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Matches 1 - 50 out of 153,745

Document Document Title
WO/2019/016062A9
Human immunodeficiency virus (HIV) envelope proteins having specified mutations that stabilize the trimeric form of the envelope protein are provided. The HIV envelope proteins described herein have an improved percentage of trimer forma...  
WO/2019/047904A1
Provided in the present invention are an oral hypoglycemic polypeptide, fatty acid modified derivatives thereof, and uses of the polypeptide and the fatty acid modified derivatives thereof. The sequence of the polypeptide is shown in SEQ...  
WO/2019/051127A1
The present disclosure provides T-cell modulatory multimeric polypeptides ("T-Cell-MMPs") comprising an immunomodulatory polypeptide ("MOD") that may be selected to exhibit reduced binding affinity to a cognate co-immunomodulatory polype...  
WO/2017/219034A3
The present disclosure provides methods for manufacturing a fXa derivative protein at large scale leading to high yield of highly pure protein product. The method may include adding a detergent to a sample that contains a polynucleotide ...  
WO/2019/051033A1
The disclosure provides nucleic acid molecules, including cDNA, comprising an alteration that encodes variant human Solute Carrier Family 14 Member 1 (SLC14A1) proteins that associate with protection against coronary artery disease (CAD)...  
WO/2019/051128A1
The present disclosure provides tag-specific fusion proteins for selectively detecting molecules containing a strep-tag peptide or cells containing a strep-tag peptide. Disclosed embodiments include tag-specific fusion proteins that can ...  
WO/2019/050998A1
The present disclosure relates to a method of targeting extracellular vesicles employing a molecule comprising a GLA domain and extracellular vesicles obtained or obtainable from a method disclosed herein.  
WO/2019/051155A1
The present invention includes methods of treating or preventing HER-driven drug-resistant cancers. In certain embodiments, the cancer comprises lung cancer.  
WO/2019/047299A1
Provided is a transdermal short peptide having nuclear positioning capability, the amino acid sequence thereof being as represented by SEQ ID No. 1; also provided is a fusion protein having nuclear positioning capability, comprising a ma...  
WO/2019/050857A1
Some embodiments of the methods and compositions provided herein relate to the preparation surfactant protein-D (SP-D). Some embodiments include the expression of human SP-D in certain cell lines, and the purification of human SP-D from ...  
WO/2019/048871A1
There is provided a phospholipid composition which is a bilayer or micelle comprising at least one embedded protein-polymer surfactant conjugate comprising an anchor protein, wherein the anchor protein is a cationised protein or an anion...  
WO/2019/048679A1
The present invention relates to the field of oncology. More specifically, it relates to the use of peptidomimetic compounds in the treatment of multiple myeloma, especially in refractory or relapsing multiple myeloma and/or in combinati...  
WO/2019/028235A3
Compositions having pesticidal activity and methods for their use are provided. Compositions include isolated and recombinant polypeptide sequences having pesticidal activity, recombinant and synthetic nucleic acid molecules encoding the...  
WO/2019/051443A1
Methods and compositions for enhancing the immunogenicity of a tumor of interest by modulating/altering the expression of specific complement proteins and complement protein receptors associated with the immune suppression of a tumor/tum...  
WO/2019/051428A1
In certain embodiments a construct for performing gene editing in a mammalian cell is provided. In certain embodiments the construct comprises a targeting moiety that binds a surface marker on a cell (e.g., surface receptor), where the t...  
WO/2019/050362A2
The present invention relates to an antibody against delta-like 1 homolog (Drosophila) (DLK1) or an antigen-binding fragment thereof, a nucleic acid encoding the same, a vector comprising the nucleic acid, a cell transformed with the vec...  
WO/2019/050036A1
The present invention provides: a peptide that includes a partial amino acid sequence of the C16orf74 protein, includes the cysteine at position 7 and/or the cysteine at position 14 of the C16orf74 protein, and inhibits dimer formation o...  
WO/2019/050872A1
Provided herein are methods for the improved production of periplasmic- targeted recombinant proteins in E. coli host strains. Also provided are E. coli host strains with improved capacity for producing recombinant proteins.  
WO/2019/051091A1
The present disclosure provides T-cell modulatory multimeric polypeptides that comprise an immunomodulatory polypeptide that exhibits reduced binding affinity to a cognate co- immunomodulatory polypeptide. A T-cell modulatory multimeric ...  
WO/2019/051204A1
Methods and compositions are disclosed for treating a subject with a cancer. The compositions can include a chimeric molecule comprising an agent that specifically binds the interleukin 4 receptor (IL-4R) and a toxic moiety, an interfero...  
WO/2019/046952A1
A subcutaneous pharmaceutical composition comprising insulin(s) and an anti-inflammatory agent to treat diabetes and reduce tissue inflammation response in diabetic patients.  
WO/2019/048859A1
A sensor array comprising at least two sensors, wherein each sensor comprises a protein barrel and a reporter dye; wherein the protein barrel defines a lumen; the reporter dye is bound to the lumen reversibly; and wherein the protein bar...  
WO/2019/051179A1
Provided herein are a vector, a genetically modified bacterium including the vector, methods of making the bacterium, methods of using the bacterium, and kits including the bacterium. The vector includes a coding region encoding at least...  
WO/2019/014418A9
The present disclosure provides, in some embodiments, methods for treating a neurodegenerative disease in a subject using a histone deacetylase 2 (HDAC2)/Sp3 inhibitor, which may be a peptide inhibitor comprising the carboxyl-terminus of...  
