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WO/2021/002984A1 |
The present disclosure relates to a device, comprising a base and a plurality of microneedles attached to the base, wherein each microneedle has an outer surface; the outer surface of at least one microneedle being coated with a composit...
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WO/2021/002030A1 |
A purpose of the invention is to develop and provide a detection reagent for easily determining the serotype of a dengue virus at high sensitivity. Provided is a dengue virus detection reagent that includes a primer set configured to p...
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WO/2021/003114A2 |
A kit and method for analyzing nucleic acid molecules encoding T cell receptor (TCR) a and β from individual T cells are disclosed. In particular, a method for analyzing individual T cells using high-throughput multiplex amplification a...
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WO/2020/247685A3 |
The present invention provides methods to barcode nucleic acid for detection and sequencing. It applies a barcode template in a compartment with various targets, including nucleic acid fragments, nuclei and/or cells. After clonal amplifi...
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WO/2021/003331A1 |
Methods for use in multiplex amplification and or detection of Trichomonas vaginalis. The multiphase amplification provides fast, quantitative, sensitive detection with lower variability at low analyte concentrations. Described are detec...
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WO/2020/176801A9 |
The described invention provides compositions and methods for wound healing in a subject. The methods include administering a therapeutic amount of a pharmaceutical composition comprising extracellular vesicles from amniotic fluid and a ...
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WO/2021/003197A1 |
Disclosed herein are systems and methods for identifying biomarkers. Biomarker identification can be achieved while increasing efficiency and decreasing data and computation complexity but maintaining accuracy. Such biomarker identificat...
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WO/2021/001834A1 |
A method of selecting a ruminating animal having a desirable, hereditable trait is disclosed. The method comprises analyzing in the microbiome of the animal for an amount of a hereditable microorganism which is associated with the heredi...
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WO/2021/003222A1 |
Disclosed herein are microfluidic devices that may be used to mimic human organ systems, in particular, pancreatic function, and methods of using same. In particular, disclosed are microfluidic devices that may include a first chamber ha...
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WO/2021/002735A1 |
The present invention relates to Leukocyte-associated immunoglobulin-like receptor 1 (Lair-1) protein, which is a cell surface antigen present specifically on activated regulatory T cells and various uses thereof.
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WO/2021/002371A1 |
Provided is a glycosylated protein assay reagent containing at least Trinder reagent, 4-Aminoantipyrine, a protease, a protease stabilizer, and a ferrocyanide, wherein at least the Trinder reagent is included in a Trinder reagent-contain...
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WO/2021/002311A1 |
In order to provide a biological sample analysis device whereby A biological sample analysis device (100) whereby a container in which a sample is accommodated can be prevented from becoming charged, and it is possible to accurately meas...
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WO/2021/000893A1 |
Provided are methods for determining an endometrial status using a sample, for example, an endometrial biopsy, from a woman, comprising: (a) performing an assay on the endometrial sample from the woman to determine a microRNA (miRNA) exp...
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WO/2020/225286A9 |
The invention relates to a method for extracting a target nucleic acid (22) from a sample liquid (500). The method comprises providing a heating device having a heating element (10) in contact with the sample liquid (500), wherein the he...
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WO/2021/003255A1 |
Provided herein are methods and systems for detection of nucleic acids for single cell samples. As part of the detection, a unique step of normalization of different single cell samples is included. One embodiment of the method includes ...
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WO/2021/003176A1 |
Disclosed herein are methods of treating and identifying subjects with cancer that will respond to chemotherapy treatment. Methods can be used to treat or identify subjects with lung or colorectal cancer that will respond positively (or ...
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WO/2021/000889A1 |
Provided is a chemical tagging-based method for modified nucleoside sequencing, enrichment, and measurement, comprising reacting a thiol compound with an N-hydroxymethyl chemically modified nucleoside, then using a chemical tag such as b...
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WO/2020/242988A3 |
Provided herein are affinity agents comprising ligands that specifically bind adeno-associated virus. The affinity agents are useful for binding, isolation, and/or purification of adeno-associated virus. Further disclosed are amino acid ...
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WO/2021/002941A1 |
A system and method for automated cell lysis and purification processing including a tray having a series of open fluid wells. A first well is a process well for cell processing and additional wells are for buffer storage. A sonication c...
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WO/2021/003456A1 |
The present disclosure provides non-parenteral compositions comprising a recombinant Spirulina comprising at least one exogenous therapeutic. Compositions of the present disclosure can be used as vaccines and/or therapeutic drugs. The pr...
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WO/2021/000380A1 |
The present disclosure relates to the technical field of nucleic acid medicines, in particular to a modified nucleoside, a nucleotide and a modified nucleic acid polymer, as well as a preparation method therefor and an application thereo...
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WO/2021/003192A1 |
The present disclosure provides methods for the treatment of a subject having BRAF-mutated cancer cells comprising administering an effective amount of an elF4E inhibitor, which may be optionally used in combination with other therapies,...
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WO/2021/000667A1 |
Disclosed is the use of a quantitative detection reagent of an Rbm46 mRNA or protein in preparing a reagent or kit for the diagnosis and/or prognosis evaluation of triple-negative breast cancer.
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WO/2021/000043A1 |
A system and method for detecting interactions between a first protein or fragment thereof (bait protein) and a second protein or fragment thereof (prey protein) comprising: (a) a bait construct comprising the bait protein, a first epito...
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WO/2021/001539A1 |
The present invention relates to the diagnostic of eosinophilic fasciitis. In this study, the inventors have highlighted an important pathway through one protein (cadherin 13) and its ligand (adiponectin). Their work, through two differe...
