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JP6884108B2 |
The present invention relates to guanidine compounds for inhibiting mitochondrial oxidative phosphorylation (OXPHOS) and use thereof. More specifically, the present invention relates to a pharmaceutical composition for preventing or trea...
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JP6880023B2 |
The present invention relates to new pharmaceutical salts of β-GPA which exhibit improved physical properties. In particular, the invention relates to salts of β-GPA with improved flow properties (e.g., improved Carr's index and/or Hau...
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JP6877424B2 |
The present invention relates generally to therapeutics targeting the bacterium Porphyromonas gingivalis, including its proteases arginine gingipain A/B (Rgp), and their use for the treatment of disorders associated with P. gingivalis in...
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JP2021512891A |
The present disclosure is based on formula (I). [Chemical 1]Compound or pharmaceutically acceptable salt thereof (here, R1And R2), The manufacture of the compounds of the present disclosure, and their therapeutic use. The disclosure furt...
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JP6822401B2 |
The present invention relates to a compound represented by the general formula (A), a base- and/or radical-generating agent comprising the compound, and so on. In the formula, four pieces of R 1 each independently represents a hydrogen a...
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JP6813485B2 |
Amino acids present in domains of an umami taste receptor are described herein, wherein the amino acids interact with at least one nucleotide derivative and/or at least one transmembrane compound that potentiates, modulates, increases, a...
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JP6807764B2 |
To provide a material that enhances various smells.A smell enhancer contains arginine as an active ingredient.SELECTED DRAWING: None
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JPWO2019088270A1 |
The present invention is a highly safe compound useful for the prevention, alleviation and / or treatment of various diseases associated with enteropeptidase inhibition and / or trypsin inhibition, a pharmaceutical composition containing...
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JP6793184B2 |
Therein, R1 and R2 are in each case hydrogen, halogen and alkyl, and R3 and R4 are in each case hydrogen, alkyl, cycloalkyl and aryl.
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JP2020532562A |
The present invention relates to the PEGylated amino acid compound of formula (I) and its pharmaceutically acceptable salts [X, R].1, R2, R3A, R3BAnd n are as defined herein. ]. The present invention may also relate to compositions compr...
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JP2020180147A |
To provide (2S,4R)-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-4-(ethoxyoxalyl
amino)-2-hydroxymethyl-2-methylpentanoic acid as a neprilysin inhibitor, and processes for preparing the same.The present invention provides a compound having a stru...
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JP2020172500A |
To provide cationic lipids and lipid particles comprising lipids, which are advantageous for in vivo delivery of nucleic acids, as well as nucleic acid-lipid particle compositions suitable for in vivo therapeutic use, and additionally, p...
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JP6773938B2 |
The present invention provides a benzoic acid ester compound that has an enteropeptidase inhibitory effect, and use of the compound as a medicament for the treatment or prevention of obesity, diabetes mellitus, or the like.A compound rep...
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JP6769414B2 |
A resist composition comprising a 2,5,8,9-teraaza-1-phosphabicyclo[3.3.3]undocane, biguanide or phosphazene salt of an iodinated aromatic group-containing carboxylic acid exhibits a sensitizing effect and an acid diffusion suppressing ef...
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JP6751349B2 |
The application relates to oral care compositions comprising substantive polyesters formed from xylitol, polycarboxylic acids (or esters, acid halides or anhydrides thereof) and optionally arginine. The formed polyesters or polyesteramid...
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JP6748188B2 |
The present invention relates to a process for the preparation of the compound N-(3,5-dimethylphenyl)-N'-(2-trifluoromethylphenyl) guanidine of formula (I) which comprises reacting a salt of a compound of formula (II) or a mixture of the...
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JP6713687B2 |
An anti-inflammatory drug containing a G0/G1 switch 2 (G0S2) inhibitor as an active ingredient is useful as a novel anti-inflammatory drug.
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JP6692372B2 |
The invention describes membrane permeable creatine prodrugs, pharmaceutical compositions comprising membrane permeable creatine prodrugs, and methods of treating diseases such as ischemia, heart failure, neurodegenerative disorders and ...
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JP6688729B2 |
A process for the preparation of the fluoroalkyl sulfonate salt of a nitrogen-based organic base said process comprising the step of reacting a fluoroalkyl sulfonyl halide with an organic base selected from the group consisting of tertia...
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JP6643335B2 |
Provided are compounds described by the Formula I:wherein: R1 is a linear or branched, saturated or unsaturated aliphatic group having from 5 to 22 carbon atoms; R2 is selected from the group consisting of the functional groups:—NH2;an...
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JP2020002108A |
To provide a simple and high yield manufacturing method of 3-[(aminoiminomethyl)amino]-4-methylbenzoic acid (C1 to C4 alkyl)ester sulfate and ester thereof.There is provided a method for manufacturing 3-[(aminoiminomethyl)amino]-4-methyl...
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JP2019218371A |
To provide systems, compositions and methods for synthesis and use of imaging agents, or precursors thereof.An imaging agent is made rich inF. An imaging agent may be used to image an area of interest in a subject, including the heart, c...
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JP6602006B2 |
Reaction products of guanidine compounds or salts thereof, polyepoxide compounds and polyhalogen compounds may be used as levelers in metal electroplating baths, such as copper electroplating baths, to provide good throwing power. Such r...
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JP2019528309A |
The present disclosure is in the field of polymers and pharmaceuticals / antibacterial agents. The present disclosure provides compounds based on SNAP (Synthetic Novel Antibacterial Polymer) technology, compositions and methods for contr...