WO/2019/046943A1
Provided herein is a polypeptide encoding a modified collagen-like protein or fragment thereof, wherein the modified collagen-like protein comprises at least one of the following features: is more soluble in acidic, neutral, and/or basic...  
WO/2019/050318A2
The present invention relates to a method for effective extracellular secretion of a target protein, wherein the target protein is decreased in pI by adjusting the overall charge thereof and linked to LARD3 to prepare a fusion protein an...  
WO/2019/046901A1
The present invention provides novel methods and compositions for use in preventing infection with at least one type of influenza virus, including the use of peptides or compositions comprising a peptide comprising, consisting or consist...  
WO/2019/049144A1
Described herein are synthetic polypeptide inhibitors of the SET-domain-containing protein 6 (SETD6) methyltransferase, and polypeptide chimeras thereof including at least one cell penetrating peptide. Pharmaceutical compositions and use...  
WO/2019/048540A1
The invention relates to an isolated polypeptide comprising or consisting of an amino acid sequence according to SEQ ID NO 1 (AS 136-154) (EEAEKAKEAAEKALNEAFE) or an amino acid sequence with a sequence identity of least 70 %, preferably ...  
WO/2019/018040A9
Methods and systems are described for digitally reconstructing an unknown 3D structure of a target molecule using orthogonal extension. A plurality of 2D images of the target molecule are captured by an imaging system. An estimated low-o...  
WO/2019/051001A1
Described herein are compositions and methods for signaling and antigen-presenting bifunctional receptors (SABRs) comprising one or more antigen presenting domains; and one or more signal transduction domains, wherein the one or more ant...  
WO/2019/050856A1
Some embodiments of the methods and compositions provided herein relate to the preparation surfactant protein-D (SP-D). Some embodiments include the expression of human SP-D in certain cell lines, and the purification of human SP-D from ...  
WO/2019/050997A1
The present disclosure relates to a method of targeting stems cells, in particular non-apoptotic stem cells, employing a GLA domain, capable of binding surface exposed phosphatidyl serine.  
WO/2018/134691A8
Provided herein are cell surface conjugates containing a cell surface molecule and at least one agent, such as at least one affinity tag, and engineered cells expressing such cell surface conjugates. In some embodiments, the cell surface...  
WO/2018/182983A9
Disclosed herein are vaccine compositions, in particular, polyvalent icosahedral compositions for antigen presentation. The disclosed compositions may contain an S particle made up of recombinant fusion proteins. The recombinant fusion p...  
WO/2019/051002A1
The present disclosure relates to a method of intracellular delivery of a molecule employing a GLA domain to facilitate entry into the cell.  
WO/2019/051041A1
A method is provided for prognosing a risk in a patient diagnosed with a premalignant lesion of the breast of the lesion progressing to breast cancer, the method comprising: providing a tissue sample of the premalignant lesion; detecting...  
WO/2019/049933A1
Provided are novel peptides. These peptides specifically inhibit activity of proteases which include an amino acid sequence expressed by SEQ ID NO: 23 and have a target molecule.  
WO/2019/048440A1
The present invention provides phytase enzymes exhibiting a surprisingly high thermostability as compared to commercially available phytases. Additionally some of the new phytase variants display up to four fold increased catalytic rate ...  
WO/2019/049939A1
Disclosed herein are methods and compositions for expanding and/or maintaining stem cells in an undifferentiated state.  
WO/2019/050948A1
The invention provides a recombinant RNA molecule comprising (i) a sequence of a gene-editing molecule mRNA, or a sequence of a functional fragment or derivative thereof, and (ii) at least one sequence of a coding or non-coding enrichmen...  
WO/2019/051202A1
The present invention provides a therapy for treating neuropathic pain by subpial administration of small quantities of a composition for spinal segment-specific upregulation of GAD65 (glutamatedecarboxylase) gene and VGAT (vesicular GAB...  
WO/2019/051126A1
The present disclosure provides antigen-presenting polypeptides, including single-chain antigen-presenting polypeptides and multimeric antigen-presenting polypeptides comprising one or more chemical conjugation sites for incorporation of...  
WO/2019/051445A1
Arbovirus carries an altered furin cleavage site that results in enhanced cleavage of a precursor polyprotein, such as, prE2 or prM. Dengue virus particles can have an amino acid alteration within amino acids 80-130 of prM. Zika virus pa...  
WO/2019/051015A1
The present invention provides compositions and methods comprising an activator of IL-18 activity for use in therapeutic and non-therapeutic applications. The activator provides IL-18 signaling activity even in the presence of an inhibit...  
WO/2019/048936A1
Provided herein is technology relating to vaccines and particularly, but not exclusively, to compositions, methods, and uses of a mixture of immunogenic vaccine molecules comprising components for targeting the dimeric vaccine molecules ...  
WO/2019/051327A2
Among other things, the present disclosure provides technologies for modulating functions of beta-catenin. In some embodiments, the present disclosure provides stapled peptides that interact with beta-catenin. In some embodiments, provid...  
WO/2019/051132A1
The present disclosure provides immunoglobulin binding proteins and fusion proteins that specifically bind to a strep tag peptide, such as a peptide having the amino acid sequence set forth in SEQ ID NO: 19. Also provided are methods for...  
WO/2019/051381A1
Provided herein are methods and compositions related to Prevotella EVs useful as therapeutic agents.  
WO/2019/047608A1
The present invention relates to the technical field of animal virology and animal infectious disease detection. Specifically disclosed are a duck Tembusu virus E protein truncated protein and applications. A protein of the amino acid se...  

Matches 1 - 50 out of 153,745