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JP3850870B2 |
A group of functionalized polyaminocarboxamide modified chelators, such as 1,4 7,10-tetraaza-1-N-(1-carboxy-3-(4-aminophenyl)propyl)-7-N-(1
-carboxymethyl)bis-4,10-N,N-(carboxamidomethyl)cyclododecane
and 1,4 7,10-tetraaza-1-N-(1-carbox...
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JP2006315958A |
To provide a method for producing a compound, in which an aromatic compound containing a radioactive halogen-substituted group is combined with an amine or phosphine, in a yield to stand practical use.The production method comprises dire...
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JP2006525279A |
The invention relates to a device and a process for nucleophilic fluorination of a substance, especially for synthesis of an 18F-labeled substance for examination using a positron emission tomograph. The device comprises an anion exchang...
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JP3839050B2 |
PCT No. PCT/SE95/01247 Sec. 371 Date Aug. 21, 1997 Sec. 102(e) Date Aug. 21, 1997 PCT Filed Oct. 20, 1995 PCT Pub. No. WO96/15086 PCT Pub. Date May 23, 1996The present invention discloses a method and an apparatus for high yield producti...
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JP3835831B2 |
PURPOSE: To provide novel compounds contg. a heteroatom-bearing bridge which have a bioactive group preferentially taken into hypoxia tissues of a specimen and provide a radioactive metal complex being useful as diagnostic and therapeuti...
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JP2006519777A |
The present invention encompasses a compound of Formula (I) useful as caspase active site probes. These probes can be used to determine whether a caspase has been activated, in cells or in tissues of animal models of various pathologies....
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JP2006516547A |
The present invention relates to Halogenated amino acid analogues for use in diagnosis, which compounds have the general formula wherein: R is (C1-C6)alkyl optionally substituted with thioether or ether oxygen atom when n=0, or a substit...
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JP3789972B2 |
To evaluate the oxygen addition activity by using a specific formula and detect a micro unstable material as an intermediate or product generating through reaction by introducing positron nuclear species as addition oxygen in the oxygen ...
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JP2006515835A |
The present invention relates to a radionuclide-labeled ethylenedicysteine (EC) derivative comprising a disease cell cycle targeting compound, wherein (i) the EC forms an N 2 S 2 chelate with the radionuclide, (ii) the disease cell cycle...
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JP2006137751A |
To provide a series of compounds useful for the diagnosis of thrombosis and embolism of vein and artery, or a site of infectious disease, and a medicinal preparation containing them and capable of performing the diagnosis of these diseas...
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JP3774238B2 |
This invention relates to calcitonin receptor binding reagents comprising compounds which are covalently linked to a radiometal chelator. The invention is embodied as calcitonin receptor binding peptide derivatives and analogues of calci...
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JP2006510686A |
The present invention concerns deuterated catecholamine derivatives as well as pharmaceuticals containing these compounds. In addition, the invention concerns the use of deuterated catecholamine derivatives as well as physiologically com...
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JP2006510709A |
The invention relates to a process for the production of an [18F]fluorohaloalkane which comprises treatment of a solid support-bound precursor of formula (I): SOLID SUPPORT-LINKER-SO2—O—(CH2)nX (I) wherein n is an integer of fro...
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JP2006510705A |
The invention provides a process for the production of an 18F-labelled tracer which comprises treatment of a solid support-bound precursor of formula (I) SOLID SUPPORT-LINKER-X-TRACER (I) wherein X is a group which promotes nucleoph...
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JP2006510706A |
A process for the production of an 18F-labelled tracer which comprises treatment of a solid support-bound precursor of formula (I): SOLID SUPPORT-LIKER-SO2-O-TRACER (I) with 18F- to produce the labelled tracer of formula (II).
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JP2006510707A |
The invention relates to a process for the production of an 18F-labelled tracer which comprises treatment of a solid support-bound precursor of formula (I): SOLID SUPPORT-LINKER-I+-TRACER (I) Y- wherein the TRACER is of formula (A): or a...
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JP2006070021A |
To provide compounds that are anandamide transport inhibitors, and to provide pharmacological use thereof.The inhibitor is an anandamide analog indicating tail, central and head pharmacophore portions represented by structural formula (I...
