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WO/1996/011920A1 |
This invention relates to novel benzopyran and other benzo-fused leukotriene B4 (LTB4) antagonists of formula (I), and the pharmaceutically acceptable salts thereof, wherein A1 is O, CH2, S, NH or N(C1-C6)alkyl; R3 is hydrogen or hydroxy...
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WO/1996/006073A1 |
The invention relates to novel compounds of formula R1-A1-Z1-A2-Z2-A3-R2 in which Z1 and Z2 are laterally substituted cyclohexane and cyclohexene rings such as (2), (3), (4), (5), (6), (7), (8), (9). The compounds are useful as component...
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WO/1996/000710A1 |
The invention describes liquid crystal compounds of formula (I) which are suitable for use in liquid crystal devices including those devices which exploit the electroclinic effect. The compounds of formula (I) may also be used as chiral ...
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WO/1995/031424A1 |
The present invention provides a process for preparing optically active 2-arylcyclohexanol and its esters and ethers and which process comprises the step of subjecting 1-aryl-cyclohexane-1,2 diol and its diethers and diesters to hydrogen...
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WO/1995/030764A1 |
The production of cis-dihydrodiol compounds of formula (1) where n is 0 or 1 (preferably 0) by the microbial oxidation of a compound of formula (2) using a mutant of a Pseudomonas bacteria at 25 �C to 35 �C and pH 6-8 is disclosed. F...
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WO/1995/026928A1 |
Vanadium-containing Beta zeolite, and its use as catalyst in organic reactions.
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WO/1995/025079A1 |
Epoxides containing hydroxy groups are rearranged enantioselectively using a chiral base to give allyl alcohols in high enantiomeric excess, e.g. (I) If R3�H, the reaction also has the effect of generating a chiral tetrasubstituted car...
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WO/1995/021817A1 |
A class of substituted spiro compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by formula (III), wherein n is a number selected from 0, 1 and 2; where...
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WO/1995/016442A1 |
The present invention relates to novel potassium channel agonists which are useful in activating the calcium activated Maxi-K potassium channel in mammalian neuronal and smooth muscle tissue. The claimed compounds are of general formula ...
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WO/1995/015321A1 |
The invention relates to a process for producing 8'alpha',12-oxido-13,14,15,16-tetranorlabdane through the cyclizing dehydration of 8'alpha',12-dihydroxy-13,14,15,16-tetranorlabdane in the presence of aluminophyllosilicates.
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WO/1995/015299A1 |
A process for preparing the chiral (4S)-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenone is disclosed wherein racemic 4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenone is asymmetrically reduced by contacting the racemic tetralon...
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WO/1995/013257A1 |
The invention concerns 2,6-difluorobenzenes of general formula (I) in which the symbols and indices are defined as follows: R1 is H, a straight-chain or branched-chain alkyl (with or without an asymmetric C-atom) with 1 to 15 C-atoms, wh...
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WO/1995/009172A1 |
A novel transition metal compound useful as a compound of an olefin polymerization catalyst, a compound usable as a ligand of the above compound, an efficient process for producing the transition metal compound, and a polymerization cata...
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WO/1995/007878A1 |
Novel antibiotic compounds being tricyclic sesquiterpenes of formula (I) and derivatives thereof are described, wherein R1, R2, R3, R4 and R5 independently are the same or different substituents chosen from the group comprising =O, -OH, ...
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WO/1995/007253A1 |
This application relates to 3-substituted and 4-substituted cis-diols. Specifically, there are provided 3-substituted diols of formula (II) and 4-substituted cis-diols having (1S, 2R) and (1R, 2S) absolute configurations of formulae (III...
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WO/1995/004711A1 |
A process for producing D-chiro-inositol which comprises either mixing an aqueous solution of kasugamycin or a salt thereof with a strongly acidic ion-exchange resin (of H+ type) in a reactor or bringing the aqueous solution into contact...
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WO/1995/002569A1 |
A cis-3-hydroxy-2,2,6-trimethyl-5-cyclohexenemethanol of formula (I), the preparation thereof and the use thereof for total taxoid synthesis, are disclosed.
