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JPS58118588A |
New thienamycin analogues of the general formula (I), wherein Y<1> and Y<2> represent a removable carbonyl protecting group, Q' is a C1-5 alkyl group, a substituted benzyl group, hydrogen atom or an alkali metal ion, and R'' is an option...
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JPS58118563A |
Heterocyclic acetic acid derivatives of the general formula (I), wherein Y<1> and Y<2> form together a removable carbonyl protecting group, and X is a selectively removable esterifying group, are prepared by esterifying a compound of the...
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JPS58118587A |
New bicyclic compounds of the general formula (I), wherein Y<1> and Y<2> represent a removable carbonyl protecting group, and Q is a C1-5 alkyl group or a substituted benzyl group, are prepared, e.g. in the way that leaving group X of a ...
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JPS58118589A |
Bicyclic compounds of the general formula (I), wherein Y<1> and Y<2> represent a removable carbonyl protecting group, and Q is a C1-5 alkyl group or a substituted benzyl group, are prepared in such a way that a) a compound of the general...
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JPS58118564A |
New compounds of the general formula (I), wherein Y<1> and Y<2> form together a removable carbonyl protecting group and X is a selectively removable esterifying group, are prepared in the way that a compound of the general formula (IV), ...
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JPS58116485A |
NEW MATERIAL:3-Hydroxymethylsulfinyl-6- ( 1-hydroxysulfonyloxyethyl ) -7-oxo- 1-azabicyclo[3,2,0]-hept-2-ene-2-carboxylic acid shown by the formula and its salt. USE: An antibiotic. Having a wide range of antibacterial spectrum and-lacta...
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JPS58110587A |
NEW MATERIAL:The compound of formulaI, its salt or its ester. EXAMPLE: (5R, 6R)-3-[(E)-2-Acetamidoethenylsulfinyl]-6-(2-hydroxy-2-propyl
)-7- oxo-1-azabicyclo[3,2,0]hept-2-ene-2-carboxylic acid p-nitrobenzyl ester. USE: An antibacterial ...
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JPS58109488A |
Compound of formula (II) and salts and esters are useful for treating bacterial infections: wherein: R<1> is hydrogen, -CHO, or -SO3H or a pharmaceutically acceptable salt thereof; R<2> and R<3> are independently hydrogen, hydrocarbon, h...
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JPS58101696A |
A method for isolating a chemically unstable carbapenum antibiotic from a fermentation solution by adsorbing the antibiotic on an ion exchanger resin at the maximum of product formation, thus converting it to a stabilized form, and then ...
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JPS5888380A |
The compound of formula (II): namely (5R, 6S)-3-[2-(Z)-(2-aminoethoxycarbonyl)ethenylthio]-6-[(R)-1-hy
droxyethyl ]-7-oxo-1- azabicyclo[3.2.0]-hept-2-ene-2-carboxylic acid; is useful in the treatment of a bacterial infection in animals a...
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JPS5883692A |
NEW MATERIAL:PA-41746-B of the formula or its salt, which has following physical and chemical properties: UV spectrum: λH2Omax=285nm (E11cm113); high- voltage paper electrophoresis: in 1/30M phosphate buffer solution of 7pH, the migrati...
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JPS5820593B2 |
It has been found that an antibiotic can be obtained by the fermentation of certain strains of Streptomyces olivaceus and related organisms and when pure this antibiotic is an extremely potent inhibitor of many beta -lactamases. This ant...
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JPS5865291A |
NEW MATERIAL:A compound shown by the formulaI[R1 is H, alkyl, alkoxy, etc.; R2 is (lower alkyl-substituted)amino, carbamoyl, etc.; Alk is lower alkylene; R3 is H or carboxyl-protecting group). EXAMPLE: ( 5R,6S,8R )-6-( 1-Hydroxyethyl )-2...
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JPS5849384A |
NEW MATERIAL:A compound of formulaI[R1 is hydrocarbon or heterocyclic group; R2 is H or protecting group of OH; (n) is 0, 1 or 2; provided that (n) is 2 when R1 is acetamidoethyl or acetamidoethenyl and R2 is H or sulfonic acid] or a sal...
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JPS5846087A |
PURPOSE: To obtain the optically active isomer of the titled compound having antibacterial activity, in high yield, via a novel intermediate, by using an optically active (4S)-4-alkoxycarbonylmethyl-2-azetidinone as a starting material. ...
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JPS5841882A |
A compound of formula (I): or a pharmaceutically acceptable salt or cleavable ester thereof, wherein RCONH- represents an organic acylamino group, and E is a carboxy group or a pharmaceutically acceptable salt or C1-10 alkyl or substitut...
