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WO/1993/018210A1 |
Process for electrochemical preparation of taxane derivatives of general formula (I) based on a product of general formula (II). In general formula (I), Ar denotes an aryl radical, R1 is a benzoyl radical or R2-O-CO- radical in which R2 ...
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WO/1993/017997A1 |
A method for preparing beta-phenylisoserine and analogues thereof having general formula (I) from an aromatic aldehyde and an alpha-methylarylamine-S, and through a lactam of general formula (II). In formulae (I) and (II), Ar is an aryl ...
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WO/1993/018018A1 |
Taxol, 10-deacetyltaxol and other taxane derivatives are prepared from naturally occurring taxane-7-xylosides by the oxidative cleavage of the 7-xyloside moieties.
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WO/1993/017016A1 |
The invention relates to compounds of formula (I) in which E is -CH= or -N=, and with the proviso that a) at least one of the radicals R3, R4, R5, R6 and R7 is C1-C4 alkyl, b) E is -CH= when X is halogen and c) E is -CH= when X or Y are ...
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WO/1993/017015A1 |
Compounds of formula (I) in which Q is a radical of formula (A) or (B) and in which R, X and Y are as defined in claim (1) have good pre- and postemergence-selective herbicidal and growth-regulating properties.
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WO/1993/016060A1 |
Novel taxane derivatives of general formula (I), their preparation, and pharmaceutical compositions containing same. In general formula (I), Ar is an aryl radical; R1 is hydrogen or acetyl; R is optionally substituted alkyl, alkenyl, alk...
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WO/1993/016079A1 |
Triazolo[1,5-a]pyrimidine-2-sulfonamides of formula (I), in which R1 and R2 independently of one another are hydrogen, halogen, C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy, C1-C4haloalkoxy, C1-C4alkoxy-C1-C4-alkyl, nitro, phenyl or S(O)nR3; ...
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WO/1993/016058A1 |
Novel anhydrides of general formula (I), wherein Ar is an aryl radical, and either R1 is C6H5-CO or (CH3)3C-O-CO, R2 is a hydrogen atom and R3 is a hydroxy function protective grouping, or R1 is (CH3)3C-O-CO and R2 and R3 together form a...
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WO/1993/016059A1 |
Method for preparing taxane derivatives of general formula (I) by esterification at a temperature between -10 and 60 °C of a derivative of baccatine III or 10-deacetyl baccatine III of general formula (II) by means of an acid of general...
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WO/1993/015112A2 |
A method of interfering with the interaction and/or function of alpha1-antichymotrypsin (ACT) and Alzheimer's beta-protein and, as a result, reducing the adverse side effects associated with formation of a complex comprising the two or w...
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WO/1993/012102A1 |
This invention discloses novel compounds, 3-hydryl-F-oxetane and 3,3-dihydryl-F-oxetane, for use as refrigerants or solvents. The compounds will serve as close replacements for CFC's R-11 and R-113.
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WO/1993/010076A1 |
This invention relates to a method for the production of a substantially optically pure taxane side chain comprising the steps of synthesizing a racemic mixture of enantiomers of the taxane side chain that is capable of exhibiting conglo...
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WO/1993/008800A1 |
A method for activating potassium channels and for treating hypertension, addiction, asthma, incontinence, and other conditions treatable by potassium channel activators, comprising administering a compound having formula (I), wherein R ...
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WO/1993/006093A1 |
The present invention relates to 10-desacetoxytaxol and derivatives thereof, which are useful as antitumor agents. These compounds have formula (1) wherein R¿2? is hydrogen, hydroxy or a protected hydroxy group; R¿3? and R¿4? are inde...
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WO/1993/006094A1 |
A metal alkoxide having formula (1) wherein T¿1? is hydrogen or a hydroxy protecting group, Z is -OT¿2?, or -OCOCH¿3?, T¿2? is hydrogen or a hydroxy protecting group, and M is selected from the group comprising Group IA, IIA and tran...
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WO/1993/006079A1 |
A process for preparing N-acyl, N-sulfonyl and N-phosphoryl substituted isoserine esters in which a metal alkoxide is reacted with a $g(b)-lactam.