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JP6587648B2 |
The present invention provides compounds of formula (I), and pharmaceutical compositions thereof.
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JP6586416B2 |
The present invention relates to macrocyclic amidinourea derivatives of formula 8, methods of preparation and uses thereof, pharmaceutical compositions in particular to be used as chitinase inhibitors in the treatment of a fungal infection.
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JP2019156803A |
To provide a new compound that functions as an amine or base catalyst with high basic strength by irradiation with an active energy ray, and also has a high quantum yield of cleavage.The invention provides a compound represented by the f...
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JP2019524781A |
The present invention relates to lipid-substituted amino 1,2-diol compounds and lipid-substituted amino 1,3-diol compounds, pharmaceutical compositions containing the compounds, and inflammatory signaling processes including, but not lim...
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JPWO2018097172A1 |
In the present invention, the formula [IV] (in the formula, Ar represents a substituted or unsubstituted phenylene group, X and Z each independently represent a substituted or unsubstituted alkylene group, etc., and TaAnd Tb bIndependent...
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JP6526275B2 |
Compounds of formula (I): where n, R1, R4a, R4b, R5, R7 and R8 are defined herein, or pharmaceutically acceptable salts thereof, are described herein. The disclosed compounds have activity as SHIP1 modulators, and thus may be used to tre...
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JP6507398B2 |
A novel guanidine compound having excellent fungicidal activity is represented by formula [I]. (In the formula, Y represents a divalent group represented by formula [II] (wherein each of R 7 -R 9 independently represents a hydrogen atom ...
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JP2019055921A |
To provide a method of efficiently and easily producing a stereoisomer from various amino compounds in spite of a scale of a system.The method of producing a stereoisomer includes the followings (1) and (2): (1) reacting a substance cont...
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JP6498127B2 |
Provided are a photobase generator having higher sensitivity to light than do conventional photobase generators, and a photosensitive resin composition containing the photobase generator. The present invention is a photobase generator ch...
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JP6495714B2 |
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JP6487031B2 |
The present invention relates to guanidine compounds for inhibiting mitochondrial oxidative phosphorylation (OXPHOS) and use thereof. More specifically, the present invention relates to a pharmaceutical composition for preventing or trea...
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JP6484220B2 |
A tri-carbobenzoxy-arginine represented by the following formula (2): is produced by carbobenzoxylating the arginine or arginine derivative (1) represented by the following formula (1), or a salt thereof: by adding carbobenzoxy chloride ...
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JP6483332B2 |
This invention relates to a method of preparing D-arginine, and more particularly to a method of preparing D-arginine by optically resolving DL-arginine using D-3-bromocamphor-8-sulfonic acid or a salt thereof as an optical resolving agent.
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JP6472578B2 |
The present invention provides a blocked polyisocyanate-type thermosetting coating composition that, without using a metal catalyst, exhibits the coating stability and effectiveness as with a catalyst. The thermosetting coating compositi...
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JP6469053B2 |
To provide a composition comprising a solid crystal with a predetermined crystalline structure that is easy to handle and excellent in semiconductor characteristics.Provided is a composition comprising a solid crystal containing 2 kinds ...
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JP6462002B2 |
The present invention relates to a novel compound capable of effectively preventing and treating immune diseases and a use thereof. The novel compound of the present invention has effects of inhibiting the formation of proinflammatory cy...
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JP6428646B2 |
An object of the present invention is to provide a compound which is capable of attaining a composition having high storage stability without reacting with a base-reactive compound, even in the case of storage for a long period of time i...
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JP6407950B2 |
where R1, R2, R3, R4a, R4b, R5, R6 and R7 are defined herein, or stereoisomers or pharmaceutically acceptable salts thereof, are described herein. Such compounds have activity as SHIP1 modulators, and thus may be used to treat any of a v...
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JP6407951B2 |
R1, R2, R5 and R13 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds h...
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JP6403671B2 |
The present invention concerns a method for preparing a creatine fatty ester or derivative thereof comprising at least one step consisting in reacting a diprotected creatinine with a molecule bearing at least one alcohol functional group...
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JP6397407B2 |
The present invention includes compounds useful in preventing, treating or ameliorating Sigma-related disorders or diseases. The compounds of the invention may modulate cellular protein homeostasis, which includes: translation initiation...
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JP6385059B2 |
A solvent system comprising a diluent and a nitrogenous base for the removal of CO 2 from mixed gas streams is provided. Also provided is a process for removing CO 2 from mixed gas streams using the disclosed solvent system. The solvent ...
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JP2018131459A |
To provide oligo-benzamide compounds that block AR signaling and have anticancer activity.The present invention provides bis-and tris-benzamide compounds, represented by formula (A), and pharmaceutical compositions containing these compo...
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JP6374320B2 |
Provided herein are phenyl-guanidine derivatives for the inhibition of Rac1 which blocks its interaction with guanosine exchange factors (GEFs) belonging to the DBL family as agents for the treatment of aggressive and/or resistant tumors...
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JP6364025B2 |
The present invention relates to compounds of the formula (I) and in particular to medicaments comprising at least one compound of the formula I for use in the treatment and/or prophylaxis of physiological and/or pathophysiological condi...
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JP6360074B2 |
The present invention relates to the mannose-receptor selective lysinylated cationic amphiphile and a process for preparation thereof. The compounds of the present invention can target DNA vaccines to antigen presenting cells (APCs) such...
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