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JPS5841881A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
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JPS5818384A |
NEW MATERIAL:The antibiotic substance KA-6643-G of formula, its salt or its ester. USE: Antibiotic substance. PROCESS: A bacterial strain belonging to Streptomyces genus and capable of producing antibiotic substance KA-6643-G (e.g. strep...
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JPS582675B2 |
An antibiotic called MM 13902 is obtained by fermentation of certain strains of Streptomyces olivaceus and related organisms, e.g. Streptomyces olivaceus ATCC 31226. Besides good antibiotic activity, the antibiotic displays a synergistic...
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JPS58891A |
PURPOSE: To prepare a novel stable carbapenem type antibiotic PA-41746-A having a wide antibacterial spectrum and inhibiting action on β-lactamase, by cultivating a bacterium belonging to the genus Streptomyces. CONSTITUTION: A bacteriu...
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JPS57193486A |
The inversion of the chiral centre bearing the hydroxy function in alcohols of the formula R=H, lower alkyl; X, Y are widely defined, covering a large number of beta - lactam systems and precursors therefor may be achieved by converting ...
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JPS57159761A |
New beta -lactam acetic acid derivatives I I wherein R represents alkyl, alkyl substituted with amino, protected amino, mono- or di-alkylamino, hydroxy, protected hydroxy or alkoxy, and alkenyl, and their salts are useful as intermediate...
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JPS57158785A |
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JPS57158786A |
The present invention provides a compound of the formula (I): or a pharmaceutically acceptable salt or an ester thereof wherein R<1> and R<2> each represent a hydrogen atom or an organic group bonded via a carbon atom to the carbapenem r...
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JPS57146780A |
The present invention provides a compound of the formula (I): (I) or a pharmaceutically acceptable salt or in-vivo hydrolyzable ester thereof wherein R1 is a hydrogen atom, an alpha -sulphonato-oxyethyl group, an alpha -sulphonato-oxypro...
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JPS57146777A |
Compounds of the general formula: in which R1, R2, R3, X and 2 are as defined herein, and their pharmaceutically acceptable salts; especially those subject to the following provisos: (i) when X is S, Z is O or =NR7 (R7 being as defined h...
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JPS57146778A |
A process for the preparation of an antibacterially active compound of the formula (I): (I) and salts and esters thereof wherein R1 and R2 independently are hydrogen or an organic group, and R3 is an organic group bonded via a carbon ato...
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JPS57146779A |
A process for the preparation of an antibacterially active compound of the formula (I): and salts and esters thereof wherein R<1> and R<2> independently represent hydrogen or an organic group, and R<3> is an optionally substituted aromat...
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JPS57145877A |
PURPOSE: The titled compound of E (trans) configuration is isomerized by dissolving it in a nonpolar solvent in the presence of an excess amount of quaternary ammonium halide to give the titled compound of Z (cis) configuration, which is...
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JPS57145878A |
A process for 5-aroylation of 1,2-dihydro-3H-pyrrolo [1,2-a]pyrrole-1-carboxylic esters and nitriles by reacting a pyrrolo pyrrole with an aroyl morpholide and an inorganic acid chloride in an inert aprotic solvent; followed by treatment...
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JPS57144285A |
Bicyclic compounds of the general formula in which R<1> and R<2> represent hydrogen, the acyl radical of an organic acid having 1-7 C atoms, an unsubstituted or substituted C1-8-alkyl, C3-8-cycloalkyl, C2-6-alkenyl or heterocyclic radica...
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JPS57134484A |
Antibiotic 1-carba-6-(1-hydroxyethyl-2-carbonyl-penem-3-carboxylic acid is prepared by total chemical synthesis from 4-iodomethyl-1-(t-butyldimethylsilyl)-2-azetidinone.
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JPS57116073A |
NEW MATERIAL:A compound shown by the formulaI(R is H or -SO3H; n is 0 or 1) and its salt. EXAMPLE: Sodium[ 5R,6R ]-3-[ 2-acetamidoethylthio ]-6-[1-(hydroxysulfonyloxy)-1-methylethyl]-7-oxo-1-azabicycl
o[3,2,0]hept-2-ene-carboxylate. USE:...
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JPS57116072A |
NEW MATERIAL:A compound shown by the formulaI(R is H or -SO3H and its salt. EXAMPLE: Sodium[ 5R,6R ]-3-[ (Z)-2-acetamidoethynylthio ]-6-[1-(hydroxysulfonyloxy)-1-methylethyl)-7-oxo-1-azabicycl
o[3,2,0]hept-2-ene-2-caboxylate. USE: An ant...
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JPS57109786A |
NEW MATERIAL:An antibiotic C-19353E5 of the formula and a salt thereof. USE: An antimicrobial agent, germicide and synthetic intermediate for medicines, exhibiting the powerful antimicrobial activity against Gram-positive and Gram- negat...
