USE OF TRANS AMANTADINE DERIVATIVE OR SALT THEREOF

WIPO Patent Application WO/2022/193369

A1

The present invention relates to the technical field of pharmaceutical chemistry. Disclosed is a use of a trans amantadine derivative having a structure as represented by formula I or a pharmaceutically acceptable salt thereof in the preparation of drugs for preventing or/and treating respiratory diseases. The trans amantadine derivative of the present invention and the salt thereof have better efficacy with respect to ambroxol hydrochloride and an amantadine hydrochloride derivative mixture (an isomer mixture). By means of an acute lung injury test in a mouse and a mouse cough model induced by ammonia, it is shown that the drug has an excellent effect of treating lung injury and cough, the effect is better than that of ambroxol hydrochloride and the amantadine hydrochloride derivative mixture, and drug has statistical significance. Compared with ambroxol hydrochloride, the trans adamantane derivative and hydrochloride thereof can significantly increase the sputum excretion of a rat, and can significantly increase the phenolsulfonphthalein excretion of the mouse, and the effects are better than those of ambroxol hydrochloride and the amantadine hydrochloride derivative mixture.

JPS5697236	MANUFACTURE OF ORGANIC COMPOUND
WO/2018/062162	DETECTION METHOD AND DETECTION KIT FOR COMPOUND CONTAINING FORMYL DEHYDROPIPERIDINE STRUCTURE

MOU XIA (CN)
DONG BO (CN)
ZHANG HAI (CN)
ZENG YANQUN (CN)
XU XIA (CN)
JINAG JIE (CN)

PCT/CN2021/084409

September 22, 2022

March 31, 2021

Click for automatic bibliography generation  

CHENGDU SHIBEIKANG BIOMEDICAL TECH CO LTD (CN)

C07C211/52; A61K31/137; A61P11/00; A61P11/10; A61P11/14; C07C209/52; C07C213/02; C07C215/44; C07C249/02; C07C251/24

CN112279774A	2021-01-29
CN201910671508A	2019-07-24

XU, SHEN: "氨溴索的临床应用进展 Advances in Clinical Application of Ambroxol", JOURNAL OF CLINICAL PULMONARY MEDICINE, vol. 14, no. 8, 1 August 2009 (2009-08-01), pages 1053 - 1055, XP055967936
YAO, JIAN: "Therapeutic Effect of Domestic Ambroxol Hydrochloride and Sodium Chlorid Injection", JOURNAL OF CLINICAL PULMONARY MEDICINE, vol. 12, no. 01, 8 January 2007 (2007-01-08), pages 17 - 18, XP055967941
ZHOU, XINMING ， 。 ，: "Clinical effect of different doses of Ambroxol in the treatment of postop- erative acute lung injury", CHINA MODERN MEDICINE, vol. 12, no. 26, 1 December 2019 (2019-12-01), XP055967946
LI, SHUDI: " Effects of Ambroxol Hydrochloride on Coughing and Serum Levels of CRP, IL-6, and TNF-α in Children with Pneumonia", MODERN MEDICINE AND HEALTH RESEARCH, vol. 4, no. 3, 31 December 2020 (2020-12-31), XP055967951

CHENGDU JIUDING TIANYUAN INTELLECTUAL PROPERTY AGENCY LTD. (CN)

View/Download PDF      PDF Help

Previous Patent: TRANS-AMANTADINE DERIVATIVE OR SALT THEREOF, AND PREPARATION METHOD THEREFOR, COMPOSITION THEREOF AN...

Next Patent: CAPACITOR AND POWER DEVICE ASSEMBLY HAVING COOLING STRUCTURE