Title:
USE OF SESQUITERPENE POLYKETONE COMPOUND FOR PREVENTING AND TREATING PULMONARY ARTERIAL HYPERTENSION
Document Type and Number:
WIPO Patent Application WO/2023/232126
Kind Code:
A1
Abstract:
The present invention relates to use of a sesquiterpene polyketone compound and a salt thereof for preventing and treating pulmonary arterial hypertension. A biological activity experiment shows that the compound can reverse pulmonary vasculature reconstruction and is used for treating pulmonary arterial hypertension.
Inventors:
WANG CHEN (CN)
GAO HAO (CN)
YIN ZHINAN (CN)
WANG LEI (CN)
WANG CHUANXI (CN)
TANG XIN (CN)
LIU JIE (CN)
YAO XINSHENG (CN)
YANG HENGWEN (CN)
WANG WANG (CN)
HU DAN (CN)
LI ZHENHUA (CN)
KUANG RUNQIAO (CN)
REN FEIFEI (CN)
HAN XUE (CN)
GAO HAO (CN)
YIN ZHINAN (CN)
WANG LEI (CN)
WANG CHUANXI (CN)
TANG XIN (CN)
LIU JIE (CN)
YAO XINSHENG (CN)
YANG HENGWEN (CN)
WANG WANG (CN)
HU DAN (CN)
LI ZHENHUA (CN)
KUANG RUNQIAO (CN)
REN FEIFEI (CN)
HAN XUE (CN)
Application Number:
PCT/CN2023/097907
Publication Date:
December 07, 2023
Filing Date:
June 01, 2023
Export Citation:
Assignee:
UNIV JINAN (CN)
CHINESE ACAD OF MEDICAL SCIENCES (CN)
CHINESE ACAD OF MEDICAL SCIENCES (CN)
International Classes:
A61K31/11; A61P9/12; A61P11/00; C12P7/24; C12R1/645
Domestic Patent References:
| WO2021254697A1 | 2021-12-23 |
Foreign References:
| CN114796171A | 2022-07-29 | |||
| CN114956974A | 2022-08-30 | |||
| CN115040507A | 2022-09-13 | |||
| US20170290819A1 | 2017-10-12 | |||
| CN108947859A | 2018-12-07 | |||
| CN101357144A | 2009-02-04 | |||
| US20210260013A1 | 2021-08-26 | |||
| CN113248524A | 2021-08-13 |
Other References:
TANG XIN, WANG CHUANXI, WANG LEI, REN FEIFEI, KUANG RUNQIAO, LI ZHENHUA, HAN XUE, CHEN YIMING, CHEN GUODONG, WU XIUQING, LIU JIE, : "Aureane-type sesquiterpene tetraketides as a novel class of immunomodulators with interleukin-17A inhibitory activity", ACTA PHARMACEUTICA SINICA B, vol. 13, no. 9, 1 September 2023 (2023-09-01), pages 3930 - 3944, XP093115352, ISSN: 2211-3835, DOI: 10.1016/j.apsb.2023.03.017
邝润桥 (KUANG, RUNQIAO): "一株湿地来源漆斑属真菌次生代谢产物研究 (Non-official translation: Study on Secondary Metabolites of a Strain of Wetland Myrothecium Fungi)", 暨南大学硕士学位论文 (MASTER'S DISSERTATION OF JINAN UNIVERSITY), 18 December 2018 (2018-12-18)
邝润桥 (KUANG, RUNQIAO): "一株湿地来源漆斑属真菌次生代谢产物研究 (Non-official translation: Study on Secondary Metabolites of a Strain of Wetland Myrothecium Fungi)", 暨南大学硕士学位论文 (MASTER'S DISSERTATION OF JINAN UNIVERSITY), 18 December 2018 (2018-12-18)
Attorney, Agent or Firm:
BEIJING CEMO LEADER INTELLECTUAL PROPERTY AGENCY (CN)
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