| Document |
Document Title |
|
JPS54144394A |
This invention provides the anti-bacterial compounds (III) and (IV):and salts and esters thereof wherein X is a -CH2-CH2- or trans -CH =CH- group and R is a group R1 or NH.R1 wherein R1 is an alkyl group of up to 6 carbon atoms, an alken...
|
|
JPS54135790A |
NEW MATERIAL:An antibiotic substance PS-5.S-oxide of formula I and its salt. USE: Antibiotic agent, antibiotic activity improving agent, and their intermediate. Effective to Gram-positive and Gram-negative bacteria. Synergetically improv...
|
|
JPS54125694A |
The compounds of the formulae (V) - (X): wherein R is a group of the sub-formula (a), (b) or (c): -CHR1-O-CO-R2 (a) -CHR1-O-CO-OR2 (b) Artworks where R1 is a hydrogen atom or a methyl or ethyl group; R2 is a lower alkyl, lower-alkylaryl ...
|
|
JPS54112887A |
The present invention provides the antibacterial agents of the formula (II): Wherein R1 is a group such that CO2R1 is a carboxylic acid group or a salt thereof or is a group of the formula CO2R1_1 wherein R1_1 is a group such that CO2R1_...
|
|
JPS5484589A |
NEW MATERIAL:An ester derivative of PS-5 of formula I. EXAMPLE: Benzyl ester of PS-5 expressed by formula II. USE: An antibacterial and an intermediate for their synthesis. Effective against Gram- positive and Gram-negative bacteria. Use...
|
|
JPS5476593A |
The present invention provides a compound of formula (I):- wherein G is hydrogen, alkyl, alkenyl, substituted alkyl or substituted alkenyl, R1 is alkyl or aryl, substituted alkyl or substituted aryl, and R is an organic group such that -...
|
|
JPS5473788A |
NEW MATERIAL:N-Desacetyl PS-5 of formula I. USE: Antibacterials effective against a wide range of Gram-positive and Gram-negative bacteria including bacteria resistant to β-lactam antibacterials. Far more powerful antibacterial actions ...
|
|
JPS5463097A |
Disclosed are substituted N-methylene derivatives of thienamycin sulfoxide (I, n=1) and sulfone (I, n=2) which may be represented by the following structural formula: I wherein X and Y are selected from the group consisting of hydrogen, ...
|
|
JPS5455789A |
The disclosed invention is directed to a process for preparing N-acyl-thienamycins from thienamycin and the appropriate acyl group by reacting the same in the presence of certain penicillin amidohydrolases capable of producing N-acyl thi...
|
|
JPS5452092A |
Disclosed are O-, N- and substituted carboxyl derivatives of thienamycin sulfoxide (I, n = 1) and thienamycin sulfone (I, n = 2): wherein n is 1 or 2; R and R are independently selected from hydrogen and acyl; R is, inter alia, hydrogen,...
|
|
JPS5448786A |
This invention provides synthetic beta -lactam antibacterial compounds, a process for their preparation and pharmaceutical compositions containing them. The compounds are those of the formula (II): wherein: R1 is a group such that CO2R1 ...
|
|
JPS5414594A |
PURPOSE: To separate and purify MC696-SY2-A substance which is a strong βlactamase-inhibitor, by culturing MC696-SY2-producing fungi belonging to Streptomyces genus, and treating the cultured medium with various ion exchange resin, adso...
|
|
JPS549295A |
|
|
JPS53130494A |
Antibiotic N-acetyl-dehydro-thienamycin is active against both gram-positive and gram-negative bacteria. The antibiotic is produced by growing a species of Streptomyces in suitable fermentation media.
|
|
JPS53127491A |
The compound of the formula I and its pharmacologically acceptable salts are described. They can be obtained by reduction of the compound of the formula (III) in which R and R' have the meaning given in Claim 4. The compound (I) and its ...
|
|
JPS53119886A |
7-Oxo-1-azabicyclo 3,2,0 hept-2-en-2-carboxylic acid derivs. of formula (I) are new. In the formula, R1 is an ester residue; A1 is H or Me A2 is H or CR2R3R4. R2 is H or OH; R3 is H or 1-8C alkyl and R4 is H, benzyl, phenyl or 1-8C alkyl...
|
|
JPS53116396A |
The novel derivatives are compounds of the formulae I and II and their salts. These compounds are prepared by culturing Streptomyces olivaceus or Streptomyces gedanensis and recovering the compounds formed and/or their salts from the cul...
|
|
JPS53107483A |
A thienamycin-containing fermentation broth or solution is brought into contact with a liquid ion exchanger which is dissolved in an organic solvent and is insoluble in water. In this process, the antibiotic is transferred, by forward ex...
|
|
JPS53103494A |
The cpd. desacetyl-dihydro-890A9 of formula (I) and its salts are new. In the prepn. of (I), the cpd. dihydro-890A9 (II) is treated with an enzyme capable of hydrolysing the N-acetyl group, pref. N-acetyl-dihydro-890A9-amidohydrolase. In...
|
|
JPS53101395A |
Antibiotic deacetyl 890A10 of the structure and its pharmaceutically acceptable salts; it is produced from the compound 890A10 of the structure by treatment with an enzyme which is capable of hydrolysing the N-acetyl group.
|
|
JPS5363396A |
The novel compound of the formula and its pharmaceutically acceptable salts are prepared by culturing an appropriate strain of Streptomyces flavogriseus in aqueous nutrient medium which contains assimilable sources of carbon, nitrogen an...
|
|
JPS5323995A |
Salts of the compounds of the formula II are obtained by esterifying a salt of a corresponding 2-carboxylic acid. The products are antibacterially active and can increase the activity of penicillins and cephalosporins against ss-lactamas...
|
|
JPS535195A |
Compounds of the formula (IV), (V) or (VI) and salts thereof are useful both for their antibacterial activity and as synergists in combination with penicillins and cephalosporins.
|
|
JPS52111591A |
Thienamycin sulphoxide of the structural formula I and the non-toxic, pharmaceutically acceptable salts thereof are obtained by oxidising thienamycin and converting the resulting compound where appropriate into the non-toxic, pharmaceuti...
|
|
JPS5283994A |
|
|
JPS5283992A |
|
|
JPS5277085A |
N-Alkylated derivatives of thienamycin of the formula and their pharmacologically compatible salts, in which the substituents are defined in Claim 1, are prepared. These compounds are obtained by reacting an appropriate thienamycin deriv...
|
|
JPS5265295A |
Thienamycin of the structural formula I or its isomer called compound 890 A1 or 890 A3 is contacted with an amidohydrolase which is able to hydrolyse the N-acetyl group. The process for the preparation of the antibiotic thienamycin also ...
|
