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WO/1999/038829A1 |
A compound represented by formula (1) wherein each of ring A, ring B and ring C is independently a substituted or unsubstituted aromatic ring or a substituted or unsubstituted five or six-membered heterocycle which may be condensed with ...
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WO/1999/038477A1 |
The invention relates to a method for permanently deforming keratin fibers in which the fibers are treated with an aqueous preparation of a keratin reducing substance before and/or after a mechanical deforming process. The fibers are sub...
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WO/1999/037294A2 |
The present invention relates generally to mitochondria protecting agents for treating diseases in which mitochondrial dysfunction leads to tissue degeneration and, more specifically, to compounds, compositions and methods related to the...
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WO/1999/036388A1 |
The invention relates to a method for producing a N-alkylated aniline of formula (I) Ar-N(R?1¿)¿2-n?(CHR?2¿CHR?3¿Ar')¿n? by reacting an aromatic olefin of formula (II) Ar'CR?3¿=CHR?2¿ with an aniline of formula (III) Ar-N(R?1¿)¿...
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WO/1999/034788A1 |
A newly discovered antineoplastic compound denominated 'phenstatin' is herein described as are synthetic methods for producing phenstatin and the active prodrug thereof. Phenstatin was converted to the sodium phosphate prodrug (3d) by a ...
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WO/1999/033783A1 |
The invention relates to a method for producing oxalkylated amines or alcohols, whereby a reaction mixture containing an amine or an alcohol or a mixture of two or more amines and/or alcohols and an alkylene oxide or a mixture of two or ...
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WO/1999/033493A1 |
The present invention relates to new polyamide oligomers. These oligomers can be conjugated to lipids, nucleic acids, peptides, proteins, $i(etc). The oligomer-lipid conjugates can be used to form liposomes, virusomes, micelles, $i(etc.)...
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WO/1999/032431A1 |
The present invention relates to a novel monophosphate salt of isopropyl-methyl-[2-(3-n-propoxyphenoxy)ethyl]amine. Moreover, the present invention also relates to a process for the preparation of the monophosphate salt of isopropyl-meth...
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WO/1999/032103A1 |
The present invention discloses a new use of a compound of formula (I) wherein R?1¿ represents C¿3-5? alkyl; and R?2¿ and R?3¿ independently represent C¿1-3? alkyl; or a pharmaceutically acceptable salt thereof; for the manufacture ...
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WO/1999/032430A1 |
The present invention relates to a novel process for the synthesis of isopropyl-methyl-[2-(3-n-propoxyphenoxy)ethyl]amine. Moreover, the present invention also relates to a novel intermediate and an optional purification step in the nove...
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WO/1999/031054A2 |
Compounds of general formula (I), wherein A, B,C and D represent, independently from each other, an -OH- or -NHR- group, wherein R stands for a hydrogen atom or a C¿1-4? alkyl radical, with the proviso that A, B, C or D respectively sta...
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WO/1999/029655A1 |
The invention relates to compounds of formula (I), wherein R?1¿ and R?2¿, independently from each other, mean hydrogen, halogen or C¿1-4? alkyl group; R?3¿, R?4¿ and R?5¿, independently from each other, stand for hydrogen or C¿1-4...
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WO/1999/027783A1 |
Fungicidal compositions and methods comprising acylated aminosalicylamides (AASA) described herein. Novel cyclic amines and 3-nitrosalicylamides, and their use as pesticides and in the preparation of the antifungal AASA compounds are als...
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WO/1999/023072A1 |
A compound having formula (I) or its salt, hydrate, hydrate salt or solvate, wherein R?1¿ to R?4¿ independently represent H, halogen, OH, alkoxy, optionally substituted alkyl, aryl, or aralkyl group, R?5¿ represents H, optionally subs...
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WO/1999/023073A1 |
Compounds of formula (I) wherein R¿1?, R¿2?, R¿3?, R¿4? and R¿5? are as defined in the description, are useful as pharmaceuticals.
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WO/1999/021849A1 |
Processes for producing 7-isoindolinequinolonecarboxylic derivatives useful as antibacterials and represented by general formula (1) and intermediates therefor; salts of 7-isoindolinequinolonecarboxylic derivatives represented by formula...
