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WO/2000/002551A2 |
The present invention features compounds active at both the serotonin euptake site and the N-methyl-D-aspartate (NMDA) receptor and the use of such compounds for treating different disorders. Compounds having activity at the serotonin re...
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WO/2000/002845A1 |
There is described an oxygen substituted quaternary alkyl ammonium cation of formula (I), and salts thereof, in which R¿1?, R¿2? and R¿3?, which may be the same or different, are each alkyl C1 to 20; and m and n, which may be the same...
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WO/2000/002866A1 |
The invention relates to novel substituted phenyl uracils of general formula (I) wherein n, Q, R?1¿, R?2¿, R?3¿, R?4¿, R?5¿ and X have the meanings given in the description, to methods and novel intermediate products for producing s...
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WO/2000/001875A1 |
The invention relates to softening agents containing (a) quaternary esters and (b) amine oxides. These mixtures result in improved soft handle and, in particular, better hydrophilia and rewettability. At the same time they also reduce th...
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WO/2000/000497A1 |
Metalorganic precursors for deposition of strontium tantalum and strontium niobium oxides by MOCVD techniques have the formula: SR[M(OR¿1?)¿6-x?L¿x?]¿2? wherein x is from 1 to 6; M is Ta or Nb; R¿1? is a straight or branched chain a...
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WO/2000/000459A1 |
A process for the preparation of optically active cyclohexylamine compounds useful as intermediates for the preparation of 1-phenyl-2-(3-phenylcyclohexyl-amino)ethanol compounds exhibiting a selective $g(b)¿3?-adreneric receptor stimula...
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WO/1999/067198A1 |
The ($i(R, R)) -, ($i(S, S)) -, ($i(R, S)) -, ($I(R, S)) - isomers of 3 - amino- 4- hydroxy-$g(a)- [[[2- (4- methoxyphenyl)- 1-methylethyl]amino]methyl] -benzenemethanol (D) are disclosed, as well as an efficient method for their stereos...
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WO/1999/067231A1 |
Nitric acid salts with medicines having an antihypertensive activity.
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WO/1999/067197A1 |
The invention relates to a compound of formula (I), wherein R is an alkyl unsubstituted or substituted by one or more polar substituents or an alkenyl unsubstituted or substituted by one or more polar substituents, and X is aryl, or salt...
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WO/1999/067196A1 |
A synthesis of fluoxetine is disclosed. The process begins with a lower alkyl ester of 3-benzoylpropionic acid, which is reduced in the presence of a chiral ligand to produce the corresponding $g(g)-hydroxy ester, and the ester is cleave...
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WO/1999/065877A1 |
The present invention relates to therapeutic biaryl derivatives of formula (I), and pharmaceutically acceptable derivatives thereof; wherein R?1¿ is a phenyl, naphthyl, pyridyl, thiazolyl, phenoxymethyl, or pyrimidyl group, optionally s...
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WO/1999/065891A1 |
The invention relates to diaminophenol derivatives having general formula (I), wherein R?1¿ represents a substituent -(CH¿2?)¿n?-X, whereby n is a whole number from 1 to 4 and X represents a saturated, unsaturated or aromatic 6-ring o...
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WO/1999/065865A1 |
The invention relates to a diaminophenol derivatives having general formula (I), wherein the substituents R?1¿ to R?5¿ independently represent hydrogen, a C¿1?- to C¿4?-alkyl group, a C¿1?- to C¿4?-monohydroxyalkyl group, a C¿2?- ...
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WO/1999/064042A1 |
Disclosed are novel multi-binding compounds (agents) which bind alpha-1A adrenergic receptors. The compounds of this invention comprise a plurality of ligands each of which can bind to such receptors thereby modulating the biological pro...
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WO/1999/063996A1 |
Disclosed are multibinding compounds which are agonists, partial agonists, inverse agonists or antagonists of the 5HT¿2? receptors, which are involved in neurological disorders. The multibinding compounds of this invention containing fr...
