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WO/2018/162525A1 |
The present invention relates to the field of medicine and molecular diagnostics. In particular, it relates to a novel RNA next generation sequencing-based profiling assay allowing simultaneous detection of transcripts and alternative sp...
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WO/2018/165593A1 |
The present disclosure relates to methods for amplifying nucleic acids that avoid problems associated with primer-dimer formation. The present methods are referred to herein as dimer avoided multiplex polymerase chain reaction (dam-PCR)....
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WO/2018/162892A1 |
The present invention relates to methods or assays for detecting proteins or molecules of interest in a sample. Aptamers specific to the protein of interest are obtained and are then incubated with the sample. If the protein of interest ...
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WO/2018/162696A1 |
The invention relates to a method of evaluating thymic function in a subject comprising the detection of a genetic polymorphism in the T-cell receptor alpha-T cell receptor delta (TCRA-TCRD) locus associated with the level of T lymphocyt...
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WO/2018/161141A1 |
The present invention relates to methods for identifying and validating gene products from the Cryptococcus fungus as effective targets for therapeutic drug screening. The use of five genes identified in Cryptococcus, responsible for the...
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WO/2018/165621A1 |
Embodiments of the present invention relate to a combination of experimental and computational workflows that allow characterization of skin and subcutaneous tissue microbial flora and its associated metabolome, aiming to first evaluate ...
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WO/2018/161981A1 |
The method comprises: the reverse transcription of the template RNA; the amplification and high-throughput sequencing of the cDNAs obtained therefrom; the mapping of the sequenced cDNAs/reads to the reference genome using computer-assist...
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WO/2018/165459A1 |
Methods, compositions and kits are provided to amplify the amount of genomic methylated DNA can by subsequently analyzed and/or sequenced. It has particular use with small amounts of DNA, including, but not limited to cell free DNA sampl...
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WO/2018/164518A1 |
The present invention provides MEL-18, which is a biomarker for human epidermal growth factor receptor2 (HER2) positive cancer and anti-HER2 therapy and the use thereof. According to the present invention, MEL-18 is a prognostic factor a...
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WO/2018/161177A1 |
Described is an approach that takes advantage of rolling circle amplification (RCA) and an RNA-cleaving DNAzyme (RCD) to achieve massive signal amplification for biosensing via a cross-feedback mechanism. An RCA reaction generates copies...
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WO/2018/163051A1 |
The present invention provides compositions comprising a UBC antagonist and methods of use thereof for treating cancer in a patient. In some embodiments, the cancer patient may have a reduced expression level of a UBB gene product. Furth...
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WO/2018/165350A1 |
The embodiments herein provide methods to analyze the in vitro stability of recalcitrant or membrane-bound proteins in simulated gastric fluid (SGF) comprising the proteolytic enzyme, pepsin, and in combination with a novel pepsin-trypsi...
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WO/2018/165080A1 |
Described are methods for identifying antibiotic resistant bacteria, quantifying bacteria growth, and applying an antibiotic susceptibility test (AST) in one or more biological samples containing a bacteria and chips used in these methods.
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WO/2018/165099A1 |
Disclosed is a system for determining the nucleotide sequence of polynucleotides. The system can comprise a light source, such as a laser or a LED, configured to generate light at a predetermined wavelength. A detector of the system can ...
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WO/2018/165366A1 |
The present disclosure provides a method for making an amplified methylome by extending fragments and treating the extended fragments with a methyl transferase and source of methyl groups to transform hemi-methylated double stranded DNA ...
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WO/2018/162376A1 |
Herein is reported a method for selecting a variant of a parental antibody variable domain encoding nucleic acid, wherein the parental antibody variable domain amino acid sequence encoded by said encoding nucleic acid has at least one de...
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WO/2018/162623A1 |
The present invention relates to 3D cell cultures, which contain hepatic cells and are infected by a pathogen, methods for preparing such cell cultures and uses thereof.
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WO/2018/162931A1 |
The present invention provides a method for determining whether a patient will respond to treatment with a myostatin pathway inhibitor, the method comprising : (a) determining a level of myostatin and/or activin type II receptor (ActRII)...
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WO/2018/163610A1 |
In the present invention, RNA quality is evaluated on the basis of a feature value corresponding to the position of a degradation product peak P3 that appears in conjunction with degradation of RNA in a region on a low-molecular-weight s...
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WO/2018/165600A1 |
The present invention relates to methods, systems and kits for the diagnosis, prognosis and the determination of progression of cancer in a subject. The invention also provides biomarkers that define subgroups of prostate cancer, clinica...
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WO/2018/165532A1 |
Dysregulated expression of microRNAs (miRNAs) has emerged as a hallmark feature in human cancers. Aspects of the disclosure relate to methods for selecting optimal therapy for a patient from several alternative treatment options. A major...
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WO/2018/161140A1 |
The present invention relates to the use of nucleic acid amplification technology through two-stage (duplicate) polymerase chain reactions with multiple markers, also known as multiplex nested PCR, using general consensus oligonucleotide...
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WO/2018/165475A1 |
Compositions and methods for identifying antigen-specific T cells, including determining paired T cell receptor sequences for a specific antigen, are described. Compositions and methods for identifying neoantigen-specific T cells are als...
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WO/2018/164385A1 |
Provided in the present invention are a diagnostic composition for differentiating dry eye from dry eye caused by Sjögren's syndrome by using ATG5 and LC3B-II as biomarkers, a diagnostic method, and a screening method thereof. It is asc...
