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WO/2009/112645A1 |
The present invention relates to a peptide of general formula (I): R1‑(AA)n-X1-X2-X3-Pro-X4-X5-X7-(AA)P-R2, capable of activating the synthesis of proteins of the aquaporin family. The present invention also relates to a cosmetic, nutr...
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WO/2002/072597A9 |
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WO/2009/106715A2 |
The present invention relates to a peptide of general formula (I): R1‑(AA)n-X1-X2-X3-PrO-X4-X5-X7-(AA)P-R2, derived from a protein of the aquaporin family. The present invention also relates to a cosmetic, nutraceutical or pharmaceutic...
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WO/2009/096112A1 |
Disclosed is a tag peptide having an amino acid sequence represented by formula (I): X1-Tyr-X2-Gly-Gln-X3 [wherein X1, X2 and X3 independently represent any amino acid residue]. Also disclosed is an antibody directed against the tag pept...
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WO/2009/093962A1 |
The present invention relates to multifunctional protein production tags comprising at least 4, preferably 4-8 amino acids, for optimising expression of proteins and purification thereof by various multi-step processes including chromato...
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WO/2009/070786A2 |
This invention encompasses compositions and methods for treating and imaging vulnerable plaque and other inflamed regions in a subject.
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WO/2009/052572A1 |
Isolated M proteins, or M-like proteins, of Streptococcus iniae, encoding nucleic acids, genetic constructs and antibodies which bind the isolated M proteins are provided. Also provided are isoforms and/or fragments of the M proteins, or...
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WO/2009/037592A2 |
Aminoglycoside-amino acid and -peptide conjugates comprising a triazolyl linker are provided along with efficient methods of their preparation. The aminoglycoside may be an aminoglycoside antibiotic. Conjugates comprising an aminoglycosi...
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WO/2009/026615A1 |
Isolated proteins and immunogenic fragments thereof, for use in the treatment and prevention of a Group A Streptococcus infection are provided. In particular, the invention provides pharmaceutical compositions and methods of prophylactic...
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WO/2009/026653A1 |
An avian embryo model system is disclosed which provides an assay for investigating cellular and molecular mechanisms of neuroplasticity induced by stem/precursor cells and/or the effect of various agents (including stem/precursor cells)...
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WO/2009/028943A1 |
The invention relates to field of biochemistry, molecular biology as well as medicinal chemistry. More in specific, the invention relates to polypeptides derived from human lactoferrin and their use in therapeutic or prophylactic treatme...
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WO/2009/022154A2 |
The present invention relates to peptides comprising multiple MHC Class II-binding T cell epitopes for tolerisation therapy.
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WO/2009/000971A2 |
The present invention relates to peptid es comprising the amino acid sequence C X1 X 2 X3 X4 X5 X6 C wherein C is cysteine, X1 is Phenylalanine, X2 is Serine, X3 is Isoleusine, X4 is Alanine, X5 is Histidine, X6 is Glutamic acid, or a co...
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WO/2008/148170A1 |
Isolated immunogenic peptides of eight to ten contiguous amino acids of a hMPV protein and a variants thereof are provided herein. Typically, the isolated immunogenic peptides are T cell epitopes. Also provided are isolated proteins comp...
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WO/2008/113796A1 |
The present invention relates to the production of novel peptides which have a length of between 4 and 8 amino acids and comprises the amino acid sequence -Xaa- Xbb-Xcc-Xdd-, whereby Xaa and Xdd can be His (H), Arg (R) or Lys (K), and Xb...
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WO/2008/108668A1 |
The invention provides compositions and methods for modulating GDP-L-Galactose Guanyltransferase (also known as GDP-L-Galactose phosphorylase) activity; and/or GDP-D-Mannose epimerase activity; and/or ascorbate content in plants. The inv...
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WO/2008/106551A2 |
It is disclosed herein that Brachyury is expressed in human tumors, specifically in tumors of the small intestine, stomach, kidney, bladder, uterus, ovary, and testes, as well as in lung, colon and prostate carcinomas. Immunogenic Brachy...
