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JP5510045B2 |
A compound represented by formula (1) or (2) and a polymer obtained by polymerizing the compound are provided: wherein Ra is one of the groups represented by Formulas (3-1) to (3-5); Rb is hydrogen, halogen, or a side chain such as -CN, ...
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JP5507285B2 |
Disclosed is a method of producing an optically active fluorinated oxetane, which can be an important pharmaceutical or agricultural intermediate, by reaction of a fluorinated ±-keto ester with an acyl alkenyl ether in the presence of a...
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JP5493414B2 |
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JP2014074054A |
To provide a novel crystal form of dimethoxy docetaxel or 4-acetoxy-2α-benzoyloxy-5β,20-epoxy-1-hydroxy-7β,10β-dim
ethoxy-9-oxotaxa-11-en-13α-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenyl propinate (compound A), and to pr...
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JP5479336B2 |
The present invention provides processes and synthetic intermediates for the synthesis of 4-substituted ((1 S , 2 S , 4 R )-2-hydroxy-4-{7H-pyrrolo[2,3-d]pyrimidin-7-yl}cyclopentyl)m
ethyl sulfamates, which are E1 activating enzyme inhib...
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JP5470706B2 |
To provide hole transport materials suitable for wet film formation method. This invention relates to hole transport materials, expressed by formula (I) the molecular weight range of which is 300 to 5,000. The organic electric field ligh...
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JP5464230B2 |
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JP5442287B2 |
The invention relates to methods and compositions for converting taxane amides to paclitaxel or other taxanes. In one alternative embodiment, the present invention comprises; (i) selectively protecting at least one OH group of a taxane a...
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JP2014037388A |
To provide a method for manufacturing an ester compound, reducing use of an organic solvent.A compound represented by the formula (I) is reacted with a nitrous acid compound in the presence of an acid catalyst in a solvent in the manufac...
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JP2014037389A |
To provide a method for manufacturing an object compound with high purity.The method for manufacturing an ester compound (7a) includes an imidation step of manufacturing an imidate compound (6a) by imidating an oxetane compound (Ia) and ...
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JP5417976B2 |
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JP2014503504A |
The present invention relates to compounds which are inhibitors of the activity of Complex III of the mitochondrial electron transport chain and pharmaceutical compositions comprising said compounds alone or in combination with other act...
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JP2014019654A |
To provide a polymerizable compound having high storage stability and inducing no crystallization when added to a polymerizable composition, to provide a polymerizable composition containing the above polymerizable compound, having such ...
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JP2014501266A |
The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 and A are as described herein, compositions including the compounds and methods of using the compounds.
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JP5354762B2 |
A method for treating abnormal cell proliferation in the brain by administering to a mammal in need thereof an effective amount of a taxoid derivative of formula (I) or a pharmaceutically acceptable salt or solvate thereof, wherein Z rep...
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JP2013540154A |
The present invention provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof. Also, the present invention provides a pharmaceutical composition comprising a compound of Formula (I) or a pharmaceutically accepta...
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JP5330717B2 |
To provide an oxetane-ring-containing vinyl ether compound which exhibits a high curing rate and forms a cured product excellent in transparency and heat resistance. The oxetane-ring-containing vinyl ether compound has an aromatic or non...
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JP5326417B2 |
To provide a long-life organic electroluminescent element equipped with a charge transport film including a crosslinkable polymer. The organic electroluminescent element is equipped with the charge transport film containing the crosslink...
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JP5319714B2 |
Methods and compound useful for detecting a source of hydrogen peroxide are disclosed wherein a signalling compound of formula is reacted with peroxide. A detectable product compound of the formula Sig - OH or Sig-O is produced and detec...
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JP2013209300A |
To provide a material for an organic electroluminescence device, capable of being formed into a film by coating, and containing a useful arylamine polymer in the case of being used as a positive hole transport material and a positive hol...
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JP2013208882A |
To provide a producing method hardly causing white turbidity associated with crystallization of a crystalline compound as a method for producing a laminate film including formation of a polymer layer on a layer formed of a crystalline co...
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JP2013203664A |
To provide an amino acid derivative synthesizable without using any strongly toxic substance and industrially suitable for production of a polymer using an amino acid wherein a substituent possibly inhibiting a self-polyaddition reaction...
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JP5305580B2 |
To provide a new oxetane compound. The compound is represented by general formula (I) (wherein, R1and R4are each independently an alkyl group, a cycloalkyl group or an aryl group; R3is an alkylene group, a cycloalkylene group or an aryle...
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JP5301676B2 |
The present invention relates to a high-yield method for preparing highly pure (3S,4S)-4-((R)-2-(benzyloxy)tridecyl)-3-hexyl-2-oxetanone using a metal salt of (2S,3S,5R)-2-hexyl-3,5-dihydroxyhexadecanoic acid as an intermediate.
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JP5293979B2 |
Provided are a polymerizing liquid-crystalline compound of formula (1). In formula (1), Q1 to Q4 each independently represent a formula (2), a hydrogen atom, a halogen atom, an alkyl group or the like; at least two of Q1 to Q4 are a form...
