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WO/2018/218737A1 |
Disclosed in the present application are graded models of imprinted genes in bladder tumours and a system composed of same, the models grading the change of imprinted genes in tumours by means of calculating the amount of imprinted gene ...
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WO/2018/220136A1 |
The present invention relates to Solanum lycopersicum (S. lycopersicum) plants with resistance to Tomato Yellow Leaf Curl Virus (TYLCV), powdery mildew (PM) and nematodes. According to the invention, the resistances are provided by coupl...
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WO/2018/223014A1 |
Provided herein are DNA-glycan conjugates that include a glycan and a covalently attached polynucleotide. The polynucleotide includes a plurality of modules. Each module includes a nucleotide string, and the plurality of modules includes...
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WO/2018/222687A1 |
According to the present invention a method of determining a concentration of sulfate reducing bacteria (SRB) comprising is provided. The method comprises preparing a standard growth medium in a group of test vials, adding ferrous chlori...
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WO/2018/221779A1 |
The present invention relates to a composition for detecting a sexually transmitted infection (STI)-causing bacteria or virus, wherein the composition includes at least one type of detection probe selected from the group consisting of SE...
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WO/2018/218510A1 |
Provided in the present invention are a kit and method for labeling bacterial flora, fluorescence-labeled bacterial flora and an application thereof. The method comprises: using a first type of fluorescence probe and a second type of flu...
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WO/2018/219214A1 |
Disclosed is a PCR-HRM detection method for rapidly identifying a PRRSV vaccine strain, i.e. GDr180 strain, and other virulent strains. The method of the present invention is based on PCR in combination with HRM, comprising a first round...
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WO/2018/220249A2 |
The present invention shows that miR-185-5p exhibits higher levels of relative expression (2-ΔCt, where ΔCt= Ct miRNA of interest (miR-185-5p) -Ct endogenous miRNA) in asthma patients than in healthy individuals. Moreover, the levels o...
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WO/2018/222883A1 |
Molecular profiles of metastatic tumors can be more accurately determined using combination of DNA mutational profiles and RNA expression profiles of selected genes that show substantial changes upon anti-tumor treatment. Such combinator...
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WO/2018/222773A2 |
The measurement of Factor Xa (FXa) enzymatic activity using novel fluorogenic peptide substrates that have a C-terminus cleavable fluorophore and optionally the ability to attach to a solid support. Fluorogenic measurements increase sens...
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WO/2018/219342A1 |
Provided are an imprinted gene graded model and an application thereof, the model being used for detecting the benignity or malignancy of bladder tumours. The model grades the change of imprinted genes in a bladder tumour by means of cal...
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WO/2018/219581A1 |
The present invention relates to methods and systems for nucleic acid sequencing. In particular, the present invention relates to methods and systems for reducing the number of false-positives in nucleic acid sequencing. The method compr...
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WO/2018/221446A1 |
A method for measuring glycated hemoglobin in a hemoglobin-containing sample characterized in that an enzyme that catalyzes a reaction that oxidizes glycated amino acids or glycated peptides without oxidizing glycated hemoglobin to gener...
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WO/2018/219264A1 |
A long-chain non-coding RNA marker lncLOX5-1 for early diagnosis and prognosis of prostatic cancer and use thereof. Said lncLOX5-1 has the characteristics of high accuracy, high specificity, and high sensitivity, being able to be used fo...
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WO/2018/218332A1 |
In an aspect, there is provided, a method of capturing a population of T-Cell receptor and/or immunoglobulin sequences with variable regions within a patient sample, said method comprising: extracting/preparing DNA fragments from the pat...
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WO/2018/220385A1 |
The invention relates to methods of predicting resistance to Piscirickettsia salmonis infection in a salmonid, the method comprising determining in the salmonid the alleles present at one or more DNA polymorphism within a QTL, and predic...
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WO/2018/221479A1 |
The purpose of the present invention is to provide a fluorescent substrate for a transporter, the fluorescent substrate maintaining high transport performance while being unlikely to be quenched and exhibiting strong fluorescent intensit...
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WO/2018/220173A1 |
The present invention relates to the immobilisation of nucleic acids or other biomolecules on surfaces which are suitable amongst other purposes for biosensors. The invention provides a method and use of an azide-terminated CNM that may ...
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WO/2018/222830A1 |
In one aspect, the invention provides a method of detecting cerebral palsy in a subject. The method includes: determining a methylation state for each of a plurality of cytosine-guanine dinucleotide (CpG) sites in a sample obtained from ...
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WO/2018/222587A1 |
Provided are VHH or nanobodies that specifically bind to cystic fibrosis transmembrane conductance regulator (CFTR) inhibitory factor (Cif), and uses thereof for diagnosis and treatment of Pseudomonas infection.
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WO/2018/219998A1 |
The present invention relates to a method of diagnosing an individual as having/suffering from a systemic inflammatory response syndrome (SIRS) or not. Further, the present invention relates to a method of determining the severity of a s...
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WO/2018/223001A1 |
The present invention relates to methods for treating an open wound. The levels of certain cytokines in serum and wound effluent from a human subject with an open wound are compared to cytokine levels in persons whose wounds were closed ...
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WO/2018/222022A2 |
The present invention relates to a single nucleotide polymorphic marker composition for predicting response to an anti-TNF preparation, and a method using same to predict response to an anti-TNF preparation. With respect to IFX, the inve...
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WO/2018/222941A1 |
Methods for preparing concatenated nucleic acid molecules are provided. The methods herein include adaptors with complementary sequences for preparation of concatenated nucleic acid molecules, and methods of sequencing such nucleic acids.
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WO/2018/220198A1 |
The invention relates to a device and a method for detecting and imaging biocontaminating elements (BC), comprising a matrix (M) of detecting pixels having an active face (FA) on which a light (L) is incident, a mounting (S) transparent ...
