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WO1999064055A9 |
Disclosed are multibinding compounds which are agonists, partial agonists, inverse agonists or antagonists of the 5HT4 receptors, which are involved in gastrointestinal disorders. The multibinding compounds of this invention containing f...
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WO/2002/064544A1 |
A process for industrially producing in a high yield 1,3-bis(3-aminophenoxy)benzene, which is effective as, e.g., a material for polyimides having high heat resistance, which comprises reacting 1,3-difluorobenzene with an alkali metal sa...
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WO/2002/064130A1 |
PPAR alpha activators, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipo-protein-cholesterol and to lower certain plasma lipid levels, ...
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WO/2002/062307A1 |
The invention relates to colouring agents for keratin fibres containing [1.1'-biphenyl]-2.4-diamine derivatives of general formula (I) or physiologically acceptable, water soluble salts thereof in addition to novel [1.1'-biphenyl]-2.4-di...
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WO/2002/062308A2 |
Primary intermediates for hair coloring compositions for oxidative dyeing of hair are compounds of the formula (1): where R¿1?, and R¿2? are each individually selected from a hydrogen atom, a C¿1? to C¿3? alkyl group, a C¿...
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WO/2002/060857A1 |
The present invention relates to novel pharmaceutical formulations and methods of using Form A of fluoxetine hydrochloride.
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WO/2002/058632A2 |
Primary intermediates for hair coloring compositions for oxidative of hair are compounds of the formula (1): where R¿1? and R¿2? are each individually selected from a hydrogen atom, a C¿1? to C¿3? alkyl group, a C¿1? to C¿5? mono o...
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WO/2002/058655A1 |
Couplers for hair coloring compositions for oxidative dyeing of hair are compounds of the formula (1): wherein X is selected from halogen and R?5¿SO¿4? where the halogen is preferably CI, Br or I; R, R?1¿ and R?2¿ are each individual...
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WO/2002/058658A1 |
Primary intermediates for hair coloring compositions for oxidative dyeing of hair are compounds of formula (I), wherein R is hydrogen, hydroxy, nitro, amino, halogen, C¿1? to C¿5? alkyl or haloalkyl, C¿1? to C¿5? alkoxy or cyclic alk...
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WO/2002/058659A1 |
Couplers for hair coloring compositions for oxidative dyeing of hair are compounds of the formula (1) wherein X is CI, Br, I, or R?4¿SO¿4?; R¿3? is a C¿1? to C¿22? alkyl group or a C¿1? to C¿22? mono or dihydroxyalkyl group; R?1¿...
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WO/2002/058656A1 |
Couplers for hair coloring compositions for oxidative dyeing of hair are compounds of the formula (1): where R¿1? and R¿2? are each individually selected from a hydrogen atom, a C¿1? to C¿3? alkyl group, a C¿1? to C¿5? mono or dihy...
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WO/2002/058631A2 |
Primary intermediates for hair coloring compositions for oxidative dyeing of hair are compounds of the formula (1): wherein R is hydrogen, hydroxy, nitro, amino, halogen, C¿1? to C¿5? alkyl or haloalkyl, C¿1? to C¿5? alkoxy, C¿1? to...
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WO/2002/057216A1 |
Compounds represented by the general formula (|), which exhibit excellent immunosuppressive and/or antiallergic effects and are useful as drugs: (|) wherein R?1a¿, R?1b¿, R?1c¿, and R?1d¿ are each independently hydrogen, lower alkyl,...
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WO/2002/057201A2 |
Higher diamondoid derivatives capable of taking part in polymerization reactions are disclosed as are intermediates to these derivatives, polymers formed from these derivatives and methods for preparing the polymers.
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WO/2002/057215A2 |
The invention provides sodium channel modulating compounds which are useful for treating diseases or conditions associated with sodium channel activity, such as neuropathic pain. The invention also provides pharmaceutical compositions co...
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WO2000073263A9 |
A composition is provided comprising a novel cationic lipid compound having hydrophobic tails and two quaternary ammonium headgroups bridged by a linker. The composition is useful as a cytofectin for facilitating delivery and transfectio...
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WO/2002/051793A1 |
Compounds according to structural diagram (I) useful for treating neurological disorders wherein: R?1¿ and R?3¿ are selected from benzyl, phenethyl, naphthylmethyl, C¿1-8?alkyl, C¿3-6?cycloalkylC¿1-4?alkyl and CH¿3?SC¿1-4?alkyl; R...
