Title:
VECTOR, RECOMBINANT VERTEBRATE CELL TO WHICH VECTOR IS INTRODUCED, METHOD FOR PRODUCING SAME, AND METHOD FOR PRODUCING TARGET PROTEIN
Document Type and Number:
WIPO Patent Application WO/2022/163653
Kind Code:
A1
Abstract:
The present invention enhances the amount of a protein produced in a cell. Provided is a vector including an exogenous gene sequence that encodes a target protein expressibly linked downstream of the 3' side of a gene sequence that is upstream of the 5' side of an mRNA transcription region in an IER3 gene of a vertebrate cell, the gene sequence including a promoter region sequence.
Inventors:
ICHIMURA NAOYA (JP)
Application Number:
PCT/JP2022/002696
Publication Date:
August 04, 2022
Filing Date:
January 25, 2022
Export Citation:
Assignee:
ZEON CORP (JP)
International Classes:
C12N5/10; C12N15/11; C12N15/85; C12P21/02
Domestic Patent References:
| WO2006017741A2 | 2006-02-16 | |||
| WO2015199119A1 | 2015-12-30 |
Other References:
ARLT A; MINKENBERG J; KOCS B; GROSSMANN M; KRUSE M-L; FÖLSCH U R; SCHÄFER H: "The expression of immediate early gene X-1 (IEX-1) is differentially induced by retinoic acids in NB4 and KG1 cells: possible implication in the distinct phenotype of retinoic acid-responsive and -resistant leukemic cells", LEUKEMIA, NATURE PUBLISHING GROUP UK, LONDON, vol. 18, no. 10, 12 August 2004 (2004-08-12), London, pages 1646 - 1655, XP037779795, ISSN: 0887-6924, DOI: 10.1038/sj.leu.2403481
IM HEE-JEONG; CRAIG THEODORE A; PITTELKOW MARK R; KUMAR RAJIV: "Characterization of a novel hexameric repeat DNA sequence in the promoter of the immediate early gene, IEX-1, that mediates 1α,25-dihydroxyvitamin D3-associated IEX-1 gene repression", ONCOGENE, NATURE PUBLISHING GROUP UK, LONDON, vol. 21, no. 23, 23 May 2002 (2002-05-23), London , pages 3706 - 3714, XP037737702, ISSN: 0950-9232, DOI: 10.1038/sj.onc.1205450
HUANG YAN-HONG; WU JIM YUJIN; ZHANG YUJIN; WU MEI X: "Synergistic and opposing regulation of the stress-responsive gene IEX-1 by p53, c-Myc, and multiple NF-κB/rel complexes", ONCOGENE, NATURE PUBLISHING GROUP UK, LONDON, vol. 21, no. 44, 2 October 2002 (2002-10-02), London , pages 6819 - 6828, XP037736535, ISSN: 0950-9232, DOI: 10.1038/sj.onc.1205854
KOCHAN JAKUB, WAWRO MATEUSZ, KOLKA AGNIESZKA, MACZUGA PIOTR, KASZA ANETA: "Transcription factor Elk-1 participates in the interleukin-1β-dependent regulation of expression of immediate early response gene 3 (IER3)", CYTOKINE, ACADEMIC PRESS LTD, PHILADELPHIA, PA, US, vol. 70, no. 2, 1 December 2014 (2014-12-01), US , pages 120 - 125, XP055954321, ISSN: 1043-4666, DOI: 10.1016/j.cyto.2014.06.021
SOLECKA ALEKSANDRA, WIELENTO ALEKSANDRA, JURCZAK JOANNA, SOWIŃSKA WERONIKA, WAWRO MATEUSZ, KASZA ANETA: "Influence of the reporter vector backbone on 2-deoxyglucose dependent promoter activation", ACTA BIOCHIMICA POLONICA, POLSKIE TOWARZYSTWO BIOCHEMICZNE, PL, PL , XP055954336, ISSN: 0001-527X, DOI: 10.18388/abp.2020_5356
JUNG M; DIMTCHEV A; VELENA A; DRITSCHILO A: "Combining radiation therapy with interstitial radiation-inducible TNF-α expression for locoregional cancer treatment", CANCER GENE THERAPY, NATURE PUBLISHING GROUP US, NEW YORK, vol. 18, no. 3, 5 November 2010 (2010-11-05), New York, pages 189 - 195, XP037762127, ISSN: 0929-1903, DOI: 10.1038/cgt.2010.69
DATABASE GenBank NCBI; . : "Predicted: Cricetulus griseus immediate early response 3 (Ier3) , mRNA", XP055954346
IM HEE-JEONG; CRAIG THEODORE A; PITTELKOW MARK R; KUMAR RAJIV: "Characterization of a novel hexameric repeat DNA sequence in the promoter of the immediate early gene, IEX-1, that mediates 1α,25-dihydroxyvitamin D3-associated IEX-1 gene repression", ONCOGENE, NATURE PUBLISHING GROUP UK, LONDON, vol. 21, no. 23, 23 May 2002 (2002-05-23), London , pages 3706 - 3714, XP037737702, ISSN: 0950-9232, DOI: 10.1038/sj.onc.1205450
HUANG YAN-HONG; WU JIM YUJIN; ZHANG YUJIN; WU MEI X: "Synergistic and opposing regulation of the stress-responsive gene IEX-1 by p53, c-Myc, and multiple NF-κB/rel complexes", ONCOGENE, NATURE PUBLISHING GROUP UK, LONDON, vol. 21, no. 44, 2 October 2002 (2002-10-02), London , pages 6819 - 6828, XP037736535, ISSN: 0950-9232, DOI: 10.1038/sj.onc.1205854
KOCHAN JAKUB, WAWRO MATEUSZ, KOLKA AGNIESZKA, MACZUGA PIOTR, KASZA ANETA: "Transcription factor Elk-1 participates in the interleukin-1β-dependent regulation of expression of immediate early response gene 3 (IER3)", CYTOKINE, ACADEMIC PRESS LTD, PHILADELPHIA, PA, US, vol. 70, no. 2, 1 December 2014 (2014-12-01), US , pages 120 - 125, XP055954321, ISSN: 1043-4666, DOI: 10.1016/j.cyto.2014.06.021
SOLECKA ALEKSANDRA, WIELENTO ALEKSANDRA, JURCZAK JOANNA, SOWIŃSKA WERONIKA, WAWRO MATEUSZ, KASZA ANETA: "Influence of the reporter vector backbone on 2-deoxyglucose dependent promoter activation", ACTA BIOCHIMICA POLONICA, POLSKIE TOWARZYSTWO BIOCHEMICZNE, PL, PL , XP055954336, ISSN: 0001-527X, DOI: 10.18388/abp.2020_5356
JUNG M; DIMTCHEV A; VELENA A; DRITSCHILO A: "Combining radiation therapy with interstitial radiation-inducible TNF-α expression for locoregional cancer treatment", CANCER GENE THERAPY, NATURE PUBLISHING GROUP US, NEW YORK, vol. 18, no. 3, 5 November 2010 (2010-11-05), New York, pages 189 - 195, XP037762127, ISSN: 0929-1903, DOI: 10.1038/cgt.2010.69
DATABASE GenBank NCBI; . : "Predicted: Cricetulus griseus immediate early response 3 (Ier3) , mRNA", XP055954346
Attorney, Agent or Firm:
SUGIMURA Kenji (JP)
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