| Document |
Document Title |
|
JP2015172034A |
To coupledly and batch-simultaneously produce 18 kinds of liquid amino acids other than either one kind of glutamine or glutamic acid and either one kind of asparagine or asparaginic acid among 20 kinds of amino acids.Dust obtained in su...
|
|
JP2015523382A |
A trisalt containing a compound containing two acidic and one basic functional groups (eg, asparagate or glutamate), metformin, and a polyunsaturated fatty acid such as eicosapentaenoate or docosahexaenoate. The compounds are provided he...
|
|
JP2015143193A |
To provide a material showing strong inhibitory activity against cholesterol ester transfer protein (CETP).This invention relates to a compound such as 2-((1S,4R)-4-(((2-((((S)-1-(3,5-bis(trifluoromethyl)phenyl)e
thyl)(5-ethoxypyrimidine...
|
|
JP2015518855A |
The present invention relates to compounds of formula I or pharmaceutically acceptable salts thereof, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates. Pharmaceutical compositions comprising formula I, and effecti...
|
|
JP5733988B2 |
The present invention relates to linear and cyclic guanidine derivatives, method of preparation and uses thereof, pharmaceutical compositions to be used as antifungal agents, in particular against Candida species.
|
|
JP2015091842A |
To provide an amine derivative useful for treatment of eye diseases and disorders, e.g. age-related macular degeneration and Stargardt Disease, and a pharmaceutical composition using the same.There are provided an amine derivative repres...
|
|
JP5709688B2 |
Compounds I-III wherein U is CH, O, or S; Z is mono- or di-substituted carbon; R is (CH2)nCO2H, (CH2)nSO3H, (CH2)nPO3H2, (CH2)nNO2, CH(SCH3)3, esters; R1 is H, hydroxyalkyl, aminoalkyl, alkoxyalkyl; RR1 is O; n is 0-4; R2, R3 is H, hydro...
|
|
JP5701832B2 |
The present invention provides a method represented by Scheme 1: wherein X represents I, Br, Cl, alkylsulfonate, or arylsulfonate; Z represents optionally substituted aryl, heteroaryl or alkenyl; L represents hydrogen or a negative charg...
|
|
JP2015063557A |
To provide novel 4-dedimethylamino tetracycline compounds which can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms.The present invention provides substituted tetracycline com...
|
|
JP2015038096A |
To provide an efficient method of producing arginine bicarbonate at low pressure.A method of producing arginine bicarbonate comprises bringing carbon dioxide of a pressure of 6,895 Pa(1 psi) to 6,8947 Pa(10 psi) into contact with an inci...
|
|
JP5671626B2 |
A method of buffering a chemical or biological composition, comprising adding to the composition an effective buffering amount of at least one protonated or un-protonated amine-quaternary ammonium compound having a general formula: where...
|
|
JP2015502330A |
A polyamide composition containing a guanidinyl radical, for example a tetramethylguanidinyl radical, will be described. Such polyamides are useful, for example, in medical applications for treating human papillomavirus infections. [Sele...
|
|
JP5656408B2 |
Novel compounds that find use as imaging agents within nuclear medicine applications (PET imaging) for imaging of cardiac innervation are disclosed. These PET based radiotracers may exhibit increased stability, decreased NE release (ther...
|
|
JP5654190B2 |
The present invention relates to the use of compounds of general formula (I) as ligands to the melanocortin receptors and/or for treatment of disorders in the melanocortin system: wherein X is H or OH; R1, R2, R3, R4 and R5 are the same ...
|
|
JP5648083B2 |
A pest control agent containing a compound represented by the following Formula (1), wherein A represents a carbon atom, a nitrogen atom, or the like, K represents a non-metal atom group necessary for forming a cyclic linking group deriv...
|
|
JP5649909B2 |
|
|
JP5647201B2 |
The present invention relates to an organopolysiloxane composition that can be vulcanized at room temperature into an elastomer that is crosslinked by polycondensation and that does not contain alkyltin-based catalysts which exhibit toxi...
|
|
JP2014237597A |
To provide a new compound suitable as a photo-base generator, which can maintain high basicity for a long period of time with ultraviolet irradiation.A compound is represented by the formula (1). (In the formula, Rand Reach independently...
|
|
JP2014237598A |
To provide a new compound suitable as a photo-base generator, which can maintain high basicity for a long period of time with ultraviolet irradiation.A compound is represented by the formula (1).
|
|
JP5625914B2 |
An object of the invention is to provide a novel arginine derivative and a cosmetic satisfactory in compatibility with the skin and hair, excellent in skin softening effect and skin-conditioning effect, and satisfactory in use feeling wi...
|
|
JP5619867B2 |
The present invention provides an enantioselective composite membrane useful for separation of optical isomers and the process for the preparation thereof. The invention further provides a membrane based pressure driven separation proces...
|
|
JP5616410B2 |
The present invention relates to novel compounds and compositions having antiviral activity. The invention also relates to methods for the therapeutic or prophylactic treatment of viral infections in mammals.
|
|
JP2014196287A |
To provide alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds, which are useful for treating neurodegenerative diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's ...
|
|
JP5603328B2 |
The invention provides a novel apparatus and method for preparing a solution of a shear sensitive material.
|
|
JP2014166987A |
To provide compounds useful for curative treatment of neurodegenerative disease, or useful as a muscle relaxant, an analgesic, or an adjunct in general anesthesia.The invention provides compounds represented by the specified structure or...