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JP3753383B2 |
To provide a method for labeling one or the two oxygen atoms of a carboxy group of a carboxylated compound with an oxygen isotope which is either oxygen of mass number 17 (17O) or oxygen of mass number 18 (18O). The method is characteriz...
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JP3754084B2 |
Human, swine and rat growth hormone secretagogue receptors have been isolated, cloned and sequenced. Growth hormone secretagogue receptors are new members of the G-protein family of receptors. The growth hormone secretagogue receptors ma...
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JP2006008591A |
To provide a new oxygen isotope-labeled organic carbonyl compound enabling elucidation of distribution of a complicate metabolic pathway or determination of minute substance in a living thing and to provide a method for efficiently produ...
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JP3732856B2 |
PCT No. PCT/DE95/00025 Sec. 371 Date Jul. 9, 1996 Sec. 102(e) Date Jul. 9, 1996 PCT Filed Jan. 10, 1995 PCT Pub. No. WO95/18668 PCT Pub. Date Jul. 13, 1995Ionizable or polarizable, carrier-free radionuclides may be separated by electrofi...
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JP2006500419A |
The invention provides a process for preparation of a fluorohaloalkane, preferably an [18F]fluorohaloalkane of formula (I) wherein X is halo and n is an integer of from 1 to 6; which comprises: reaction of the corresponding organosilicon...
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JP3728376B2 |
To obtain the subject new compound useful as a labeled compound for measuring positron emission tomography(PET). This compound is represented by formula I. The compound of formula I is obtained by synthesizing 11C labeled carbon dioxide ...
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JP2005343904A |
To provide a new cyclosporine derivative of a chemically substituted and deuterated analogue of cyclosporine A and a related cyclosporine.The cyclosporine derivative is disclosed which possesses enhanced efficacy and reduced toxicity ove...
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JP2005537226A |
The present invention provides isotopically labeled oxazinocarbazole derivatives having a ring connecting position 8 (C-8) and position 9 (N-9), and more specifically, provides compounds of formula (I) wherein R1, R2, R3 and R4 are descr...
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JP2005330202A |
To provide an α-haloacrylic acid derivative, especially an α-chloroacrylate deuteration product, useful for optical materials such as optical members, especially plastic optical fibers.This compound represented by the general formula (...
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JP2005320293A |
To provide a method for simply producing a 2-haloacrylic ester from an inexpensive material.The invention relates to the method for producing the 2-haloacrylic ester represented by formula (I) by reacting a halogenating agent to a 2-oxoc...
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JP2005314398A |
To provide a heavy-nitrogenized nitrobenzenesulfonamide derivative and an efficient production method thereof.The heavy-nitrogenized nitrobenzenesulfonamide compound is represented by general formula [2]. An amino group of the heavy-nitr...
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JP3701984B2 |
PURPOSE: To provide new (2S, 1'S, 2'S)-α-(2-labeled-2-carboxycylopropyl)glycine which is a selective agonist of metabolism-regulation type glutamic acid receptor and its new intermediate. CONSTITUTION: A (2S, 1'S, 2'S)-α-(2-labeled-2-c...
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JP2005528915A |
This invention provides an NMR method for obtaining both entropic and enthalpic data on proteins and protein/ligand complexes which can be used to obtain accurate structural and dynamic data of proteins and protein complexes having a wid...
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JP3696884B2 |
A method of enhancing the efficiency and increasing the duration of action of drugs (e.g. dihydropyridines and anti-bacterials) and particularly of nifedipine and penicillins wherein one or more hydrogen atoms are deuterated and wherein ...
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JP2005239577A |
To provide a deuterium-labeled diazirine compound which is prepared by deuterating in the presence of a Wilkinson catalyst and is useful as a photoaffinity labeling reagent capable of being used for analyzing the functions of biopolymers...
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JP2005220118A |
To provide a method for producing an aromatic compound having deutrium, excellent in an economical property and an all purpose property.This method for producing the aromatic compound is characterized by producing a compound having deutr...
