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JPS60163882A |
NEW MATERIAL:The compound of formula I {R1 is group of formula II; R2 is -COOR3 [R3 is H or (substituted) hydrocarbon group], etc.}. EXAMPLE: ( 5R, 6R )-6-[( R )-1-Fluoroethyl]-3-( pyridin-4-yl )thio-7-oxo-1-azabicyclo [3.2.0]hept-2-ene-...
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JPS60152461A |
NEW MATERIAL:A pyrrolidine derivative of formula I (X is amino-protecting group represented by COOR1, H; R1 is t-butyl, p-methoxybenzyl, etc., which can be eliminated under acidic conditions; Y is CH2OR2, CH2OCOR4, COOR5; R2, R5 are H, h...
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JPS6033836B2 |
A process for separating and recovering organic vapors (e.g., chlorofluorocarbons) from a feed stream of organic vapors and air wherein organic vapors are present in the "window concentration" range being too high for conventional carbon...
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JPS6061581A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
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JPS6054387A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
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JPS6051171A |
NEW MATERIAL:The compound of formula I (R1 is N-protecting group or substituent group; R2 is H or OH-protecting group; R3 is H, alkyl, aryl, aromatic heterocyclic group, halogen, acyl, substituted silyl, substituted hydroxy, substituted ...
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JPS6048936A |
Reaction of carboxylic-acid esters with an alkyl thiol and a Lewis acid mildly and efficiently effecting de-esterification. The de-esterification process is carried out on esters of Cephalosporin, oxadethiacephalosporin, carbacephalospor...
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JPS6048964A |
NEW MATERIAL:A compound shown by the formula I (R1 is H- or N-protecting group; R2 is H-, or OH-protecting group; R3 is H, alkyl, allyl, vinyl, ethynyl, aralkyl, aryl, substituted alkyl, substituted thio, or substituted amino); EXAMPLE: ...
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JPS6045582A |
NEW MATERIAL:The compound of formula I (R is lower alkyl, alkanoyloxyalkyl or lower alkoxymethyl) and its salt. EXAMPLE: Methyl 3-( sodium-sulfonato )-6-( sodium- 1 -sulfonatoxyethyl )-7-oxo-1- azabicycloz(3,2,0)hept-2-ene-2-carboxylate....
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JPS6045583A |
NEW MATERIAL:The compound of formula (R is H, lower alkyl or lower alkanoyl; R1 is sugar alcohol residue; n is 1 or 2). EXAMPLE: Triacetonamine xylite monoketal. USE: Useful as an excellent light stabilizer for synthetic polymers such as...
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JPS604719B2 |
PURPOSE:Antibiotic PS-5 and its derivatives, particularly a trityl derivative. Characteristics thereof are as follows: soluble in water of pH6-9; thin layer chromatography: shows Rf=0.94, in an example, using Avicel SF cellulose thin-lay...
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JPS59231091A |
A process for the preparation of a compound of the general formula I is described according to which a compound of the general formula IIb is reacted with a compound of formula III L - R<1> - S - R<2> (III) in which L represents a leavin...
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JPS59216886A |
NEW MATERIAL:A compound of formula I (R is H, methyl) and its salt. EXAMPLE: ( 3RS,4SR )-{3-[( 1RS )-Fluoroethyl]-2-oxozethidin-4yl}acetic acid benzyl ester. USE: Antibacterial: it is used as an acetive ingredient for antibacterial prepa...
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JPS59212493A |
NEW MATERIAL:The compound of formula I (R is H or -SO3H; n is 0 or 1), its salt or its ester. EXAMPLE: ( 5R,6R )-3-[ (E)-2-Acetamido-1-fluoroethenyl-(R)-sulfinyl ]-6-( 1-hydroxy- 1-methylethyl)-7-oxo-1-azabicyclo[3,2,0]hept-2-ene-2-carbo...
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JPS59210897A |
NEW MATERIAL:A β-lactam antibiotic TAN-458 represented by formula I and its salt. USE: It shows antibacterial activity against gram-positive and -negative bacteria and is used as a synthetic intermediate of medicines and as a reagent. P...
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JPS59193886A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
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JPS59140893A |
NEW MATERIAL:(5R,6R)-3-( 2-Hydroxyethyl )sulfinyl-6-[1(S)-hydroxysulfonyloxyethyl]-7-oxo-1-azabicycl
o[3,2,0]-hept-2-ene-2-carboxylic acid of formula (the configuration of S-oxide is R or S). USE: It has β-lactamase inhibiting activity ...
