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JP5430943B2 |
The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, wherein Y, L, A, W1, W2, and R′1 are defined herein. These compounds are useful as immunosuppr...
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JP5427894B2 |
The present invention relates to a novel compound having excellent antioxidant activity, isolated from Ramalina terebrata, and more particularly to a novel compound, Ramalin, having excellent antioxidant activity, isolated from the Antar...
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JP5372556B2 |
To provide a method for highly stereoselectively producing a homoallyl compound in a high yield by an optically active α-addition-type allylation reaction. The α-addition-type allylated compound is stereoselectively produced by a catal...
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JP5322564B2 |
Preparation of monomethylhydrazine (MMH) comprises methylating hydrazine or hydrazinium hydro- or -dihydrochloride with methyl chloride and/or methanol/hydrochloric acid mixture, reacting the reaction mixture, resulting from the methylat...
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JP5291854B2 |
The present invention provides a method represented by Scheme 1: wherein X represents I, Br, Cl, alkylsulfonate, or arylsulfonate; Z represents optionally substituted aryl, heteroaryl or alkenyl; L represents hydrogen or a negative charg...
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JP5266499B2 |
The present invention provides a method represented by Scheme 1: wherein X represents I, Br, Cl, alkylsulfonate, or arylsulfonate; Z represents optionally substituted aryl, heteroaryl or alkenyl; L represents hydrogen or a negative charg...
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JP2013151628A |
To provide a new gelatinizer.A new gelatinizer includes an alkyl hydrazide compound represented by formula [I] or a dialkyl hydrazide compound represented by formula [II] (wherein R1 and R2 are each independently a 1-30C aliphatic group ...
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JP5238159B2 |
The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding...
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JP5227523B2 |
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JP5214608B2 |
A method for producing 3-(2,2,2-trimethylhydrazinium)propionate dihydrate by saponification of salts of 3-(2,2,2-trimethylhydrazinium)propionate esters with subsequent purification step using saturation with carbon dioxide or sulphur dio...
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JP5209302B2 |
Compounds useful in modulating angiogenesis and uses thereof in methods of treating or preventing diseases associated with angiogenesis by administering a polycationic compound; and compositions for use in inhibiting angiogenesis-mediate...
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JP5184565B2 |
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JP5173791B2 |
Acylhydrazide compounds (I) or their derivatives, salts, solvates and/or stereoisomers, are new. Acylhydrazide compounds of formula (I) or their derivatives, salts, solvates and/or stereoisomers, are new. Either R 1>-R 9>H, A, OSO 2A, ha...
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JP2013010739A |
To provide a new method for producing an isoxazoline compound, and provide an intermediate for the production of the isoxazoline compound.There is disclosed a method for producing the isoxazoline compound represented by formula (8). In t...
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JP2013010740A |
To provide a new method for producing an isoxazoline compound and production intermediates thereof.The method for producing the isoxazoline compound represented by chemical formula includes: (1) producing a carbamic acid ester compound b...
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JP5117377B2 |
Chemical compounds identified by in silico molecular modelling, and having an structure that allows the blocking of the phosphorylation event, through the interaction of such compounds with the phosphorylation domain or its milieu in the...
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JP5120962B2 |
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JP2013001692A |
To provide a compound which can form a coating film removable without deteriorating coated objects, a coating composition, and a coating removal method to remove the coating film formed with the coating composition.A coating composition ...
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JP2012246276A |
To provide a method for producing a phenylhydrazine (II) in good yield.There is provided a method for producing a phenylhydrazine (II) comprising reacting a diazonium salt (I) with at least one selected from the group consisting of sulfi...
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JP2012246274A |
To provide a method for producing phenylhydrazines (II) in good yield.There is provided a method for producing a phenylhydrazine (II) comprising mixing a diazonium salt (I), at least one selected from the group consisting of sulfites and...
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JP5093429B2 |
Ectoparasitic insect pest controllers for animals, containing hydrazine derivatives of the general formula (I) as the active ingredient, and methods for application of the same: (I) Äwherein A is (II), (III), (IV), (V) (wherein R<4> and...
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JP5086069B2 |
A process is provided for preparing the HIV protease inhibitor atazanavir bisulfate wherein a solution of atazanavir free base is reacted with concentrated sulfuric acid in an amount to react with less than about 15% by weight of the fre...
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JP5086635B2 |
Antibacterial compounds of formula (I) are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; treating bacterial infections by the a...
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JP5072026B2 |
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JP2012188412A |
To provide an N-nitrosoaniline derivative capable of positionally and temporally controlling generation of peroxynitrite (ONOO-) by ultraviolet irradiation, a highly reactive ROS generating agent using the N-nitrosoaniline derivative, an...