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WO/1993/003838A1 |
Chiral catalysts for enantioselectively epoxidizing a prochiral olefin and for enantioselectively oxidizing a prochiral sulfide are disclosed, together with methods of using such catalysts. In accordance with one aspect of the invention,...
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WO/1993/004038A1 |
Process for the preparation of novel beta-phenylisoserine derivatives of general formula (I) and use thereof in the preparation of biologically active taxane derivaties.
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WO/1993/002067A1 |
A taxol analog represented by estimated structural formula (I). It is one of the structural isomers of taxol and intensely inhibits the growth of mouse and human cancer cells. The production process comprises tissue culture of albumens o...
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WO/1993/002065A1 |
New derivatives of taxol analogues having general formula (I), preparation thereof and compositions containing them. In the formula (I), Ar is an aryl radical, R is a radical having the general formula (II): R7O-, wherein R7 is an option...
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WO/1993/002064A1 |
A novel 7-deacetoxy baccatine IV derivative having formula (I), the preparation thereof from taxine B, and its use in preparing biologically active products, are described. In said formula (I), R is a hydrogen atom or acetyl radical and ...
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WO/1993/002066A1 |
A method for preparing 13alpha-cinnamoyl baccatine III or 10-deacetyl baccatine III of formula (I) by condensation of a mixed anhydride having general formula (II) on a derivative of baccatine III or 10-deacetyl baccatine III of general ...
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WO/1993/001179A1 |
Process for the preparation of a taxane derivative of general formula (I) and use of the product obtained for the preparation of taxane derivatives of general formula (II). In the general formula (I), R1 is an acetyl radical or a protect...
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WO/1992/022313A1 |
A renin inhibiting compound of formula (I), wherein R�0? is a mimic of the Phe-His dipeptide sequence of angiotensinogen which precedes the renin cleavage site; R�4? is loweralkyl, cycloalkylalkyl or arylalkyl; R�5? is hydrogen, lo...
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WO/1992/018492A1 |
Methods of obtaining renewable sources of taxanes including taxol are provided. Compositions comprising taxanes which are useful as source materials for the further purification of taxanes are also disclosed. Specifically, a method of dr...
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WO/1992/013848A1 |
Certain novel hydroxamic acid and hydroxyurea derivatives having structure (I), wherein R1 is hydrogen, alkyl, alkenyl, amino or substituted amino, R4 is hydrogen, a pharmaceutically acceptable cation, aroyl or alkoyl, A is alkylene or a...
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WO/1992/012958A1 |
beta-phenylisoserine-(2R,3S), salts and preparation thereof through the action of ammonia on beta-phenylglycidic-(2R,3R) acid and its use in the preparation of taxane derivatives of general formula: (I), (R = H, COCH3; R1 = C6H5, (CH3)3C...
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WO/1992/011250A1 |
Method for preparing a "syn" derivative of propanamide of forumula (I) by the action of a derivative of camphosultam of general formula (II) or (III) on aldehyde of formula (IV) in the presence of a Lewis acid and an organic base. In for...
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WO/1992/009589A1 |
A method for preparing taxane derivatives having general formula (I), novel derivatives thereby obtained and compositions containing same. In general formula (I), R is t.butoxy or phenyl, R¿1? is hydrogen or acetyl, and Ar is substitute...
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WO/1992/007842A1 |
An improved method for isolating certain clinically important taxane derivatives from the crude extract of a naturally occurring Taxus species comprising treating the extract by reverse phase liquid chromatography on an adsorbent; causin...
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WO/1991/017977A1 |
Process for the stereoselective preparation of phenylisoserin derivatives of general formula (I) from benzylamine. In the general formula (I), R is a phenyl radical or tert.butoxy and R1 is a hydroxy function protective group.
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WO/1991/017976A1 |
Process for the enantioselective preparation of phenylisoserin derivatives of general formula (I) from phenylglycine S(+). In the general formula (I), R is a phenyl radical or tert.butoxy and R1 is an alcohol function protective group. T...
