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WO/2001/036595A2 |
This invention relates to constructs for the conditional or regulated expression or excision of transgenes in plants using site-specific recombinase systems. The constructs comprise a variety of constitutive, inducible, tissue specific o...
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WO/2001/032760A1 |
A porous, molecularly imprinted polymer and a process for its preparation are described. The porous, molecularly imprinted polymer is characterised in that it is obtainable by providing a porous silica; attaching a molecular template to ...
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WO/2001/031038A1 |
A method of immobilizing heteromer peptides having a plural number of subunits, which are formed by cutting off precursor peptides, on a chitin or cellulose carrier by expressing a protein carrying a chitin-cellulose binding domain (CBD)...
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WO/2001/028575A1 |
The invention relates to a proteoglycan, a bioactive substance from plants obtained by disintegration of dividing plant cells, for example from shoots of the Solanum tuberosum of Solanaceous family. The inventive substance is extracted f...
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WO/2001/025287A1 |
Affinity macroligands (AML) comprising a reversibly water soluble poly-N-alkylacrylamide linked to a ligand, and their use in the separation of a target substance from a mixture comprising the target substance and other materials are dis...
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WO/2001/023413A1 |
This invention describes blood treating material having the capacity to selectively remove endotoxin and cytokine inducing substances from blood or plasma by extracorporeal adsorption for therapeutic septic shock treatment. The endotoxin...
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WO/2001/021635A2 |
The present invention relates to a method for electrochemically detecting sequence-specific nucleic acid-oligomer hybridisation events. DNA-/RNA-/PNA oligomer single strands which are bound to a conductive surface at one end and are link...
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WO2000032823A9 |
The invention provides methods for covalently tagging proteins with their encoding DNA sequences as shown in the Figure. These DNA-protein fusions may be used in molecular evolution and recognition techniques.
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WO/2001/021660A1 |
The invention relates to peptides for combating the autoantibodies that have a causal pathological relationship with dilatative cardiomyopathy (DCM). Said peptides can be e.g. bonded to a solid phase. Said autoantibodies can be eliminate...
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WO/2001/019405A2 |
The invention relates to magnetic nanoparticles, to the production thereof and to their use. The aim of the invention is to prepare nanoparticles which, also in the intracellular area of cells, can specifically bond to intracellular biom...
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WO/2001/018060A1 |
Available adsorbents which make it possible to selectively adsorb and eliminate diabetic complication factors such as carbonyl stress products causing various vascular lesions (arteriosclerosis, etc.) in a state where carbonyl stress has...
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WO/2001/018059A2 |
The present invention relates to a proteinaceous compound or functionally active derivative or part thereof having a binding site for a group represented by formula (I) which is part of a group of toxins derived from various cyanobacteri...
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WO/2001/018172A2 |
The present invention provides Fibroblast Growth Factor-like (FGF-like) polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, antibodies and methods for producing FGF-like polypeptide...
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WO/2001/016328A2 |
The invention relates to a method for the production of regular nanostructures comprising the following steps: preparation of channel-forming proteins from Gram-positive bacteria and application of said channel-forming proteins to a subs...
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WO/2001/016352A1 |
Described herein are methods and reagents for encoding and sorting in vitro translated proteins.
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WO/2001/015736A2 |
A conjugate exhibiting interferon β activity and comprising at least one first non−polypeptide moiety covalently attached to an interferon β polypeptide, the amino acid sequence of which differs from that of wildtype human interferon...
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WO/2001/014425A1 |
The present invention provides protein chips on which high density of protein probe arrays are fixed, a method for manufacturing the protein chips, atomized diagnostic systems comprising the protein chips and the use thereof. The highly ...
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WO/2001/012232A2 |
This invention pertains to a process for making a sustained release complex, Compound (I), which comprises Compound (A), having formula (A), and a copolymer comprising poly-(1)-lactic-glycolic-tartaric acid (P(1)LGT), wherein the amino g...
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WO/2001/011050A1 |
The present invention provides a purified polynucleotide encoding a novel polypeptide, designated Fhm, which belongs to the TNF gene superfamily; to purified Fhm polypeptide molecules; to antibodies that bind Fhm; to materials comprising...
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WO/2001/007657A1 |
Described herein are methods and reagents for the ligation of a peptide acceptor to an RNA, as well as the RNA-peptide acceptor products.
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WO/2001/007477A1 |
The present invention provides novel VGF polypeptides and selective binding agents. The invention also provides host cells and methods for producing VGF polypeptides. The invention further provides VGF pharmaceutical compositions and met...
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WO/2001/007581A1 |
The invention relates to a method for encapsulating macromolecules and/or particles. The method is characterised in that at least two substances A and B are used for the encapsulation of the macromolecules and/or particles. Substance A p...
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WO/2000/074722A2 |
A method of modifying the biological and/or physicochemical properties of biological elements such as viruses and other micro-organisms is disclosed in which the biological element is modified by providing it with a coating of a multival...
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WO/2000/073341A1 |
Polypeptides containing a series of heptad-repeats that mimic a transmembrane domain and a selected cytoplasmic domain attached to the series of heptad repeats are provided which can be used in construction of structural models for evalu...
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WO2000034784A9 |
Disclosed herein are proteins that include a fibronectin type III domain having at least one randomized loop. Also disclosed herein are nucleic acids encoding such proteins and the use of such proteins in methods for evolving novel compo...
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WO/2000/068690A1 |
A method for detecting proteins under mutual interaction which comprises mixing a protein having a label for detection synthesized by a cell-free protein synthesis method with another protein having a modification for separation, or synt...