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JP5010788B2 |
Carboxylic acid amides of general formula which inhibit telomerase and are useful for treating tumor diseases such as carcinomas, sarcomas and leukaemias. Exemplary compounds are: (1) trans-3-(naphth-2-yl)-but-2-enoic acid-N-(2-carboxy-p...
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JP5002452B2 |
The invention relates to substituted enaminones of Formula I and their derivatives and the discovery that these compounds modulate the effect of γ-aminobutyric acid (GABA) on the GABAA receptor complex in a therapeutically relevant fash...
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JP2012516308A |
The present invention provides a method for the synthesis of radioiodinated compounds which is advantageous over prior art methods. Using a hydrazine or an aminoxy in place of a primary amine for indirect radioiodination facilitates a mu...
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JP4975201B2 |
Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
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JP4965779B2 |
Use of compounds of general formula (I) or salts thereof as phytopathogenic fungicides wherein the various radicals and substituents are as defined in the description, pesticidal compositions containing them and method for combatting pes...
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JP4966659B2 |
Acrylic acid derivatives (C1), hydrazones (C2), imines (C3), bicyclic compounds (C4), hydrazine or azo compounds (C5), hexafluoropropane derivatives (C6), amino acids (C7), heterocyclic compounds (C8), alkenyl cyclic compounds (C9), bicy...
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JP4968602B2 |
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JP2012121809A |
To provide an industrially satisfactory advantageous method for producing a compound or a salt thereof which is useful for the treatment of neurodegenerative diseases such as Alzheimer's disease and Down's syndrome; and an intermediate u...
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JP2012514655A |
Fluorinated compounds and methods of making fluorinated compounds are described herein.
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JP4939216B2 |
The invention provides novel compounds according to formula I relates to compounds with the general formula I said compounds being useful, e.g. in the treatment of inflammatory, ophthalmic diseases or cancer.
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JP4913077B2 |
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JP2012046525A |
To provide a compound and method useful in modulating angiogenesis, and to provide a method of treating or preventing a disease or disorder associated with angiogenesis by administering a polycationic compound.There is provided a salicyl...
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JP4886967B2 |
One aspect of the present invention relates to ionic liquids comprising a pendant Bronsted-acid group, e.g., a sulfonic acid group. Another aspect of the present invention relates to the use of an ionic liquid comprising a pendant Bronst...
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JP4870298B2 |
N-nitrosohydroxylamine compounds exhibiting minimal or no degradation are disclosed. The N-nitrosohydroxylamines can be stabilized in the presence of a compound capable of removing water from the environment.
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JP4855924B2 |
The invention relates to conjugates of formula (V) or (VI): wherein X is —CO—NH—, —NH—, —O—, —NHCONH—, or —NHCSNH—; their use as radiopharmaceuticals, processes for their preparation, and synthetic intermediates use...
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JP4854854B2 |
A process for preparing pesticides or pesticidal intermediates, particularly 5-amino-1 aryl-3-cyanopyrazoles, having the formula said process comprising reacting a compound having the formula with a cyanide salt.
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JP4844961B2 |
To provide compounds which have high angiogenesis inhibiting activity, and are useful as agents for effective treatment and prevention of diseases involving pathologic angiogenesis, for example, cancer and cancer metastasis, methods for ...
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JP4836396B2 |
The invention relates to novel naphthalene derivatives of formula (I) and their use as cannabinoid receptor agonists wherein X, R 1 , R 2 and R 3 are as defined in the description, processes for their production, their use as pharmaceuti...
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JP4826282B2 |
The present invention relates to a diketohydrazine derivative of formula (I) and a pharmaceutically acceptable salt thereof (the symbols in the formula have the same meaning as described in the specification). The compound of formula...
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JP4809239B2 |
Continuous synthesis of monoalkylhydrazines (I). Continuous synthesis of monoalkylhydrazines (I) comprises: (a) reaction of anhydrous amine NH 2R (II) and monochloroamine (III) at 25-45[deg]C in alkaline medium; (b) separating the reacti...
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JP4784803B2 |
Phenylalanine derivatives of the following formula and analogues thereof have an antagonistic activity to alpha 4 beta 7 integrin and a selectivity toward alpha 4 beta 1 integrin. They are used as therapeutic agents for various diseases ...
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JP4690733B2 |
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JP4673568B2 |
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JP4669612B2 |
A process for preparing compounds of the formula Iin which R1 is hydrogen, an aliphatic group having 1-8 carbon atoms, Cl-C6-alkoxycarbonyl, Cl-C6-alkylthiocarbonyl or a cyclic ring system having 3-14 ring atoms, and R2 is hydrogen, an a...
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JP2011510085A |
Disclosed herein are compounds useful in treating glaucoma, inflammatory bowel disease, the stimulation of hair growth, and the stimulation of the conversion of vellus hair to terminal hair. The compounds themselves are herein.
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