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WO/2021/002306A1 |
In an embodiment of the present invention, the present invention addresses the problem of providing a method for determining whether a target gene is a cancer gene. In an embodiment of the present invention, the present invention relat...
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WO/2021/003482A1 |
This document relates to methods and materials involved in identifying and/or treating mammals having a CMV infection. For example, methods and materials for assessing a mammal having a CMV infection (e.g., a CMV seronegative human who r...
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WO/2021/002476A1 |
A method for detecting a target nucleic acid fragment in a sample, said method comprising a step in which the sample is contacted with a gRNA, a Cas protein and a substrate nucleic acid fragment (wherein: the Cas protein expresses nuclea...
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WO/2021/000673A1 |
Disclosed by the present application is an application of Rbm46 as a testicular tumor marker. Disclosed is an application of a quantitative detection agent for Rbm46 mRNA or protein in the preparation of a reagent or kit used for the dia...
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WO/2021/000714A1 |
A non-contact cell flux-weakening determination method, comprising: placing cells in a non-magnetic environment and giving an external stimulus to the cells; and using a magnetic sensor to detect the weak magnetic field of the cells subj...
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WO/2021/001469A1 |
The invention relates to new cancer treatment strategies based on the inhibition of acid lipase. In addition, the invention relates to methods for discovering new active substances suitable for cancer therapy.
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WO/2021/003246A1 |
The present disclosure relates generally to methods and compositions for cancer immunotherapy, and more specifically, liquid markers for predicting effectiveness of cancer therapies. The disclosure features compositions and methods that ...
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WO/2021/003330A1 |
Provided herein are method of treating cancer using agents that inhibit the interaction between Methyltransferase like 3 (METTL3) and Eukaryotic Translation Initiation Factor 3 Subunit H (EIF3h), and optionally agents that inhibit Bromod...
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WO/2021/003195A1 |
The present invention provides methods of generating a recombinant AAV vector with reduced immunogenicity, comprising: providing eukaryotic cells with a nucleic acid comprising a sequence of interest that is flanked by AAV inverted termi...
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WO/2020/259847A1 |
The invention relates to managing and processing of digitalized copy of human genome, which falls into the field of bioinformatics. The subject-matter of the invention is a set of mutually related computer implemented methods focused on ...
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WO/2020/264313A1 |
Provided herein are aqueous compositions, kits and methods for the stabilization of cell-free nucleic acids. Provided herein are aqueous compositions for the stabilization of a cell-free nucleic acid (cfNA) population in a blood sample. ...
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WO/2020/264388A1 |
A modular microfluidic device for simulating in vivo conditions of a biological system may include a first perfusion chamber having an inlet and an outlet, a second perfusion chamber having an inlet and an outlet, a well configured to ho...
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WO/2020/262704A1 |
The present invention provides a method in which the susceptibility of a subject to the onset of normal-pressure hydrocephalus is tested by detecting the presence or absence of decreased-function mutations in the CFAP43 gene in DNA in a ...
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WO/2020/261569A1 |
The purpose of the present invention is to provide: a method which is for assessing the differentiation state of cells and by which the differentiation state of a wide variety of cells can be assessed; and gelatin nanoparticles which can...
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WO/2020/259210A1 |
Disclosed is a method for quickly detecting African swine fever virus, in particular a nucleic acid detection method based on a gene editing system, and specifically, a rapid detection method for viral nucleic acid based on CRISPR-Cas12a...
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WO/2020/264239A1 |
The invention relates to methods for diagnosing or assessing the risk of developing chronic lung and bowel disease in pre-term infants by measuring the nitrate reductase activity in oral microbiome samples from the infant. The invention ...
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WO/2020/261455A1 |
An embodiment of the present invention is a method for evaluating a cell function of test cells which are stem cells, the method comprising: an image acquisition step (S1, S2) for acquiring a cell image obtained by capturing an image of ...
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WO/2020/258531A1 |
Provided is a detection primer, kit and quantitative measurement method for a cable bacteria, Candidatus Electronema.
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WO/2020/262551A1 |
An embodiment of the present invention is a method for evaluating a cell function of a target cell that is a stem cell, the method comprising: an image acquisition step (S1, S2) for acquiring a photographed cell image of a target cell; a...
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WO/2020/260697A1 |
The invention concerns a method and a new in vitro cell culture system, wherein the cells, preferably isolated from the human central or peripheral nervous system but also from any other human tissue, are incubated on a new conception ph...
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WO/2020/264341A1 |
Provided herein are, inter alia, methods and kits for diagnosing post-treatment Lyme disease syndrome (PTLDS) or Lyme disease in a subject.
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WO/2020/262983A1 |
The present invention relates to a pharmaceutical composition comprising an inhibitor against the expression or activation of novel ADP-ribosyl cyclase or a naturally occurring mutant thereof as an active ingredient for preventing or tre...
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WO/2020/262429A1 |
Provided is a cancer biomarker that comprises placental leucine aminopeptidase in urine. Also provided is a method for judging the onset of ovarian cancer, said method comprising a step for measuring the amount of placental leucine amino...
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WO/2020/259722A1 |
Provided is a preparation method for a DNA library, comprising a pre-library preparation process, the pre-library preparation process comprising DNA preparation, end repair and 3' A-tailing, linker connection using an anti-contamination ...
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WO/2020/259455A1 |
Provided in the present invention is a method for constructing a PacBio sequencing library, comprising the following steps: (1) obtaining a target double-stranded DNA; (2) adding a thermostable RNA ligase to respectively connect two ends...
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