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JPH10152448A |
To provide a method for hydrogenating or deuterating an unsaturated compound by which a C-C unsaturated bond is economically hydrogenated under a mild condition without using a dangerous hydrogen gas, and is deuterated by the similar met...
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JP2760466B2 |
PURPOSE: To make it easy to detect a polynucleotide or the like by chemically modifying or labeling. CONSTITUTION: An olygonucleotide or a polydeoxyribonucleotide comprising a nucleotide of the general formula P-S-B-Sig (P is a phosphate...
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JPH10139694A |
To obtain a new liquid crystal compound useful as electro-optical liquid crystal display material constituting a liquid crystal composition having low viscosity and a wide liquid crystal temperature range not easily deposits, makes phase...
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JPH10504534A |
Radiolabeled annexin-galactors conjugates useful for imaging vascular trombi are discussed. Methods for making such radiolabeled annexin-galactose conjugates are also addressed.
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JP2738224B2 |
PURPOSE: To produce the 18F-labeled organic compound in a yield of ≥80% even when an ordinary glass reaction vessel is used. CONSTITUTION: 18F-containing water is thermally evaporation-dried in the presence of a macrocyclic polyether a...
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JPH10502648A |
The invention relates to novel chelate formers containing sulphonamide groups and their metallic chelates of general formula (I) in which n, m, p, V<1>, V<2>, V<3>, V<4>, X<1>, X<2>, X<3>, R<1>, R<2>, R<3> and R<4> have different meaning...
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JPH1059990A |
To obtain the subject compound capable of accumulating to primary tumors and bone metastatic tumors at the same time and useful as an imaging agent for tumors, a tumor-therapeutic agent, a pain-emollient, etc., by marking a uridine 5'-ph...
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JPH1057090A |
To enable to efficiently produce the subject compound reduced in the dilution of the isotope due to the contamination of a non-labeled substance by consuming starch in a fine alga and subsequently subjecting the fine alga to a photosynth...
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JP2708204B2 |
PCT No. PCT/FR88/00188 Sec. 371 Date Dec. 15, 1988 Sec. 102(e) Date Dec. 15, 1988 PCT Filed Apr. 19, 1988 PCT Pub. No. WO88/07986 PCT Pub. Date Oct. 20, 1988.Compound useful particularly for the treatment by targetted radiotherapy or ima...
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JPH10501220A |
A method of radiolabeling a protein with a radionuclide including contacting the protein with a protected tertiary thiol-containing bifunctional chelating agent that is capable of reacting with the protein at one end of the agent and is ...
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JPH10500942A |
Compounds of the formula and the metalated forms and salts thereof; wherein n is an integer of 1-4; and wherein each Pi is independently a pyrrole residue of the formula wherein each Ria and Rib is independently a noninterfering substitu...
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JPH09512796A |
A compound consisting essentially of a multidentade ligand including at least two thioether groups for being complexed to Rhodium-105 in specific activities that are sufficiently high for use in formulating therapeutic <105>Rh-radiopharm...
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JPH09512251A |
Metal-containing steroid mimic complexes are provided. Compositions containing a metal ion incorporated into a steroid skeleton structure and ligands useful in the preparation of such compositions are also provided. The metal ion is pref...
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JPH09511750A |
A compound and method of making a compound for use as a diagnostic or therapeutic pharmaceutical comprises either a phosphorous or germanium core and at least two hydrazine groups forming a ligand for bonding to a metal extending from th...
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JP2670574B2 |
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JPH09208507A |
To synthesize a radioactive halogenated small molecule for the protein labeling used in in-vitro diagnostic measurement of ferritin concentration in serum. In order to synthesize a radioactive halogenated small molecule represented by th...
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JPH09194406A |
To obtain the subject compound useful for clinic diagnosis and suitable as a diagnostic agent and a therapeutic agent, especially in vitro diagnostic measurement of ferritin in serum. This radioactive compound is shown by the formula *X-...
