(Z)-STYRYL ACETOXYPHENYL SULFIDES AS CYCLOOXYGENASE INHIBITORS

Title:

(Z)-STYRYL ACETOXYPHENYL SULFIDES AS CYCLOOXYGENASE INHIBITORS

Document Type and Number:

WIPO Patent Application WO2000077169

Kind Code:

A3

Abstract:

Compounds of formula (I) are provided wherein R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen, halogen, hydroxyl, C1-C8 alkyl, C1-C6 alkoxy, nitro, cyano, acetoxy, amino, carboxy, sulfamyl, lower acylsulfamyl and trifluoromethyl. The compounds are inhibitors of cyclooxygenase-2 activity, useful for treating inflamation and cyclooxygenase-mediated disorders.

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Inventors:

REDDY E PREMKUMAR (US)
REDDY M V RAMANA (US)

Application Number:

PCT/US2000/016725

Publication Date:

July 05, 2001

Filing Date:

June 16, 2000

Export Citation:

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Assignee:

UNIV TEMPLE (US)
REDDY E PREMKUMAR (US)
REDDY M V RAMANA (US)

International Classes:

A61K31/215; A61K31/275; A61K31/31; C07C67/02; C07C69/02; C07C323/20; C07C381/00; (IPC1-7): A61K31/215; A61K31/275; A61K31/31; C07C67/02; C07C69/02; C07C381/00

Foreign References:

JPH093037A	1997-01-07
US6025353A	2000-02-15

Other References: