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JPS6247185B2 |
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JPS6247184B2 |
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JPS62212388A |
NEW MATERIAL:A compound expressed by formula I [R1 is H, lower alkyl or aralkyl; R2 is (substituted) alkyl or heterocyclic ring; R3 is H or carboxyl- protecting group]. EXAMPLE: p-Nitrobenzyl (1R, 5S, 6S)-2-oxo-6-[(1R)-1-hydroxyethyl]-1-...
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JPS62209079A |
NEW MATERIAL:A compound shown by formula I (R1 is alkyl or haloalkyl; R2 is alkyl, haloalkyl, aralkyl, COOR4 (R4 is alkyl or aralkyl) or SO2R5 (R5 is alkyl or aryl); R3 is H or carboxyl protecting group]. EXAMPLE: 3, 7-Dioxo-6-[ N-methyl...
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JPS62201889A |
NEW MATERIAL:A 1-alkyl-2-carbamoyloxymethyl-carbapenem compound expressed by formula I (R1 is H or OH-protecting group; R2 is lower alkyl; R3 is H or lower alkyl; R4 is H, salt-forming group or ester-forming group). EXAMPLE: p-Methoxyben...
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JPS62195382A |
A novel series of carbapenem derivatives characterized by a 2-substituent of the formula in which n has a value of 1, 2 or 3; R5 represents an optionally substituted aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, araliphatic, heter...
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JPS6237630B2 |
7-Oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid derivatives of formula (I): (I) (in which:) R1 represents a hydrogen atom or an optionally substituted alkyl group; X represents an oxy group, a thio group, a sulphinyl group or a sul...
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JPS6228143B2 |
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JPS6215558B2 |
NEW MATERIAL:Antibiotic KA-6643-A of the formula and its salts. Physical and chemical properties of its sodium salt is as follows: a colorless powder; melting point, gradually decomposing from 145 deg.C; ultraviolet absorption spectra, m...
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JPS6215557B2 |
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JPS6215556B2 |
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JPS6213356B2 |
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JPS6213355B2 |
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JPS6261980A |
Novel carbapenem antibiotics are prepared in which the 2-substituent has the formula wherein n is 0, 1, 2, 3, m, is 1 or 2, and R is C1-C6 alkyl, allyl, propargyl, carboxymethyl, cyanomethyl or aralkyl wherein the aryl moiety is phenyl o...
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JPS6210639B2 |
A method is disclosed for cleaving N-acylthienamycin compounds to yield thienamycin. The new method disclosed herein utilizes enzymes which are penicillin amidohydrolases to treat the starting compounds resulting in the antibiotic thiena...
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JPS6210640B2 |
The microorganism Streptomyces cattleya, preferably the strain NRRL 8057, is cultivated under submerged aerobic conditions in an aqueous nutrient medium containing assimilable C and N sources as well as inorganic salts. N-Acetylthienamyc...
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JPS6160816B2 |
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JPS61275279A |
NEW MATERIAL:A compound expressed by formula I (R1 is carboxy, cyano, hydroxymethyl, etc.; R2 is H, alkyl heteroaryl, benzyl, phenyl, etc.; R3 is H or alkyl; R4 is H or a protecting group of the carboxy group) and a salt thereof. EXAMPLE...
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JPS61268666A |
NEW MATERIAL:The compound of formula I [R1 is H or OH-protecting group; R2 is alkyl, alkenyl or (substituted)phenyl; R3 is H, alkyl or phenyl; R4 is H or carboxy-protecting group]. EXAMPLE: (3S,4R)-1-(1-benzyloxycarbonylvinyl)-3[(1S)-t-b...
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JPS61215367A |
A process for the preparation of a 4-[3-carboxy-3-diazo-2-oxopropyl]azetidin-2-one of the formula comprising reacting a 4-acetoxy-2-azetininone of the formula with a compound of the formula in an inert solvent, in the presence of a base ...
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JPS6139308B2 |
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JPS61191685A |
Carbapenems having the formula: wherein R<3> is H; R<4> is a bridging group comprising substituted or unsubstituted C2-C4 straight, C2-C6 branched or C3-C7 cycloalkyl groups wherein the substituents are selected from C1-C6 alkyl, O-C1-C6...
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JPS61172878A |
PURPOSE: To obtain a stable freeze-dried preparation exhibiting remarkable stabilizing effect, by adding sodium chloride to a specific carbapenem derivative. CONSTITUTION: A carbapenem derivative of formula such as (5R,6S,8R)-2-[(3S)-1- ...
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JPS61155387A |
Carbapenems having the formula:wherein:R1 is H;R4 and R5 are independently H, CH3-, CH3CH2-, (CH3)2CH-, HOCH2-, CH3CH(OH)-, (CH3)2C(OH)-, FCH2, F2CH-, F3C-, CH3CH(F)-, CH3CF2-, (CH3)2C(F)-;X is -S-, -SO-, -S02-, -O- or -NH;L is a bridgin...
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JPS61151190A |
NEW MATERIAL:A compound shown by the formula I {R1 is CH= CHNHCOCH3, or CH2CH2NHR3 [R3 is H, CH3, or group shown by the formula II (R4 and R5 are H, lower alkyl, phenyl, benzyl, or diphenylmethyl)]; R2 is ester-protecting group of carbox...
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JPS61151192A |
1-Methylcarbapenems having the formula: wherein: R<1> and R<2> are independently H, CH3-, CH3CH2-, (CH3)2CH-, HOCH2-, CH3CH(OH)-, (CH3)2C(OH)-, FCH2, F2CH-, F3C-, CH3CH(F)-, CH3CF2- or (CH3)2C(F)-; R<3> is CH3; R<4> is a bridging group c...
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JPS6129357B2 |
NEW MATERIAL:The compound of formulaI[R<1> is H, alkyl, alkoxy, or R<4>A- (R<4> is OH, alkoxy, acyloxy, alkylsulfonyloxy, amino, etc.; A is CF3 or alkylene which may be substituted with phenyl); R<2> is cycloaliphatic amine residue; R<3>...
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JPS61129123A |
PURPOSE: To obtain a lyophilized pharmaceutical preparation having no reduction in titer even if it is preserved at high temperature with time, obtained by blending a specific carbapenem derivative with a stabilizer such as urea, nicotin...
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JPS6125356B2 |
NEW MATERIAL:Antibiotic substance C-19393S2. Appearance, white powder; specific rotatory power, [alpha]D<22>=-152+ or -15 deg. (c=0.5, water), molecular formula (estimation), C14H16N2Na2O9S2; solubility, insoluble in chloroform, ethyl ac...
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JPS6187682A |
Disclosed are novel carbapenem derivatives characterized by a 2-substituent of the formula wherein A represents C2-C6 straight or branched chain alkylene group and R10 and R11 each independently represents optionally substituted aliphati...
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JPS6183183A |
Carbapenems having the formula: is a mono-or bicyclic quaternary heteroaryl, their preparation and antibiotic use are disclosed.
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JPS6183184A |
Compounds of the formula: wherein is a substituted or unsubstituted quaternized, monocyclic or bicyclic heteroaryl group, their preparaton and use as antibiotics are disclosed.
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JPS6163679A |
Compounds of the formula: wherein -@ is a substituted or unsubstituted quaternized, monocyclic or bicyclic heteroaryl group, their preparation and use as antibiotics are disclosed.
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JPS6163678A |
Carbapenems having the formula: wherein is a mono- or bicyclic quaternary heteroaryl, their preparation and antibiotic use are disclosed.
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JPS6118759A |
Chiral azetidinones II (R1 optionally substituted phenyl, R2 = C1-C4 alkyl or aryl, R3 = H or an N-protecting group) are prepared by reacting compound III (R4 = carboxy protecting group) with an organometallic derivative and treating the...
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JPS6118779A |
The carbapenems of the formula in which R<1> is lower alkyl, aryl or aryl-lower-alkyl, R<2> is carboxyl or 5-tetrazolyl, R<3> is hydrogen or a substituent customary for position 6 of carbapenems, and R<4> is hydrogen or a substituent cus...
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JPS615081A |
PURPOSE: To produce the titled compound, by reacting a specific azetidinone compound with a compound such as triethyl phosphite, and cyclizing the obtained compound. CONSTITUTION: The 1-substituted carbapenem-3-carboxylic acid derivative...
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JPS61345B2 |
Novel thienamycin derivatives of formula wherein the substituents are defined in Claim 1, are prepared by introducing the radical R<3> into thienamycin by acylation. The compounds obtained may be used as antibiotics.
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JPS61347B2 |
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JPS61346B2 |
N-Acyl derivatives and phosphorus-containing N-acyl derivatives of the antibiotic thienamycin of the general formula (II) in which R<1> and R<2>, independently of each other, are selected from hydrogen, acyl and phosphorus-containing acy...
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JPS60260580A |
NEW MATERIAL:The compound of formula I [R1 is H, alkyl, alkoxy, or R4A (R4 is OH, amino, alkoxy, etc.; A is CF3 or alkylene which may be substituted with phenyl); R2 is cycloaliphatic amine residue forming a 4W8-membered ring (N atom in ...
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JPS60255763A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
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JPS60248612A |
A combination of a carbapenem of the formula: where R is H or CH3 and R min is -S-CH2-@@N(CH3)2 or with a renal dipeptidase inhibitor is disclosed.
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JPS60233077A |
Disclosed are 1-hetero-6-[1-hydroxyethyl]-2-SR<8>-1-carbadethiapen-2-em-3-
COOR<4> compounds having the structure: wherein R<4> is, e.g., hydrogen, R<8> is, e.g., alkyl and R<9> is, e.g., halogen; the pharmaceutically acceptable salt and...
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JPS60233078A |
Disclosed are antibiotic 6-[1-hydroxyethyl]-2-SR8-1-methyl-1-carbadethiapen-2-em-3-ca
rboxylic acids and their pharmaceutically acceptable salts and esters (I): I wherein: R8 is and I wherein: R8 is and wherein n and m are independently ...
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JPS60228482A |
Crystalline dimethyliminothienamycin having the formula and its preparation are disclosed.
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JPS6048160B2 |
A method of recovering the antibiotic thienamycin from fermentation broths or solutions containing said antibiotic, which consists in passing a fermentation broth or a solution containing said antibiotic through a column filled with a ca...
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JPS60185778A |
The novel compounds of the formula I wherein R1 is hydrogen, a residue readily removable by reduction, lower 1-hydroxyalkyl or lower alkanoyl and R2 is hydrogen, or each of R1 and R2 is a residue readily removable by reduction; R3 is hyd...
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JPS60178888A |
NEW MATERIAL:A compound of formula I [X is methylene, ethylidene or S; R1 is formula II (R2 is H, F, etc.; R3WR5 are H, lower alkyl or cycloalkyl, etc., provided that R2WR5 do not represent H at the same time, at least one has F, at leas...
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JPS60166683A |
NEW MATERIAL:A compound shown by the formula I (R1 is H, or OH-protecting group; R2 is H, or amino-protecting group; R3 and R4 are H, or carboxyl- protecting group) and its pharmaceutically acceptable salt. EXAMPLE: ( 5R,6S,8R,2'S,4'S )-...
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