| Document |
Document Title |
|
JP2018515424A |
In particular, the present specification provides methods and compositions that inhibit αvβ1 integrin and treat fibrosis.
|
|
JP2018513883A |
Provided herein are polymers containing metformin residues ("PolyMet") as useful therapeutic agents, delivery vehicles and transfection agents for nucleotides. Also provided herein are methods for the treatment of a disease or undesired ...
|
|
JP6332870B2 |
It is a subject of the present invention to provide a base generator which has high solubility to general-purpose organic solvents, can dissolve directly into a base-reactive compound, such as an epoxy-based compound, further is provided...
|
|
JP2018513122A |
Provided herein are processes and intermediates for the preparation of compounds of formula (I) or pharmaceutically acceptable salts thereof using cyanamide in the reaction. Where Y is CH2CO2H, CH2CONR1R2Or CH2CO2R1And R1, R2Are independ...
|
|
JP6325986B2 |
The invention is in the field of salt forms of an immunopotentiator compound and their formulation for in vivo use. In particular the invention relates to arginine salts.
|
|
JP6314129B2 |
[Problem] To provide a compound which is useful as an agent for preventing and/or treating kidney diseases. [Means for Solution] The present inventors have studied compounds having a trypsin inhibitory activity, and have confirmed that a...
|
|
JP6280175B2 |
Methods for incorporating chlorhexidine salts into solvent based adhesives are described. The methods involve freeze drying an aqueous solution of the chlorhexidine salt and obtaining the chlorhexidine salt in a particulate form. The dry...
|
|
JP6252991B2 |
|
|
JP2017537223A |
The present invention relates to Eq. (I) Eq. (Ia) or Eq. (Ib): [RF-CFR'F-SO3]-A+ (Ia) [(RF-CFR'F-SO2)2N]-A+ (Ib) (in formula:-RFOccasionally contains one or more catenary ether oxygen atoms, C1~ C25It is a fluoroalkyl group and-R'FIs -F ...
|
|
JP6243718B2 |
|
|
JP6232475B2 |
Disclosed is a composition for contact lens care, which is capable of effectively exhibiting the bactericidal effect of a polihexanide and/or a salt thereof even after storage and is also capable of maintaining excellent appearance witho...
|
|
JP6218742B2 |
The present invention concerns the absorption and in situ oxidation of nitric oxide (NO) in the presence of water and oxygen in ionic liquid compositions at ambient temperature.
|
|
JP6215324B2 |
Disclosed herein are novel pharmaceutical agents which are useful as integrin receptor antagonists that mediate the pathologic processes of angiogenesis and fibrosis and as such are useful in pharmaceutical compositions and in methods fo...
|
|
JP6216421B2 |
The present invention generally relates to novel synthetic methods, systems, kits, salts, and precursors useful in medical imaging. In some embodiments, the present invention provides compositions comprising an imaging agent precursor, w...
|
|
JP2017178962A |
To provide a novel 4-dedimethylamino tetracycline compounds that can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms.The present invention pertains to substituted tetracycline...
|
|
JP6203746B2 |
Provided are cajanine structure analogous compounds, synthesis method and pharmacological effects thereof, the compounds of the present invention having the structure as represented by general formulas I, II, III, IV and V. Also provided...
|
|
JP2017165760A |
To provide compositions comprising high oxidation state metal compounds, in particular silver(III) compounds, for the treatment or prophylaxis of microbial, including bacterial, infections, such compositions being stable at room temperat...
|
|
JP6198741B2 |
The invention relates to oseltamivir derivatives as influenza neuraminidase inhibitors for treating influenza infections and to a method for producing said compounds.
|
|
JP2017145219A |
To provide a novel eutectic mixture utilizable for various applications, which is a novel eutectic mixture utilizable for an absorber or the like of various gases, especially carbon dioxide or the like, as one application.In an eutectic ...
|
|
JP6186236B2 |
|
|
JP6174117B2 |
Novel dual-targeted, bifunctional anti-influenza drugs formed by conjugation with anti-inflammatory agents are disclosed. Exemplary drugs according to the invention include caffeic acid (CA)-bearing zanamivir (ZA) conjugates ZA-7-CA (1),...
|
|
JP6175145B2 |
|
|
JP2017512762A |
The techniques of the invention provide peptides, methods of producing peptides, and pharmaceutically acceptable salts of peptides. In some embodiments, the peptide is 2'6'-Dmt-D-Arg-Phe-Lys-NH.2Or Phe-D-Arg-Phe-Lys-NH2Is.
|
|
JP2017061430A |
To provide a prodrug which can be applied to many useful compounds, has higher solubility in an aqueous solvent than a useful compound and can rapidly generate a useful compound under neutral to weakly basic conditions.There is provided ...
|
|
JP6081152B2 |
|
|
JP6073929B2 |
The invention relates to complex compounds of germanium with amino acids and carboxylic acids of the general formula Ge[OH] a [AA] b [CA] c (I), where AA is an amino acid, CA is a carboxylic acid, a = 0-3, b = 1-3, c = 0-3, and 1
|
|
JP6048409B2 |
[Problem] Provided is a compound which is useful as an agent for preventing and/or treating renal diseases. [Means for Solution] The present inventors have conducted extensive studies on compounds having a trypsin inhibitory action, and ...
