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JPWO2011096374A1 |
To provide a novel iodobenzyl-bleomycin compound. In addition, a metal complex of an iodobenzyl-bleomycin compound and various metal atoms, for example, a metal complex capable of accumulating in a malignant tumor having better biologica...
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JP5204401B2 |
A radioisotope labeled reagent includes a compound having the general formula (I), L-(aCbH2)naCbH3 (I) where a in each occurrence independently is a carbon mass number between 11 and 14 inclusive, b in each occurrence independently ...
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JP2013100349A |
To provide a novel radioactive octreotide derivative, which is glycosylated and bound to a somatostatin receptor.There is provided an improved sst-receptor binding peptidic ligand for the diagnosis and therapeutic application in nuclear ...
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JP2013518830A |
The invention relates to novel chemical compounds, which can be fluorinated with 18F under especially mild conditions. The novel chemical compounds thereby enable the use of a novel fluorination method according to the invention, wherein...
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JP2013515746A |
Compounds represented by Formula I: (I) or pharmaceutically acceptable salts thereof, wherein A, B, B′, X, Y, R1, R2, R2′, R3, R3′, R4, R4′, R5′, R5′m, n, or p are as defined herein, are useful for treating flaviviridae viral...
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JP2013515083A |
The present invention claims fluoro- & iodo-containing aldehydes as ALDH substrates for use as diagnostic imaging agents or as therapeutic agents. The aldehydes are both directly and indirectly attached to an aromatic or a straight chain...
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JP2013514317A |
This invention relates to novel compounds suitable for labelling by 18 F and the corresponding 18 F labelled compounds themselves, 19 F-fluorinated analogues thereof and their use as reference standards, methods of preparing such compoun...
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JP2013513578A |
The present invention provides a novel method for labeling a biotargeting molecule (BTM) of interest with radioactive iodine. Also provided are novel radioiodinated BTMs prepared using this method and radiopharmaceutical compositions con...
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JP2013513571A |
There are provided new iodo- and bromo-compounds, and their use as diagnostic agents and imaging agents for diseases and disorders wherein S1P receptor expression is altered.
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JP2013510891A |
This invention relates to methods, which provide access to F-18 labeled glutamic acid derivatives.
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JP2013510894A |
This invention relates to derivatives of Iodine-labeled homoglutamic acids and glutamic acids and their analogues suitable for labeling or already labeled by Iodine, methods of preparing such compounds, compositions comprising such compo...
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JP5165671B2 |
The present invention relates to a novel diamine derivative, a method for preparation thereof, and an organic electronic device using the same. The diamine derivative according to the present invention can serve as a hole injecting, hole...
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JP5152750B2 |
To provide a method of rapid methylation of alkenes, which is applicable to the preparation of a PET tracer and which enables alkenes to be methylated through cross coupling between SP 2 (alkenyl) and SP 3 (alkyl) carbon atoms rapidly an...
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JP5151659B2 |
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JP5140824B2 |
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JP5137824B2 |
The invention relates to new processes for the manufacture of N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylp
henyl}-4-(3-pyridyl)-2-pyrimidine-amine (compound of formula I, new processes for the manufacture of metabolites o...
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JP5137168B2 |
The present invention herein provides a combination of stable isotope-labeled aliphatic amino acids, which permits the structural analysis of a high molecular weight protein, in particular, a high molecular weight protein whose molecular...
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JP5128956B2 |
This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compound...
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JP2013500347A |
The present invention relates to deuterated compounds having a modulatory activity at the P2Y12 receptor for use in the treatment of myocardial infarction, stroke or acute coronary syndrome.
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JP2013500294A |
A method produces a radioactively marked carboxylate, at least one precursor molecule of the carboxylate being prepared in a solvent including a conductive salt. Radioactively marked carbon dioxide is fed into the solvent. The precursor ...
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JP2012533567A |
The present disclosure provides biologically active deuterated 2,4-pyrimidinediamine compounds and prodrugs thereof, compositions comprising the deuterated compounds, intermediates and methods for synthesizing the deuterated compounds an...
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JP2012532834A |
This invention relates to novel cyclo alkyl compounds suitable for labeling by 18F, methods of preparing such a compound, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, ...
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JP2012532164A |
The invention relates to a process for the production of radiotracers. In particular, this invention relates the isolation of radiotracers with containers filled with a stationary phase.
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JP2012246255A |
To provide a method for easily producing a 11C-labeled amino acid analogue labeled with a radioisotope of carbon.The method for producing a 11C-labeled amino acid analogue labeled with a radioisotope of carbon includes: a first step S1 o...
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JP2012229185A |
To provide a novel aniline derivative having pharmaceutical actions such as excellent neuroprotective action, neurogenesis (neurorestorative) promoting action and cognitive function improving action.The aniline derivative is a compound r...
