Login| Sign Up| Help| Contact|

Patent Searching and Data


Matches 1 - 50 out of 149,427

Document Document Title
WO/2018/011266A1
The present invention relates to reagents comprising a substituted acyl borate or a substituted hydroxyl amine, to a method of synthesizing a carrier-linked prodrug using said reagents and to carrier-linked prodrugs obtainable by said me...  
WO/2018/013585A1
Thymus modulating compositions and methods are disclosed.  
WO/2018/013924A1
The present disclosure provides a synthetic nanoparticle comprising a peptide nucleic acid (PNA) oligomer conjugated to a lipid, wherein the PNA oligomer noncovalently complexes with an immunomodulatory compound, thereby forming a nanopa...  
WO/2018/013333A1
Methods and compositions are provided which employ a silencing element that, when ingested by a plant insect pest, such as Coleopteran, Hemiptera, or Lepidopteran plant pest, including a Diabrotica, Leptinotarsa, Phyllotreta, Acyrthosiph...  
WO/2018/012669A1
The present invention relates to a mesitylene-cored amphiphile, a method of preparing the same and a method of extraction, solubilization, stabilization, crystallization or analysis of a membrane protein using the same. When a mesitylene...  
WO/2018/011302A1
The present invention relates to a method or process of producing a glycoprotein that interacts with, or acts as an agonist to, the erythropoietin receptor (EpoR), which glycoprotein has modified efficacy, wherein the method or process c...  
WO/2018/012895A1
The present invention relates to an immune cell surmounting an immune checkpoint, a preparation method thereof, and a pharmaceutical composition comprising the immune cell and, more particularly, to an immune checkpoint-surmounting immun...  
WO/2018/011799A1
Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotropin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pha...  
WO/2018/013759A1
Chickens that selectively produce female offspring are provided. In some aspects, a bird or cells thereof are provided that comprise an autosomal repressor cassette integrated on at least one copy of an autosome, which can suppress the e...  
WO/2018/011381A1
Herein is reported a method for the purification of a protein comprising erythropoietin and a single poly (ethylene glycol) residue from reaction by- products or not reacted starting material by a cation exchange chromatography method. I...  
WO/2018/010513A1
A cotton GhTCP4 gene and an application thereof in modifying the length of a cotton fiber. The cotton GhTCP4 gene is isolated, cloned and subjected to functional identification, and an expression level of the GhTCP4 gene is regulated by ...  
WO/2018/013250A1
The present invention generally relates to improved methods of assembly of two or more DNA fragments, methods of rapid ligation-independent cloning, and kits for rapid ligation-independent cloning and their uses.  
WO/2018/013509A1
The present invention relates to compositions and methods for diagnosing and treating arrhythmias. In particular, the present invention provides IL-18 markers and uses thereof.  
WO/2018/014008A1
Compositions of a recombinant adenovirus based vector vaccine containing one or more alphavirus antigen genes are disclosed herein. Methods for constructing and producing such vaccines and methods of using these vaccines to generate broa...  
WO/2018/011573A1
The invention relates inter alia to antigen binding ligands, wherein each ligand comprises a polypeptide comprising a T-cell receptor (TCR) variable domain and an antibody constant domain, non-human vertebrate comprising in its germline ...  
WO/2018/013803A1
The present invention provides a compound or a pharmaceutically acceptable salt of the Formula : X1 I V X2 S L D V P I G L L Q I L X3 E Q E K Q E K E K Q Q A K* T N A X4 I L A Q V-NH2 wherein the X1 denotes that the I residue is modified...  
WO/2018/013546A1
The invention includes methods for modulating a reaction dependent on a blue light-dependent protein interaction between a CRY protein and a CRY-signaling protein. The method comprises combining a CRY protein and a CRY-signaling protein ...  
WO/2018/011750A1
Provided is a plant or plant part comprising a polynucleotide encoding a mutated TriA polypeptide. The expression of said polynucleotide confers to the plant or plant part tolerance to herbicides.  
WO/2018/011738A1
The present technology relates to a method and a kit for immunological serological diagnosis that is sensitive to and specific for canine and human visceral leishmaniasis, comprising the use of 17 (seventeen) antigenic proteins from Leis...  
WO/2018/013013A1
´╗┐The invention relates to molecular biology, biotechnology, medicine, veterinary science. A group of inventions is proposed: a fusion protein comprising a ligand to MATN1 protein, and a growth factor of EGF, TGF, FGF, IGF, the construc...  
WO/2018/013551A1
Described herein are methods and compositions for the rapid production of therapeutic molecules using an inducible cell culture system.  
WO/2018/013053A1
The invention relates to an ELABELA polypeptide or nucleic acid for use in the treatment, alleviation or prophylaxis of pre-eclampsia in an individual. In another aspect of the invention, there is provided a method of diagnosing or detec...  
WO/2018/012952A1
The present invention relates to a novel recombinant nanocage and use thereof and to an anticancer agent comprising as an effective ingredient a complex nanocage including a nanocage and an immunogenic apoptosis inducer loaded inside the...  
WO/2018/013483A1
Disclosed herein are Kv1.3 channel inhibitor peptides and compositions comprising a peptide Kv1.3 inhibitor connected to an antibody sequence. These molecules may be useful for the treatment of T-cell mediated diseases and conditions suc...  
WO/2018/012497A1
The present invention mainly addresses the problem of providing a novel and specific knockout model animal that presents a symptom of a disease accompanied by a synapse abnormality in the brain, a method for producing same, and a therape...  
WO/2018/013791A1