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JP5290272B2 |
Compounds of the Formula (I) wherein x is an integer from 1-4; p is an integer from 1-3; q is an integer from 0-3; Ar is phenyl, naphthyl, anthryl or phenanthryl each of which optionally is substituted by one or more Cl, CN, OR5, C3-C5al...
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JP5293588B2 |
There are provided various optical materials which contain a curable fluorine-containing polymer (I) having a number average molecular weight of from 500 to 1,000,000 and represented by the formula (1): &lparstr& M &rparstr& &lparstr& A ...
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JP5274745B2 |
The invention provides low molecular weight or polymeric organic materials in which at least one hydrogen atom is replaced by a group of the formula (A) where R is alkyl group, alkoxyalkyl group, alkoxy group, thioalkoxy group, aryl grou...
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JPWO2012002140A1 |
The polymerizable liquid crystal compound of the present invention is represented by the general formula (I). A1~ A3Represents a 1,4-phenylene group, a naphthalene-2,6-diyl group, an alicyclic group represented by the general formula (II...
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JP2013155191A |
To provide a new anhydrous form of docetaxel, and to provide a process of producing anhydrous docetaxel and docetaxel trihydrate.New anhydrous forms of docetaxel include crystalline N-debenzoyl-N-tert-butoxycarbonyl-10-deacetyl taxol tri...
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JP5259087B2 |
A compound having the formula Y-A-Z, wherein: A is a phenyl group which is unsubstituted or substituted; Y and Z are substituents at adjacent positions on ring A; Y represents: Z represents: and wherein the remaining variables are as def...
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JP2013531001A |
The invention relates to spirocyclically substituted 1,3-propane dioxide derivatives, and to the physiologically compatible salts thereof. The invention relates to compounds of the formula I in which R1, R2, R3, R4, R5, R6, R7, R8, A and...
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JP2013147443A |
To provide a therapeutic drug and/or prophylactic drug of diabetes or the like having superior activity and safety.There is provided a compound or medicinally permissible salt thereof represented by general formula (I) [in the formula, A...
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JP5238822B2 |
Described is a process for preparing docetaxel 1, including the following steps: a) hydroxyl acylation reaction of compound 2 and 3 to obtain compound 4; b) deprotection group R1 of the hydroxyl group of compound 4 obtained from step a t...
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JP5232083B2 |
The properties of biologically active compounds, for example drugs and agrochemicals, which contain in their molecular structure one or more functional groups selected from alcohol, ether, phenyl, amino, amido, thiol, carboxylic acid and...
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JP5225540B2 |
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JP5221055B2 |
This application is directed to novel fluorinated polymers and prepolymers derived from mono-substituted oxetane monomers having fluorinated alkoxymethylene side-chains and the method of making these compositions. The mono-substituted fl...
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JP2013121919A |
To provide a pharmaceutical product, particularly a pharmaceutical composition having a plasma kallikrein inhibition activity, useful as a prophylactic or therapeutic agent for edemas (particularly hereditary vascular edema), and useful ...
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JP5197908B2 |
A process for the preparation of N-debenzoylpaclitaxel (I) through esterification of 7-protected baccatin III with a carboxylic acid reactive derivative of general formula (II), and elimination of the ester-protecting groups in acid cond...
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JP2013516422A |
The present invention relates to enzyme inhibitors. More specifically, the present invention relates to ligand-directed covalent modification of proteins; method of designing same; pharmaceutical formulation of same; and method of use.
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JP2013516406A |
A method for preparing highly pure anhydrous crystalline docetaxel is provided. The method for preparing highly pure anhydrous crystalline docetaxel enables preparation of anhydrous crystalline docetaxel that has purity of 99.5% or more,...
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JP5187929B2 |
Epoxides, aziridines, thiiranes, oxetanes, lactones, lactams and analogous compounds are reacted with carbon monoxide in the presence of a catalytically effective amount of catalyst having the general formula [Lewis acid]{[QM(CO)x]}y...
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JP5173775B2 |
The present invention relates to a novel process for producing a delta -lactone of the formula: using an acyl halide of the formula: wherein R<1>, R<2> R<3> and X are described herein, as well as novel intermediates. In particular, the p...
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JP5162078B2 |
Methods of preparing amino acid-substituted taxanes such as:using selected blocked amino acids are disclosed. After coupling of the blocked amino acid to the taxane, deprotection is carried out with about an equimolar amount of a seconda...
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JP5162985B2 |
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JP5151979B2 |
An aldehyde derivative represented by the general formula (2) is reacted with ketene in the presence of a Lewis acid catalyst to produce a novel 2-oxetanone derivative (1), which is then purified to a 2-oxetanone derivative having a high...
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JP5151812B2 |
To provide an organic electroluminescence element, which has high luminescent efficacy and high driving stability, by using a polymer compound suitable for a wet film-forming method, the polymer compound being capable of being dissolved ...
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JP5149810B2 |
This invention is directed to a method for the preparation of docetaxel having an amorphous, anhydrous crystalline, or hydrated crystalline structure. In accordance with the invention, highly pure amorphous, anhydrous crystalline, or hyd...
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JP5139814B2 |
The invention provides a medical device comprising a hydrophobic analog of a medicament known to inhibit cell proliferation and migration. The invention also provides a method of treating a narrowing in a body passageway comprising placi...
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JP5125076B2 |
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