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WO/2000/055125A2 |
The present invention relates to novel N-cyanomethyl amides which are cysteine protease inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
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WO/2000/055124A2 |
The present invention relates to novel cysteine protease inhibitors; the pharmaceutically acceptable salts and $i(N)-oxides thereof; their uses as therapeutic agents and the methods of their making.
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WO/2000/049002A1 |
An improved process and intermediate compounds (N) for the preparation of 2-(N,N-disubstituted)amino-4-(perfluoroalkyl)-1,3-oxazin-6-o
ne compounds having structural formula (I) and an improved process for the preparation of 6-(perfluoro...
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WO/2000/043358A1 |
The invention relates to a process for the preparation of urea from ammonia and carbon dioxide, the preparation being effected in whole or in part in a vertical combi-reactor. The gas stream leaving the stripper is fed to the condenser s...
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WO/2000/042009A1 |
The invention concerns the use of isocyanates obtained from amino acid derivatives for preparing and optionally isolating stable activated carbamic acid derivatives, or stable activated carbamates.
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WO/2000/040529A1 |
The invention relates to the use of compounds of formula (I): wherein X is -C(O)-, -C(S)-, -C=NOH, or -CH(R?7¿)- wherein R?7¿ is hydrogen, hydroxy, C¿1-7?alkoxy, -OR?8¿ or -NR?8¿R?9¿ (wherein R?8¿ is a group -Y?1¿R?10¿ (wherein ...
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WO/2000/037570A1 |
The invention provides a process for preparing an allophanate-containing compound in the presence of a metal catalyst and a tertiary amine. In a preferred process, the tertiary amine compound also has a hydroxyl group. The hydroxyl group...
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WO/2000/035864A1 |
The present invention relates to biphenyl and biphenyl-analogous compounds, their preparation and use as pharmaceutical compositions, as integrin antagonists and in particular for the production of pharmaceutical compositions for the tre...
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WO/2000/032566A1 |
The invention relates to a method for producing urea. According to said method, the off-gases which originate from a melamine plant and essentially consist of NH¿3? and CO¿2? are introduced into the high-pressure zone of the urea plant...
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WO/2000/024707A1 |
The present invention discloses compounds having formula (I) wherein the substituents are defined in the application. The compounds are useful as chloride channel blockers.
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WO/2000/012468A1 |
This invention relates to a process for making 3-hydroxy-4-amino-benzonitrile.
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WO/2000/012472A2 |
This invention relates to a process for making certain phenyl urea compounds by using a Lewis acid to effect the ring opening of a benzoxazolinone by an amine.
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WO/2000/000466A1 |
Process for the preparation of urea from ammonia and carbon dioxide in which a submerged condenser is used as high-pressure carbamate condenser and the urea synthesis solution leaving the submerged condenser is transferred to the reactor...
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WO/1999/067206A1 |
Compounds of general formula (I) are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular...
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WO/1999/067204A1 |
Compounds of general formula (I) are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular...
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WO/1999/067228A1 |
This invention is directed to a fluorophenyl resin compound, to methods of its preparation; and to its use in the solid phase synthesis of amides, peptides, hydroxamic acids, amines, urethanes, carbonates carbamates, sulfonamides and $g(...
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WO1999029663A9 |
The invention relates to a process for the preparation of urea from ammonia and carbon dioxide in which the low-pressure carbamate stream formed in the further upgrading of the urea synthesis solution is stripped in a CO2-carbamate strip...
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WO/1999/050235A1 |
Apparatus for the urea synthesis from ammonia and carbon dioxide of the kind comprising a number of separate reaction compartments; the compartment separating means consist of one or more net layers wherethrough the gas phase coming out ...
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WO/1999/046037A1 |
An apparatus for effecting gas/liquid contact in a system in which the liquid is the continuous phase, the apparatus consisting of a vertical column fitted with a series of perforated trays (1). The perforated trays provide openings (3) ...
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WO/1999/033790A1 |
Fluoro-substituted benzoylureas of formula (I) wherein R?1¿, R?2¿ and R?3¿ each independently represent a hydrogen atom, nitro, cyano, halogen, C¿1-3?-alkyl, C¿1-3?-haloalkyl, C¿1-3?-alkoxy, C¿1-3?-haloalkoxy, C¿1-3?-alkylthio or...
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WO/1999/031053A1 |
An improved process for the synthesis of urea from ammonia and carbon dioxide by the use of a vertically or horizontally placed condenser, enabling the corrosion prevention of the areas in which the tube plate of the condenser is joined ...
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WO/1999/025698A1 |
The invention relates to a method for producing ar(alk)yluraciles of general formula (I), wherein A represents a single bond or an alkanediyl, Ar represents optionally substituted aryl, R?1¿ represents optionally substituted alkyl, and ...
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WO/1999/021828A1 |
The present invention provides a simple, 1-step process for preparing a N-(aryl or heteroaryl)-hydroxyurea comprising reacting the corresponding alcohol, ester or ether with hydroxyurea and acid. This reaction is particularly useful for ...
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WO/1999/018084A1 |
A method of N-alkoxyalkylating ureides according to the invention comprises reacting a ureide of structure (I) with an alkylating agent of structure (III) in the presence of a basic catalyst in an aprotic reaction medium. The ureide may ...
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WO/1998/035930A1 |
Process for the preparation of an N-acyl amino carboxylic acid by means of a carboxymethylation reaction. In this reaction, a reaction mixture is formed which contains a base pair, carbon monoxide, hydrogen and an aldehyde with the base ...