|
|
JP2016204283A |
To provide a compound and a photo-base generator, being photosensitive materials, serving as an initiator for polymerization reaction and chemical reaction when used in photoresist and the like, as well as suitable as a photo-base genera...
|
|
JP6034960B2 |
The present invention relates to novel neuraminidase activity inhibitors and use thereof for prophylaxis and treatment of influenza infection, that is, to fluorosubstituted 4-acetamido-5-guanidino-3-(pentan-3-yloxy)cyclohex-1-enecarb
oxy...
|
|
JP2016536372A |
The present invention provides a method of using a compound and its medicine constituent, or a tablet of a useful new creatine analog and the present invention, and treating and preventing creatine deficiency, in order to treat arbitrary...
|
|
JP6026400B2 |
The present invention relates to (1S,2S,3S,4R)-3-[(1S)-1-acetylamino-2-ethyl-butyl]-4-guanidi
no-2-hydroxy-cyclopentyl-1-carboxylic acid hydrates compounds, preparing methods thereof, pharmaceutical compositions containing said compounds...
|
|
JP6021860B2 |
Novel compounds that find use as imaging agents within nuclear medicine applications (PET imaging) for imaging of cardiac innervation are disclosed. These PET based radiotracers may exhibit increased stability, decreased NE release (ther...
|
|
JP6017565B2 |
The invention relates to compounds of formula (I), and the use thereof as a drug, particularly for the treatment of tumors associated with hyperactivation of the hedgehog protein signaling pathway, treatment of neurodegenerative diseases...
|
|
JP2016183164A |
To provide novel compounds that can be used as imaging agents in nuclear medicine applications (PET imaging) for imaging of cardiac innervation.The present invention provides a compound having a delta structure represented by the formula...
|
|
JP2016172696A |
To provide an amino acid production method capable of producing amino acid simply and safely.An amino acid production method has a first step in which minerals subjected to the soil formation after receiving weathering and erosion are pr...
|
|
JP5992399B2 |
The present invention generally relates to novel synthetic methods, systems, kits, salts, and precursors useful in medical imaging. In some embodiments, the present invention provides compositions comprising an imaging agent precursor, w...
|
|
JP5993088B2 |
The invention relates to the development of drugs intended for the prophylaxis and/or treatment of viral diseases caused, in particular, by herpes viruses. What are proposed are complex compounds of germanium having the general structura...
|
|
JP2016160225A |
To provide a method for forming a basic compound by efficiently separating a basic compound blocked by a blocking group, and the basic compound obtained by the method.A method for forming a basic compound is characterized by separating a...
|
|
JP2016525508A |
Disclosed herein are compounds, compositions, and their use for the treatment of cystic fibrosis. [Selection diagram] Fig. 1
|
|
JP2016121144A |
To provide novel compounds, and compositions and formulations comprising the same, for improving in vivo delivery to cells, tissues, organs and the like and intracellular delivery of drugs such as an RNA interference inducing agent usefu...
|
|
JP5918538B2 |
This invention relates to a prodrug comprising a partial structure having the general formula (I) or (II), where R1 and R2 are hydrogen, alkyl, or aryl radicals.
|
|
JP5911514B2 |
A composition which includes a salt of metformin and the use of the composition for treatment of or use in prediabetes, diabetes, lowering triglycerides and/or other conditions in mammals.
|
|
JP5902676B2 |
The present invention provides uses of a glucokinase activator in combination with metformin. Uses include treating type 2 diabetes, lowering blood glucose, improving insulin sensitivity, enhancing phosphorylation of glucose, and improvi...
|
|
JP2016510320A |
Equation (I):Compounds or pharmaceutically acceptable salts thereof are described herein. In equation (I), N, R1, R4a, R4b, R5, R7And R8Is as defined herein. The compounds of the present disclosure have activity as SHIP1 modulators and c...
|
|
JP5894915B2 |
The present invention relates to acyl guanidine derivatives modulating the hedgehog protein signaling pathway to be used as drugs, in particular for treating diseases involving a tissue dysfunction associated with a deregulation of the h...
|
|
JP5878539B2 |
A method is described for separating CO2 and/or H2S from a mixed gas stream by contacting the gas stream with a non-aqueous, liquid absorbent medium of a primary and/or secondary aliphatic amine, preferably in a non-aqueous, polar, aprot...
|
|
JP2016502505A |
The present invention relates to azine metal phosphates, compositions containing them, methods for preparing them, and their use as flame retardants. A typical example is (AH)(+)[MtPO4](-) 2H2O and (Mel-H)(+)[AlP2O7](-)(In the formula, A...
|
|
JP5844955B2 |
A nutrient composition comprises an essential nutrient in which at least one exchangeable H atom is 2 H and/or at least one C atom is 13 C. The nutrient is thus protected from, inter alia, reactive oxygen species.
|
|
JP5809304B2 |
The present invention relates to an automatic system for synthesizing iodine-123 meta-iodobenzylguanidine (123I-MIBG), which comprises a first reactor for subjecting radioactive iodine-containing sodium iodide and meta-iodobenzylguanidin...
|
|
JP5805742B2 |
To provide a slowly available liquid fertilizer including guanylurea and capable of reducing additional fertilization workload by reducing a number of addition of fertilizer.The slowly available liquid fertilizer comprises guanylurea obt...
|