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WO/1995/001960A1 |
The present invention relates to analogues of vitamin D, which lack the combined presence of the trans-fused six-membered C-ring and of five-membered D-ring, but still possess a central part consisting of a subsituted chain of five atoms...
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WO/1994/028885A1 |
A method of inhibiting viruses in which a virus is contacted with diamondoid alcohol, ketone, keton derivative, adamantyl amino acid, quaternary salt or combinations thereof which have antiviral properties. These diamondoid derivatives a...
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WO/1994/026751A1 |
The enantioselective borane reduction of prochiral ketones to optically pure alcohols is effectively achieved by performing the reduction in the presence of catalytic amounts of the new and valuable oxazaborolidine compounds of formulae ...
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WO/1994/018146A1 |
Disclosed is a novel process for the manufacture of 2,2,4,4-tetramethylcyclobutane-1,3-diol commencing with the pyrolysis of isobutyric anhydride to produce dimethylketene. Dimethylketene is absorbed into 2,2,4,4-tetramethylcyclobutane-1...
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WO/1994/017796A1 |
Process of treatment of mammals, including humans to treat diseases or conditions of the type which are normally treated with retinoid-like compounds is disclosed, with pharmaceutical compositions containing an active compound which is a...
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WO/1994/013613A1 |
Method for the continuous preparation of a mixture of a cycloalkanone, a cycloalkanol and a cycloalkylhydroperoxide, according to which the corresponding cycloalkane is oxidized wherein the cyclic alkane has between 5 and 20 carbon atoms...
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WO/1994/007897A1 |
There are described novel biocatalytic and chemical processes for the synthesis of various oxygenated compounds. Particularly, there are described processes for the synthesis of a useful synthon (12) made by reacting a protected diol (ac...
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WO/1994/006740A1 |
A taxane analog represented by general formula (I) and a process for producing the same, wherein R1 represents hydrogen, acetyl, propionyl or 2-methylbutyryl; and R2, R3 and R4 may be the same or different from one another and each repre...
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WO/1994/006433A1 |
The present invention provides cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives, substituted in the 1-position with halo, methyl, hydroxyl, nitro, amino, amido, azido, oxime, cyano, thiol, ether or thioether groups, e.g...
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WO/1994/005617A1 |
Alternative methods for synthesizing haloenones and haloalkenes and their use as starting materials for synthesis of substituted or unsubstituted alkyl and aryl substituted enones and alkenes, including tamoxifen and tamoxifen analogs, u...
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WO/1994/000423A1 |
A process is disclosed for preparing compounds having general formula (I) by cross-coupling boric acids, borine acids or boric anhydrides derived therefrom having general formula (II), in which x1, x2, x3 and x4 represent independently f...
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WO/1994/000428A1 |
The invention concerns vitamin D derivatives, modified at the 20 position, of general formula (I), in which L, X, Y, Z, R1, R2 and R3 are as defined in the description, a method of preparing them and their use as agents in the treatment ...
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WO/1993/024214A1 |
A supported catalyst comprising a carbon fibril aggregate and a catalytically effective amount of a catalyst supported therein, a process for performing a catalytic reaction in fluid phase using the supported catalyst and a process for m...
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WO/1993/023408A1 |
The borane reduction of prochiral ketones to optically pure alcohols is effectively achieved by the utilization of catalytic amounts of the new and valuable oxazaborolidine catalysts of formula (I).
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WO/1993/023356A1 |
There are described processes for the removal and recovery of polar oxygenated organic compounds (e.g. 2,3-dihydroxy-1-chlorocyclohexa-4,6-diene) from aqueous solutions. Such processes comprise sorption/leaching processes whereby polar o...
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WO/1993/021765A1 |
A process for producing a stable, bactericidal and fungicidal composition which consists essentially of bubbling air or oxygen into limonene, to produce an oxidized limonene having a rapid bactericidal activity as evidenced by the capabi...
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WO/1993/021175A1 |
An optically-purified enantiomer of the lactone 4-hydroxy-2-oxabicyclo-[3.3.0]oct-7-en-3-one or an acylate thereof can be obtained by biotransformation. It is a useful synthon in the preparation of an enantiomer of 3-hydroxymethyl-2-hydr...