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WO/1998/032731A1 |
Process for the preparation of urea, in which the gas stream which is released during the synthesis of melamine and is composed essentially of ammonia and carbon dioxide is used to synthesize urea, in which process the gas stream which o...
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WO/1998/017635A1 |
Process for the manufacture of urea from carbon dioxide and ammonia with high conversion yields including a urea synthesis section and an ammonia stripping section of carbamate obtained as by-product, characterized in that the urea synth...
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WO/1998/008808A1 |
In the present process for the preparation of urea, an off-gas stream released during the synthesis of melamine in a high-pressure melamine process which consists predominantly of ammonia and carbon dioxide, is introduced into at least o...
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WO/1998/007921A1 |
Aqueous solutions of N-methylolethers of carboxylic acid amides, urethanes, ureas and aminotriazines suitable for finishing cellulosic textile materials are prepared by reacting the corresponding N-methylol compounds with an alcohol in t...
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WO/1998/007763A1 |
This invention relates to methods for preparing novel, solid-phase transfer reagents, specifically phosgenated oxime resins and non-symmetrical ureas, that are useful as supports in combinatorial synthesis for the creation of libraries o...
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WO/1998/007771A1 |
A process is disclosed for producing a polyisocyanate containing biuret groups from at least one aliphatic, cycloaliphatic or araliphatic diisocyanate or a mixture of two or more such substances, and from at least one amine or water or a...
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WO/1998/003477A1 |
A urea synthesis process starting from ammonia and carbon dioxide carried out under a pressure of 120x10?2� to 400x10?2� KPa and a temperature of 140 to 215 �C, in which the reaction takes place in a reactor in which gaseous CO�2...
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WO/1998/003518A2 |
Bis-platinum(II) complexes with polymethylene derivatives, the method of making the complexes, and the use of the complexes for the treatment of tumors in mammals, are disclosed. The method of making the polymethylene derivatives, is als...
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WO/1998/000394A1 |
The present invention relates to a novel benzoyl urea derivative which exhibits potent growth-retarding activity against pests and which is represented by formula (I), in which A represents N or CH, and X?1� and X?2� independently of...
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WO/1997/049680A1 |
This invention relates to the use of phenyl ureas of formulas (I) and (II) in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8). The variables of (I) and (II) are defined herein.
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WO/1997/045400A1 |
The present patent application relates to compounds having formula (I) or a pharmaceutically acceptable salt thereof wherein one of R1, R2 and R3 is a non-cyclic acidic group having a pKa value below 8 or a group which is in vivo convert...
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WO/1997/042230A1 |
Novel polymer-supported quenching reagents of Formula (I): P-L-Q, wherein P is a polymer of low chemical reactivity which is soluble or insoluble; Q is one or more quenching reagents, or an acid or base addition salts thereof, that are c...
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WO/1997/038789A1 |
A method of detecting clogging of the air-feeding pipes, comprising a plurality of air-feeding pipes (15) having outlets (13) for blowing the air into a granulating section (1), and nozzles (3) formed at the central portions of the air o...
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WO/1997/034690A1 |
Method for the safety and extension of the operating life of pressure equipment comprising an internal chamber suitable for containing a process fluid, surrounded by a pressure-resistant body (1) equipped with weep-holes (2), consisting ...
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WO/1997/033895A1 |
The invention relates to isolated RNA molecules with high affinity for particular amino acids, processes for isolating these, and uses thereof. Via a process which includes various washing and heating steps, one isolates these RNA molecu...
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WO/1997/028100A1 |
The present invention provides a process for preparing granular urea, which solves a problem for removing a moisture in a prilling tower method and a problem for concentrating diluted formaldehyde in granulation by a fluidized, spouted b...
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WO/1997/025308A1 |
Products prepared by reacting polyisocyanates with alkenyl or alkynyl compounds; then with perfluoroalkyl iodides and dehydroiodinating the product.
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WO/1997/021685A1 |
A compound of formula (I) is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
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WO/1997/015280A1 |
The use of at least one NO synthase inhibitor as the active principle in a cosmetic composition for treating and/or preventing sensitive skin is disclosed. The use of at least one NO synthase inhibitor for preparing a pharmaceutical and ...
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WO/1997/015388A1 |
A hydrolysis reactor for removal of urea, ammonia and carbon dioxide from a liquid phase comprising urea in aqueous solution advantageously, advantageously comprises: a dividing baffle (8) extending horizontally at a preset height in the...
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WO/1997/010206A1 |
The present invention provides a process for the preparation of a compound of formula (I), wherein R is a straight or branched alkyl group of from one to twelve carbon atoms; M represents hydrogen or a pharmaceutically acceptable cation;...
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WO/1997/006134A1 |
A novel and advantageous method for preparing N,N-dimethyl-N'-phenylurea and phenyl ring substituted derivatives thereof, wherein phenylisocyanate or ring substituted derivatives thereof are reacted with an excess amount of boiling dimca...
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WO/1997/006135A1 |
A process for producing carbamoylmethylurea derivatives represented by general formula (I), characterized by reacting a compound represented by general formula (II) with a compound represented by general formula (III).
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WO/1997/003044A1 |
A process and device are disclosed for preparing (cyclo)aliphatic biuret groups-containing polyisocyanates from (cyclo)aliphatic diisocyanates and steam or a dehydrating substance as reactives that are mixed with each other in a stirring...
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WO/1996/039382A1 |
A compound of formula (I) wherein R1 is cyano, thiocarbamoyl, a group of formula (a) in which R4 is hydrogen, lower alkyl which may have optionally substituted aryl, acyl, optionally substituted aryl, lower alkylthio or 1-lower alkylindo...
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