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JPS57108091A |
NEW MATERIAL:A compound shown by the formulaI(R is H or sulfonic group; X is iodine atom), its salt or ester. EXAMPLE: Disodium salt of (5R,6R)-3-(2-acetamido-1-iodoethenylsulfinyl)-6-(2-hydroxysu
lfonyloxy-2-propyl)-7-oxo-1-azabicyclo[3...
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JPS57108066A |
NEW MATERIAL:The 4-substituted-2-oxoazetidine derivative of formulaI[R1 is (OH-substituted) alkyl, phthalimido, benzyloxycarbonylamino or halogen; R2 is H, alkyl, alkylthio or arylthio; R3 and R4 are acyl or cyano]. EXAMPLE: [3S,4S]-4-Bi...
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JPS57102890A |
NEW MATERIAL:An antibiotic substance PA-31088-II, chemical name: (5R,6R)- 3-[(E)-2-acetamidoethenylsulfinyl]-6-[(S)-1-hydroxyethyl]-7-
oxo-1-azabicyclo [3.2.0]hept-2-ene-2-carboxylic acid of the formula and a salt thereof. USE: An antimi...
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JPS5799587A |
The present invention provides a process for inversion of the absolute stereochemistry at the alpha -carbon atom of a C-6 substituent of a bicyclic carbapenem antibiotic via a phosphorus - azodicarboxylate mediated reaction. Novel azides...
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JPS5795989A |
Disclosed are 2- and 6-substituted-1-carbadethiapen-2-em-3-carboxylic acids having the structure: wherein R@, and R@ are, inter alia, independently selected from the group consisting of hydrogen, alkyl, alkenyl, aryl and aralkyl; A ist a...
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JPS5795988A |
NEW MATERIAL:A compound shown by the formulaI(R is or sulfonic group; X is Cl), its salt or ester. EXAMPLE: Disodium salt of (5R, 6R)-3-(2-acetamido-1-chloroethenylsulfinyl)-6- (2-hydroxysulfonyloxy-2-propyl)-7-oxo-1-azabicyclo-[3,2,0]he...
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JPS5793981A |
NEW MATERIAL:The compound of formulaI(R1 is alkyl, aryl, alkylthio, arylthio or acylaminoalkylthio; R2 and R3 are alkoxycarbonyl, cyano or COR1; R3 may be alkyl or aryl; R4 is H, alkyl, hydroxyalkyl, aryl, or amino), its salt and ester. ...
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JPS5788178A |
NEW MATERIAL:The compound of formulaI[R1 is lower alkyl which may be substituted with hydroxyl group; R2 is H or ester residue; Y is nitrogen-containing heterocyclid group or group of formula II (R3 and R4 are H or alkyl; R5 is H or este...
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JPS5785389A |
NEW MATERIAL:A desacetyl-KA-6643 substance shown by the formulaI[R is H, or -SO3H; A is -CH=CH-, -CX=CH-(X is halogen), etc.; n is 0 or 1] or its salt or its ester. USE: An antibacterial agent and a β-lactamase inhibitor. Having antibac...
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JPS5772982A |
NEW MATERIAL:Antibiotic substance KA-6643-D of formulaI, antibiotic substance KA-6643-F of formula II, their salts or their esters. USE: Antimicrobial agent effective to Gram-positive and Gram-negative bacteria, and having strong β-lact...
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JPS5764694A |
NEW MATERIAL:The compound of formulaI(R is H or sulfonic acid group; X is h alogen), its salt, or its ester. EXAMPLE: (5R, 6R)-3-[(E)-2-Acetamido-1-bromoethenylsulfinyl]-6-(2-hydroxy-
sulfonyloxy-2-propyl)-7-oxo-1-azabicyclo[3.2.0]hept-...
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JPS5764693A |
NEW MATERIAL:The compound of formulaI, its ester or its salt. USE: Synthetic intermediate of pharmaceuticals having antimicrobial and β-lactamase- inhibiting activities. PROCESS: The compound of formulaIis prepared by removing sulfuric ...
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JPS5745184A |
The present invention provides the compound of the formula: …… and salts and esters thereof obtained via cultivation of a strain of Streptomyces. These compounds are of use in the treatment of bacterial infection.
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JPS5742667A |
PURPOSE: To prepare the titled compound useful as an intermediate of thienamycin, etc., in high stereo-selectivity, by reacting 3-(substituted)-alkyl-4-acyloxyazetidin-2-one with an α-diazoacetoacetic acid ester in the presence of a bas...
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JPS5740487A |
The present invention provides the compounds of the formula (II): (II) and salts and esters thereof wherein R3 is a hydrogen atom or is an organic bonded via a carbon atom to the carbapenem ring, n is zero or one, X is a saturated or uns...
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