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JPS59130884A |
Disclosed are 6-[1-hydroxyethyl]-2-SR<8>-1-methyl-1-carbadethiapen-2-em-3-
carboxylic acid esters (I) which are orally active antibiotics: wherein: R is a pharmaceutically acceptable ester moiety consistent with oral delivery; and R<8> i...
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JPS59104312A |
There is presented a method, in the form of a dosage formulation, for transforming substantially orally inactive beta -lactam antibiotics or their pharmaceutically acceptable salts or the esters, ethers, or hydrates of said antibiotics o...
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JPS5998057A |
NEW MATERIAL:The azetidinone derivative of formula I [X is H or group of formula II; Y is H or group of formula III; Z is H, R1'OCH2- or R1'O-CO-; R1 and R1' are OH or carboxyl-protecting group; R2 is H or OH; R3 is H or group of formula...
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JPS5998085A |
NEW MATERIAL:The compound of formula I (R1 is lower alkyl which may be substituted with amino or OH, or N-containing heterocyclic residue which may be substituted with aryl or lower alkyl; R2 is H or benzyl which may have substituent gro...
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JPS5989683A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
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JPS5984887A |
(57)【要約】 本公報は電子出願前の出願データであるため
要約のデータは記録されません。
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JPS5984885A |
NEW MATERIAL:The compound of formula I {R1 is alkyl or hydroxyalkyl; R2 is the group of formula II [n is 1W3; X is lower alkyl, amino or substituted amino; Y is OH, OR3 (R3 is alkyl, aralkyl or aromatic group), SR3, amino or substituted ...
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JPS5982387A |
NEW MATERIAL:A compound of formula I {either one of R1s is H, the other is methyl or both are methyl or ethyl; R2 is H, lower alkyl or -S(O)n-R4[n is 0 or 1; R4 is (amino-substituted) lower alkyl, etc.]; R3 is H, alkali metal or ester re...
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JPS5970687A |
NEW MATERIAL:The compound of formula I [R is (substituted) benzyl]. EXAMPLE: (5R,6R)-p-Nitrobenzyl 6-(1-hydroxy-1-methylethyl)-1-azabicyclo-[3.2.0] heptane-3,7-dione-2-carboxylate. USE: An intermediate for the preparation of an antibacte...
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JPS5959687A |
NEW MATERIAL:A compound shown by the formula I [R is H, lower alkyl, or (substituted)benzyl; m is 0, or 1; n is 0W2] and its salt. EXAMPLE: Sodium (5R, 6R)-3-cyanomethylthio-6-(1-hydroxy-1-methylethyl)-7-oxo- 1-azabicyclo[3,2,0]hept-2-en...
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JPS5939895A |
NEW MATERIAL:A compound(salt) shown by the formula I , whose disodium salt having the following physical and chemical properties. Electrophoresis mobility of filter paper: 2.3(mobility of epithienamycin A is 1.0). 13C Nuclear magnetic re...
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JPS599155B2 |
A novel antibiotic designated herein MM 17880 may be obtained from the cultivation of strains of Streptomyces olivaceus and related organisms. In addition to being potent antibacterial agents, MM 17880 and its salts inhibit beta -lactama...
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JPS5936677A |
NEW MATERIAL:A compound shown by the formula I [X is O, or S; Y is H, or OH which may be protected; Z is H, alkali metal atom, or carboxy-protecting group; R is 4-pyridyl, or heterocyclic group shown by the formula II, or formula III(R1 ...
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JPS5916892A |
NEW MATERIAL:A carbapenem-3-carboxylic acid derivative of formula I (R1 is H, alkyl, alkoxy; R2 is residue of 4W8-membered ring cyclic amine; R3 is H, COOH-protecting group) and its salt. EXAMPLE: (5R, 6S, 8R)-6-(1-Hydroxyethyl)-2-(4-met...
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JPS5913757A |
NEW MATERIAL:The compound of formula 1 [R1 is H or alkali metal; R2 is H, group of formula 5 (R4 and R5 are H or lower alkyl; R5 may be NH2- protecting group), acyl or NH2-protecting group; R3 is H, lower alkyl, halogen, (protected-)OH o...
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JPS5910588A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
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JPS596893A |
PURPOSE: To prepare an atibiotic substance KA-6643-I, exhibiting the antimicrobial activity against Gram-positive and Gram-negative bacteria, and having a powerful inhibitory activity against β-lactamases, by cultivating a microorganism...
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JPS595190A |
Novel 5-aroyl-6-methylthio-, 6-methylsulfinyl-, or 6-methylsulfonyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carb
oxylic acids represented by the formulasand the pharmaceutically acceptable, non-toxic esters and salts thereof, whereinR, is...
