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JP4531865B2 |
A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces ...
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JP2010523685A |
Polyamine, polyamine/guanidino, and polyamine/biguanide compounds bearing allene, propargyl, cyclopropyl, and other reactive moieties are disclosed. The compounds are useful as irreversible inhibitors of the enzyme lysine-specific demeth...
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JP4503232B2 |
The present invention relates to methods for the prophylaxis, management and treatment of certain diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD) by the administration ...
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JP4477301B2 |
The present invention relates to a compound of formula III, method of making the same and its use in the treatment of diabetes.
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JPWO2008105441A1 |
A water-soluble polyamino acid compound represented by the following general formula (I) or a salt thereof. This compound is a novel compound that has an inhibitory effect on phosphorus absorption in a living body and is water-soluble.(I...
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JP4467084B2 |
The invention concerns compounds for transferring nucleic acids into cells. The compounds are more particularly related to the lipopolyamine family, and comprise amidine functions. The compounds are useful for transferring nucleic acids ...
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JP4469273B2 |
The invention provides MRI detectable species of formula (I) Dp-Sn-Nm wherein D is a MRI detectable moiety S is a spacer N is a molecule of a nutrient or pseudo-nutrient n is 0 or an integer m is an integer and p is an integer. These...
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JP2010111690A |
To provide new 4-dedimethylamino tetracycline compounds for treating numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms.The substituted tetracycline compounds are represented by formula I. Wherei...
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JP2010513530A |
Provided are compounds that are modulators of C3a receptor activity, compositions containing the compounds and methods of use of the compounds and compositions. In certain embodiments, the compounds are pyridones. In certain embodiments,...
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JP2010090138A |
To provide a novel substituted tetracycline compound useful to treat numerous tetracycline compound-responsive states such as bacterial infections and neoplasms.The compound is represented by formula (I), wherein X is CH2, CH-alkyl or th...
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JP4451058B2 |
This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, their use in treating human or animal disorders. The compounds of the invention are useful as modulators of th...
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JP2010077150A |
To provide methods for prophylaxis, management and treatment of specific diseases modulated by inhibition of enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD) by administration of a composition containing as an act...
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JP4439265B2 |
This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, TNF-alpha or combinations thereof.
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JP4430135B2 |
Cationic lipids having a derivatized quaternary ammonium head group that provide improved cell targeting ability and enhanced transfective efficacy for introducing molecules into cells are provided.
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JP4430301B2 |
Double fumarates of L-carnitine or isovaleryl L-carnitine and an amino acid are disclosed which are useful as active ingredients of food supplements, dietary supplements or drugs.
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JP4421293B2 |
The current invention provide novel compounds, methods of treating or preventing emphysema, cancer and dermatological disorders, pharmaceutical compositions suitable for the treatment or prevention of emphysema, cancer and dermatological...
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JP4421680B2 |
The present invention relates to compounds as represented by formula (I) that can maintain, increase, or restore sensitivity of cells to therapeutic or prophylactic agents. This invention also comprises pharmaceutical compositions compri...
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JP4410562B2 |
The current invention provide novel compounds, methods of treating or preventing emphysema, cancer and dermatological disorders, pharmaceutical compositions suitable for the treatment or prevention of emphysema, cancer and dermatological...
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JP4405088B2 |
New thyroid receptor ligands are provided which have general formula (I) in which: n is an integer from 0 to 4; R1 is halogen, trifluoromethyl, or alkyl of 1 to 6 carbons or cycloalkyl of 3 to 7 carbons; R2 and R3 are the same or differe...
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JP4402747B2 |
Thiophenylalkenylcarboxylic acid guanidide derivatives of formula (I) and their salts are new. at least one of R1-R3 = Op(CH2)sCqF2q+1, R40CO or R31SOk; and the others = H, F, Cl, Br, I, CN, OnaCmaH2ma+1 or OgaCraH2raR10; p = 0 or 1; s =...
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JP2010006817A |
To provide a hydroxamic acid or carboxylic acid-functional compound (which can inhibit production of a tumor necrosis factor alpha (TNF-)), a pharmaceutical composition containing such a compound and a curing method using such a compound...
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JP4383177B2 |
Compounds of formula (1) or a pharmaceutically acceptable salt, solvate, acid isostere, or hydrolyzable ester thereof, are disclosed. Methods of making and using the compounds are also disclosed. In particular methods for treating diseas...
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JP4383343B2 |
N-((4-Polyfluorocycloalkyl-oxy, -thio or -amino)-benzoyl)-guanidine derivatives (I) are new. Benzoyl-guanidine derivatives of formula (I) and their salts are new. [Image] X : O, S or NR 6; R 6H, 1-4C alkyl or -(CH 2) k-CF 3; k, l, m, n, ...
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JP2009280569A |
To provide a method for N-methylation of an amino acid compatible with Fmoc (9-fluorenylmethoxycarbonyl)/tBu SPPS (tert-butyl solid phase peptide synthesis).Compounds represented by formula I, and an N-protective method of an amino acid ...
