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WO/2019/028529A1 |
The present invention relates to an array of nucleic acid for verifying, validating or calibrating PCR or a PCR instrument, comprising a substrate comprising a plurality of reference zones, each reference zone comprising a reference nucl...
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WO/2019/028556A1 |
Methods for detecting and analyzing low abundance and fragmented nucleic acids are provided, for example for amplifying and analyzing cancer cell DNA having a known pattern of DNA methylation. The example method includes a linear amplifi...
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WO/2019/029807A1 |
The present invention relates to a method of identifying a predisposition for inherited cancer in individuals, in particular, in individuals of the Middle Eastern Population. The invention also relates to kits that can be used in such me...
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WO/2019/023776A1 |
The present invention relates to a method for characterizing bioactive (or active or dynamic or biological) hydration by means of the use of techniques for utilizing gene and protein expression which makes it possible to identify new ing...
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WO/2019/026903A1 |
The present invention provides a method for evaluating the tumorigenicity of test cells, the method including transplanting the cells into the anterior chamber of an experimental animal and observing the presence/absence of tumor formati...
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WO/2019/025815A1 |
The invention provides compositions and systems that allow the sensitive determination of the level of creatinine in a particular solution. Through the optimisation of enzymatic methods to detect creatinine the real-time determination of...
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WO/2019/023751A1 |
The present invention relates to medicinal cannabis plants, and cannabis plant-derived products. In particular, the present invention relates to medicinal cannabis plants having a desired cannabinoid content, methods of selecting cannabi...
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WO/2019/024707A1 |
Metal nanoparticles are directly synthesized on polymers comprising a plurality of thiol groups to form compositions useful as electron microscopy tags.
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WO/2019/026924A1 |
Provided are a new powdery mildew resistance marker of Cucurbita maxima, powdery-mildew-resistant Cucurbita maxima, and a method for producing powdery-mildew-resistant Cucurbita maxima in which the same is used. This powdery mildew resis...
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WO/2019/027869A1 |
Provided herein are genetic circuits and encoded RNA transcripts that produce an output molecule in response to an RNA cleavage event that removes a degradation signal. In some embodiments, the genetic circuits described herein may be us...
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WO/2019/026075A1 |
Methods and kits for detecting the presence of at least one target DNA sequence without a modification in a DNA molecule are provided.
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WO/2019/028272A1 |
Disclosed herein are compositions and methods for stabilizing a benzothiazole luciferin analog such as D-luciferin and 6-amino-D-luciferin. The compositions may include the benzothiazole luciferin analog, a thionucleobase compound of for...
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WO/2019/027877A1 |
Microorganisms are prolific producers of natural products, a group of molecules that make up the majority of drugs approved by the FDA in the past 35 years. After decades of mining, the low-hanging fruit has been picked and so discovery ...
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WO/2019/024404A1 |
The present invention provides a genetic marker for detecting pancreatic cancer, a kit, and a pancreatic cancer detection method The genetic marker comprises one or more of the following genes: maltase, C-type exogenous lectin family 4 m...
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WO/2019/026359A1 |
Provided are a biological sample analysis device and a biological sample analysis method, both of which are free of the problem that the accuracy of the decoding of a nucleotide sequence is decreased by environmental vibrations. The biol...
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WO/2019/024524A1 |
A gene sequencing chip and a sequencing method thereof, and a gene sequencing device. The gene sequencing chip comprises: a first substrate (110) having a first surface (101); at least one recessed part (120) which is recessed in the fir...
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WO/2019/024534A1 |
Disclosed are a rice ALS mutant protein for conferring herbicide resistance to plants, and a nucleic acid encoding the protein. The protein is derived from a rice mutant plant resistant to an ALS inhibitor herbicide, and compared to the ...
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WO/2019/026082A1 |
A recombinant protein, including: (a) alpha subunit of an FAD-GDH; and (b) a minimal cytochrome c peptide is provided. Additionally, an electrode coupled to a recombinant protein, the recombinant protein made of: (a) a cofactor of a redo...
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WO/2019/027407A1 |
Compositions and methods for detecting food-based allergens on a surface are disclosed. A composition can include ninhydrin and a protease enzyme. The protease enzyme can be a cysteine protease enzyme, an aspartic protease enzyme, or com...
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WO/2019/028047A1 |
Implementations of a method for seeding sequence libraries on a surface of a sequencing flow cell that allow for spatial segregation of the libraries on the surface are provided. The spatial segregation can be used to index sequence read...
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WO/2019/028462A1 |
Embodiments of a method and/or system for facilitating characterization of one or more conditions can include: generating a set of target-associated molecules; generating a reference-associated set of molecule; facilitating generation of...
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WO/2019/028361A1 |
Methods and materials are provided for detecting nucleic acid sequence differences including single nucleotide mutations or polymorphisms, one or more nucleotide insertions, and one or more nucleotide deletions in single molecule target ...
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WO/2019/025004A1 |
The invention relates generally to the field of non-invasive prenatal screening and diagnostics. The invention provides reliable method that is applicable to the practice of non-invasive prenatal screening for sex chromosomes aneuploidie...
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WO/2019/026517A1 |
The objective of the present invention is to provide a versatile method that makes highly sensitive detection of nucleic acid, and the like, possible even if a solution has a high salt concentration. This objective has been achieved thro...
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WO/2019/027728A1 |
Compositions comprising synthetic two-part aptamer-containing guide RNAs and methods of using said synthetic two-part aptamer-containing guide RNAs with CRISPR/Cas activator systems.