An ethanologen for producing biofuel from one or more carbohydrates and reducing lactate and acetate production in a biofuel manufacturing process. The ethanologen is made by introducing into the ethanologen one or more exogenous genes r...  
WO/2018/011433A1
The invention relates to a polypeptide comprising or consisting of the polypeptide of SEQ ID NO: 1 wherein the residue X at position 89 of SEQ ID NO: 1 is not a cysteine, or a functionally equivalent variant of said polypeptide wherein t...  
WO/2018/013967A1
The disclosure relates to lantibiotic structural variants that have improved antimicrobial properties when compared to wild-type lantibiotics, and uses thereof. Embodiments include non- naturally occurring lantibiotics.  
WO/2018/013704A1
Engineered Influenza polynucleotides, viruses, vaccines, and methods of making and using the same are provided. More specifically, the present inventors have developed replication competent engineered influenza viruses having, for exampl...  
WO/2018/013395A1
A detergent composition comprising a Bs1A-like protein and a surfactant system  
WO/2018/013820A1
Disclosed herein are methods and platforms for increasing utility and efficacy of a cellular vaccine. Specifically, disclosed are steps that optimize ex vivo B cell expansion and boost host in vivo immunity. Also disclosed is a platform ...  
WO/2018/009006A1
The present invention relates to a mutated immunoglobulin-binding protein having increased alkaline tolerance and, more specifically, to an immunoglobulin-binding protein in which, with respect to the A-domain of Staphylococcal protein A...  
WO/2018/009553A1
Methods for treating glaucoma and/or Fas ligand-dependent inflammatory conditions in a subject using soluble Fas ligand (sFasL) or a fragment thereof, which may be rAAV- mediated delivery of sFasL or a fragment thereof to a subject.  
WO/2018/006750A1
Provided is a secretory protein sDSS1 of a higher primate. The protein can be detected in human blood serum and cerebrospinal fluid. The sDSS1 protein can bind, under non-enzymatic conditions, with an oxidized protein to form a polymer, ...  
WO/2018/006939A1
The present invention refers to aninactivated isolated microorganism belonging to the Mycobacterium tuberculosis complex that comprises the deletion or previous disruption of the phoP gene; and a second gene to prevent DIM production. Al...  
WO/2018/007597A1
The invention features soluble fibroblast growth factorreceptor3 (sFGFR3) polypeptides. The invention also features methods of using sFGFR3 polypeptides to treat skeletal growth retardation disorders, such as achondroplasia.  
WO/2018/008772A1
The present invention relates to a cancer treatment composition for inhibiting angiogenesis, and a preparation method therefor. An angiogenesis inhibitor according to the present invention is a cancer treatment composition containing a f...  
WO/2018/007560A1
The present invention relates to a new method for the production of a molecule of interest by conversion of a source of carbon in a fermentative process comprising culturing a microorganism genetically modified for the production of mole...  
WO/2018/009896A1
Phosphorylation and dephosphorylation of MENA and MENA isoforms regulates the metastatic activity of cancer cells. Administration of a MENA kinase inhibitor results in significant reduction in the development of cancer metastasis in esta...  
WO/2018/007976A1
The present application provides materials and methods for treating a patient with one or more conditions associated with SCN10A whether ex vivo or in vivo. In addition, the present application provides materials and methods for editing ...  
WO/2018/009832A1
This document relates to materials and methods for controlling ligand gated ion channel (LGIC) activity. For example, modified LGICs including at least one LGIC subunit having a modified ligand binding domain (LBD) and/or a modified ion ...  
WO/2018/007575A1
The present invention relates to a genomic sequences encoding for an attenuated mutant Zika virus. The inventors have introduced some specific substitutions at very specific positions in the epidemic genomic sequence for restoring some f...  
WO/2018/009461A1
Provided are Listeria-based immunogeniccompositions comprising Wilms tumor protein (WT1) antigens and methods for treating and vaccinating against cancer and inducing an immune response against the same in a subject. Also provided herein...  
WO/2018/009624A1
The present invention discloses heterodimers comprising endoglin-Fc and ALK1-Fc, or heterodimers comprising endoglin-Fc and ALK2-Fc. The Fc domains can include amino acid mutations that promote heterodimer formation. In certain aspects, ...  
WO/2018/009921A1
The present invention provides fusion proteins comprising leptin and a second protein. The presence of the second protein provides increased biological activity and/or increased half-life in vivo. The present invention also provides huma...  
WO/2018/009457A1
Compositions and methods for using actin-based peptides to modulate cellular bioactivity, including modulation of cellular susceptibility to intracellular pathogens, such as bacteria and viruses.  
WO/2018/007263A1
The invention pertains to the field of adaptive cell immunotherapy. It aims at reducing the occurrence of translocations and cell deaths when several specific endonuclease reagents are used altogether to genetically modify primary immune...  
WO/2018/009604A1
Chimeric flaviviruses that include non-coding regions, non-structural proteins, a capsid (C) protein and a portion of a premembrane (prM) signal sequence from an attenuated or wild-type dengue serotype 2 virus (DENV-2), and a portion of ...  
WO/2018/009923A1
The present disclosure provides methods for genetically modifying lymphocytes and methods for performing adoptive cellular therapy that include transducing T cells and/or NK cells. The methods can include inhibitory RNA molecule(s) and/o...  
WO/2018/009050A1
The present invention relates to four CpRap2 genes isolated from Carica papaya, identified as CpRap2.4a, CpRap2.4b, CpRap2.1, CpRap2.10 and consisting of sequences SEQ. ID NO: 1, SEQ. ID NO: 2, SEQ. ID NO: 3 and SEQ. ID NO: 4, as well as...  

Matches 1 - 50 out of 149,427