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JP2020070291A |
To provide a method of producing a deuterated organic compound excellent in the deuterium conversion rate, and in particular a method of producing a deuterated organic compound excellent in the deuterium conversion rate in which the solu...
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JP6690957B2 |
To provide a manufacturing device that can surely maintain a connected state of a connection part between collecting devices such as columns or filters.A manufacturing device 100 of a radioactive marker compound is a device that manufact...
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JP6682687B1 |
To realize a good synthesis yield of a radioactive iodine-labeled compound. A device 1 for synthesizing a radioactive iodine-labeled compound is a device for synthesizing a radioactive iodine-labeled compound from a non-radioactive iodin...
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JP2019535727A |
The present invention is [18F] Includes an aromatic or heteroaromatic ring having fluorine as the first substituent, a connecting unit capable of connecting to a peptide or a peptide mimetic, and a spacer group that binds the aromatic or...
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JP2019534284A |
2- (1- {6- [(2- [F-18] fluoroethyl) (methyl) amino] -2-naphthyl} etylidene) -malononitrile ([F-18] FDDNP) production method, semi-automatic A module is used, which is used for fluorination, prepurification, separation, product extraction...
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JP2019178128A |
To provide a novel oxygen isotope-labeled compound in which a carbonyl site is substituted with heavy oxygen, and a method for producing the same.The present invention provides a method for producing an oxygen isotope-labeled compound re...
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JP2019163230A |
To provide novel boron isotope-tracing agents having broad molecular tracking and stereotaxic destructive power by neutron irradiation, and used in neutron beam dynamic therapy (NBDT) and boron neutron capture therapy (BNCT) because of h...
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JP2019163229A |
To provide a drug transport (delivery) material with excellent specific accumulation property to tumor cells or cancer cells which is produced by chemically bonding oligosaccharide and oligopeptide, which are excellent in specific bindin...
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JP6574379B2 |
The present invention provides a method for the production of [18F]-FACBC which has advantages over know such methods. Also provided by the present invention is a system to carry out the method of the invention and a cassette suitable fo...
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JP6554753B1 |
An initial introduction control unit 10 introduces an aqueous solution W containing molybdenum 99 and technetium-99m and an organic solvent O into an extraction tank 20. The fine mixing control unit 11 heats the mixed solution M of the a...
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JP6555719B2 |
The present invention provides a phosphonium compound of formula (II). Also provided is a method for producing a quaternary phosphonium compound labeled with a positron emitting radionuclide, the method comprising the step of reacting an...
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JP6544596B2 |
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JP6544595B2 |
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JP6506174B2 |
Provided is a compound of formula (I), or a pharmaceutically acceptable salt thereof. Also provided is a method of treating, prophylaxis, or amelioration of a disease, comprising administering to a subject in need of treatment for the di...
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JP6496726B2 |
The invention provides a new chemical process, a new cassette configuration, and new software. The invention allows one synthesizer in one hot cell to produce sequentially two batches of [18F]-labelled PET tracer in the same day.
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JP6485878B2 |
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JP6450808B2 |
The invention relates to a process for preparation of radiopharmaceutical precursors, and in particular protected amino acid derivatives which are used as precursors for production of radiolabelled amino acids for use in vivo imaging pro...
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JP2018193356A |
To provide deuterated catecholamine derivatives which have improved pharmacokinetic and/or pharmacodynamic properties compared to already known compounds and can be used for producing pharmaceuticals for prophylaxis of psychoses, particu...
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JP6410351B2 |
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JP6412629B1 |
To provide a radioactive fluorine-containing hydroxamic acid type contrast agent for effectively detecting cerebellar atrophy and a method for producing the same. A radioactive fluorine-containing hydroxamic acid type contrast agent repr...
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JP6386382B2 |
The present invention relates to deuterated thiazolidinone analogues as agonists for follicle stimulating hormone receptor and their use for treating fertility disorders.
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JP6374538B2 |
According to the present invention, a deuterium-substituted marker for fuel is synthesized through substitution with deuterium so as to have structurally and chemically similar properties to those of a molecule configuring fuel oil. A mo...
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JP6372880B2 |
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JP2018518492A |
This disclosure relates to radioiodine-labeled compounds useful as bioconjugate reagents and intermediates for making radioiodine-labeled bioconjugate reagents.
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JP2018089623A |
To provide EWOD devices, reactant delivery systems, and methods of preparing radio-compounds using these devices and delivery system.An EWOD device comprises: a first substrate 38 having one or more fluid paths 42 and including multiple ...
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JP6280507B2 |
An embodiment of the invention comprises method of imaging a target site comprising administrating ligand of Formula I complexed to 99mTc wherein R1 and R2 are independently an alkyl or cycloalkyl; R3 is and alkyl; X is CO or SO2; Y is (...
