Title:
SYNTHESIS GENES FOR SESQUITERPENE POLYKETONE, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/232124
Kind Code:
A1
Abstract:
Provided are genes having a key effect on isopentenyl chain cyclization and post-translational modification in biosynthesis of sesquiterpene polyketone compounds, and respectively named as myrD, myrF, myrJ, and myrK, and polypeptides encoded by the genes. Also provided is a use of the polypeptides in biosynthesis of the sesquiterpene polyketone compounds.
More Like This:
Inventors:
GAO HAO (CN)
HU DAN (CN)
CHEN GUODONG (CN)
LV JIANMING (CN)
WANG CHUANXI (CN)
LI SHAOYANG (CN)
XIE CHAO (CN)
HU DAN (CN)
CHEN GUODONG (CN)
LV JIANMING (CN)
WANG CHUANXI (CN)
LI SHAOYANG (CN)
XIE CHAO (CN)
Application Number:
PCT/CN2023/097905
Publication Date:
December 07, 2023
Filing Date:
June 01, 2023
Export Citation:
Assignee:
UNIV JINAN (CN)
International Classes:
C12N9/02; C12N9/88; C12N15/53; C12N15/60; C12N15/80; C12P7/24; C12R1/69
Foreign References:
| CN114940980A | 2022-08-26 | |||
| US20160319251A1 | 2016-11-03 |
Other References:
JUNYA TAKINO ET AL.: "Unveiling Biosynthesis of the Phytohormone Abscisic Acid in Fungi: Unprecedented Mechanism of Core Scaffold Formation Catalyzed by an Unusual Sesquiterpene Synthase", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 140, no. 39, 18 September 2018 (2018-09-18), XP055886239
DONG JIAYU, LI MIN, XIAO ZONGHUA, HU MING, MATSUDA YUDAI, WANG WEIGUANG: "Recent advances in heterologous production of natural products using Aspergillus oryzae", SYNTHETIC BIOLOGY JOURNAL, vol. 3, no. 6, 1 January 2022 (2022-01-01), pages 1126 - 1149, XP093115348, DOI: 10.12211/2096-8280.2022-007
LIN, FULONG ET AL.: "Mechanistic Characterization of the Fusicoccane-type Diterpene Synthase for Myrothec-15(17)-en-7-ol", ACS CATALYSIS, vol. 10, no. 7, 18 March 2020 (2020-03-18), XP093115349
DONG JIAYU, LI MIN, XIAO ZONGHUA, HU MING, MATSUDA YUDAI, WANG WEIGUANG: "Recent advances in heterologous production of natural products using Aspergillus oryzae", SYNTHETIC BIOLOGY JOURNAL, vol. 3, no. 6, 1 January 2022 (2022-01-01), pages 1126 - 1149, XP093115348, DOI: 10.12211/2096-8280.2022-007
LIN, FULONG ET AL.: "Mechanistic Characterization of the Fusicoccane-type Diterpene Synthase for Myrothec-15(17)-en-7-ol", ACS CATALYSIS, vol. 10, no. 7, 18 March 2020 (2020-03-18), XP093115349
Attorney, Agent or Firm:
BEIJING CEMO LEADER INTELLECTUAL PROPERTY AGENCY (CN)
Download PDF: