABANIOLS JEAN-PIERRE (FR)
CHAMES PATRICK (FR)
CHOULIKA ANDRE (FR)
DUCHATEAU PHILIPPE (FR)
EPINAT JEAN-CHARLES (FR)
GOUBLE AGNES (FR)
LACROIX EMMANUEL (FR)
PAQUES FREDERIC (FR)
PEREZ-MICHAUT CHRISTOPHE (FR)
SMITH JULIANNE (FR)
SOURDIVE DAVID (FR)
ARNOULD SYLVAIN (FR)
BRUNEAU SYLVIA (FR)
CABANIOLS JEAN-PIERRE (FR)
CHAMES PATRICK (FR)
CHOULIKA ANDRE (FR)
DUCHATEAU PHILIPPE (FR)
EPINAT JEAN-CHARLES (FR)
GOUBLE AGNES (FR)
LACROIX EMMANUEL (FR)
PAQUES FREDERIC (FR)
PEREZ-MICHAUT CHRISTOPHE (FR)
SMITH JULIANNE (FR)
SOURDIVE DAVID (FR)
International Classes:
A01K67/027; A61K38/46; C12N9/22; C12N15/55; C12N15/85; C12N15/90; A61K38/00; A61K48/00; (IPC1-7): C12N15/90; A61K38/46; C12N15/55
Domestic Patent References:
| WO2000046386A2 | 2000-08-10 | |||
| WO2000046385A1 | 2000-08-10 | |||
| WO2003078619A1 | 2003-09-25 |
Foreign References:
| US5830729A | 1998-11-03 |
Other References:
JASIN M: "Genetic manipulation of genomes with rare-cutting endonucleases", TRENDS IN GENETICS, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 12, no. 6, 1 June 1996 (1996-06-01), pages 224 - 228, XP004037289, ISSN: 0168-9525
GUO H ET AL: "GROUP II INTRONS DESIGNED TO INSERT INTO THERAPEUTICALLY RELEVANT DNA TARGET SITES IN HUMAN CELLS", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 289, 21 July 2000 (2000-07-21), pages 452 - 457, XP002938491, ISSN: 0036-8075
BIET E ET AL: "Homologous recombination and gene targeting", COMPTES RENDUS - BIOLOGIES, ELSEVIER, PARIS, FR, vol. 326, no. 1, January 2003 (2003-01-01), pages 51 - 64, XP004412396, ISSN: 1631-0691
WILSON J H: "pointing fingers at te limiting step in gene targeting", NATURE BIOTECHNOLOGY, NATURE PUBLISHING, US, vol. 21, no. 7, July 2003 (2003-07-01), pages 759 - 760, XP002974230, ISSN: 1087-0156
GUO H ET AL: "GROUP II INTRONS DESIGNED TO INSERT INTO THERAPEUTICALLY RELEVANT DNA TARGET SITES IN HUMAN CELLS", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 289, 21 July 2000 (2000-07-21), pages 452 - 457, XP002938491, ISSN: 0036-8075
BIET E ET AL: "Homologous recombination and gene targeting", COMPTES RENDUS - BIOLOGIES, ELSEVIER, PARIS, FR, vol. 326, no. 1, January 2003 (2003-01-01), pages 51 - 64, XP004412396, ISSN: 1631-0691
WILSON J H: "pointing fingers at te limiting step in gene targeting", NATURE BIOTECHNOLOGY, NATURE PUBLISHING, US, vol. 21, no. 7, July 2003 (2003-07-01), pages 759 - 760, XP002974230, ISSN: 1087-0156
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