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WO/2000/066156A1 |
The present invention relates to novel Death Domain Containing Receptor-5 (DR5) proteins which are members of the tumor necrosis factor (TNF) receptor family, and have now been shown to bind TRAIL. In particular, isolated nucleic acid mo...
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WO/2000/064936A2 |
The invention relates to homodimers and heterodimers consisting of peptide monomers which have the amino acid sequence WDETLLKFYTELYQQL (monomer I), SLFSCLKDRHDFGFPQEEFGNQ (monomer II) or QGVGVTETPLMKEDSILAV (monomer III), or variants th...
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WO/2000/062758A1 |
This invention relates to methods of increasing the half-life of a viral-specific ligand on a mucosal membrane by modifying the viral-specific ligand to bind the bacteria colonized on the mucosal membrane. The invention also provides a c...
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WO/2000/063373A1 |
The invention relates to methods of altering the properties of membrane-associated proteins, by substituting the transmembrane region. In this way, for example, the level of expression of the protein can be altered as well as properties ...
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WO/2000/061194A2 |
The invention relates to compounds which are used for diagnosing tumors comprised of conjugates of dyes having short-chain peptides that are derived from the vasoactive intestinal peptide, from somatostatin or from neurotensin. The inven...
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WO/2000/061813A1 |
A new protein named Tankyrase II is described in this disclosure. Sequences for the human Tankyrase II cDNA and the protein translation product are provided. Also provided are species homologs, muteins, related nucleic acids, peptides, a...
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WO/2000/061069A2 |
Methods of treating a host suffering from hyperlipidemia resulting from elevated levels of at least one of VLDL and triglycerides are provided. In the subject methods, an effective amount of agent that reduces the level of active apoE, e...
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WO/2000/060090A1 |
Compounds and methods for the diagnosis and treatment of $i(B. microti) infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a $i(B. microti) antigen and DNA sequences encodi...
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WO/2000/058005A2 |
The invention relates to an immunoabsorber for use in sepsis therapy, especially for removing complement factors and lipopolysaccharides (LPS) and optionally other sepsis mediators such as TNF and interleukins from body fluids. The inven...
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WO/2000/053631A1 |
Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also...
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WO/2000/050570A2 |
This invention relates to compositions and methods for modifying growth or differentiation of growth-factor dependent cells, using fusion proteins composed of a growth factor and a binding domain derived from a polysaccharidase linked di...
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WO/2000/042069A1 |
Polypeptides which increase or promote mammalian bone growth, related nucleotide sequences, antibodies, diagnostic kits and treatments. Subsequences of the polypeptide Ile Lys Thr Thr Ser Gly Ile His Pro Lys Asn Ile Glu Ser have been sho...
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WO/2000/036145A1 |
The invention concerns a method for making a biochip and a biochip, said biochip consisting in particular of biological probes grafted on an conductive polymer. The inventive method comprises the following steps: a) structuring a substra...
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WO/2000/036136A1 |
Metallopeptide combinatorial libraries and methods of making libraries and metallopeptides are provided for use in biological, pharmaceutical and related applications. The combinatorial libraries are made of peptides, peptidomimetics and...
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WO/2000/033881A1 |
The aim of the invention is to provide a new method for identifying or analysing polymer linkage sites on macromolecules using amino acid reporter binding. Another aim of this invention is to provide a compound FE - L - M, where M is a m...
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WO/2000/032767A1 |
Recombinant soluble Fc receptors according to the present invention are characterized by the absence of transmembrane domains, signal peptides and glycosylation. Such Fc receptors can easily be obtained by expressing respective nucleic a...
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WO/2000/031114A1 |
Human heat-shock protein-binding proteins (HspBP-1 and HspBP-2) are disclosed with the polynucleotides which identify and encode them. Genetically engineered expression vectors and host cells comprising the nucleic acid sequences encodin...
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WO/2000/029548A2 |
The present invention is directed to a process for coupling an adhesive glycoprotein to a surface of a bulk material comprising the following steps: a) a layer of a volatile aldehyde is deposited to the surface of the bulk material from ...
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WO/2000/025725A2 |
Variants of hedgehog protein that contain N-terminal modifications are described that can block hedgehog function; thus allowing these variants to serve as functional antagonists. These peptides have a primary amino acid sequence lacking...
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WO/2000/023472A2 |
A fusion polypeptide is described having the amino acid sequence X-Y-Z, or portion thereof, comprising the amino acid sequence of a glycosylated interferon-beta (X); Y is an optional linker moiety; and Z is a polypeptide comprising at le...
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WO/2000/023955A1 |
The invention described herein relates to compositions and methods for stimulating immune responses $i(in vivo) against a tolerogen. Novel biotechnological tools, pharmaceuticals, therapeutics and prophylactics, which concern chimeric or...
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WO/2000/023478A1 |
A storage stable composition comprising a carrier usable for the immobilization of compounds containing an amine group, for instance biomolecules and/or affinity ligands. The carrier has been activated to exhibit a squaric acid derivativ...
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WO/2000/021567A1 |
A copolymer comprising an N-acylated derivative, and a composition comprising said copolymer and a polypeptide, said polypeptide comprising at least one effective ionogenic amine, wherein at least 50 percent, by weight, of said polypepti...
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WO/2000/018823A2 |
The present invention relates to macromonomers containing ethylene glycol repeat units, to chemically inert polymers prepared therefrom and to the use of such polymers in solid phase biochemical assays. A macromonomer of polyethylene gly...
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