Title:
CONJUGATES OF GLYCOSYLATED/GALACTOSYLATED PEPTIDE
Document Type and Number:
WIPO Patent Application WO2002043771
Kind Code:
A9
Abstract:
A conjugate of formula A-L-P, in which: A represents a glycosylated/galactosylated peptide that binds to a cell-surface receptor, L represents a bifunctional linker, which does not comprise a naturally occurring amino acid and is covalently bonded to A and P in a regiospecific manner, and P represents a monomer, homopolymer or heteropolymer comprising at least one nucleotide or an analogue thereof, which inhibits the intracellular biosynthesis of nucleotides or nucleic acids in a sequence-independent manner, wherein either or both of the covalent bond between A and L and the covalent bond between L and P can be cleaved intracellularly; a composition comprising such a conjugate; and a method of inhibiting a abnormal cellular proliferation in a mammal; and a method of inhibiting replication of a virus in a mammal.
Inventors:
TS O PAUL O P (US)
DUFF ROBERT (US)
DEAMOND SCOTT (US)
DUFF ROBERT (US)
DEAMOND SCOTT (US)
Application Number:
PCT/US2001/044943
Publication Date:
April 29, 2004
Filing Date:
November 30, 2001
Export Citation:
Assignee:
CELL WORKS INC (US)
UNIV JOHNS HOPKINS (US)
TS O PAUL O P (US)
DUFF ROBERT (US)
DEAMOND SCOTT (US)
UNIV JOHNS HOPKINS (US)
TS O PAUL O P (US)
DUFF ROBERT (US)
DEAMOND SCOTT (US)
International Classes:
A61K31/7072; A61K38/00; A61K47/48; A61P1/16; A61P31/12; A61P31/14; A61P31/20; A61P35/00; C07K9/00; (IPC1-7): A61K47/48; A61K51/08
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