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JPS58222088A |
NEW MATERIAL:A compound shown by the formula I (R' is H, lower alkyl, or 1-hydroxyethyl; R2 is H, or carboxy-protecting group; R3 is carboxy, cyano, lower alkylsulfinyl, etc.; R4 is carboxy, cyano, OH, etc.). EXAMPLE7- Oxo-2,3-dimethoxyc...
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JPS58222089A |
NEW MATERIAL:A compound shown by the formula I (R1 is 2-pyridyl, 4-pyridyl, lower alkyl, etc.; R2 is H, or carboxyl-protecting group). EXAMPLE: 5,6-Trans-3-( 4-piperidinylthio )-6-( 1-hydroxy-1-methylethyl )-1-azabicyclo [3,2,0]hept-2-en...
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JPS58208292A |
3-Heterocyclylamino-ethylthio- 6-substd.-7-oxo carbapen-2-em-2-carboxylic acids and their S-oxides of formula (I) and their salts and esters are new. (R is 1-6C alkyl or 3-6C alkenyl; n is 0 or 1; and ring X is a mono- or poly-cyclic N-c...
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JPS58185585A |
PURPOSE: To obtain a carbapenem compound in high yield, by oxidizing the sulfur atom in a compound isolated from a metabolite of a microorganism Streptomyces sp. KC-6643 belonging to the genus Streptomyces or a compound derived therefrom...
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JPS58174383A |
1. A compound of the formula (II): or a pharmaceutically acceptable salt or pharmaceutically acceptable ester thereof, wherein R<1> is hydrogen, -CHO or -SO3H or a pharmaceutically acceptable salt thereof, R<2> is C1-6 alkyl or benzyl, a...
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JPS58157786A |
NEW MATERIAL:The (5R, 6R)-3-(2-aminoethylsulfinyl)-6-(2-hydroxypropyl)-7-oxo- 1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid of formulaI, its salt or its ester. USE: Antibacterial agent. PROCESS: The compound of formulaIcan be prepared ...
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JPS58152886A |
The invention provides a compound of formula (II): R<1>-CO-O-CHR<2>-O-CO-R<3> (II) or a salt or ester therof: wherein R<1> is a substituted or unsubstituted 7-oxo-1-azabicyclo[3.2.0]hept-2-ene ring system, R<2> is hydrogen or a hydrocarb...
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JPS5839519B2 |
1498087 Thienamycin MERCK & CO Inc 24 Nov 1975 [25 Nov 1974] 48208/75 Headings C2C and C2A [Also in Division A5] Novel thienamycin, believed to have the formula is obtained by cultivating Streptomyces cattleya in an aqueous nutrient medi...
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JPS58144386A |
PURPOSE: To prepare the titled compound useful as an intermediate of antibiotic substance, easily and economically, by reacting a specific compound with lithium bistrialkylsilyl amide in an anhydrous aprotic organic solvent at a low temp...
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JPS58144390A |
NEW MATERIAL:The compound of formulaI(X1 and X2 are H, nitro or halogen). EXAMPLE: 6-( 2-Chlorophenyl )-4-hydroxy-8-nitro-4H-imidazo[1,2-a] [1,4]-benzodiazepin. USE: An agent for improving cerebral metabolism. Useful also as a minor tran...
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JPS58144387A |
Compounds of the general formula I I where R1 is hydrogen, unsubstituted or substituted alkyl, cycloalkyl or aryl, acyl, alkoxycarbonyl, phenoxycarbonyl, unsubstituted or substituted carbamyl, thiocarbamyl or sulfamyl, or alkylsulfonyl o...
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JPS58144388A |
PURPOSE: To prepare the titled compound useful as synthetic intermediates of antibacterial agents photosensitive dyes for direct positive photographic emulsion, etc., easily, in high yield, by the thermal decarbonation of 3-carboxy-pyraz...
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JPS58128386A |
PURPOSE: To obtain the titled compound useful as an intermediate for synthesizing biotin, etc. in high yield, by reducing a lower alkoxycarbonyl group of an optical active cis-imidazolidinedicarboxylic acid mono ester derivative, followe...
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JPS5834115B2 |
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JPS58124785A |
NEW MATERIAL:A compound of formulaI(R is carboxymethyl or dihydroxymethyl) and a salt thereof. EXAMPLE: 3-Carboxylmethylthio-6-(1-hydroxysulfonyloxyethyl )-7-oxo-1-azabicyclo [3.2.0]-hept-2-ene-2-carboxylic acid. USE: A carbapenem antibi...
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