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JP6245981B2 |
A method for synthesizing an 18F-labeled probe. The method includes a step of eluting an amount of 18F with a first solvent which includes a predetermined amount of water and at least one organic solvent. In this step, the 18F elutes as ...
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JP6244303B2 |
The present invention provides a method for the synthesis of 18F-labelled biomolecules, which is amenable to automation. The present invention also provides a cassette for automating the method of the invention. The method of the present...
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JP6240507B2 |
The invention relates to a process for preparation of radiopharmaceutical precursors, and in particular protected amino acid derivatives which are used as precursors for production of radiolabelled amino acids for use in in vivo imaging ...
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JP6231882B2 |
The present invention relates to the field of radiopharmaceuticals for in vivo imaging, in particular to a method of labelling via an aminooxy group a biological targeting molecule bearing an aldehyde or keto group with a radioisotope. T...
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JP6219815B2 |
This invention relates to novel precursors suitable for 18 F radiolabeling of glutamate derivatives, methods for preparing such compounds and its intermediates, compositions comprising such compounds, kits comprising such compounds or co...
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JP6195906B2 |
The invention relates to fluorinated compounds and their use as anti-epileptic, muscle-relaxing, fever-reducing and peripherally analgesically acting medications and as imaging agents. Novel fluorinated 2-amino-4-(benzylamino)phenyl carb...
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JP6191325B2 |
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JP6161547B2 |
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JP6154815B2 |
The present invention provides a method for the synthesis of 18F-labelled biomolecules, which is amenable to automation. The present invention also provides a cassette for automating the method of the invention. The method of the present...
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JP6125599B2 |
The present invention provides a tissue-targeting complex comprising a tissue targeting moiety, an octadentate hydroxypyridinone-containing ligand and the ion of an alpha-emitting thorium radionuclide. The invention additionally provides...
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JP6097295B2 |
Methods of halogenating a carbon containing compound having an sp3 C—H bond are provided. Methods of fluorinating a carbon containing compound comprising halogenation with Cl or Br followed by nucleophilic substitution with F are provi...
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JP6092628B2 |
The present invention generally relates to methods and system for the synthesis of imaging agents, and precursors thereof. The methods may exhibit improved yields and may allow for the large-scale synthesis of imaging agents, including i...
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JP2016222590A |
To provide a manufacturing method capable of providing an isotope-labeled compound having a steric configuration of a double bond the same as that in aliphatic acid which is a starting material.There is provided a method of manufacturing...
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JP6035328B2 |
Disclosed is the synthesis of [ 18 F]flumazenil that is useful in imaging epileptic lesions by PET (positron emission tomography). A method for preparing [ 18 F]flumazenil by reacting a diaryliodonium salt precursor with the positron-emi...
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JP6018578B2 |
The invention relates to a process for preparation of radiopharmaceutical precursors, and in particular protected amino acid derivatives which are used as precursors for production of radiolabeled amino acids for use in in vivo imaging p...
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JP6018581B2 |
The present invention provides a pharmaceutical composition comprising [18F]FACBC having certain advantages over known compositions comprising [18F]FACBC. Also provided by the present invention is a method to obtain the composition of th...
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JP6018637B2 |
The present invention relates to calibration and normalization systems and methods for ensuring the quality of radiopharmaceuticals during the synthesis thereof, such as radiopharmaceuticals used in Positron Emission Tomography (PET) and...
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JP5964840B2 |
This invention relates to novel compounds suitable as precursors for the preparation of certain 18 F labelled positron emission tomography (PET) tracers. Furthermore, the invention relates to the preparation of such precursor molecules a...
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JP5936659B2 |
Compounds of Formula (Ia)wherein R is a C6-C12 substituted or unsubstituted aryl, a C6-C12 substituted or unsubstituted heteroaryl, a C1-C6 substituted or unsubstituted alkyl or -NR'R',Q is C(O), O, NR', S, S(O)2, C(O)2 (CH2)pY is C(O), ...
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JP5925301B2 |
The present invention relates to a process for deuteration of amines in the alpha and/or beta position of the N-atom by using a deuterium source and a Ruthenium(II) based catalyst.
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JP5878170B2 |
[Problem] To provide a novel isotope-labeled compound that can be used as a trapping agent and that is useful for picking out drug-candidate compounds that produce reactive metabolites. [Solution] Provided is a glutathione alkylester iso...
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JP2016506375A |
The present invention is an improvement that identifies and suppresses impurities that affect in vivo imaging.18Regarding F-labeled aldehyde composition. A method for preparing a radioactive fluorinated biological targeting molecule usin...
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JP5869562B2 |
This invention relates to methods, which provide access to [F-18]fluoropegylated (aryl/heteroaryl vinyl)-phenyl methyl amine derivatives.
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JP5860808B2 |
The present invention provides a novel method of labelling biological targeting molecules (BTMs) of interest with radioiodine. Also provided are novel radioiodinated BTMs prepared using the method, as well as radiopharmaceutical composit...
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