Title:
USE OF SMAD3 INHIBITOR IN THE TREATMENT OF FIBROSIS DEPENDENT ON EPITHELIAL TO MESENCHYMAL TRANSITION AS IN THE EYE AND KIDNEY
Document Type and Number:
WIPO Patent Application WO2004064770
Kind Code:
A3
Abstract:
The invention is related to inhibition of Smad3 to ameliorate Smad3 mediated epithelial to mesenchymal transition.
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Inventors:
ROBERTS ANITA (US)
SAIKA SHIZUYA (JP)
OOSHIMA AKIRA (JP)
SAIKA SHIZUYA (JP)
OOSHIMA AKIRA (JP)
Application Number:
PCT/US2004/003563
Publication Date:
September 15, 2005
Filing Date:
January 16, 2004
Export Citation:
Assignee:
US GOV HEALTH & HUMAN SERV (US)
ROBERTS ANITA (US)
SAIKA SHIZUYA (JP)
OOSHIMA AKIRA (JP)
ROBERTS ANITA (US)
SAIKA SHIZUYA (JP)
OOSHIMA AKIRA (JP)
International Classes:
C07K5/00; G01N33/50; G01N33/53; A61K; (IPC1-7): G01N33/53; C07K5/00
Other References:
KALLURI R. ET AL.: "Epithelial-mesenchymal transition and its implications for fibrosis.", JOURNAL OF CLINICAL INVESTIGATION., vol. 112, no. 12, 2003, pages 1776 - 1784, XP002988689
SAIKA S. ET AL.: "Smad3 signalin is required for epithelial-mesenchymal transition of lens epithelium after injury.", AMERICAN JOURNAL OF PATHOLOGY., vol. 164, no. 2, 2004, pages 651 - 663, XP002988690
SAIKA S. ET AL.: "Smad3 signalin is required for epithelial-mesenchymal transition of lens epithelium after injury.", AMERICAN JOURNAL OF PATHOLOGY., vol. 164, no. 2, 2004, pages 651 - 663, XP002988690
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