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WO/1999/064052A1 |
This invention relates to novel multibinding compounds that bind to leukotriene receptors and inhibit their activity. In particular, cysteinal leukotriene receptor antagonists and, most particularly leukotriene D¿4? receptor antagonist ...
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WO/1999/063944A2 |
Disclosed are novel multi-binding compounds (agents) which bind estrogen receptors. The compounds of this invention comprise a plurality of ligands each of which can bind to such receptors thereby modulating the biological processes/func...
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WO/1999/064393A1 |
The invention relates to novel antiestrogens of general formula (I), wherein the substituents which have the meanings cited in the description. The novel compounds concern a) pure antiestrogens or b) antiestrogens having a partial estrog...
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WO/1999/063993A1 |
Disclosed are multibinding compounds which are agonists, partial agonists, inverse agonists or antagonists of the D¿1? receptors, preferably, agonists of the D¿1? receptors, which are involved in neurological disorders. The multibindin...
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WO/1999/063999A1 |
This invention relates to novel multibinding compounds (agents) that are H1-histamine receptor antagonists and pharmaceutical compositions comprising such compounds. Accordingly, the multibinding compounds and pharmaceutical compositions...
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WO/1999/063984A1 |
The compounds of this invention comprise 2 - 10 ligands covalently connected, each of the ligands being capable of binding to a ligand binding site in an Na?+¿ channel, thereby modulating the biological activities thereof.
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WO/1999/063930A2 |
This invention relates to novel multibinding compounds that bind to angiotensin (AT) receptors and modulate their activity. The compounds of this invention comprise 2-10 AT receptor ligands covalently connected by a linker or linkers, wh...
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WO/1999/064053A1 |
The present invention is directed to multibinding compounds which are $g(b)3-adrenergic receptor agonists and are therefore useful in the treatment and prevention of metabolic disorders such as obesity, diabetes, and the like.
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WO/1999/064032A1 |
Disclosed are methods for synthesizing large collections of diverse multimeric compounds as well as iterative processes for evaluating key molecular constraints imparting multibinding properties to multimeric compounds. Also disclosed ar...
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WO/1999/062870A1 |
A novel compound 3-{4-[2-(4-$i(tert)-Butoxycarbonylaminophenyl)ethoxy]phenyl}
-(S)-2-ethoxy propanoic acid having formula (I) and pharmaceutically acceptable salts, solvates, and crystalline forms thereof, a process and intermediates for...
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WO/1999/062872A1 |
A novel 3-aryl-2-hydroxypropionic acid derivative, having formula (I) and pharmaceutically acceptable salts, solvates, and crystalline forms thereof, a process and intermediate for its manufacture, pharmaceutical preparations containing ...
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WO/1999/062871A1 |
Novel 3-aryl proprionic acid derivatives and analogs, having general formula (I) and stereo- and optical isomers and racemates thereof as well as pharmaceutically acceptable salts, solvates and crystalline forms thereof, process for thei...
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WO/1999/062861A1 |
A process for producing protected 3-amino-1,2-dihydroxypropane acetal, particularly in chiral forms, for use as an intermediate in the preparation of various 3-carbon compounds which are chiral. In particular, the present invention relat...
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WO/1999/062520A1 |
Certain six-membered aromatic and heteroaromatic-dioxo-butyric acid derivatives are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV...
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WO/1999/062505A2 |
The invention is directed to a method of treating a neurodegenerative disorder in a subject in need thereof which comprises administering to the subject an amount of a compound effective to inhibit the interaction of amyloid-beta with al...
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WO/1999/061405A1 |
(R*,R*)-2-[ (dimethylamino) methyl]-1-( 3-methoxyphenyl) cyclohexanol (Tramadol) is synthesized in a Grignard reaction in the presence of an additive resulting in a higher trans:cis ratio of product than is obtained in the absence of the...
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WO/1999/059527A2 |
The invention relates to oxidizing agents for coloration of keratin fibers, especially hair, based on a combination of developer-coupler substances, characterized in that they contain at least one 2,5-diamino-1-phenylbenzene derivative o...
