Title:
VARIANT NEURODEGENERATIVE DISEASE-ASSOCIATED PROTEIN
Document Type and Number:
WIPO Patent Application WO/2023/210405
Kind Code:
A1
Abstract:
This variant neurodegenerative disease-associated protein comprises an amino acid sequence in which one or several amino acids present in a region of interaction between two protofilaments (PF) among the amino acid sequences of the neurodegenerative disease-associated protein are deleted, substituted or added, and has a reduced activity of seeds serving as a core of an aggregate of said protein.
Inventors:
NONAKA TAKASHI (JP)
Application Number:
PCT/JP2023/015155
Publication Date:
November 02, 2023
Filing Date:
April 14, 2023
Export Citation:
Assignee:
TOKYO METROPOLITAN INST MEDICAL SCIENCE (JP)
International Classes:
C12N15/12; A01K67/027; A61K35/76; A61K38/17; A61K39/00; A61K48/00; A61P25/16; A61P25/28; A61P37/04; C07K14/47; C07K16/18; C12N5/10; C12N15/63; C12Q1/02
Domestic Patent References:
| WO2007066809A1 | 2007-06-14 |
Foreign References:
| JP2011518874A | 2011-06-30 | |||
| JP2007209227A | 2007-08-23 |
Other References:
BRACZYNSKI ANNE K., SCHULZ JÖRG B., BACH JAN‐PHILIPP: "Vaccination strategies in tauopathies and synucleinopathies", JOURNAL OF NEUROCHEMISTRY, WILEY-BLACKWELL PUBLISHING LTD., GB, vol. 143, no. 5, 1 December 2017 (2017-12-01), GB , pages 467 - 488, XP093100484, ISSN: 0022-3042, DOI: 10.1111/jnc.14207
JULIANE ADLER; MONIKA BAUMANN; BRUNO VOIGT; HOLGER A. SCHEIDT; DEBANJAN BHOWMIK; TILMANN HÄUPL; BERND ABEL; PERUNTHIRUTHY K. MADHU: "A Detailed Analysis of the Morphology of Fibrils of Selectively Mutated Amyloid β (1–40)", CHEMPHYSCHEM, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 17, no. 17, 27 June 2016 (2016-06-27), DE , pages 2744 - 2753, XP072154946, ISSN: 1439-4235, DOI: 10.1002/cphc.201600413
JULIANE ADLER; MONIKA BAUMANN; BRUNO VOIGT; HOLGER A. SCHEIDT; DEBANJAN BHOWMIK; TILMANN HÄUPL; BERND ABEL; PERUNTHIRUTHY K. MADHU: "A Detailed Analysis of the Morphology of Fibrils of Selectively Mutated Amyloid β (1–40)", CHEMPHYSCHEM, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 17, no. 17, 27 June 2016 (2016-06-27), DE , pages 2744 - 2753, XP072154946, ISSN: 1439-4235, DOI: 10.1002/cphc.201600413
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
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