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WO/2002/051908A1 |
Diaminobenzene derivatives of the general formula [1]; polyimide precursors and polyimides prepared by using the derivatives as part of the raw materials; and liquid crystal aligning agents containing the polyimide precursors and/or the ...
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WO/2002/051909A1 |
Diamines represented by the general formula [1]; polyimide precursors and polyimides produced by using the diamines as one of the raw materials; and liquid crystal aligning agents containing the precursors and/or the polyimides: [1] wher...
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WO/2002/050077A2 |
The invention relates to novel triazolopyrimidines of formula (I) in which R1, R2, R3 and X have the meaning given in the description, a method for the production of said novel materials and the use thereof for combating undesired micro-...
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WO/2002/050017A1 |
Disclosed is a process for the preparation of a compoud of formula wherein R¿1? is hydrogen, hydroxyl, or unsubstituted or substituted alkyl or alkoxy, R¿2? is hydrogen or a substituent which can be converted to hydrogen, and n is 0, 1...
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WO/2002/048078A1 |
The invention concerns 2-butyl-3-(4-[3(dibutylamino)propoxy]benzoyl)-5-nitro-benzof
uran hydrochloride, its preparation and its use as synthesis intermediate in particular for preparing 2-butyl-3-(4-[3-(dibutylamino)propoxy]benzoyl)-5-ni...
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WO/2002/047635A1 |
Couplers for hair coloring compositions for oxidative dyeing of hair are compounds of the formula at least one coupler comprising a compound of the formula (1): wherein R is selected from of C¿1? to C¿2? alkyl and hydroxyethyl, R?1¿ a...
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WO/2002/048123A2 |
The instant invention discloses a process for preparation of compounds of the formula (I), wherein the general symbols are as defined in claim 1, which process comprises reacting a compound of formula (II), wherein the general symbols ar...
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WO/2002/045658A2 |
The present invention relates to novel essentially pure venlafaxine and the process of preparation thereof. The present invention also relates to novel solvate forms of venlafaxine hydrochloride and the process of preparation thereof. Fu...
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WO/2002/046140A1 |
The present invention relates to novel crystalline polymorphic Forms of Venlafaxine hydrochloride and a process for their preparation. The present invention relates to two polymorphic Forms of Venlafaxine hydrochloride. Venlafaxine hydro...
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WO/2002/046139A2 |
The invention concerns 1,7-diarylpentamethine and 1,9-diarylhetptamethine salts, in particular heptacarbon or nonacarbon carboxonium salts, and streptocyanines. The compounds correspond to the formula [G-D-G']?+¿ Q?-¿ wherein Q is a st...
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WO/2002/044120A1 |
This invention relates to novel compounds that are liver selective glucocorticoid receptor antagonists, to methods of preparing such compounds, and to methods for using such compounds in therapy and in the regulation of metabolism, espec...
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WO/2002/044127A1 |
Novel substituted carboxylic acid derivatives which bind to human peroxisome proliferator-activated receptor $g(a) (PPAR$g(a)) as a ligand thereof and activate the same to thereby exert a lipid-lowering effect, an arteriosclerosis-preven...
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WO/2002/042259A2 |
A synthetic reaction to produce [2-(2-aminoethoxy)ethoxy] acetic acid (AEEA) derivatives, comprising the steps of: converting 2-(2-(2-chloroethoxy)ethoxy)-ethanol to an azide derivative reacting the azide derivative with triphenylphosphi...
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WO/2002/042248A2 |
The present invention relates to naphthalene derivatives of formula (I), wherein X is S, S(O), S(O)¿2?, S(O)¿2?NH, P(O)OCH¿3?, P(O)OH, NH, N(CH¿3?), NHC(O)NH, C(O), C(O)O, NHC(O), CH(OH), CH=N, CH=CH, CH¿2?NH, C(=NH); R?1¿ is aryl ...
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WO/2002/038533A1 |
The invention relates to 4,5-dialkoxy-1,2-diaminobenzenes of the formula (I), and the salts thereof that are suitable for use as coupling agents for producing oxidation colorations with known developer components. Oxidation dyes for dyei...
