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WO/2012/061412 |
The invention provides efficient methods of preparing a target nucleic acid in a form suitable for sequencing. The methods are particularly amenable for preparing high quality nucleic acids for massively parallel sequencing. The methods ...
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WO/2012/060315 |
The objective of the present invention is to provide a method for producing intestinal cells using pluripotent stem cells as the starting material. The present invention provides a method for producing intestinal cells that includes: a s...
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WO/2012/061723 |
The present invention relates to a cell-based model useful for identifying molecules that modify intracellular pathways of a-synuclein and tau aggregation and degradation.
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WO/2012/059888 |
The present invention concerns a method of detecting the presence of a DNA minor contributor in a DNA mixture by determining several haplotypes present in said one or more DNA samples.
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WO/2012/061036 |
Provided herein is a method of reducing adapter dimer formation comprising contacting a sample comprising target nucleic acid sequences with 5' and 3' adapters in the presence of one or more hairpin oligonucleotides. Also provided is a m...
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WO/2012/060595 |
Disclosed are a structure with a nanopore and an apparatus for determining sequences of nucleic acids including the structure, the structure including three or more structures having facing surfaces, a plurality of oligonucleotides attac...
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WO/2012/059615 |
The invention relates to a method for determining the production of reactive oxygen species in a cellular population. The invention also relates to a method for determining the need for an antioxidant treatment of a male subject, and to ...
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WO/2012/061513 |
This disclosure concerns compositions and methods for identifying the SCN resistant phenotype in soybean. In some embodiments, the disclosure concerns methods for performing marker assisted breeding and selection of plants carrying one o...
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WO/2012/061788 |
The present invention provides the surprising finding that alpha-synuclein exists in vivo as a folded tetramer. Provided are various methods and technologies that arise from this finding, including methods and kits for identifying indivi...
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WO/2012/061226 |
A biological sterilization indicator (BI) and method of using same. The BI can include a housing, and a container positioned in the housing. The container can contain a liquid and at least a portion of the container can be frangible. The...
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WO/2012/061212 |
A method of detecting a biological activity is provided. The method includes contacting; in a liquid medium selected to facilitate a predetermined biological activity; a sample, an indicator reagent, and a substrate that receives and con...
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WO/2012/061719 |
Provided herein are DNA origami devices useful in the targeted delivery of biologically active entities to specific cell populations.
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WO/2012/059695 |
The invention relates to a method of screening for colorectal cancer in an individual, comprising a step of measuring the degree of methylation of at least one of the genes selected from NPY and PENK, and fragments or variants thereof, i...
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WO/2012/060596 |
The present invention relates to an apparatus and method for simultaneously detecting various types of target nucleic acids in real time, whereby various types of target nucleic acids can be simultaneously detected in real time to allow ...
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WO/2012/061726 |
Provided are compositions and methods for sequencing a target polynucleotide that has been used to generate an elongated polynucleotide having a plurality of segments, each segment corresponding to one of the nucleic acid residues of the...
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WO/2012/060845 |
Methods of inhibiting ischemia-related and ischemia-reperfusion-related injury are provided. Remote administration of a C-fiber activator or TRPV1 agonist or remote electrical stimulation and activation of TRPV1 reduces ischemia-related ...
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WO/2012/061814 |
Described herein are compositions and methods for performing PCR-based amplification of a target nucleic acid for the specific, efficient, reproducible, and accurate genotyping of single nucleotide polymorphisms in DNA.
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WO/2012/061789 |
Disclosed herein are methods and related compositions for identifying compounds that stabilize natively folded tetrameric α-synuclein. These methods and compositions are useful for the treatment and diagnosis of α-synuclein -associated...
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WO/2012/061600 |
The present invention provides methods for sequencing and genotyping of DNA useful for analysis of samples in which the target DNA represents a small portion (e.g., 10-1000-fold less) that a contaminating DNA source. Accordingly, the met...
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WO/2012/061225 |
The present invention relates to nucleic acid amplification assays for the detection of nucleic acid sequences of Gardnerella vaginalis. The present invention provides oligonucleotides that are complementary or that anneal to nucleic aci...
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WO/2012/059563 |
The invention relates to a method for obtaining a specific signature of a DNA molecule. This method makes it possible in particular to obtain signatures for long DNA fragments. It also makes it possible to analyse and compare genomic dif...
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WO/2012/061157 |
The present invention relates to high-throughput methods of screening biological samples to identify microorganisms having potential utilities as biocontrol agents. The methods include, for example, the use of multitest platforms for the...
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WO/2012/061227 |
A biological sterilization indicator (BI). The BI can include a housing, and a container positioned in the housing. The container can contain a liquid and at least a portion of the container can be frangible. The BI can further include a...
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WO/2012/061451 |
The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a disposable cartrid...
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WO/2012/061213 |
The present invention provides method of detecting a predetermined biological activity. The method includes using an aqueous mixture comprising a first indicator reagent with a first absorption spectrum and a second indicator reagent. Th...
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WO/2012/060635 |
The present invention provides a polynucleotide including a gene which is related to the metabolism of isoflavone, and especially a single-nucleotide polymorphism (SNP) that is induced from a gene which is on the signaling path of NF-κB...