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WO/2008/064401A1 |
A peptide sequence of the form: X(Lys,Arg)XXXXX(Arg,Lys)X, wherein Lys and Arg are replaceable and X is preferably one or more of the following amino acids: hydrophobic amino acid residues (eg Pro, Leu. Met, Ile), basic amino acid residu...
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WO/2008/050898A1 |
It is intended to provide a cancer cell apoptosis inducer containing a REIC/Dkk-3 gene fragment and a therapeutic agent for cancer containing the apoptosis inducer. The following (a) or (b) polynucleotide, which is a fragment of a polynu...
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WO/2008/048121A2 |
The present invention provides a novel class of macrocyclic compounds, which are useful as cysteine protease inhibitors. Also provided are novel intermediates and methods of preparing the compounds. The invention also provides pharmaceut...
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WO/2008/028251A1 |
The invention provides an isolated nucloprotein complex comprising a mammalian Ifi202 protein and foreign double stranded DNA, which complexes may be involved in intracellular recognition of, and cellular activation by, foreign double st...
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WO/2008/019888A2 |
Briefly, the present invention refers to the transcription factors PAX2 and PAX8 expressed in solid tumours and haematologic malignancies, and their utility as a target in immunotherapy and molecular therapy. In more detail, the inventio...
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WO/2008/017372A1 |
Peptides and their functionally equivalent derivatives, in salified or non-salified form, with the general formula L1-X1-X2-X3-X4, wherein: L1 is H, or acyl, or any natural or non-natural amino acid, optionally N-acylated, N-alkylated an...
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WO/2008/011672A1 |
A cancer vaccine, and a composition for the ex vivo priming of dendritic cells, is disclosed which comprises a MUC1 T cell epitope-derived peptide or peptide analogue capable of provoking a cytotoxic T cell immune response. Particular MU...
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WO/2008/011335A2 |
Compositions are provided comprising a family of peptides having binding specificity for metal, and their use to produce coating compositions. The coating compositions are used to deliver a pharmaceutically active agent to metal, and are...
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WO/2008/006125A1 |
The present invention relates to peptides with antimicrobial or endotoxin-neutralizing activity having the general formula (Xaa1)M- (Xaa2)0-Xaa3- (Xaa4)P- (Xaa5)Q- (Xaa6)M- (Xaa7)R- (Xaa8)S.
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WO/2008/003773A1 |
The present invention relates to a method for detecting by fluorescence an interaction between (i) a peptide containing at least one phosphorylated or phosphorylatable amino acid and (ii) a target enzyme such as a protein phosphatase or ...
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WO/2007/086637A1 |
The present invention relates to a method for producing large amounts of human giowth factors from human adipose-derived stem cells. More specifically, the invention provides a method capable of synthesizing human growth factors in signi...
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WO/2007/076776A1 |
Disclosed are a method and a device for vacuum drying papaya latex to be used for producing papain. The aim of the invention is to be able to produce a high-quality final product, reduce the amount of time and energy required for the pro...
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WO/2007/072973A1 |
The current invention relates to a multimeric capture agent for binding a ligand, the multimeric capture agent comprising at least first and second peptide chains, wherein said first and second peptide chains each comprise a chain of 2 t...
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WO/2007/072975A1 |
The current invention relates to a method of functionalising a substrate comprising immobilising at least one multimeric peptide on the substrate, wherein, the at least one multimeric peptide comprises at least first and second peptide c...
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WO/2007/072976A1 |
The current invention relates to a method of fabricating a multimeric capture agent for binding a ligand, the capture agent comprising at least first and second monomers units, the first monomer unit further comprising a first ligand-bin...
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WO/2007/051477A2 |
The present invention relates to peptide sequences capable of stimulating neuronal cell differentiation, neural cell survival and neuronal plasticity associated with memory and learning. The peptide sequences of the invention are derived...
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WO/2007/046729A1 |
This invention relates to biology and medicine and, in particular, can be used in medicine to make a pharmaceutical composition for targeted delivery of biologically active substances into mitochondria, driven by proton electro-chemical ...