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WO/2019/027879A1 |
Composition(s), device(s), kit(s), and method(s) for an improved analyte detection sensor(s) comprising at least one scavenger protein and method(s) of preserving the functioning and functional life of the improved analyte detection sens...
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WO/2019/025607A1 |
The present invention relates to a method for predicting or diagnosing a cardiovascular disease or a metabolic disease associated with cardiovascular disease by determining the capacity of high- density lipoprotein (HDL) to acquire surfa...
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WO/2019/024341A1 |
A method for constructing a library of cell-free DNAs in body fluids, comprising directly acting a transposase or an endonuclease on a body fluid sample, fragmenting the cell-free DNAs within, and performing amplification to obtain a lib...
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WO/2019/024579A1 |
The present invention provides a gene marker for detecting a lung cancer, a kit, and a lung cancer detection method. According to the present invention, the content of 5-hydroxymethylcytosine in one or more genes of RUNX1 transposition p...
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WO/2019/023917A1 |
A biomarker, the use of the biomarker in predicting the risk of atherosclerotic cardiovascular disease or related disorder thereof, and a method of predicting the risk of atherosclerotic cardiovascular disease or related disorder thereof.
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WO/2019/024578A1 |
The present invention provides a gene marker for detecting benign and malignant liver tumors, a kit, and a detection method. According to the present invention, the content of 5-hydroxymethylcytosine in one or more marker genes of FAT at...
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WO/2019/023951A1 |
Provided is a method for sequencing a nucleic acid by using an immersion reaction scheme. The immersion reaction scheme comprises sequentially immersing a solid support with nucleic acid molecule immobilized thereon in different reaction...
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WO/2019/028430A1 |
A method for optical super-multiplexing using polyynes to provide enhanced images from stimulated Raman microscopy is disclosed. In some exemplary embodiments, the polyynes are organelle-targeted or spectral barcoded. Imaging can be enha...
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WO/2019/027987A2 |
The present disclosure relates to compositions and methods for treating cancers. In particular, the present disclosure provides materials and methods for identifying mis-splicing-associated surface antigens (MASAs) generated by altered s...
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WO/2019/026884A1 |
Provided is a method for rapidly detecting a nucleic acid. This nucleic acid detection method involves detecting a nucleic acid of interest from a fluid containing a nucleic acid of interest, wherein: the method is provided with a detect...
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WO/2019/028285A2 |
Methods, systems, and kits for the diagnosis, prognosis and the determination of cancer progression of prostate cancer in a subject are disclosed. In particular, the disclosure relates to the use of immune cell-specific gene expression i...
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WO/2019/027005A1 |
Provided is a method for evaluating an onset risk of tuberculosis on the basis of genetic information of a subject, said subject being infected with Mycobacterium tuberculosis, specifically to each genetic lineage of M. tuberculosis. The...
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WO/2019/028273A1 |
The present invention provides polynucleotide vectors for high expression of heterologous genes. Some vectors further comprise novel elements that further improve expression. The gene transfer systems can be used in methods, for example,...
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WO/2019/028044A1 |
The present disclosure provides compositions including recombinant KIE bacteriophages, methods for making the same, and uses thereof. The recombinant KIE bacteriophages disclosed herein are useful for the identification and/or antibiotic...
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WO/2019/025776A1 |
The present invention provides nucleic acid products and corresponding methods for identifying the presence or absence of Nairovirusin a sample.
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WO/2019/025387A1 |
The invention relates to a composition for use as a stabilizer and a method for stabilizing biological samples, in particular of whole blood, in particular for stabilizing the content and the integrity of cell-free nucleic acids. The com...
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WO/2019/023924A1 |
The present invention provides methods, compositions and kits for enriching and determining nucleotide sequences of a plurality of target loci from a sample comprising nucleic acids. The methods comprise one or more cycles of primer exte...
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WO/2019/028106A1 |
Disclosed herein are biomarkers related to the identification or diagnosis of Parkinson's disease in a subject. The disclosed biomarkers and related methods are used to detect or predict Parkinson's disease status in a subject. The discl...
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WO/2019/028470A2 |
Embodiments of a method and/or system can include generating a set of target- associated molecules (e.g., spike-in molecules) associated with one or more biological targets; generating one or more spike-in mixtures based on processing th...
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WO/2019/027414A1 |
Provided herein are genetic circuits and cell state classifiers for detecting the microRNA profile of a cell. The cell state classifiers of the present disclosure are designed to incorporate multiple genetic circuits integrated together ...
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WO/2019/028166A1 |
Systems, methods, and compositions provided herein relate to preparation of beads encapsulating genetic material. Some embodiments include preparation of nucleic acid libraries within the bead, wherein the bead includes pores that allow ...
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WO/2019/027234A1 |
The present invention relates to markers for diagnosing Acinetobacter baumannii infection, and a use thereof. Markers of six proteins or genes coding for the proteins, provided by the present invention, enable preferential detection of a...
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WO/2019/028126A1 |
Cucumber plants exhibiting resistance to Fusarium oxysporum f.sp. radicis cucumerinum (FORC) are provided, together with methods of producing, identifying, or selecting plants or germplasm with a FORC resistance phenotype. Such plants in...
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WO/2019/024081A1 |
The present invention provides an RVD having recognition preference for and different binding properties to 5mC, 5hmC, and 6mA, an isolated DNA-binding polypeptide comprising a TALE repeat domain containing the RVD, a fusion protein, a p...
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WO/2019/024598A1 |
A DNA probe library for hybridization with micro-satellite instability (MSI) detection related micro-satellite sites, comprising one or more DNA probes capable of hybridizing with the MSI state related microsatellite sites. In the DNA pr...
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