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JP2009541220A |
Described herein is a compound of Formula I, which is the metformin salt of the naturally occurring endogenous biological compound, (R)-(+) α lipoic acid, pharmaceutical compositions containing the compound of Formula I, and methods of ...
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JP2009541225A |
The present invention provides the use of pelorol analogs of Formula, (I) and pharmaceutical compositions thereof as modulators of SHIP 1 activity. A compound or a pharmaceutical composition of the present invention may be used for the t...
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JP4360854B2 |
To provide a new guanidine derivative and its salt and applications thereof. The guanidine derivative is represented by general formula (1) (wherein, A is an aromatic ring; R1and R2are each mutually independently a 10-25C alkyl group or ...
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JP2009256232A |
To provide a drug delivery system, capable of solving conventional technological problems and easily utilized.This medicine having magnetism is provided by containing an acid salen complex expressed by formula (I) [wherein, R is a substi...
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JP2009256233A |
To provide a drug delivery system, capable of solving conventional technological problems and easily utilized.This medicine having magnetism is provided by containing an acid salen complex expressed by formula (I) [wherein, R is a substi...
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JP2009235034A |
To provide a stabilizer for an aqueous solution of a physiologically active substance, which suppresses deactivation of a physiologically active substance in an aqueous solution, stabilizes an aqueous solution of a physiologically active...
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JP2009533315A |
What is provided herein is an aromatic compound substitution agent that is a tRNA synthetase inhibitor and thus can be used as an antibacterial agent. The compounds described herein are Gram-positive, Gram-negative, anaerobic or fungal m...
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JP2009209090A |
To provide an insecticide which exhibits a high insecticidal effect even in a low dosage.There are provided a compound represented by general formula (1) and an insecticide containing the compound as an active ingredient. In the formula ...
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JP4298098B2 |
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JP2009143927A |
To provide a compound useful for therapeutic treatment of a neurological disease or disorder such as stroke, head trauma, spinal cord injury, epilepsy, and anxiety, or a neurodegenerative disease such as Alzheimer's disease, Huntington's...
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JP4278863B2 |
Novel salts of the antidiabetic agent metformin acre provided which are metformin salts of dibasic acids (2:1 molar ratio), preferably metformin (2:1) fumarate and metformin (2:1) succinate, which may be employed alone or in combination ...
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JP2009521430A |
The present invention relates to novel imidazole derivatives having a positive allosteric GABAB receptor (GBR) modulator effect, methods for the preparation of said compounds and to their use, optionally in combination with a GABAB agoni...
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JP2009520694A |
A nitrogen complex of an inorganic phosphate comprising the anionic sub-structure (I); whereby a nitrogen atom (N) of a complexing agent is complexed to an oxygen atom (O) of the inorganic phosphate; wherein the nitrogen atom is selected...
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JP4267920B2 |
The present invention relates to novel compounds (I), their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating certain metabolic diseases and diseases m...
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JP4269580B2 |
To obtain an injection of 6'-amidino-2'-naphthyl 4-guanidinobenzoate 2 methanesulfonate (compound (A)) which has excellent long-term storage stability than that of a freeze-dried preparation and has storage stability after preparation fo...
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JP4267922B2 |
(R)-2-Arylpropionamide compounds of formula (I), pharmaceutical preparations of the compounds and a process for making the compounds are described. The 2-Arylpropionamides of the invention are useful in the prevention and treatment of ti...
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JP2009108048A |
To provide a new hydroxylamine derivative falling within the scope of formula (I) or (II) for increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells as well as a pharmaceuti...
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JP2009102474A |
To provide a new proton-conducting polymer solid electrolyte which functions under an unhumidified or low humidified condition.There are provided a proton-conducting compound comprising a guanidine compound salt produced by reacting a gu...
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JP4262920B2 |
The invention relates to a process for preparing substituted cyclopentane derivatives represented by the formula (I)wherein R1, R2, R3, R4, X and Y are as described in the specification, and pharmaceutically acceptable salts thereof.The ...
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JP4261223B2 |
To provide a chiral derivative of a low environmental load type which can be simply obtained at a low cost, and an ionic liquid as a new solvent. The organic ionic liquid is a quaternary nitrogen compound represented by formula I [wherei...
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JP4256160B2 |
Phenyl acetamide compounds are described, including compounds of or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R3-R6, R11, B, Y and W are set forth in the specification. The compounds of the invention are pot...
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JP4251892B2 |
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JP2009512659A |
The present invention provides for compounds useful for treating an HIV-1 infection, or preventing an HIV-1 infection, or treating AIDS or ARC. The compounds of the invention are of formula I wherein R1, R2, R3, R4, R5 and X are as herei...
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JP4242366B2 |
Disclosed herein is a method of forming a guanidine group on carbon nanotubes to improve the dispersibility of carbon nanotubes, a method of attaching carbon nanotubes having guanidine groups to a substrate, and carbon nanotubes and a su...
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JP4236578B2 |
A simple and economical process for the preparation of polyphosphates of organic bases consists of reacting a mixture of phosphorus pentoxide and at least one organic nitrogen base with at least one compound which releases water accompan...
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JP4234917B2 |
Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibit...
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