| Document |
Document Title |
|
JP2015182957A |
To provide a new compound which can improve the reliability of material used in the production process of an electronic apparatus.A compound is shown by the formula (1), where n is 0, 1 or 2, X is a single bond or a 1-6C bivalent organic...
|
|
JP5792070B2 |
|
|
JP5785491B2 |
wherein A, Y, Z, R3 to R6, R20 to R22 and R50 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they are inhibitors of the endothelial differentiation gene receptor 2 (Edg-2, EDG...
|
|
JP2015163626A |
To provide dimethoxy docetaxel or crystalline forms of 4-acetoxy-2α-benzoyloxy-5β,20-epoxy-1-hydroxy-7β,10β-dim
ethoxy-9-oxotax-11-en-13α-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenyl-propio
nate (compound A), which is ef...
|
|
JP5769195B2 |
To provide an oxetane derivative for a monomer for producing a polymer which is used for a polymer solid electrolyte with large conductivity.The oxetane derivative is represented by general formula (1) (where Rrepresents a 1-6C alkyl gro...
|
|
JP5764133B2 |
Provided is a compound represented by formula (1) or a pharmacologically acceptable salt thereof. (In the formula, A is C 6-10 arylene, etc.; R 1a , R 1b and R 1c each independently is a hydrogen atom, a halogen atom, a C 1-4 alkyl group...
|
|
JP5763621B2 |
Provided is a novel compound which is useful as a pharmaceutical composition by inhibiting an LpxC activity, thereby exhibiting potent antimicrobial activity against gram-negative bacteria including Pseudomonas aeruginosa and its drug re...
|
|
JP2015522546A |
The present invention relates to inhibitors of the activity of the mitochondrial electron transport chain complex (III) and its use in the treatment and / or prevention of cancers that present tumor-initiating cells. The present inventio...
|
|
JP5750925B2 |
|
|
JP5744215B2 |
The present invention relates to 13-[(N-tert-butoxycarbonyl)-2'-O-hexanoyl-3-phenylisoserinyl
]-10-deacetylbaccatin III in a crystalline form.
|
|
JP2015108017A |
To provide a method for producing a β-lactone product.The present application provides a method for producing a β-lactone product. The method includes the steps of: reacting an epoxide, a solvent with a carbonylation catalyst and carbo...
|
|
JP5712546B2 |
The invention provides a compound represented by formula (1). In the formula (1), R1 is hydrogen, methyl or ethyl; X1 is a single bond, -O- or -OCO-; X2 is a single bond, -O-, -COO- or -OCO-; A1 and A2 are each independently a divalent a...
|
|
JP2015509929A |
The present invention is for its use in the treatment of pediatric cancer, formula (I) :. [Chemical 1]The compound may be in the form of an anhydrous base, a hydrate or a solvate.
|
|
JP2015057423A |
To provide an improved method for chemically producing docetaxel having antitumor activity in a chemically stable form.There is provided a method for producing docetaxel trihydrate, which comprises: a) a step of mixing a new anhydrous cr...
|
|
JP2015508809A |
The present invention relates to phenylalkanoic acid derivatives (compounds represented by formula (I)); and their isotope forms, steric isomers and tautomers and mixtures thereof in any ratio, or pharmaceutically acceptable salts. With ...
|
|
JP2015507622A |
Compounds of formula (I) (where m, n, A, X1, X2, X3, X4, R1, R2, R3a, R3b, R4a, and R4b are as defined herein). Or its pharmaceutically acceptable salt. Also disclosed are methods of making the compounds and using the compounds for the t...
|
|
JPWO2013005621A1 |
Provided is a palladium complex having high heat resistance and high activity against a vinyl exchange reaction. The palladium complex of the present invention is a palladium complex represented by the following formula (1). [Chemical fo...
|
|
JP5669534B2 |
|
|
JP2015028073A |
To provide compounds useful as medicament.The invention relates to novel cyclic hydrocarbon compounds and derivatives thereof, processes for the preparation thereof, to the compounds for use as a medicament, to the compounds for use in t...
|
|
JP2015021045A |
To provide a method for industrially manufacturing, in a high yield, a cyclic ether group-containing (meth)acrylate and to provide an active energy ray-curable three-dimensional contouring resin composition obtained by blending the cycli...
|
|
JP2015501315A |
The present invention provides a compound having the formula (I): [Chemical formula 1] or a salt, N-oxide or tautomer thereof, wherein A is CH, CF or nitrogen; E is CH, CF. Or nitrogen; R0 is hydrogen or C1-2 alkyl; R1a is CONH2; CO2H; o...
|
|
JP5645340B2 |
The present invention relates to the use of pharmaceutical preparations comprising paclitaxel for administration to a human patient in need thereof.
|
|
JP5641943B2 |
Provided is an adamantane compound which contains a specific adamantane backbone, a polymerizable group, and a ligand having a specific structure for linking the adamantane backbone and the polymerizable group, and has high solubility in...
|
|
JP2014533675A |
The present invention relates to N-substituted aminobenzocycloheptenes, aminotetralins, aminoindanes and phenalkylamine derivatives of formula (I), (II), (III) or (IV), or physiologically acceptable salts thereof. .. The present inventio...
