Title:
VASCULAR FLEXIBILITY IMPROVING COMPOSITION, VASCULAR ENDOTHELIAL FUNCTION IMPROVING COMPOSITION, PLATELET AGGREGATION INHIBITORY COMPOSITION, BLOOD FLOW IMPROVING COMPOSITION, AND ORAL COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2023/188320
Kind Code:
A1
Abstract:
The present invention relates to a composition comprising (A) catechin and (B) procyanidin B3, the composition being characterized in that the mass ratio [(A)/(B)] of the content of the component (A) to the content of the component (B) in the composition is 0.60 to 15 inclusive. The composition according to the present invention has excellent vascular flexibility improving action, vascular endothelial function improving action, blood flow improving action, and platelet aggregation inhibitory action, and can be used as a vascular flexibility improving composition, a vascular endothelial function improving composition, a blood flow improving composition, and a platelet aggregation inhibitory composition.
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Inventors:
MOTOOKA KANA (JP)
UENO SHIORI (JP)
KAMIYA TOMOYASU (JP)
UENO SHIORI (JP)
KAMIYA TOMOYASU (JP)
Application Number:
PCT/JP2022/016683
Publication Date:
October 05, 2023
Filing Date:
March 31, 2022
Export Citation:
Assignee:
TOYO SHINYAKU CO LTD (JP)
International Classes:
A23L33/105; A61K31/353; A61P7/02; A61P9/00; A61P43/00
Foreign References:
| US20100047372A1 | 2010-02-25 | |||
| JP7055507B1 | 2022-04-18 |
Other References:
GHISELLI A., ET AL.: "ANTIOXIDANT ACTIVITY OF DIFFERENT PHENOLIC FRACTIONS SEPARATED FROMAN ITALIAN RED WINE.", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 46, no. 02, 1 February 1998 (1998-02-01), US , pages 361 - 367, XP000741721, ISSN: 0021-8561, DOI: 10.1021/jf970486b
QUIÑONES M., GUERRERO L., FERNÁNDEZ-VALLINAS S., PONS Z., AROLA L., ALEIXANDRE A., MUGUERZA B.: "Involvement of nitric oxide and prostacyclin in the antihypertensive effect of low-molecular-weight procyanidin rich grape seed extract in male spontaneously hypertensive rats", JOURNAL OF FUNCTIONAL FOODS, ELSEVIER BV, NL, vol. 6, 1 January 2014 (2014-01-01), NL , pages 419 - 427, XP093097771, ISSN: 1756-4646, DOI: 10.1016/j.jff.2013.11.008
MOINI HADI, GUO QIONG, PACKER LESTER: "Enzyme Inhibition and Protein-Binding Action of the Procyanidin-Rich French Maritime Pine Bark Extract, Pycnogenol: Effect on Xanthine Oxidase", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 48, no. 11, 1 November 2000 (2000-11-01), US , pages 5630 - 5639, XP093097772, ISSN: 0021-8561, DOI: 10.1021/jf000618s
DONOVAN J L, ET AL: "Procyanidins are not bioavailable in rats fed a single meal containing a grapeseed extract or the procyanidin dimer B3", BRITISH JOURNAL OF NUTRITION, UK, vol. 87, no. 4, 1 January 2002 (2002-01-01), UK , pages 299 - 306, XP002583532, ISSN: 0007-1145, DOI: 10.1079/BJNBJN2001517
QUIÑONES M., GUERRERO L., FERNÁNDEZ-VALLINAS S., PONS Z., AROLA L., ALEIXANDRE A., MUGUERZA B.: "Involvement of nitric oxide and prostacyclin in the antihypertensive effect of low-molecular-weight procyanidin rich grape seed extract in male spontaneously hypertensive rats", JOURNAL OF FUNCTIONAL FOODS, ELSEVIER BV, NL, vol. 6, 1 January 2014 (2014-01-01), NL , pages 419 - 427, XP093097771, ISSN: 1756-4646, DOI: 10.1016/j.jff.2013.11.008
MOINI HADI, GUO QIONG, PACKER LESTER: "Enzyme Inhibition and Protein-Binding Action of the Procyanidin-Rich French Maritime Pine Bark Extract, Pycnogenol: Effect on Xanthine Oxidase", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 48, no. 11, 1 November 2000 (2000-11-01), US , pages 5630 - 5639, XP093097772, ISSN: 0021-8561, DOI: 10.1021/jf000618s
DONOVAN J L, ET AL: "Procyanidins are not bioavailable in rats fed a single meal containing a grapeseed extract or the procyanidin dimer B3", BRITISH JOURNAL OF NUTRITION, UK, vol. 87, no. 4, 1 January 2002 (2002-01-01), UK , pages 299 - 306, XP002583532, ISSN: 0007-1145, DOI: 10.1079/BJNBJN2001517
Attorney, Agent or Firm:
SHOWA INTERNATIONAL PATENT FIRM (JP)
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