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JP2005523235A |
The present invention relates to novel bifunctional chelates that are based on asymmetrical cyclen derivatives. The chelates contain either three acetates and one methylphosphonic arm or three acetates and one methylphosphonic arm enabli...
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JP2005200363A |
To provide a method for producing a deuterated norborneol and a deuterated dinorbornyl ether; and to provide a method for producing an unsaturated carboxylic ester of a deuterated norbornyl synthesized by using the deuterated norborneol ...
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JP2005194270A |
To provide a method for safely and efficiently producing a deuterated perfluoroalykyl methanol.This method for producing the deuterated perfluoroalykyl methanol expressed by general formula (I): RfCD2O-A (Rf is a perfluoroalkyl; and A is...
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JP2005520827A |
This invention relates to the miniaturization of radiosyntheses onto microfabricated devices, and in particular to use of microfabricated devices for radiosynthesis, isolation, and analysis of radiotracers for use in Positron Emission To...
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JP2005145856A |
To provide a method for efficiently deuterating caffeine, tricyclene and isoborneol / borneol.This method comprises thermally deuterating at least one of caffeine, tricyclene and isoborneol in deuterium in the presence of an acid having ...
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JP3657313B2 |
To produce the subject new compound, useful as an [18F] fluorine- labeling reagent for a polymeric physiologically active substance and a diagnostic agent for position emission tomography and stable at high temperatures. This [18F]fluoro...
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JP2005112768A |
To provide a method for producing a [1-13C]DOX (1-deoxy-D-xylulose) synthesizable in a large amount and to obtain a DOX derivative that is stable and efficiently taken by a cell.The [1-13C]DOX represented by formula (III) (R1, R2 and R3 ...
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JP2005075820A |
To provide a method for efficiently synthesizing a perfluoroalcohol at a low coat.This method for producing the perfluoroalcohol expressed by general formula (I) (Rf is a perfluoroalkyl; and YA and YB are each independently hydrogen or d...
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JP2005507885A |
The invention concerns a ligand comprising (I) wherein n is an integer from 1 to 5 Y is CO2H or PO3H2T represents -X or -phenyl-X, wherein X represents NO2, NH2, NCS, NHCOCH2-Z, NHCO-W-COCNHS, -NH-Q, -NHCS-Q, -NHCOCH2-Q, or NHCO(CH2)m-Q ...
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JP2005502446A |
The present invention describes a generic methodology to formulate a composite solid useful for catalyzing variety of reactions, the present invention in particular relates to a heterogeneous catalyst as a formulation constituting a soli...
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JP2004534802A |
The invention discloses deuterated N-substituted alpha,alpha-diphenyl alpha-alkoxy acetic acid aminoalkyl esters as well as the physiologically tolerated salts thereof. Furthermore, the invention concerns the use of deuterated N-substitu...
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JP2004532787A |
A new method for the production and use of a carbon-isotope monoxide enriched gas-mixture from an initial carbon-isotope dioxide gas mixture is presented. The method comprises the steps of providing carbon-isotope dioxide in a suitable c...
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JP2004279192A |
To provide a radioactivity prediction apparatus for predicting the intensity of radioactivity of a labeled compound to be produced, a radioactivity prediction method, and a labeled compound production apparatus.The amount of radiation ra...
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JP3537914B2 |
PURPOSE: To obtain an aromatic compound labeled with 18F and useful as a diagnostic agent for positron emission tomography(PET) and its intermediate by a [19F]-[18F] exchange reaction. CONSTITUTION: A [18F]fluorinated aromatic compound i...
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JP3535154B2 |
Radioactive high molecular weight metal-binding protein compositions and a method for therapeutic radiation treatment including the treatment of rheumatoid arthritis comprising injection of a radioactive high molecular weight metal-bindi...
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JP2004143168A |
To provide a cyclosporin derivative with more improved effectiveness and reduced toxicity, when compared with cyclosporins and their derivatives which naturally occur and are well known presently.This cyclosporin derivative is formed by ...
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JP2004514721A |
The present invention provides a compound for chelating a metal or a metal complex, characterized in that it consists of a bis-dithiocarbamate structure (F) having the formula below: in which n and m are integers such that 5<=m+n<=10, X ...
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