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WO/2012/061405 |
Disclosed herein are PNA probes, or PNA probe sets and their use as well as kits useful for the analysis of certain Oxalobacter species and/or strain(s) present in a sample of interest. Probe sequences may sequence that are at least abou...
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WO/2012/060579 |
The present invention relates to a dead lactobacillus biomass for antimicrobial use; the biomass being produced by subjecting a lactobacillus fermentation liquid to tyndallisation and then separating the same into a fermentation filtrate...
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WO/2012/061228 |
A biological sterilization indicator (BI) system and method. The system can include a BI and a reading apparatus comprising a well. The BI can include a housing, which can include a first portion, and a second portion movable between a f...
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WO/2012/058726 |
The present invention provides markers of endothelial progenitor cells (EPCs) and use of those markers and reagents that bind thereto to detect EPC cells or diagnose, prognose, treat or prevent EPC-associated conditions.
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WO/2012/059703 |
The present invention relates to an in vitro or ex vivo method for storing and/or keeping an epidermis alive. According to another aspect, the present invention relates to the resulting epidermis model and to the use thereof in a kit or ...
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WO/2012/061502 |
The present invention provides compositions and methods based on genetic polymorphisms that are associated with response to statin treatment (particularly for reducing the risk of venous thrombosis). For example, the present invention re...
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WO/2012/061620 |
Methods of identifying, diagnosing, and prognosing rheumatoid arthritis are provided, as well as methods of treating rheumatoid arthritis. Also provided are methods for identifying effective rheumatoid arthritis therapeutic agents and pr...
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WO/2012/061229 |
A biological sterilization indicator (BI) system and method. The system can include a BI and a reading apparatus comprising a well. The BI can include a housing, which can include a first portion, and a second portion movable between a f...
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WO/2012/061421 |
The present invention relates to methods for identifying individuals with intermediate age-related macular degeneration (AMD) who possess a greater risk of progression to advanced AMD, using a polygenic score calculated based on the resu...
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WO/2012/060025 |
The present invention addresses the problem of providing a vaccine which as yet has not been provided for the disease HHV-6B, which is the cause of exanthema subitum in infants, and the problem of providing an effective screening method ...
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WO/2012/059616 |
The invention relates to in vitro methods for determining the prognosis of a subject diagnosed with pulmonary adenocarcinoma. In particular, the invention relates to a gene signature, the expression of which correlates with the prognosis...
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WO/2012/061529 |
An isolated polynucleotide encoding a modified luciferase polypeptide and novel coelenterazine- based substrates. The OgLuc variant polypeptide has at least 60% amino acid sequence identity to SEQ ID NO: 1 and at least one amino acid sub...
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WO/2012/059583 |
A novel type of dye systems comprises a selection of 10H-indolo[1,2-a]indole compounds (henceforth abbreviated as IO compounds) and (5H,7H)-indolo[1,2- a]quinoline compounds (henceforth abbreviated as IQ compounds) showing a solvatochrom...
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WO/2012/061676 |
Provided herein are compositions comprising light-activated chimeric proteins expressed on plasma membranes and methods of using the same to selectively depolarize excitatory or inhibitory neurons.
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WO/2012/061477 |
The invention provides coelenterazine derivatives which are substrates for a non-luminescent enzyme and a pro-substrate for a luminescent enzyme. The invention also provides a method of using the derivatives.
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WO/2012/061778 |
Various embodiments are drawn to systems and methods for detecting an analyte of interest in a sample including an optical sensor, a capture probe attached to a surface of the optical sensor wherein the capture probe is capable of bindin...
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WO/2012/061510 |
In one aspect, methods, markers, and expression signatures are disclosed for assessing the degree to which a cell sample has epithelial cell-like properties or mesenchymal cell-like properties. In another aspect, methods are provided for...
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WO/2012/061669 |
A method for determining radiation exposure from chromosome abnormalities present in a specimen by determining the location or locations of the centromere of each chromosome in a cell in an image of a metaphase cell by segmentation of an...
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WO/2012/060636 |
The present invention relates to a method for diagnosing stomach cancer suing a soluble truncated c-Met protein, and more particularly, to a method for diagnosing stomach cancer comprising a step of measuring the level of a soluble trunc...
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WO/2012/060323 |
Provided is a gene involved in the regulation of the amount of melanin in keratinocytes and the control of skin and hair color, said gene being selected from the group comprising the ATG7 gene, RAB11A gene, CLIP-170 gene, Rubicon gene, a...
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WO/2012/059839 |
A method comprises: recording an electronic record of diagnostic events including the performing of in- vitro diagnostic tests; during the recording, identifying the performing of a licensed in- vitro diagnostic test for which license in...
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WO/2012/060760 |
The present invention provides a method for in vitro diagnosing and/or prognosing cancer in a biological sample, wherein changes in expression levels of one or more molecular markers in the 8p11 -p12 chromosomal region, and said changes ...
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WO/2012/061515 |
In one aspect, methods, markers, and expression signatures are disclosed for assessing the degree to which a cell sample has epithelial cell-like properties or mesenchymal cell-like properties. In another aspect, methods are provided for...
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WO/2012/059102 |
A method of detecting ruminant contaminant material in a biological sample comprises the steps of (a) extracting total genomic DNA from the sample; (b) amplifying a ruminant-specific target sequence with at least 96% sequence identity to...
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