Title:
VIRUS VECTOR AND CANCER CELL PROLIFERATION INHIBITOR COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2023/234143
Kind Code:
A1
Abstract:
The virus vector according to the present invention is formed such that a full length cDNA with a stop codon of Kras is introduced into the first exon of Kras of a human cell genome DNA, in order to provide a virus vector capable of inhibiting progression of cancer cells by directly editing a genome of cancer cells to repair a gene function.
Inventors:
YOSHIDA TADASHI (JP)
HIROTA NORIFUMI (JP)
HIROTA NORIFUMI (JP)
Application Number:
PCT/JP2023/019342
Publication Date:
December 07, 2023
Filing Date:
May 24, 2023
Export Citation:
Assignee:
HIKARI BIO INC (JP)
International Classes:
C12N15/86; A61K35/76; A61K38/46; A61P35/00; C12N15/09; C12N15/12
Domestic Patent References:
| WO2021217100A1 | 2021-10-28 |
Foreign References:
| EP2522726A1 | 2012-11-14 | |||
| JPH07500241A | 1995-01-12 | |||
| CN111876421A | 2020-11-03 | |||
| JP2022521183A | 2022-04-06 |
Other References:
CHIRA, S. et al. Restoring the p53 'Guardian' Phenotype in p53-Deficient Tumor Cells with CRISPR/Cas9. Trends in Biotechnology. 2018, vol. 36, no. 7, pp. 653-660
ZHANG, L. et al. Multiple Roles of APC and its Therapeutic Implications in Colorectal Cancer. J. Natl. Cancer Inst. 2017, vol. 109, no. 8, djw332
ZHANG, L. et al. Multiple Roles of APC and its Therapeutic Implications in Colorectal Cancer. J. Natl. Cancer Inst. 2017, vol. 109, no. 8, djw332
Attorney, Agent or Firm:
TANAKA Sadatsugu et al. (JP)
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