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WO/1999/021837A1 |
Novel herbicidal and defoliant substituted aniline derived compounds represented by general structure (I) are described. W, X, Y, Z, and Q are as defined in the disclosure. Also described are the processes for the manufacture of these co...
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WO/1999/021811A1 |
A method of separating optical isomers which permits optical resolution of compounds which have been incapable of satisfactory optical resolution under the conventional reversed-phase conditions. Specifically a method of separating optic...
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WO/1999/020598A1 |
2-Phenoxyaniline derivatives of general formula (1); wherein R?1¿ is hydrogen or lower alkoxyl; R?2¿ is halogeno or nitro; and R?3¿ is hydrogen or halogeno, or pharmaceutically acceptable salts thereof.
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WO/1999/020596A1 |
An organic electroluminescent device having high efficiency and long lifetime, which contains a specific amine represented by general formula (1) as the hole transport material or the luminescent material, wherein R¿1? to R¿20? are eac...
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WO/1999/020597A1 |
The invention relates to novel aminophenol derivatives of general formula (I), wherein R?1¿ and R?2¿ represent (a) an alkyl group with 1 to 4 C-atoms or (b) an alkoxy group with 1 to 4 C-atoms on the condition that in each case, exactl...
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WO/1999/018947A1 |
A process to make the S(+)mandelic acid salt of $i(N)-methyl-3$i(R)-hydroxy-3-phenylpropylamine comprising reacting $i(N)-methyl-3($i(R,S))-hydroxy-3-phenylpropylamine with S(+)mandelic acid is described and claimed. Also described and c...
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WO/1999/019293A1 |
The present invention provides compounds useful in the synthesis of biologically active compounds, and processes for their production, the compounds having formula (I) wherein: R?1¿ and R?2¿ are, independently, selected from H; C¿1?-C...
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WO/1999/018941A2 |
The present invention relates to the use of an I¿h? channel modulator in the manufacture of a medicament for use in psychiatry. To certain novel methanamine derivatives, to processes for their preparation, to pharmaceutical formulations...
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WO/1999/018057A1 |
One aspect of the present invention relates to novel reaction conditions that allow the efficient synthesis of diaryl ethers from arenes bearing a leaving group and arenols under relatively mild conditions. Another aspect of the present ...
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WO/1999/016746A1 |
Novel aminoalkylphenols, intermediates and processes for the preparation thereof, and methods of relieving memory dysfunction utilizing the aminoalkylphenols or compositions thereof are disclosed.
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WO/1999/015129A2 |
Selective inhibitors of the cPLA¿2? enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have general formula (i), where (R?1¿), p, D, Y, Z, R?a¿, R?b¿ ...
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WO1998052898A9 |
Formation of cerebral amyloid associated with Alzheimer's disease can be treated or averted using medicaments that are effective in vivo in preventing disruption of dense microspheres (DMS) or in altering the disruption so as to (i) redu...
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WO/1999/015494A1 |
2-Aminotetralines, a process for their preparation, and pharmaceutical compositions, for the prevention and therapeutic treatment of inflammatory pathologies (particularly septic shock) and/or autoimmune pathologies in which the aetiopat...
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WO/1999/012888A1 |
The invention relates to a method for producing aryloligoamines, characterised in that an amine is reacted with an activated aromatic and a base within a temperature range from 0 and 150 °C in the presence of a palladium constituent and...
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WO/1999/012877A1 |
The invention concerns a method for the enantioselective reduction of prochiral ketones into chiral alcohol's comprising the following steps: a) reacting a prochiral ketone with a silane agent, present in stoichimetric amount, in the pre...
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WO/1999/012889A1 |
Disclosed is a quaternary ammonium phosphate compound having formula (1) and which has an anticorrosive and a biocidal effect to have a capability of preventing corrosion of various metals including corrosive metal substances, e.g. carbo...
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WO/1999/012893A1 |
Diamine compounds useful for treating neurodegenerated diseases characterized by the lack of dopamine neurons activity for imaging the dopamine neurons are provided. The diamine compounds or serotonin are characterized by formula (I), wh...
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WO/1999/008997A1 |
The invention relates to novel lipopolyamines (including their salts), characterised by a symmetrical, highly flexible lipophilic component with a buffering capacity at physiological pH, and to their use for funnelling biologically activ...
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WO/1999/008501A2 |
The present invention relates to novel antiobesity and hypocholesterolemic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmac...