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JP5077895B2 |
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JP5071796B2 |
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JP2012526129A |
Fatty acid analogue (FAA) molecules comprising positron-emitting radionuclides, salts thereof, and FAA-triglycerides are disclosed. Also disclosed are methods of synthesis, and methods of imaging distribution and metabolism of fatty acid...
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JP5053838B2 |
A fungus (A) that can produce cholesterol (I) autonomously, is new. Independent claims are also included for: (1) production of (I) by culturing (A); (2) production of (I) or its metabolic intermediates or a mixture of sterols labeled by...
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JP5040910B2 |
(PROBLEM) To provide a method for efficiently and industrially deuterating the benzyl position of a -O-benzyl group formed by introducing a benzyl group, a benzyloxymethyl group and the like as a protecting group. (SOLUTION) The deuterat...
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JP2012522751A |
A method produces a radiopharmaceutical. In the method, an H—Li exchange is made by adding an alkyllithium to an isocyanide, wherein the α-H atom of the isocyanide is replaced with an Li atom. 11CO2 is added and bonded to the α-C ato...
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JP2012522051A |
The present invention relates to the field of [18F] radiofluorination chemistry for the preparation of Positron Emission Tomography (PET) radioligands and [18F] radiofluorinating reagents. The invention further provides kits for preparat...
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JP5030175B2 |
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JP2012167109A |
To provide a new purification method of radiolabelled tracers using a scavenger group bound to a solid carrier.In the purification method, surplus precursors are reacted with solid carriers to be removed from the radiolabeled products.
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JP5015919B2 |
The invention provides a compound of formula (I); or a salt or solvate thereof, wherein: R1 is hydrogen or C1-4 alkyl; R2 and R4 are each independently selected from C1-4 alkyl, [11C]C1-4 alkyl, and [18F]—C1-4 fluoroalkyl provided that...
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JP5019280B2 |
The present invention herein provides, for instance, a stable isotope-labeled phenylalanine wherein a carbon atom of the phenyl group linked to an amino acid residue is 13 C, 2 to 4 carbon atoms of the remaining 5, carbon atoms constitut...
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JP2012162576A |
To provide trihydroxy polyunsaturated eicosanoid derivatives.The invention features methods for the preparation of naturally occurring trihydroxy polyunsaturated eicosanoids and their structural analogs. The invention further provides ne...
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JP2012519186A |
This invention relates to deuterated aryl-anthracene compounds that are useful in electronic applications. It also relates to electronic devices in which the active layer includes such a deuterated compound.
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JP5000521B2 |
The invention provides a method for the synthesis of an 18F-labelled product comprising deprotected of a protected 18F-labelled compound using a deprotection agent comprising a weak acid and wherein neutralisation and buffering of the de...
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JP4989241B2 |
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JP2012140424A |
To provide compounds that selectively bind to cells undergoing perturbations of the normal organization of cell plasma membranes.The compounds are represented by the structure as set forth in the formula (II), including pharmaceutically ...
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JP4981683B2 |
The present invention relates to a method for preparation of organofluoro compounds containing radioactive isotope fluorine-18. More particularly, the present invention relates to a method for preparation of primary or secondary organofl...
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JP4979945B2 |
A process for producing a radioactive fluorine compound which comprises a step in which [18O] water containing [18F] fluoride ions is introduced into a column packed with an ion-exchange resin to collect the [18F] fluoride ions and a ste...
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JP4965255B2 |
The present invention relates to novel pyridylacetylene derivatives of formula I their preparation, their use as radio-traces/markers and compositions containing them.
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JP4968060B2 |
[PROBLEMS] To provide a method for producing heavy hydrogen gas. which enables heavy hydrogen gas to be efficiently produced from a deuterated solvent as a reaction substrate. [MEANS FOR SOLVING PROBLEMS] (1) A method for producing heavy...
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JP4968673B2 |
The present invention relates to meta 1-phthalocyanines bearing at least a group containing boron isotopes 11B or 10B, covalently bound to the peripheral positions of meta 1-phthalocyanine nucleus; moreover it refers to the processes for...
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JP2012514655A |
Fluorinated compounds and methods of making fluorinated compounds are described herein.
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JP2012513373A |
The invention pertains to a method for eluting a radionuclide-label or a radionuclide-labeled compound using a solid phase extraction resin, to a device for performing such a method, and to a computer program for controlling such a device.
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JP4954417B2 |
There is provided a method of synthesis of a radiolabelled platinum chemotherapeutic agent comprising the steps of: converting a metal halide to a radiolabelled platinum halide wherein the radiolabel is a radioisotope of Pt; and synthesi...
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JP2012102027A |
To provide an RI (radio isotope) compound-synthesizing apparatus capable of handling a trace amount of a reaction material to reduce its amount and of improving the yield of a radioactive isotope-labeled compound by efficiently collectin...
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