Title:
USE OF O-METHYL-MODIFIED QUERCETIN IN PREPARATION OF DRUG FOR INHIBITING PROLIFERATION OF TUMOR CELLS
Document Type and Number:
WIPO Patent Application WO/2023/115766
Kind Code:
A1
Abstract:
The present invention belongs to the technical field of drug preparation, and relates to the use of O-methyl-modified quercetin in the preparation of a drug for inhibiting the proliferation of tumor cells. Provided in the present invention is the use of O-methyl-modified quercetin in the preparation of a drug for inhibiting the proliferation of tumor cells. O-methyl-modified quercetin can inhibit the proliferation of tumor cells, inhibit the proliferation of in-vivo transplantation tumors and the migration of tumor cells, and induce the apoptosis of tumor cells.
Inventors:
SUN CHONGDE (CN)
WANG YUE (CN)
CHEN YUNYI (CN)
CAO JINPING (CN)
LI XIAN (CN)
WANG YUE (CN)
CHEN YUNYI (CN)
CAO JINPING (CN)
LI XIAN (CN)
Application Number:
PCT/CN2022/087786
Publication Date:
June 29, 2023
Filing Date:
April 20, 2022
Export Citation:
Assignee:
UNIV ZHEJIANG (CN)
International Classes:
A61K31/352; A61P35/00; A61P35/04
Foreign References:
| CN114010630A | 2022-02-08 |
Other References:
BREAK MOHAMMED KHALED BIN, YOUNES KAREEM MAHMOUD, ELKAHOUI SALEM, UNISSA RAHAMAT, ALFAHIDAT SULIMAN AYAD, ALSHAWI KHALID SALEM, AB: "Achillea fragrantissima (Forssk.) Sch.Bip. methanolic extract exerts potent antimicrobial activity and causes cancer cell death via induction of caspase-dependent apoptosis and S-phase arrest", NATURAL PRODUCT RESEARCH, TAYLOR AND FRANCIS HEALTH SCIENCES, ABINGDON, GB, vol. 36, no. 18, 17 September 2022 (2022-09-17), GB , pages 4639 - 4644, XP093073737, ISSN: 1478-6419, DOI: 10.1080/14786419.2021.2010074
WU JIANGUO, YI JUN, WU YANBIN, CHEN XUZHENG, ZENG JIANWEI, WU JINZHONG, PENG WEI: "3, 3-Dimethylquercetin Inhibits the Proliferation of Human Colon Cancer RKO Cells through Inducing G2/M Cell Cycle Arrest and Apoptosis", ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, BENTHAM SCIENCE PUBLISHERS LTD., NL, vol. 19, no. 3, 25 June 2019 (2019-06-25), NL , pages 402 - 409, XP093073738, ISSN: 1871-5206, DOI: 10.2174/1871520618666181106120718
BANIK ARGHYA; GHOSH KALYAN; PATIL UMESH K.; GAYEN SHOVANLAL: "Identification of molecular fingerprints of natural products for the inhibition of breast cancer resistance protein (BCRP)", PHYTOMEDICINE, ELSEVIER, AMSTERDAM, NL, vol. 85, 20 February 2021 (2021-02-20), AMSTERDAM, NL , XP086537529, ISSN: 0944-7113, DOI: 10.1016/j.phymed.2021.153523
WENG JING-RU, BAI LI-YUAN, LIN WEI-YU, CHIU CHANG-FANG, CHEN YU-CHANG, CHAO SHI-WEI, FENG CHIA-HSIEN: "A Flavone Constituent from Myoporum bontioides Induces M-Phase Cell Cycle Arrest of MCF-7 Breast Cancer Cells", MOLECULES, vol. 22, no. 3, 15 March 2017 (2017-03-15), pages 472, XP093073739, DOI: 10.3390/molecules22030472
FENG, LI ET AL.: "Cytotoxicity of Constituents from Mexican Propolis Against a Panel of Six Different Cancer Cell Lines", NATURAL PRODUCT COMMUNICATIONS, vol. 5, no. 10, 31 October 2010 (2010-10-31), XP009547236
WU JIANGUO, YI JUN, WU YANBIN, CHEN XUZHENG, ZENG JIANWEI, WU JINZHONG, PENG WEI: "3, 3-Dimethylquercetin Inhibits the Proliferation of Human Colon Cancer RKO Cells through Inducing G2/M Cell Cycle Arrest and Apoptosis", ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, BENTHAM SCIENCE PUBLISHERS LTD., NL, vol. 19, no. 3, 25 June 2019 (2019-06-25), NL , pages 402 - 409, XP093073738, ISSN: 1871-5206, DOI: 10.2174/1871520618666181106120718
BANIK ARGHYA; GHOSH KALYAN; PATIL UMESH K.; GAYEN SHOVANLAL: "Identification of molecular fingerprints of natural products for the inhibition of breast cancer resistance protein (BCRP)", PHYTOMEDICINE, ELSEVIER, AMSTERDAM, NL, vol. 85, 20 February 2021 (2021-02-20), AMSTERDAM, NL , XP086537529, ISSN: 0944-7113, DOI: 10.1016/j.phymed.2021.153523
WENG JING-RU, BAI LI-YUAN, LIN WEI-YU, CHIU CHANG-FANG, CHEN YU-CHANG, CHAO SHI-WEI, FENG CHIA-HSIEN: "A Flavone Constituent from Myoporum bontioides Induces M-Phase Cell Cycle Arrest of MCF-7 Breast Cancer Cells", MOLECULES, vol. 22, no. 3, 15 March 2017 (2017-03-15), pages 472, XP093073739, DOI: 10.3390/molecules22030472
FENG, LI ET AL.: "Cytotoxicity of Constituents from Mexican Propolis Against a Panel of Six Different Cancer Cell Lines", NATURAL PRODUCT COMMUNICATIONS, vol. 5, no. 10, 31 October 2010 (2010-10-31), XP009547236
Attorney, Agent or Firm:
BEIJING GAOWO LAW FIRM (CN)
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