Title:
USE OF SESQUITERPENE POLYKETONE COMPOUND AS IMMUNOMODULATOR IN PREVENTING AND TREATING IMMUNE DISEASES
Document Type and Number:
WIPO Patent Application WO/2023/232123
Kind Code:
A1
Abstract:
Provided are a sesquiterpene polyketone compound, a pharmaceutical composition, and use thereof as an immunomodulator and in preventing and treating immune diseases. Biological activity assay shows that the sesquiterpene polyketone compound provided herein can be used as an immunomodulator for preventing and/or treating immune-related diseases.
Inventors:
YIN ZHINAN (CN)
GAO HAO (CN)
TANG XIN (CN)
WANG CHUANXI (CN)
YANG HENGWEN (CN)
YAO XINSHENG (CN)
LI ZHENHUA (CN)
HU DAN (CN)
REN FEIFEI (CN)
KUANG RUNQIAO (CN)
HAN XUE (CN)
GAO HAO (CN)
TANG XIN (CN)
WANG CHUANXI (CN)
YANG HENGWEN (CN)
YAO XINSHENG (CN)
LI ZHENHUA (CN)
HU DAN (CN)
REN FEIFEI (CN)
KUANG RUNQIAO (CN)
HAN XUE (CN)
Application Number:
PCT/CN2023/097904
Publication Date:
December 07, 2023
Filing Date:
June 01, 2023
Export Citation:
Assignee:
UNIV JINAN (CN)
International Classes:
A61K31/05; A61K31/015; A61P29/00; A61P33/00; C07C47/57
Foreign References:
| CN115040507A | 2022-09-13 | |||
| CN114956974A | 2022-08-30 | |||
| CN114796171A | 2022-07-29 |
Other References:
KUANG, RUNQIAO: "A Study of Secondary Metabolites of Wetland-derived Myrothecium gramineum", MASTER THESIS, JINAN UNIVERSITY, CN, 18 December 2018 (2018-12-18), CN, XP009551320
LAUBE, T. ; BERNET, A. ; DAHSE, H.M. ; JACOBSEN, I.D. ; SEIFERT, K.: "Synthesis and pharmacological activities of some sesquiterpene quinones and hydroquinones", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 17, no. 4, 15 February 2009 (2009-02-15), AMSTERDAM, NL, pages 1422 - 1427, XP025949546, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2009.01.028
LIU, Q. ; SHU, X. ; SUN, A. ; SUN, Q. ; ZHANG, C. ; AN, H. ; LIU, J. ; CAO, X.: "Plant-derived small molecule albaconol suppresses LPS-triggered proinflammatory cytokine production and antigen presentation of dendritic cells by impairing NF-@kB activation", INTERNATIONAL IMMUNOPHARMACOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 8, no. 8, 1 August 2008 (2008-08-01), NL , pages 1103 - 1111, XP022710377, ISSN: 1567-5769, DOI: 10.1016/j.intimp.2008.04.001
TANG XIN, WANG CHUANXI, WANG LEI, REN FEIFEI, KUANG RUNQIAO, LI ZHENHUA, HAN XUE, CHEN YIMING, CHEN GUODONG, WU XIUQING, LIU JIE, : "Aureane-type sesquiterpene tetraketides as a novel class of immunomodulators with interleukin-17A inhibitory activity", ACTA PHARMACEUTICA SINICA B, vol. 13, no. 9, 1 September 2023 (2023-09-01), pages 3930 - 3944, XP093115352, ISSN: 2211-3835, DOI: 10.1016/j.apsb.2023.03.017
LAUBE, T. ; BERNET, A. ; DAHSE, H.M. ; JACOBSEN, I.D. ; SEIFERT, K.: "Synthesis and pharmacological activities of some sesquiterpene quinones and hydroquinones", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 17, no. 4, 15 February 2009 (2009-02-15), AMSTERDAM, NL, pages 1422 - 1427, XP025949546, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2009.01.028
LIU, Q. ; SHU, X. ; SUN, A. ; SUN, Q. ; ZHANG, C. ; AN, H. ; LIU, J. ; CAO, X.: "Plant-derived small molecule albaconol suppresses LPS-triggered proinflammatory cytokine production and antigen presentation of dendritic cells by impairing NF-@kB activation", INTERNATIONAL IMMUNOPHARMACOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 8, no. 8, 1 August 2008 (2008-08-01), NL , pages 1103 - 1111, XP022710377, ISSN: 1567-5769, DOI: 10.1016/j.intimp.2008.04.001
TANG XIN, WANG CHUANXI, WANG LEI, REN FEIFEI, KUANG RUNQIAO, LI ZHENHUA, HAN XUE, CHEN YIMING, CHEN GUODONG, WU XIUQING, LIU JIE, : "Aureane-type sesquiterpene tetraketides as a novel class of immunomodulators with interleukin-17A inhibitory activity", ACTA PHARMACEUTICA SINICA B, vol. 13, no. 9, 1 September 2023 (2023-09-01), pages 3930 - 3944, XP093115352, ISSN: 2211-3835, DOI: 10.1016/j.apsb.2023.03.017
Attorney, Agent or Firm:
BEIJING CEMO LEADER INTELLECTUAL PROPERTY AGENCY (CN)
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