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WO/1993/020033A1 |
A process for the conversion of cyclohexyl hydroperoxide to cyclohexanone and cyclohexanol by turbulent high-intensity mixing with aqueous caustic containing a metal salt that accelerates the decomposition of cyclohexyl hydroperoxide.
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WO/1993/019029A1 |
A process of synthesizing compounds useful as chiral auxiliaries is disclosed. The process comprises, first, combining a base of Formula Y-Z+ (Formula I), wherein Y- is an organic anion and Z+ is an inorganic cation, with a compound of F...
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WO/1993/018651A1 |
Novel cyclic anti-tumor promoter compounds and therapeutic compositions are disclosed, along with method for their production and use as anti-cancer and cancer-prevention agents.
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WO/1993/016040A1 |
Fluorine-containing vitamin D3 analogues of formula (I), wherein R1, R2 and R3 are independently hydrogen atom, a hydroxy-protecting group, having excellent pharmacological activities, such as tumor cell differentiation-inducing activity...
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WO/1993/016022A1 |
An alkylative cycloaddition method is provided that is particularly useful for the synthesis of many of the Vitamin D analogues with differing side chains. Thus, a preferred synthesis is of Vitamin D analogues having a side chain R1 wher...
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WO/1993/014772A1 |
The invention relates to a new utilization of niobium derivatives in the 4 or 5 oxidation status as active principle for the production of medicaments useful in the treatment and/or prevention of glucid and/or lipid metabolism troubles. ...
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WO/1993/011098A1 |
New compounds are described typically having the formula CH3C(CH2R)3 or ZCH2C(CH2R)3 where R is a fluorohydrocarbon or perfluorocarbon group preferably containing 4-16 carbon atoms and more F atoms than H atoms. Z is a hydrophilic group ...
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WO/1993/009083A1 |
Macrocyclic enediynediols and enediynediones having a ten carbon ring and open chain enediyne dihydroperoxides having eight carbons between the hydroperoxide groups that cleave DNA are disclosed, as are methods of making and using the same.
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WO/1993/008799A1 |
Novel indane and indene derivatives are described which are endothelin receptor antagonists.
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WO/1993/005162A1 |
A method for facilitating the transfer of nucleic acids into cells comprising preparing a mixed lipid dispersion of a cationic lipid with a co-lipid in a suitable carrier solvent. The lipid has a structure which includes a lipophilic gro...
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WO/1993/004026A1 |
Disclosed is a novel process for the manufacture of 2,2,4,4-tetramethylcyclobutanediol commencing with the pyrolysis of isobutyric anhydride to produce dimethylketene. Dimethylketene is absorbed into certain carboxylate ester solvents wh...
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WO/1993/002998A1 |
Disclosed are bicyclic compounds of general formula (I), in which R is: (a) -CH=CR?1¿-CH(OH)-CH¿2?R?2¿, (b) -CH=CR?1¿-CO-CH¿2?R?2¿, (c), (d), (e) a cyclohexyl group which may be substituted in any of various positions with an OH an...
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WO/1992/022529A1 |
Process for the preparation of pure isomeric forms of 3,3,5-trimethyl cyclohexanol amino acid esters and process for the preparation of different pure isomeric forms of 3,3,5-trimethyl cyclohexanone, an intermediate product for the prepa...
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WO/1992/021647A1 |
Compounds of formula (I) wherein R1 and R4 are OH, (CHR5)mCOR6, (CHR5)mCH(OH)R5 or R5; R2 and R3 are H, C1-8alkyl, Het, C3-10cycloalkyl, Het-C1-8alkyl, C2-8alkenyl, Het-C2-8alkenyl, C3-10cycloalkyl-C1-8alkyl or C3-10cycloalkyl-C2-8alkeny...
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WO/1992/019748A1 |
In addition to virions, herpesvirus-infected cells produce non-infectious particles, termed L-particles, which consist of tegument surrounded by envelope but lack the nucleocapsid. L-particles of a herpesvirus can be prepared substantial...
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WO/1992/018444A2 |
The individual enantiomers of the compounds (Ia), (Ib), (IIa) or (IIb), optionally substituted by non-interfering substituent(s). The novel enantiomers can be obtained by biotransformation. The (Ia) or (IIa) compounds can be used for the...
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