Title:
WATER-SOLUBLE POLYMER CONJUGATES OF TRIAZINE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO2002043772
Kind Code:
A3
Abstract:
The present invention provides water-soluble polymer conjugates of triazine derivatives using water soluble and non-peptidic polymer backbones, such as polyethylene glycol. The invention includes conjugates made using mPEG, bifunctional PEG, branched or multi-arm PEG, and forked PEG. The invention further includes a method of forming such conjugates and a method of treating conditions responsive to triazine derivatives using the conjugates.
Inventors:
BENTLEY MICHAEL DAVID (US)
ZHAO XUAN (US)
SHORR ROBERT (US)
ZHAO XUAN (US)
SHORR ROBERT (US)
Application Number:
PCT/US2001/044944
Publication Date:
July 31, 2003
Filing Date:
November 30, 2001
Export Citation:
Assignee:
SHEARWATER CORP (US)
BENTLEY MICHAEL DAVID (US)
ZHAO XUAN (US)
SHORR ROBERT (US)
CORNERSTONE PHARMACEUTICALS IN (US)
BENTLEY MICHAEL DAVID (US)
ZHAO XUAN (US)
SHORR ROBERT (US)
CORNERSTONE PHARMACEUTICALS IN (US)
International Classes:
C07D251/52; A61K31/53; A61K31/787; A61K47/48; A61P35/00; C07D251/70; C08F8/30; C08G85/00; (IPC1-7): A61K47/48
Domestic Patent References:
WO2001048052A1 | 2001-07-05 |
Foreign References:
US4640835A | 1987-02-03 | |||
FR2515684A1 | 1983-05-06 | |||
JPS57192435A | 1982-11-26 | |||
JPS57212172A | 1982-12-27 | |||
JPS57118789A | 1982-07-23 | |||
JPS5911180A | 1984-01-20 |
Other References:
LUBCZAK J: "(Hydroxymethyl)melamine-oxirane derived polyetherols - Application of kinetic studies to prediction of synthesis conditions", REACTIVE & FUNCTIONAL POLYMERS, ELSEVIER SCIENCE PUBLISHERS BV, NL, vol. 38, no. 1, 1 September 1998 (1998-09-01), pages 51 - 59, XP004147135, ISSN: 1381-5148
GIBSON M ET AL: "DEVELOPMENT OF A PARENTERAL FORMULATION OF TRIMELAMOL A SYNTHETIC S TRIAZINE CARBINOLAMINE-CONTAINING CYTOTOXIC AGENT", JOURNAL OF PARENTERAL SCIENCE AND TECHNOLOGY, vol. 44, no. 6, 1990, pages 306 - 313, XP008009089, ISSN: 0279-7976
GREENWALD R B ET AL: "Drug delivery systems employing 1,4- or 1,6-elimination: poly(ethylene glycol) prodrugs of amine-containing compounds", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 42, September 1999 (1999-09-01), pages 3657 - 3667, XP002184836, ISSN: 0022-2623
GREENWALD R B ET AL: "POLY(ETHYLENE GLYCOL) CONJUGATED DRUGS AND PRODRUGS: A COMPREHENSIVE REVIEW", CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS, XX, XX, vol. 17, no. 2, 2000, pages 101 - 161, XP001020454, ISSN: 0743-4863
GRAHN M F ET AL: "mTHPC polymer conjugates: The in vivo photodynamic activity of four candidate compounds.", LASERS IN MEDICAL SCIENCE, vol. 14, no. 1, 1999, pages 40 - 46, XP001115028, ISSN: 0268-8921
COLEY HELEN M: "N-(Hydroxymethyl) melamines.", GENERAL PHARMACOLOGY, vol. 28, no. 2, 1997, pages 177 - 182, XP001115029, ISSN: 0306-3623
BEIJNEN J H ET AL: "CRC/EORTC/NCI Joint Formulation Working Party: Experiences in the formulation of investigational cytotoxic drugs.", BRITISH JOURNAL OF CANCER, vol. 72, no. 1, 1995, pages 210 - 218, XP008009087, ISSN: 0007-0920
COLEY H M ET AL: "Stable analogues of the antitumour agent trimelamol retain in vitro cytotoxicity in drug-sensitive and resistant rodent and human cell lines.", EUROPEAN JOURNAL OF CANCER, vol. 30A, no. 12, 1994, pages 1827 - 1836, XP008009088, ISSN: 0959-8049
JACKSON C ET AL: "STUDIES ON THE STABILITY OF TRIMELAMOL, A CARBINOLAMINE-CONTAINING ANTITUMOR DRUG", JOURNAL OF PHARMACEUTICAL SCIENCES, AMERICAN PHARMACEUTICAL ASSOCIATION. WASHINGTON, US, vol. 80, no. 3, March 1991 (1991-03-01), pages 245 - 251, XP001037642, ISSN: 0022-3549
GIBSON M ET AL: "DEVELOPMENT OF A PARENTERAL FORMULATION OF TRIMELAMOL A SYNTHETIC S TRIAZINE CARBINOLAMINE-CONTAINING CYTOTOXIC AGENT", JOURNAL OF PARENTERAL SCIENCE AND TECHNOLOGY, vol. 44, no. 6, 1990, pages 306 - 313, XP008009089, ISSN: 0279-7976
GREENWALD R B ET AL: "Drug delivery systems employing 1,4- or 1,6-elimination: poly(ethylene glycol) prodrugs of amine-containing compounds", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 42, September 1999 (1999-09-01), pages 3657 - 3667, XP002184836, ISSN: 0022-2623
GREENWALD R B ET AL: "POLY(ETHYLENE GLYCOL) CONJUGATED DRUGS AND PRODRUGS: A COMPREHENSIVE REVIEW", CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS, XX, XX, vol. 17, no. 2, 2000, pages 101 - 161, XP001020454, ISSN: 0743-4863
GRAHN M F ET AL: "mTHPC polymer conjugates: The in vivo photodynamic activity of four candidate compounds.", LASERS IN MEDICAL SCIENCE, vol. 14, no. 1, 1999, pages 40 - 46, XP001115028, ISSN: 0268-8921
COLEY HELEN M: "N-(Hydroxymethyl) melamines.", GENERAL PHARMACOLOGY, vol. 28, no. 2, 1997, pages 177 - 182, XP001115029, ISSN: 0306-3623
BEIJNEN J H ET AL: "CRC/EORTC/NCI Joint Formulation Working Party: Experiences in the formulation of investigational cytotoxic drugs.", BRITISH JOURNAL OF CANCER, vol. 72, no. 1, 1995, pages 210 - 218, XP008009087, ISSN: 0007-0920
COLEY H M ET AL: "Stable analogues of the antitumour agent trimelamol retain in vitro cytotoxicity in drug-sensitive and resistant rodent and human cell lines.", EUROPEAN JOURNAL OF CANCER, vol. 30A, no. 12, 1994, pages 1827 - 1836, XP008009088, ISSN: 0959-8049
JACKSON C ET AL: "STUDIES ON THE STABILITY OF TRIMELAMOL, A CARBINOLAMINE-CONTAINING ANTITUMOR DRUG", JOURNAL OF PHARMACEUTICAL SCIENCES, AMERICAN PHARMACEUTICAL ASSOCIATION. WASHINGTON, US, vol. 80, no. 3, March 1991 (1991-03-01), pages 245 - 251, XP001037642, ISSN: 0022-3549
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