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WO/2007/021253A1 |
The inventors have discovered that an ATPase-deficient dominantnegative mutant NS3 protein of hepatitis C virus inhibits activity of the wild-type NS3 protein and inhibits replication of hepatitis C virus (HCV). The solved crystal stru...
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WO/2007/017590A2 |
The invention relates to products obtainable from a modified guar protein extract, to a method for the production thereof and to cosmetic or pharmacological or plant protective compositions or to domestic care agents containing said prod...
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WO/2007/017591A2 |
The invention relates to a surface treating and/or modifying composition, for example a cosmetic or pharmaceutical or plant protective compositon or domestic care composition comprising a guar protein extract, possibly in the form of a d...
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WO/2007/010623A1 |
A novel polypeptide of the invention contains a peptide unit having an amino acid sequence represented by the following formula (1) and a peptide unit having an amino acid sequence represented by the following formula (2). -Pro-X-Gly- (1...
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WO/2006/138721A1 |
Antibodies and antibody fragments that bind to the receptor GFRalpha3 and inhibit formation of a Neublastin-GFRalpha3-Ret ternary complex are disclosed. Also disclosed are methods of using the antibodies and antibody fragments to inhibit...
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WO/2006/128027A1 |
A method is disclosed for inhibiting angiogenic activity by interacting anginex with the peptide galectin-1. Also disclosed is a method for constructing an artificial gene encoding the biologically exogenous peptide anginex and producing...
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WO/2006/123926A2 |
The present invention relates to a peptide composition for culturing and/or growing micro-organisms and/or cells on the basis of at least one vegetable protein source, wherein at least 20% of the peptides present in the peptide compositi...
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WO/2006/116737A2 |
Peptides comprising a cadherin cell adhesion recognition (CAR) sequence, and compositions comprising such peptides, are provided. Methods of using such peptides for modulating cadherin-mediated processes in a variety of therapeutic conte...
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WO/2006/112738A1 |
Isolated peptides comprising at least the amino acid sequence of either of DSWSY or YINSK or a derivative of said peptide. Nucleic acids encoding said peptides. The peptides and nucleic acids are used in modulating &agr 4 integrin functi...
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WO/2006/110881A2 |
Disclosed are compositions, including LcrV antigenic polypeptides, vaccines and antibodies, as well as associated methods for treating and/or preventing Yersinia infection in a host. The invention further provides immunomodulatory LcrV p...
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WO/2006/098074A1 |
An apoptosis inducing agent for prostate carcinoma cells comprising REIC/Dkk-3 DNA or a REIC/Dkk-3 protein, a therapeutic agent for prostate carcinoma comprising the apoptosis inducing agent, and an agent for inhibiting the metastasis of...
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WO/2006/081301A1 |
A 23 amino acid peptide, AtPtpl, plays an important role as a signaling component of the innate immune system of Arabidopsis. The peptide precursor gene is transcribed in response to elicitors generated by pathogens, and AtPepl is produc...
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WO/2006/066358A1 |
The present invention relates to a plant vacuole targeting sequence X1X2X3PX4 wherein X1 is a hydrophobic amino acid, X2 is a basic amino acid, X3 is a hydrophobic amino acid, P is proline; and X4 is a hydrophilic amino acid, such as the...
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WO/2006/030722A1 |
A region in which NRSF/REST and mSin3B interact on each other was specified. A peptide made up of 8-50 amino acid residues is provided which comprises the following amino acid sequence: Leu-Ile-Met-Leu-Ala-Asn-Val-Ala (I).
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WO/2006/028420A1 |
There is provided a method of altering the conformation of a peptide from a globular conformation to a ribbon conformation or vice versa comprising removing or introducing a conformation-inducing residue into the peptide. In particular, ...
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WO/2006/007667A1 |
The present invention relates generally to the field of immunotherapy and immunodiagnosis of autoimmune conditions. More particularly, the present invention provides agents which are recognized by or are specific for proinsulin- or insul...
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