|
|
JP5587902B2 |
A compound having a guanidine structure and uses thereof as organopolysiloxane polycondensation catalysts are described.
|
|
JP2014520246A |
The present disclosure provides aromatic-cationic peptide compositions and methods of using the same. The methods comprise use of the peptides in electron transport and electrical conductance.
|
|
JP5572318B2 |
The invention is directed to a strategy for providing therapeutic or cosmetic benefit to skin by topically applying arginine chemically bound to a second (non-oligoarginine) compound in order to increase transepithelial delivery of argin...
|
|
JP5569857B2 |
An object of the present invention is to provide a novel and excellent agent for treating or preventing dementia, schizophrenia, and the like, based on the serotonin 5-HT 5A receptor modulating action. It was confirmed that a bicyclic ac...
|
|
JP5551691B2 |
The present invention relates to metformin glycinate salt and pharmaceutical compositions thereof for the treatment of diabetes mellitus. The method includes administration of the metformin glycinate salt by various routes selected from ...
|
|
JP5520228B2 |
The invention relates to a water-dispersible derivative of a therapeutic agent having a low water solubility that comprises at least one molecule of said agent covalently bonded to at least one molecule of a hydrocarbon derivative having...
|
|
JP5520235B2 |
The present invention provides methods to produce arginine bicarbonate more rapidly and efficiently than conventional methods.
|
|
JP5510808B2 |
To provide a self-assembling organic nanotube to be used as a nontoxic excellent carrier of a nucleic acid. The compound nanotube has an organic nanotube structure formed by mixing lipid compounds represented by chemical formula (1) or (...
|
|
JP5493924B2 |
To provide a new surfactant which gives a moistness feeling after washing and has high foaming property and excellent storage stability, and a detergent composition containing the same as a deterging ingredient. The surfactant is an anio...
|
|
JP5491416B2 |
Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein that are antagonists of PGD2 receptors. Also described here...
|
|
JP5484728B2 |
Polyamine, polyamine/guanidino, and polyamine/biguanide compounds are disclosed. The compounds are useful as anti-cancer and anti-parasitic treatments. The compounds are also useful as inhibitors of the enzyme lysine-specific demethylase-1.
|
|
JP2014510038A |
Methods for incorporating chlorhexidine salts into solvent based adhesives are described. The methods involve freeze drying an aqueous solution of the chlorhexidine salt and obtaining the chlorhexidine salt in a particulate form. The dry...
|
|
JP5475643B2 |
The present invention provides a compound comprising the structure shown in Formula I for use in delivering a therapeutic nucleic acid, one or more drug agents, or a biologically active agent to a cell, R...
|
|
JP5462630B2 |
Compounds of the formula (I) or salts thereof, in which in which R1 is an optionally substituted amino group or analogous group, and R2 to R7 are each as described herein, are suitable as herbicides and crop growth regulators. The compou...
|
|
JP5421098B2 |
Unique salts of trimebutine and N-monodesmethyl trimebutine, and their corresponding stereoisomers, having improved analgesic properties useful in the treatment of visceral pain are provided. The salts of the present invention are partic...
|
|
JP5421238B2 |
Provided is a new compound with excellent MMP inhibitory effect and reduced side-effects. The compound is a matrix metalloproteinase inhibitor with, as an active ingredient, the hydroxamic acid derivative represented by general formula (...
|
|
JP5410522B2 |
The invented trehalose derivatives, prepared by introducing multiple units of the guanidine group to the backbone molecules, show excellent blood-brain barrier permeability, and accordingly, it can be easily transported to the brain tiss...
|
|
JP5373392B2 |
The present invention relates to novel compounds and compositions having antiviral activity. The invention also relates to methods for the therapeutic or prophylactic treatment of viral infections in mammals.
|
|
JP2013542059A |
A method is described for separating CO2 and/or H2S from a mixed gas stream by contacting the gas stream with a non-aqueous, liquid absorbent medium of a primary and/or secondary aliphatic amine, preferably in a non-aqueous, polar, aprot...
|
|
JP5346307B2 |
To provide a polyion dendrimer capable of intracellularly transporting a protein by such a simple operation as to merely make mixing through utilizing intermolecular interaction via no covalent bond, thus useful as a highly versatile pro...
|
|
JP5345518B2 |
A process for producing creatine, creatine monohydrate or guanidinoacetic acid is proposed, wherein firstly N-methylethanolamine or ethanolamine is catalytically dehydrogenated in each case in alkaline solution and the sarcosinate or gly...
|
|
JP2013538226A |
Prodrugs of guanfacine, pharmaceutical compositions containing such prodrugs and a method for providing therapeutic benefit in the treatment of ADHD/ODD (attention deficient hyperactivity disorder and oppositional defiance disorder) with...
|
|
JP5306189B2 |
Disclosed are compounds according to formula (I): wherein A, Q, X, Y, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R11 are as defined herein. The disclosure also relates to pharmaceutical compositions containing a compound of formula (...
|
|
JP5292404B2 |
Disclosed herein are a novel dicarboxylic acid salt of N,N-dimethylimidodicarbonimidic diamide, a preparation method thereof and a pharmaceutical composition comprising the same. More specifically, disclosed herein are a novel dicarboxyl...
|
|
JP5291854B2 |
The present invention provides a method represented by Scheme 1: wherein X represents I, Br, Cl, alkylsulfonate, or arylsulfonate; Z represents optionally substituted aryl, heteroaryl or alkenyl; L represents hydrogen or a negative charg...
|