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WO/2018/165566A1 |
Apparatus for target molecule detection includes a sample cell configured to receive a sample, reference, counter, and first and second working electrodes in communication with the sample cell, first and second working electrodes, and a ...
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WO/2018/165207A1 |
The present disclosure provides improved nucleic acid sequencing-by-synthesis (SBS) methods, related kits and reagents, and systems for performing such methods using such kits and reagents.
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WO/2018/164133A1 |
Provided is a novel simplified and easy cell separation method. Also provided are: a cell sorting method, comprising (a) performing a treatment for increasing the difference in cell membrane fluidity between a target cell and a non-targe...
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WO/2018/163800A1 |
The present invention provides a method for screening for a flavor material having a marine note. The screening method according to the present invention is a method for screening for a candidate compound having a marine note among from ...
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WO/2018/165309A1 |
Provided herein is technology relating to the detection of analytes and particularly, but not exclusively, to methods, systems, compositions, and kits for detecting analytes such as nucleic acids, proteins, small molecules, and other mol...
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WO/2018/164577A1 |
The invention relates to method for detecting HPV-induced high-grade precancerous lesions, HPV-induced invasive cancers and nonHPV-induced gynaecological and anogenital cancers, said method comprising detection of a methylation classifie...
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WO/2018/161245A1 |
Disclosed are a method and device for detecting chromosomal variations, wherein the device comprises a sequencing unit of the sample to be detected, for sequencing the sample to be detected containing nucleic acids and obtaining the sequ...
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WO/2018/164748A1 |
The present application describes structures, systems, and methods for modeling and analysis of single-strand break (SSB) signaling and repair in a cell-free system. Also provided are methods of making the SSB structures and SSB signalin...
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WO/2018/162404A1 |
The present invention relates to a method for predicting the survival time of a patient suffering from acute myeloid leukemia (AML). The inventors have reported that NK cells in AML patients display marked differences in NK maturation co...
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WO/2018/165440A1 |
Provided herein are devices, systems, and methods for specimen preparation by employing a combination of capillary and centrifugal forces, along with the addition of reagents at specified steps, followed by on-device sample analysis. For...
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WO/2018/164174A1 |
An epithelial tissue stem cell derived from an adult, said epithelial tissue stem cell lacking at least one cancer suppressor gene.
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WO/2018/165574A1 |
Methods of detecting altered HDL functionality as well as adjusting HDL functionality are described.
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WO/2018/165528A1 |
The present disclosure relates to compositions and methods for treating cancers using antisense (AS) nucleic acids directed against Insulin-like Growth Factor 1 Receptor (IGF-IR). The AS may be administered to the patients systemically, ...
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WO/2018/165625A1 |
The invention relates to apparatus and methods for apparatus for detecting presence or monitoring profession of a disease in a biological subject, comprising a chamber in which the biological subject passes through, and at least one dete...
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WO/2018/164113A1 |
A model closely resembling human high myopia can be constructed by fitting a juvenile mouse with a minus lens capable of angle and width adjustment in correspondence to the growth of the mouse, and with a protector. Analysis with this mo...
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WO/2018/165034A1 |
The present invention relates to methods for treating cancer through combination therapy with a TRP channel antagonist and standard-of-care cancer agents.
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WO/2018/162622A1 |
The present disclosure pertains to the identification of novel biomarkers for the characterization of melanocytic lesions as can be found in skin diseases such as melanomas and psoriasis. In particular, the present invention is directed ...
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WO/2018/162439A1 |
The present invention relates to a biomarker which is predictive of the sensitivity to a treatment of cancer with a Dbait molecule.
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WO/2018/161333A1 |
Disclosed in the present invention is a rapid and efficient method for screening microcystin degrading bacteria, comprising primer pair design, polymerase chain reaction (PCR) amplification, and product detection: designing a primer pair...
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WO/2018/164290A1 |
The present invention relates to an HAPLN1 protein of an aged individual. The HAPLN1 protein has reduced expression during aging and has an excellent effect of alleviating and reversing skin aging including wrinkles when administered. Th...
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WO/2018/164262A1 |
The present invention relates to a method in which a lesion collected from a human is implanted in a laboratory animal, and one or more pieces of data including the expression status of a specific biomarker in the lesion are obtained and...
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WO/2018/162538A1 |
The present invention is a method and compositions for primer extension target enrichment of nucleic acids and improvements thereto including simultaneously enriching for RNA and DNA and optionally sequencing the enriched products.
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WO/2018/162516A1 |
The present invention relates to the identification of a novel allele of the RHD gene associated with a weak D phenotype and the kits and methods for detecting this allele.
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WO/2018/159817A1 |
Provided is a low body weight-inducing agent which comprises a compound capable of inhibiting the expression of the function of GPRC5C gene or GPRC5C protein.
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WO/2018/160574A1 |
A microfluidic device includes an inlet port configured to receive a sample, a first reaction chamber fluidically coupled to the inlet port, a first pump fluidically coupled to the inlet port, a second pump fluidically coupled to a mixin...
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WO/2018/159810A1 |
Provided is a fluorescent probe for detecting alkaline phosphatase. The fluorescent probe is suitable for measurements that require high sensitivity and quantitativity. A fluorescent probe for detecting alkaline phosphatase, the fluoresc...
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