Title:
USE OF MORINDA OFFICINALIS OLIGOSACCHARIDES AND COMPOSITION THEREOF IN PREVENTION OR TREATMENT OF DEPRESSION
Document Type and Number:
WIPO Patent Application WO/2023/155865
Kind Code:
A1
Abstract:
Use of one or more morinda officinalis oligosaccharides represented by the following structural formula and a composition comprising the same and an intestinal flora in the preparation of a medicine for preventing or treating depression. (I), where n = 1, 2, 3, 4, 5, 6 or 7. By means of a Trp—5-HTP—5-HT pathway, morinda officinalis oligosaccharides and the intestinal flora are combined for use so as to increase the content of 5-HTP in the blood and the content of 5-HTP and 5-HT in the brain, thereby effectively improving the treatment on depression.
Inventors:
WANG YAN (CN)
ZHU XINJIE (CN)
LUO HAIBIN (CN)
LI SONG (CN)
ZHU XINJIE (CN)
LUO HAIBIN (CN)
LI SONG (CN)
Application Number:
PCT/CN2023/076694
Publication Date:
August 24, 2023
Filing Date:
February 17, 2023
Export Citation:
Assignee:
UNIV HAINAN (CN)
International Classes:
A61K31/702; A61K35/742; A61P25/24
Foreign References:
| CN101306103A | 2008-11-19 | |||
| CN108186686A | 2018-06-22 |
Other References:
ZHANG ZHENG-WEI, GAO CHUN-SHENG, ZHANG HENG, YANG JIAN, WANG YA-PING, PAN LI-BIN, YU HANG, HE CHI-YU, LUO HAI-BIN, ZHAO ZHEN-XIONG: "Morinda officinalis oligosaccharides increase serotonin in the brain and ameliorate depression via promoting 5-hydroxytryptophan production in the gut microbiota", ACTA PHARMACEUTICA SINICA B, vol. 12, no. 8, 1 August 2022 (2022-08-01), pages 3298 - 3312, XP093085930, ISSN: 2211-3835, DOI: 10.1016/j.apsb.2022.02.032
ZHAN, JI: "Study on Anti-depressant and Anti-fatigue Active Ingredients of Morinda Officinalis", MASTER'S THESIS, no. 12, 1 June 2019 (2019-06-01), CN, pages 1 - 56, XP009548221
ZOU LIAN-YONG, ZHANG HONG-YAN: "Research advance of morinda officinalis oligosaccharides in treatment of depression", CHINESE JOURNAL OF NEW DRUGS, GAI-KAN BIANJIBU, BEIJING, CN, vol. 21, no. 16, 1 August 2012 (2012-08-01), CN , pages 1889 - 1891, 1945, XP093085934, ISSN: 1003-3734
ZHAN, JI: "Study on Anti-depressant and Anti-fatigue Active Ingredients of Morinda Officinalis", MASTER'S THESIS, no. 12, 1 June 2019 (2019-06-01), CN, pages 1 - 56, XP009548221
ZOU LIAN-YONG, ZHANG HONG-YAN: "Research advance of morinda officinalis oligosaccharides in treatment of depression", CHINESE JOURNAL OF NEW DRUGS, GAI-KAN BIANJIBU, BEIJING, CN, vol. 21, no. 16, 1 August 2012 (2012-08-01), CN , pages 1889 - 1891, 1945, XP093085934, ISSN: 1003-3734
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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