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WO/2019/075219A1 |
The present disclosure relates to a Proteomics-to-Genomics approach allows for in silico validation of biomarkers and drug targets. Biomarkers having high prognostic value in predicting cancer patient populations that may benefit from mi...
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WO/2019/075383A1 |
Methods of detecting unknown genetic modifications in a DNA sample from an organism are disclosed.
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WO/2019/071474A1 |
The present invention relates to the field of nucleotide sequencing. Specifically, the invention relates to a modified nucleoside or nucleotide, wherein the 3'-OH of said modified nucleoside or said nucleotide is reversibly blocked, and ...
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WO/2019/074342A1 |
The present invention relates to a method for selecting highly efficient stem cells, using protein marker GRP78 and, more particularly, to a method in which old stem cells having a reduced expression of GRP78 are removed while only stem ...
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WO/2019/074642A1 |
This invention relates to a biological indicator, comprising: a carrier; and a spore deposit on the carrier, wherein from about 70% to about 95% of the area of the spore deposit comprises spores residing in a single spore layer, and the ...
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WO/2019/071450A1 |
Described herein is an integrated automated nucleic acid sample preparation, detection and analysis system, along with methods of operating such a system. Also described are methods of methods of analyzing nucleic acid molecules in a sam...
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WO/2019/074963A1 |
Embodiments of a method and/or system (e.g., for microsatellite instability detection associated with at least one cancer condition; etc.) can include: determining a microsatellite-related background model; determining one or more loci a...
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WO/2019/075460A1 |
Provided are processes for the use of a single dried blood sample for the preparation of test samples including targets of differing structures. The processes allow the same dried blood sample to be used for preparation of a first test s...
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WO/2019/073902A1 |
The present invention addresses the problem of providing a method which enables the noninvasive detection and isolation of droplets in which microorganisms have proliferated. The present invention relates to a detection method for detect...
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WO/2019/074960A1 |
Embodiments of a method and/or system (e.g., for improved single molecule sequencing, etc.) can include preparing a set of unique molecular identifier (UMI)-based molecules associated with a set of target nucleic acid sequences; facilita...
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WO/2019/071902A1 |
Provided is a use of miR-21 in the prepartion of therapeutic drugs or diagnostic reagents for intrauterine adhesion and/or thin endometrium.
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WO/2019/071471A1 |
The present invention provides a method for improving the loading of a nucleic acid on a solid support by contacting the solid support with a poloxamer-containing reagent. The present invention also provides a method for improving the st...
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WO/2019/055968A3 |
This invention relates to methods and compositions for improving plant health. The present invention includes methods for making an enriched library of treatments capable of improving plant health, methods for an making an enriched libra...
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WO/2019/075091A1 |
This invention relates to imaging, such as by expansion microscopy, labelling, and analyzing biological samples, such as cells and tissues, as well as reagents and kits for doing so.
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WO/2019/075157A1 |
Disclosed herein are protein translation switches and conditional gene expression systems that are compatible with retroviral and lentiviral gene delivery. The linking of a protein translation switch to a 3' gene of interest suppresses t...
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WO/2019/075100A1 |
In various embodiments, amplification-free DNA information methods, apparatus and systems are disclosed. A method of amplification-free information storage and retrieval comprises encoding digital data such as binary into nucleotide sequ...
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WO/2019/073951A1 |
Provided is a method for preparing hepatocytes or cells that can be differentiated into hepatocytes from pluripotent stem cells for the purpose of preparing mature hepatocytes that are similar in many respects to primary cultured hepatoc...
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WO/2019/074521A1 |
A method of sequencing multiple nucleic acid sequences, including: estimating a concentration of cells in a solution; and depositing a volume of the solution into a well on a well plate using an ejection device, the amount of solution se...
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WO/2019/071407A1 |
Provided by the present invention are a single nucleotide polymorphism (SNP) chip for the whole chicken genome and an application thereof, wherein there are 50,000 SNP loci on the chip: 19,600 SNP loci, for which minor allele frequency (...
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WO/2019/075306A1 |
The present disclosure relates to proteins comprising a target-binding domain for detection of a target of interest, methods, compositions and kits thereof.
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WO/2019/075426A1 |
Methods for assessing microbiota are disclosed. An example method for assessing microbiota may include obtaining a fecal sample from a patient, quantifying the relative abundance of bacteria from a selected group of taxonomic classes in ...
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WO/2019/075264A1 |
Provided herein is an antibiotic susceptibility test and related compositions, methods and systems based on detection of a nucleic acid from a target microorganism in a sample in the presence or absence of a lysis treatment of the sample.
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WO/2018/226193A3 |
The present invention is related to a method for providing sample preparation, nucleic acid extraction and diagnosis of cancer and infectious diseases from nucleic acids in samples like blood, tissue, saliva, urine by means of diagnosis ...
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WO/2019/074615A2 |
Methods for identifying age-preventing agents for skin is disclosed. Skin samples are transferred to a first vessel, a second vessel, and a third vessel. A skin age inducing agent is applied to the skin samples in the first vessel and th...
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WO/2019/073666A1 |
A determination device which comprises: a measurement unit for measuring the optical spectrum of an unknown biological sample; and a determination unit for determining a cancer tissue involved in the biological sample from input data bas...
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WO/2019/073965A1 |
The present disclosure provides a technique for producing regulatory T cells specific to a desired antigen. Regulatory T cells specific to an antigen are produced by a method that includes: a step for identifying a T cell receptor (TCR) ...