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WO/2002/038534A2 |
The invention relates to novel compounds which are substituted alkyldiamino derivatives of formula (I). The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions con...
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WO/2002/036542A1 |
Crystalline forms of Venlafaxine hydrochloride were found, referred to hereinafter as polymorphic Forms A, B and D. Furthermore, the present invention is directed to processes for the preparation of these crystalline forms and pharmaceut...
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WO/2002/034247A2 |
Oncoproteins such as Ras and RhoB are known to induce cell division in an unrestrained manner when such proteins are localized at the inner surface of a cancer cell membrane. The localization is effected by the prenylation reaction, wher...
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WO/2002/030869A1 |
The invention relates to 5-amino-1-pentene-3-ol substituted derivatives, a method for the production thereof, medicaments containing said compounds and the use of substituted 5-amino-1-pentene-3-ol derivatives for the production of medic...
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WO/2002/030870A2 |
The invention relates to substituted C-cyclohexylmethylamine derivatives, methods for the production thereof, pharmaceuticals containing said compounds and the use of substituted C-cyclohexylmethylamine derivatives for producing pharmace...
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WO/2002/030915A2 |
A new family of compounds, particularly aryl-indane compounds, is disclosed. The compounds may be used as inhibitors of P-glycoprotein-mediated transport. Use of the compounds to enhance bioavailability and to modulate multi-drug resista...
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WO/2002/028815A1 |
A compound of the formula in which R?1¿ and R?2¿ are each hydrogen or C¿1-4? alkyl, or R1 and R2 together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl or morpholino group...
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WO/2002/028817A1 |
The invention relates to substituted 1-aminobutan-3-ol derivatives, methods for the production thereof, pharmaceuticals containing said compounds and the use of substituted 1-aminobutan-3-ol derivatives for producing pharmaceuticals.
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WO/2002/030159A1 |
The invention relates to highly reliable organic electroluminescent materials and organic electroluminescent devices which exhibit high luminance and high light emitting efficiency, little cause luminous deterioration, and are excellent ...
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WO/2002/028816A1 |
The invention relates to substituted 5-amino-1-pentene-3-ol derivatives, to a method for the production thereof, to medicaments containing said compounds and to the use of substituted 5-amino-1-pentene-3-ol derivatives for producing medi...
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WO/2002/026694A1 |
The invention relates to O-substituted 6-methyl-tramadol derivatives, to methods for producing them, to medicaments containing these compounds and to the use of O-substituted 6-methyl-tramadol derivatives for producing medicaments for tr...
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WO/2002/024629A1 |
The present invention is directed to certain novel compounds represented by structural formula (I), or a pharmaceutically acceptable salt thereof, wherein R?3¿, R?5¿, R?6¿, R?7¿, R?8¿, R?11¿, R?12¿, R?13¿, Q, W, X, Y and Z are de...
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WO/2002/024619A1 |
Ar is a bicyclic or tricyclic aromatic group including at least one benzene ring, the oxygen group of the side chain being attached to the benzene ring of Ar; A is a straight or branched alkylene group of 6 to 16 carbon atoms which may b...
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WO/2002/024632A2 |
The invention relates to a compound of formula (I), wherein all variables are as defined herein, and pharmaceutically acceptable salts or solvates thereof. The compounds of formula (I) are useful as LXR agonists.
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WO/2002/022709A1 |
The invention relates to a highly branched water-soluble polyamine oligomer (HBPO), a process of preparation and its various applications, in particular, in paper manufacturing.The oligomer of the invention is soluble in water and alcoho...
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WO/2002/022623A1 |
Prochiral ketones are enantioselectively reduced to chiral secondary alcohols with a compound having the formula I: where, the two R¿2? groups are identical and are each a substituted or unsubstituted, aryl, alkyl, cycloalkyl or aralkyl...
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WO/2002/020459A1 |
Novel styryl compounds represented by the general formula (1) or (2); and an organic electroluminescent device with an organic compound film comprising at least a light emitting layer, wherein a novel styryl compound described above is c...
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WO/2002/018318A1 |
The invention relates to colouring agents for keratin fibres containing N-benzyl-p-phenylenediamine derivatives of general formula (I) or the physiologically compatible water soluble salts thereof, in addition to novel N-benzyl-p-phenyle...
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