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WO/2018/222800A2 |
The present disclosure provides methods, device, and system for a hybridization assay to detect nucleic acid targets. The assay may use a probe array format with addressable microwells. Each microwell may retain a plurality of copies of ...
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WO/2018/220835A1 |
This method for separating rare cells in a blood sample comprises: a step for filtering the blood sample by using a filter and capturing cells on the filter; and a step for bringing the cells captured on the filter into contact with a he...
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WO/2018/219567A1 |
The present invention concerns a process for the manufacture of marked cellulose acetate fibres, an apparatus for marking cellulose acetate fibres, a process for the detection of at least one information item on marked cellulose acetate ...
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WO/2018/223057A1 |
Provided includes methods and systems useful in array-based analysis of mixed nucleic acid populations, including for genotyping and copy number analysis of the various subpopulations of the mixed nucleic acid population. Also provided i...
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WO/2018/223093A1 |
Disclosed herein are compositions comprising a universal cancer vaccine and methods of treating and preventing cancer using such compositions.
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WO/2018/218646A1 |
A method for stepwise assembling nucleic acid origami units into a nucleic acid nanostructure, comprising the following steps: 1) preparing a first-step target nucleic acid origami unit group to a m-th-step target nucleic acid origami un...
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WO/2018/218344A1 |
A method for obtaining epithelial organoids is provided. In one embodiment, the method comprises culturing one or more epithelial ducts, epithelial duct fragments and/or epithelial stem cells isolated therefrom in contact with an extrace...
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WO/2018/223053A1 |
This disclosure provides methods and kits useful in analysis of mixed nucleic acid populations, including for multiplex genotyping of a mixed nucleic acid sample and for detecting differences in copy number of a target polynucleotide and...
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WO/2018/222548A1 |
The present disclosure provides a method for amplifying RNA using a combination of reverse transcription and multiple annealing and looping based amplification cycles. Primers are used such that the resulting amplicons include a first ce...
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WO/2018/222907A1 |
Methods of detecting actively growing host organisms, including bacterial organisms, involving the detection of ribonucleic acid (RNA) products produced by unmodified infectious bioagenis that infect the host organisms are provided. Rela...
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WO/2018/220185A1 |
The application discloses circRNAs as new biomarkers for the diagnosis of heart failure, the prediction of the clinical evolution of heart failure and/or prediction of the response to a treatment in a patient; methods for the prediction ...
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WO/2018/222061A1 |
Disclosed herein are methods and compositions for antimicrobial quantification and functional measurement. In one aspect, a method for quantifying antimicrobial comprises: obtaining a biological sample from a patient receiving an antimic...
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WO/2018/222461A1 |
Provided are compositions and methods for identifying a canine suffering from or at risk of suffering from skeletal dysplasia (SD) and/or intervertebral disc disease (IVDD) by detecting a retrogene insertion encoding canine fibroblast gr...
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WO/2018/222585A2 |
Methods for detecting nucleic acids, particularly small nucleic acids such as microRNAs, involving the use of a peptide nucleic acid (PNA) probe that lacks a base and a labelled modified base corresponding to the omitted base in the PNA ...
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WO/2018/221240A1 |
Provided is a QProbe by which costs for fluorescent labeling are lowered. When a nucleic acid probe labeled with a fluorochrome hybridizes to a target nucleic acid, the fluorochrome decreases fluorescent emission. The 5'-end region of sa...
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WO/2018/223055A1 |
This disclosure provides methods and systems useful in array-based analysis of mixed nucleic acid populations, including for multiplex genotyping of a mixed nucleic acid sample and for detecting differences in copy number of a target pol...
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WO/2018/222970A1 |
Herein disclosed are methods for treatment of cancer and methods for patient selection for administration of cancer treatment regimens comprising inhibitors of checkpoint kinase 1 (Chk1). In particular, disclosed herein are methods for i...
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WO/2018/218857A1 |
Provided are a MYH4 gene molecule marker for improved pork quality and use thereof in porcine genetic improvement. The molecule marker comprises at least one of: (I) a nucleotide Y at site 11031 from the 5' end of SEQ ID No. 1; (II) a nu...
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WO/2018/220108A1 |
The present invention relates to the identification of novel protein biomarkers for the detection and monitoring of sarcopenia in humans, in the absence of any underlying disease which could affect muscle mass or muscular strength. It is...
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WO/2018/223067A1 |
A composition is described comprising superparamagnetic particles. Optionally, the particles comprise microbeads. Optionally, the particles comprise nanobeads. Optionally, the particles are non-spherical particles. Optionally, the partic...
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WO/2018/222831A1 |
Described herein are methods for treating cancer. Aspects of the invention relate to administering to a subject a compound that targets a KDM4 or KDM5 family member, wherein the subject has at least one mutation in an epigenetic modifier...
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WO/2018/223146A1 |
Embodiments of a method and/or system for characterizing one or more sleep-related conditions can include determining a microorganism dataset associated with a set of subjects; and/or performing a characterization process associated with...
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WO/2018/221496A1 |
This method for separating rare cells in a blood sample comprises: a step for filtering the blood sample by using a filter and capturing cells on the filter; and a step for bringing the cells captured on the filter into contact with a he...
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WO/2018/219978A1 |
The present invention relates to assays for measuring meprin activity. More particularly, the assays concern rapid, sensitive, reliable and robust assays for measuring meprin activity comprising a coupled enzyme assay suitable for high-t...
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WO/2018/222144A1 |
The present disclosure provides a method for generating a predictive survival outcome of a subject affected of liver cancer. The method preferably comprises providing a tissue specimen of the subject, the tissue specimen being one of hep...
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