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JP2633944B2 |
A process for the preparation of analytically pure chelate complexes which can be used in diagnostic medicine, for example as contrast agents or radiotherapeuticals, is described. In this process, a complex of a beta -dicarbonyl compound...
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JPH09176179A |
To obtain a new derivative which is a glucose or a mannose derivative labeled with a radioactive or nonradioactive iodine and useful as a radiodiagnostic agent, etc., capable of reflecting the sugar uptake by a sugar metabolic and a suga...
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JP2625095B2 |
Disclosed is a protein to which a moiety capable of chelating an ion is directly or indirectly attached, said attachment being characterized in not interfering substantially with the ability of the moiety to chelate ions.
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JPH09165377A |
To obtain a new compound having an angiotenisn II receptor- antagonizing action, enabling the labeling of [18F] fluorine, and useful for labeling reagents for positive electron radiation tomography, etc. This compound is expressed by the...
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JPH09143200A |
To provide the new macroagglutinative human serum albumin obtained by mixing macroagglutinative human serum albumin with 111-In chloride in a sodium acetate buffer solution and incubating the albumin and useful e.g. as a radioactive diag...
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JP2607897B2 |
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JP2607896B2 |
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JP2605249B2 |
PURPOSE: To obtain the subject composition having a deuterium atom (D)- containing saturated hydrocarbon ring in its structure, free from deposition of a crystal in a low temperature region, exhibiting a low threshold voltage and a high ...
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JP2604796B2 |
Metal-chelating ligands having the formula or a salt thereof, wherein Y is oxygen or R1 is hydrogen C1-C10 alkyl, aryl-(C1-C10)alkyl, aryl, C1 to C10 alkoxy, hydroxyalkyl with 1 to 10 carbon atoms wherein G is NH2, NCS, NHR4,N(R4)2,CN, w...
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JP2586411B2 |
PURPOSE: To obtain a new compound useful as a benzodiazepine receptor- directing diagnostic medicine, a radioactive medicine, etc. CONSTITUTION: A compound of formula I (R is H, lower alkyl; X* is radioactive I or Br; Y is H, halogen; Z ...
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JP2580514B2 |
PURPOSE: To obtain a deuterium-labeled compound capable of deuterating carbon bound to bromine with ultra-high stereoselectivity by reacting a brominated cyclic secondary alcoholic derivative with a deuterated organotin hydride compound ...
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JPH09500899A |
Tris(isonitrile)copper(I) sulfate complexes and their use in synthetic methods for making radionuclide isonitrile coordination complexes such as [99mTc(1-isocyano-2-methoxy-2-methylpropane)6]+. The coordination complexes are useful as ra...
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JPH09500140A |
Radionuclide chelating compounds are provided for conjugation to targeting molecules such as proteins, peptides or antibodies. The resulting labeled targeting molecules may be used in diagnosis and therapy.
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JPH09500133A |
PCT No. PCT/US94/07769 Sec. 371 Date Jan. 16, 1996 Sec. 102(e) Date Jan. 16, 1996 PCT Filed Jul. 11, 1994 PCT Pub. No. WO95/02587 PCT Pub. Date Jan. 26, 1995The invention is directed to a series of novel compounds of the formula where Y ...
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JPH08333315A |
To obtain the subject new compound having melatonin antagonistic activity, useful for treating symptoms such as depression, disturbances due to difference in time, sleep disturbance, glaucoma, cancer, etc., caused by melatonin activity. ...
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JPH08325169A |
PURPOSE: To produce a [18F]-labeled organic compound in high yield and at a low cost while keeping high collection efficiency of a [18F]-fluoride ion by using a phosphonium resin. CONSTITUTION: A labeled organic compound of the formula 1...
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JPH08325168A |
PURPOSE: To produce a [18F]-labeled organic compound in high yield and at a low cost while keeping high collection efficiency of a [18F]-fluoride ion by using a 4-aminopyridinium resin. CONSTITUTION: A labeled organic compound of the for...