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WO/2019/038706A3 |
The disclosure provides a paper-based nucleic acid detecting device and measurement method. This device comprises paper layer set with pattern. This paper layer comprises a sample loading zone and a test zone. Herein, the pattern on pape...
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WO/2019/075181A1 |
The disclosure provides methods of identifying a human subject as a candidate for treating or inhibiting a liver disease by inhibiting HSD17B13. The disclosure also provides methods of treating a subject who is PNPLA3 Ile148Met+ by admin...
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WO/2019/074216A1 |
The present invention relates to a method for diagnosing Alzheimer dementia via bacterial metagenomic analysis and, more particularly, to methods for diagnosing Alzheimer dementia and mild cognitive impairment by performing bacterial met...
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WO/2019/075209A1 |
The present disclosure relates to a Proteomics-to-Genomics approach allows for in silico validation of biomarkers and drug targets. Biomarkers having high prognostic value in predicting cancer patient populations that may benefit from mi...
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WO/2019/074089A1 |
The present invention provides a rebaudioside M-rich-type nontransgenic stevia plant body which contains rebaudioside M in a larger amount compared with a wild-type stevia species. The present invention also provides: a method for produc...
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WO/2019/073049A1 |
The present invention relates to an amplification technology for multiple, rapid, sensitive, specific detection of nucleic acids in samples originating from the environment, water, food, animals, plants, microorganisms, cell cultures, or...
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WO/2019/060918A8 |
Aspects of the disclosure relate to methods and compositions (e.g., kits) for detecting repeat-associated non-ATG (RAN) proteins in a subject (e.g., a subject having or suspected of having a disease associated with RAN protein translatio...
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WO/2019/075365A1 |
Probe embodiments for targeting, identifying, and isolating enzymes exhibiting BSH activity as well as devices and kits that use the probes are described herein. Methods of making and using the probes, devices, and kits are also describe...
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WO/2019/075452A1 |
Provided herein are methods of identifying bacteria as a likely cancer therapeutic wherein candidate bacteria is cultured with immune cells capable of expressing IP-10 (as well as IL-10 and GM-CSF), pharmaceutical compositions comprising...
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WO/2019/074091A1 |
Provided is a primer pair of primers for methicillin-resistant gene detection for the purpose of achieving highly sensitive methicillin-resistant gene detection. Said primer pair comprises a combination of SEQ ID NO:3 and SEQ ID NO:7, a ...
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WO/2019/074972A1 |
A genomic data processing system can be configured to process next-generation sequencing information. In one embodiment, the genomic data processing system can determine forward and reverse primers from sequence reads provided by a next-...
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WO/2019/073018A1 |
The present invention relates to methods for identifying improved stereodefined phosphorothioate oligonucleotide variants of antisense oligonucleotides utilising sub-libraries of partially stereodefined oligonucleotides. The methods allo...
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WO/2019/071322A1 |
Methods and systems for assessing the risk of a human female subject for developing breast cancer. In particular, the present disclosure relates to combining a first clinical risk assessment, a second clinical assessment based at least o...
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WO/2019/017680A3 |
The present invention relates to a method for providing information on the diagnosis of Parkinson's disease. Also, the present invention relates to a composition for preventing, alleviating, or treating Parkinson's disease. The miRNA of ...
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WO/2019/075211A1 |
An oligonucleotide is prepared by the controlled, iterative addition of nucleotides to seed molecules at a functionalized electrode on a digital microfluidic device (DMF). Droplets containing a payload such as specific nucleotides and/or...
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WO/2019/074187A1 |
The present invention relates to a cancer DNA analysis method, wherein the onset of cancer can be quickly and accurately detected by analyzing a spectrum obtained by irradiating a sample including DNA with terahertz waves after applying ...
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WO/2019/073025A1 |
The present invention relates to a method of determining the concentration of intact microorganisms in a sample comprising optionally diluting an aliquot of the sample to provide a diluted aliquot at a dilution value; contacting at least...
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WO/2019/075226A1 |
The present disclosure relates to a Proteomics-to-Genomics approach allows for in silico validation of biomarkers and drug targets. Biomarkers having high prognostic value in predicting cancer patient populations that may benefit from mi...
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WO/2019/074445A1 |
The present invention provides a method for predicting the treatment response of a human gastroesophageal cancer patient, the method comprising: a) measuring the gene expression of at least 3 of the following genes: CDH1, CDK6, COX2, ELO...
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WO/2019/075233A1 |
Methods of identifying and diagnosing common uveitis associated pathogens in a sample, preferably using high resolution melting analysis, and kits for doing the same, including assays, e.g., multiplex real time PCR assays coupled with hi...
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WO/2019/075197A1 |
Methodologies to detect off-target mutations induced by the deaminase activity of Base Editing technology.
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WO/2019/075468A1 |
The disclosure provides a method for treating a subject afflicted with a tumor derived from a small cell lung cancer (SCLC) having a high tumor mutational burden (TMB) status comprising administering to the subject a monotherapy comprisi...
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WO/2019/048927A3 |
Provided herein, in some embodiments, are methods and compositions for detecting differentially expressed genes in a sample obtained from a subject having or at risk for preeclampsia.
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WO/2018/053365A8 |
Aspects of the technology disclosed herein relate to methods of preparing and analyzing nucleic acids, e.g, cfDNA. In some embodiments, methods for preparing nucleic acids for sequence analysis (e.g., using next-generation sequencing) ar...
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