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WO/1991/013066A2 |
Method for the preparation of beta-phenylglycidic-(2R,3R) acid optionally in the form of salt or ester by precipitation of the salt of the beta-phenylglycidic-(2R,3R) acid with (+)-alpha-methylbenzylamine-(R) in a solution of a mixture o...
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WO/1991/013053A1 |
New derivative of beta-phenylisoserine having the formula (I), its preparation and utilisation as intermediate compound in the synthesis of taxol or its derivatives.
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WO/1991/009025A2 |
Partially fluorinated compounds of specified formulas that are useful as chemical intermediates and monomers are disclosed. Partially fluorinated polymers prepared from one of these compounds are also disclosed. Fluoro-2,2-dimethyldioxol...
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WO/1991/005761A1 |
A method of inhibiting the growth or replication of viruses of the HIV group is disclosed. Also disclosed are compounds useful in the method and pharmaceutical formulations incorporating such compounds. The method involves the use of com...
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WO/1990/012792A1 |
beta-lactones are synthesized from a thiol ester and a ketone by a method which efficiently produces beta-lactones in high yields. The method involves combining the thiol ester, ketone, or aldehyde base and organic solvent at subambient ...
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WO/1990/010443A1 |
Derivatives of taxol represented by formula, (II) wherein R and R' are each H or the residue of an amino acid selected from the group consisting of alanine, leucine, isoleucine, saline, phenylalanine, proline, lysine and arginine or a gr...
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WO/1990/001029A1 |
A method of preparing a nitrate ester of an epoxy alcohol, which consists of reacting an epoxy alcohol with N2O5 in an inert solvent at a temperature of -10�C to -40�C, followed by quenching the reaction mixture in aqueous solution. ...
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WO/1990/001028A1 |
A continuous process for producing nitratoalkyl-substituted cyclic ethers which consists of (a) cocurrently mixing a stream of N2O5 and a stream of a hydroxyalkyl-substituted cyclic ether each dissolved in an inert organic solvent, follo...
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WO/1989/008453A1 |
Antineoplastic, water soluble, taxol derivatives and methods for preparing the same are described.
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WO/1984/001577A1 |
A process for preparing a cycloaddition compound, which comprises reacting ketene with a carbonyl group-containing compound having formula (I), which contains a highly electron-attractant group in the alpha-position relative to the carbo...
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WO/1980/002024A1 |
Lepidoptericidal and herbicidal active compounds having the generic formula (FORMULA) wherein R, R1, R2 and R3 are as disclosed herein. In general, these compounds show enhanced lepidoptericidal activity and show reduced phytotoxic effec...
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JP2024512428A |
The present invention relates to compounds that can be used to treat viral infections. The compound is a papain-like protease (PLpro) inhibitor.
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JP2024509936A |
The present inventionUSP30inhibition andUSP30Compounds, compositions thereof, and methods of use thereof for the treatment of mediated disorders are provided. [selection diagram]none
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JP7438391B2 |
The present invention provides a method for synthesizing an oxetane compound by a microreactor. The synthesis method comprises: introducing trimethylolpropane and carbonate into the microreactor in the presence of an alkaline catalyst, a...
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JP2024023301A |
The present invention provides novel compounds effective for controlling pests. The molecule of formula 1, as well as its N-oxides, agriculturally acceptable acid addition salts, salt derivatives, solvates, ester derivatives, crystalline...
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JP2024507694A |
A hybrid vertical bubble plug flow reactor consists of a bottom inlet and a top outlet between which a vertical tubular member is placed, the bottom inlet having a separate gaseous reactant inlet and a separate gaseous reactant inlet whe...
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JP7420633B2 |
To provide a fragrance composition capable of enhancing citrus-like aroma and flavor.A fragrance composition contains 3,9-dimethyl-2-oxatricyclo [4.2.1.03,8] nonane.SELECTED DRAWING: None
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JP2024502727A |
R1But -C(R2)(R3)-[C(R4)(R5)]m-LR6group or -R7and the manufacture and therapeutic use of compounds of formula (I) as agonists of the TRPM8 receptor, particularly useful in the treatment of oropharyngeal dysphagia. [Formula 1]
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