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JP2551643B2 |
Substituted benzamides of formula I wherein R<1> is <1><2><3>I, <1><2><5>I, <1><3><1>I, R<2> is a hydrogen atom or a hydroxyl group, R<3> is a hydrogen atom, a halogen atom, a hydroxyl group, or a methoxy group, R<4> is an alkyl group of...
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JPH08510245A |
2-Pyridylmethylenepolyazamacrocyclophosphonic acid compounds and their derivatives are disclosed which may form inert complexes with Gd, Mn or Fe ions. The overall charge of the complex can be varied to alter the in vivo biolocalization....
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JPH08510235A |
The present invention relates to compounds having affinity for certain cancer cells, e.g. lung carcinomas, colon carcinomas, renal carcinomas, malignant melanomas, gliomas, neuroblastomas and pheochromocytomas. The compounds also bind wi...
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JP2546697B2 |
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JPH08509206A |
In one aspect the invention relates to the preparation of deuterated sevoflurane and its use as an inhalation anesthetic. In a further aspect the invention relates to the minimization of degradation of sevoflurane to F2-C = C(CF3)OCH2F (...
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JPH08508985A |
(57) [Summary] The present invention relates to the use of a radioactive metallocene carboxylic acid of the following general formula I and a derivative thereof for the purpose of radiolabeling an NH-active compound.In the formula, R1, R...
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JPH08508263A |
Novel bifunctional chalcogenic-atom-discontinuous chelating agents, pharmaceutical preparations containing them, their use in radio diagnosis and radio therapy, and methods of preparing them. The invention concerns compounds of the gener...
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JPH08508048A |
Novel compounds of the formula where G1 and G2 are each independently -OH or -N(R2)2, provided that at least one of G1 and G2 is -N(R2)2, where each R2 is independently hydrogen, alkyl, aryl, acyl or -(A)p-Ra and the other variables are ...
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JP2523426B2 |
PURPOSE: To obtain a novel compound as an oxytocin antagonist, useful in treating preterm labor and dysmenorrhea and for the stoppage of labor preparatory to cesarean delivery. CONSTITUTION: The objective novel compound is represented by...
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JP2514137B2 |
Quinuclidine derivatives of the formula maceutically acceptable salts thereof, wherein m, P, Z, Y, R1, R2 and R3 are as defined below. The compounds are substance P antagonists and, therefore, are useful in treating gastrointestinal diso...
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JP2515929B2 |
Particle emitting radionuclides, e.g. Samarium-153, have been complexed with certain macrocyclic aminophosphonic acids wherein the nitrogen and phosphorus are interconnected by an alkylene group or substituted alkylene group. These compl...
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JP2513573B2 |
PURPOSE: To provide a halo-aromatic composition for diagnosis which can be prepared in a good yield. CONSTITUTION: This composition contg. radioactive iodine consists of a pharmaceutically-acceptable liquid blend and at least one adjuvan...
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JP2509247B2 |
Compounds of the formula I in which n denotes the figures 0, 1 or 2, R<1> and R<2> denote hydrogen atoms, lower alkyl groups, phenyl groups, benzyl groups or, if n represents the figure 0, also together denote a trimethylene or a tetrame...
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JP2504750B2 |
A coordination complex is disclosed comprising a radionuclide selected from radioactive isotopes of Tc, Ru, Co. Pt and Re and an isonitrile ligand of the formula:where X is a lower alkyl group having 1 to 4 carbon atoms, wherein R is sel...
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JPH08143490A |
PURPOSE: To obtain the subject new compound useful for labeling an antibody, and the subject new labeled protein labeled by the compound and useful as a diagnostic agent and therapeutic agent for clinical diagnosis and treatment. CONSTIT...
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JPH08504399A |
PCT No. PCT/EP93/02645 Sec. 371 Date May 24, 1995 Sec. 102(e) Date May 24, 1995 PCT Filed Sep. 28, 1993 PCT Pub. No. WO94/07894 PCT Pub. Date Apr. 14, 1994The invention relates to new 3,8-substituted deuteroporphyrin derivatives with var...
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