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WO/1999/058478A1 |
The invention concerns novel derivatives of 3,3-diphenylpropylamines, methods for their preparation, pharmaceutical compositions containing the novel compounds, and the use of the compounds for preparing drugs. More particularly, the inv...
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WO/1999/058492A1 |
The invention relates to quaternary ester compounds which have an ethoxylated hydroxycarboxylic acid as their basic framework. These cationic tensides are suitable for the production of water-white formulations, such as in particular hai...
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WO/1999/058490A2 |
The invention describes an aryl-hydronaphthalenalkanamine, having structural formula (I). The invention also provides a pharmaceutical composition comprising such a compound and the use of such a compound to effectuate partial or complet...
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WO/1999/055663A1 |
The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well ...
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WO/1999/055797A1 |
The invention concerns a composition for preventing radical polymerisation of ethylenically unsaturated monomers characterised in that it comprises at least a benzenetriamine derivative corresponding to general formula (I) wherein: the r...
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WO/1999/052847A1 |
This invention relates to ketones, alcohols and amines represented by the likes of 3-(3-cyclopentyloxy-4-methoxyphenyl)-3-phenylethynylcyclobut
an-1-one. They are useful as PDE 4 antagonists.
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WO/1999/052856A1 |
Novel 2-methylpropionic acid derivatives represented by general formula (I) and pharmacologically acceptable salts thereof which have an excellent $g(b)¿3? adrenaline receptor stimulating effect and are useful as preventives or remedies...
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WO/1999/052521A1 |
Investigation of the activity of extracts of the clam $i(Spisula polynyma) has led to antitumour long-chain, straight-chain alkane or alkene compounds which have a 2-amino group and a 3-hydroxy group.
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WO/1999/053242A1 |
Disclosed are highly efficient multiphoton absorbing compounds and methods of their use. The compounds generally include a bridge of pi-conjugated bonds connecting electron donating groups or electron accepting groups. The bridge may be ...
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WO/1999/051564A1 |
This invention relates to new propanolamine derivatives or salts thereof represented by general formula (I), wherein each symbol is as defined in the specification or salts thereof which are $g(b)¿3? adrergenic receptor agonists and the...
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WO/1999/051569A1 |
Novel calcilytic compounds, pharmaceutical compositions containing said compounds and their use as calcium receptor antagonists.
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WO/1999/051662A1 |
Novel polyimide compositions having a cinnamic acid or cinnamic acid derivative skeleton and possessing both the photoreactivity and heat reactivity characteristic to the cinnamic acid skeleton. Novel diamines and acid dianhydrides, whic...
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WO/1999/050226A1 |
A process for producing N-cyclopropylanilines usable as important intermediates for the production of quinolonecarboxylic acids having a cyclopropyl group at the 1-position, a fluorine atom at the 6-position, and an alkyl group, an alkox...
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WO/1999/050225A1 |
Aminocyclohexyl ether compounds of formula (I), or a solvate or pharmaceutically acceptable salt thereof are disclosed. In said formula, A, X and R, -R¿5? have the meanings given in the description. The compounds of the present inventio...
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WO/1999/050224A1 |
The instant invention is directed to a method for recovering surface active amines from an emulsion comprising the salt of the amine comprising: (a) contacting an emulsion layer or phase containing surface active amine salt with an acid ...
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WO/1999/048856A1 |
The invention concerns an oxidation dyeing composition for keratinous fibres containing at least a monobenzene coupling agent including at least a cationic group Z bearing at least a cyclized or non-cyclized quaternary ammonium unit, the...
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WO/1999/046230A1 |
The present invention is concerned with certain perylene diones which absorb light in the far-red region of the spectrum of general formula (I). These compounds are suitable for labels in biological systems.
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WO/1999/046234A1 |
The invention concerns methods for the preparation of an N-bis-[2-(1,2-dicarboxy-ethoxy)-ethyl]-amine derivative, products of said methods as well as uses of the products. According to the invention said derivative is prepared by reactin...
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