|
|
JP5638347B2 |
|
|
JP5629632B2 |
The present invention relates to new taxane analogs useful for the treatment of cancer as well as methods for producing the same. The chemical compounds according to the present invention have the general Formula (I) wherein R 1 and R 2 ...
|
|
JP2014530815A |
A novel method for making 7,10-dialkyl-10-DAB of formula (I): useful as an important intermediate for the preparation of cabazitaxel is the selective of the 7 and 10 positions of 10-deacetylbaccatin III. Including synthesis.
|
|
JP2014528931A |
The present invention relates to crystalline forms of cabazitaxel, including anhydrous forms, represented by forms C1, C2, C3, C4, C5, C6, C7, C8, C8b, C9, and C9p, and methods for preparing these forms. I will provide a.
|
|
JP2014185149A |
To provide a biaryl phosphodiesterase-4 (PDE4) inhibitor useful for treatment and prevention of stroke, myocardial infarction, cardiovascular inflammatory diseases and central nervous system disorders.There is provided a biaryl compound ...
|
|
JP2014177448A |
To provide a polymerizable liquid crystal compound including a liquid crystal phase having a broad temperature range, exhibiting excellent compatibilities with other compounds, and endowed with necessary characteristics such as optical a...
|
|
JP5596566B2 |
The present invention relates to specific beta-lactone compounds and compositions thereof for the treatment of infections, such as, e.g., infections with bacteria or infections with protozoa, in particular infections with Gram-positive a...
|
|
JP5593342B2 |
The invention relates to a process for the preparation of 10-deacetyl-N-debenzoyl-paclitaxel ( I ) a synthon useful for the preparation of taxanes with antitumour activity, and intermediates for the preparation thereof. The invention als...
|
|
JP5579533B2 |
The present invention provides an oxetane compound represented by the following formula (1), and a active energy ray-curable composition including the oxetane compound as a polymerizable monomer. In formula (1), R 11 to R 15 each indepen...
|
|
JP5556991B2 |
|
|
JP2014131969A |
To provide a novel fluorene compound having an oxetane ring and a (meth) allyl group at a terminal so as to easily obtain a highly polymerized polymer and make a resin superior in strength, heat resistance, water resistance, weather resi...
|
|
JP2014516920A |
Compounds of the formula (I) or salts thereof, in each case in the optically active (3R,4R)-threo form, in which R1 is hydrogen or a hydrolysable radical, and (R2)n, (R3)m, n and m are as defined in formula (I) according to claim 1, wher...
|
|
JP2014516919A |
Compounds of the formula (I) or salts thereof, in which R1 is H or a hydrolyzable radical, (R2)n is n substituents R2, where R2 independently of the others is Hal, CN, NO2, (C1-C8)-alkyl, (C1-C8)-alkoxy, (C1-C8)-alkylthio, (C1-C8)-alkyls...
|
|
JP5552489B2 |
The present invention relates to a method for producing taxane derivatives with anticancer activity. The method of the present invention produces taxane derivatives in a short time under mild conditions by employing phenyl oxazinan dione...
|
|
JP5542058B2 |
Tricyclic compounds containing a cyclopropanecarboxylic acid fused to a bicyclic ring, including pharmaceutically acceptable salts, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particular...
|
|
JP5542804B2 |
Drug derivatives are provided herein which are suitable for loading into liposomal nanoparticle carriers. In some preferred aspects, the derivatives comprise a poorly water-soluble drug derivatized with a weak-base moiety that facilitate...
|
|
JP5531668B2 |
|
|
JP2014514306A |
The invention relates to solid state forms of Cabazitaxel, and processes for preparation, via novel synthetic intermediates, thereof, and formulations comprising one or more of the solid state forms of Cabazitaxel. The present invention ...
|
|
JP5522359B2 |
The purpose the invention is to provide a polymerizable liquid crystal compound which has an excellent solubility with other compounds, a high homeotropic property, and a spirobiindan-backbone, and a liquid crystal composition comprising...
|
|
JP5524629B2 |
Cyclohexanedione compounds, and derivatives thereof, which are substituted in 5-position, are suitable for use as herbicides. The cyclohexanedione compounds and derivatives of the invention are compounds of formula (I) wherein the substi...
|
|
JP5526793B2 |
A compound represented by the formula (1) is provided. A polymerizable liquid crystal composition containing the compound can be controlled in birefringence and is excellent in stability of a liquid crystal phase. An anisotropic polymer ...
|
|
JP5525394B2 |
The present invention relates to new taxane analogs useful for the treatment of cancer as well as methods for producing the same. The chemical compounds according to the present invention have the general Formula (I) wherein R 1 and R 2 ...
|
|
JP5526362B2 |
Compounds and pharmaceutical compositions are contemplated that inhibit N-acyl-ethanolamine-hydrolyzing acid amidase (NAAA) to so increase the concentration of the substrate of NAAA, palmitoylethanolamide (PEA). NAAA inhibition is contem...
|
|
JP5518726B2 |
This invention relates to novel compounds with ester linkage(s) capped with either electron deficient olefinic linkage(s) or group(s) or reactive functional groups (termed herein as "active methylene reagents"), and curable compositions ...
|
|
JP5520228B2 |
The invention relates to a water-dispersible derivative of a therapeutic agent having a low water solubility that comprises at least one molecule of said agent covalently bonded to at least one molecule of a hydrocarbon derivative having...
|
|
JP5517202B2 |
|