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WO/1999/007667A1 |
Novel ethylamine derivatives represented by general formula (I) and pharmaceutically acceptable acid-addition salts thereof, wherein R?1¿ represents hydrogen, hydroxy, lower alkoxy or halogeno; R?2¿ represents C¿2-5? alkyl; R?3¿ repr...
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WO/1999/007377A1 |
A class of substituted benzylnaphthylene compounds of structure (1) where R?1¿ and R?2¿ are independently hydrogen, alkyl of one to six carbon atoms, acyl of two to six carbon atoms, or phenacyl; X is -(CH¿2?)¿1-6?; Y is absent or is...
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WO/1999/007674A2 |
The invention relates to novel pesticidally active compounds of general formula (I) as well as possible isomers and mixtures of isomers thereof, wherein n is a number zero or one; and R¿1? is C¿1?-C¿12?alkyl that is unsubstituted or m...
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WO/1999/007666A1 |
Novel amine derivatives represented by general formula (1) which are excellent in antifungal effect and salts thereof, wherein R?1¿ represents optionally halogenated C¿1-5? alkyl; R?2¿ represents 4-(1,1-dimethylalkyl)benzyl, 4-(1-meth...
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WO/1999/006362A1 |
Nitrones are produced by reaction of primary amine with aldehyde or ketone, in the presence of a transition metal-containing oxidation catalyst, and a peroxidic compound. The nitrone can then be reacted with a vinylaromatic compound to p...
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WO/1999/006389A1 |
O-(Perfluoroalkyl)dibenzofuranium salt derivatives represented by general formula (1) (wherein Rf is perfluoroalkyl being 1 to 10 carbon atoms; and X?-¿ is a conjugate based of a Brønsted acid); intermediates for the preparation of the...
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WO/1999/005090A1 |
Novel aminoethylphenoxyacetic acid derivatives represented by general formula (I) and pharmacologically acceptable salts thereof, which have effects of stimulating both of $g(b)¿2?- and $g(b)¿3?-adrenergic receptors and are useful in t...
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WO/1999/005088A1 |
A method of preparing a first geometric isomer of tamoxifen or an analogue comprises allowing the first isomer to crystallise in hexanol and the product thereof to crystallise in methanol and then derivatising the product of the methanol...
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WO/1999/003820A1 |
Cis-Tramadol hydrochloride is prepared by forming a Mannich hydrochloride, liberating the Mannich base, reacting the Mannich base with a Grignard reagent to form a base hydrate of cis-Tramadol which is used to form pure cis-Tramadol hydr...
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WO/1999/003819A1 |
The invention concerns novel monobenzene oxidation bases comprising at least one cationic group Z bearing at least a cyclized or non-cyclized quaternary ammonium unit, their use for oxidation dyeing of keratin fibres, dyeing compositions...
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WO/1999/002166A1 |
Colchinol derivatives of formula (I) wherein R¿1?, R¿2?, R¿3? and R¿6? are each independently H, optionally substituted alkyl, cycloalkyl, alkenyl, alkynyl, aralkyl, alkanoyl, PO¿3?H¿2?; X is carbonyl (CO), thiocarbonyl (CS), methy...
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WO/1999/002509A1 |
A process for preparing tri-arylalkylalkenes of formula (I) wherein Ar?1¿, Ar?2¿ and Ar?3¿ can be the same or different aromatic groups. R?1¿ is alkyl or substituted alkyl, by heating in a solvent a compound of the formula (II) where...
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WO/1999/001418A1 |
The invention relates to a novel method for aminating mononuclear aromatic compounds and polynuclear compounds containing at least one aromatic ring. The inventive method enables simple separation of the aminated mononuclear aromatic com...
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WO/1999/000114A2 |
The invention relates to the use of 1,3-bis-aromatic-prop-2-en-1-ones (chalcones), 1,3-bis-aromatic-propan-1-ones (dihydrochalcones), and 1,3-bis-aromatic-prop-2-yn-1-ones for the preparation of pharmaceutical compositions for the treatm...
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WO/1998/058906A1 |
The invention concerns a method for transforming an aminophenol, characterised in that it consists in a step whereby said aminophenol aniline function is in the form of am anilide function and said phenol is dissolved in a water-repellen...
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