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WO/2019/157461A1 |
Chimeric antigen receptor (CAR)-expressing Tregs specifically target an antigen present in the joint of RA patients to induce a localized and effective immunosuppressive response.
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WO/2019/157304A1 |
Molecules for inhibiting arachidonate 15-lipoxygenase (ALOX-15) gene products including dsRNA (dsRNA) agents such as small interfering RNAs (siRNAs), antisense oligonucleotides, and small molecule inhibitors for therapeutic use. Addition...
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WO/2019/154898A1 |
The invention relates to a method for quantitative or qualitative determination of at least one fungus of interest in a sample where use is made of an assay that determines enzymatic activity derived from the fungus. In addition, an enzy...
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WO/2019/157034A1 |
The disclosure provides DNA library preparation methods that do not require a purification between adapter ligation and PCR amplification. Adaptors are added to DNA fragments to form oligonucleotide extension products and the oligonucleo...
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WO/2019/155651A1 |
A bacterium detection device 100 has such a configuration that a stage 20 on which a detection chip 10 having a membrane filter 1 fixed thereon is mounted is moved in the back-and-forth direction and the side-to-side direction by means o...
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WO/2019/157087A1 |
Methods for predicting response to immunotherapy and selecting immunotherapy for treating cancer, e.g., cancer of epithelial origin, in a subject.
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WO/2019/157191A1 |
Systems and methods for multiplexed cell sorting are provided herein. The disclosed cell sorting system is referred to as DNA gated sorting (DGS). An exemplary system provides a set of orthogonal sorting probes and release probes for sor...
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WO/2019/156216A1 |
By using a drug that activates the cell cycle, such as a retinoic acid receptor agonist, a phosphatidylinositol 3-kinase (PI3K) inhibiting agent, or an isocitrate dehydrogenase 1 (IDH1) inhibiting agent, cardiomyocytes can be made to pro...
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WO/2018/125954A8 |
In some embodiments, the invention provides A method for detecting or identifying a leaky gut syndrome in a patient, comprising providing a sample of a GI barrier of the patient; analyzing the sample to determine the status of the GI bar...
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WO/2019/154997A1 |
A device for sampling microorganisms comprising a hollow probe that can be inserted into a growth substrate or water system, the probe containing a growth medium for microorganisms wherein the growth medium contains a chemoattractant par...
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WO/2019/156934A1 |
Embodiments of the invention provide multilayer analyte sensors having material layers (e.g. high-density amine layers) and/or configurations of material layers that function to enhance sensor function, as well as methods for making and ...
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WO/2019/116412A8 |
The present invention concerns a method for in vitro diagnosis of 5 Amyotrophic Lateral Sclerosis by the detection of exosomal RNAs in a biological sample such as cerebrospinal fluid (CSF).
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WO/2019/153521A1 |
Disclosed in the present invention is a method for quickly and efficiently screening SgRNA targeting DNA sequences. The method comprises: designing a plurality of SgRNA targeting primers based on a SgRNA targeting DNA sequence framework;...
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WO/2019/157529A1 |
The present disclosure provides methods for analyte characterization from a single cell. The methods disclosed herein generally describe barcoded oligonucleotides, which can be bound to a bead, such as a gel bead, useful for characterizi...
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WO/2019/153852A1 |
A micro cell ChIP method, the method comprising: 1). dividing cell samples to be detected into a number n of groups, n being a non-zero natural number; 2). crosslinking and fixing the nth group sample; 3). processing the nth group sample...
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WO/2019/157470A1 |
Treatment of a patient diagnosed with cancer is monitored by comparing sequence data from liquid biopsies obtained during and/or after treatment with tumor and patient specific sequence data from a solid tumor obtained prior to treatment.
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WO/2019/154905A1 |
The invention relates to a method for in vitro predicting the outcome of an individual having a multiple myeloma, comprising the steps of: -a) measuring the expression level of at least 2 genes encoding a ROS detoxifying (AOX) protein se...
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WO/2019/156511A1 |
Provided are a biological sample analysis method, an analysis chip and an analysis system comprising same, the method comprising the steps of: introducing structures for assisting the formation of bioreactors on a substrate; providing a ...
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WO/2019/153241A1 |
Disclosed in the present invention are 17 single nucleotide polymorphism (SNP) loci associated with major adverse cardiovascular events (MACEs) and an application thereof. The 17 SNP loci provided by the present application are obtained ...
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WO/2019/154996A1 |
The invention relates to a method for a more appropriate risk assessment for the possible occurrence of a pregnancy loss or recurrent pregnancy loss, based on the presence of different genetic variants. The invention also relates to a me...
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WO/2019/108563A3 |
The present invention relates to a method for monitoring intestinal glutamine synthetase levels in a mammal, particularly in a human subject, and is useful for detecting intestinal glutamine synthetase deficiency. The method is based on ...
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WO/2019/157154A2 |
The present disclosure provides methods for the identification of tumor-specific isoforms of polymorphic gene expression products. Methods of using said isoforms in the diagnosis and/or treatment of cancers and neoplasias are also provided.
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WO/2019/156983A1 |
The present disclosure provides methods and systems for sequencing nucleic acid molecules in a manner that enables higher sequencing accuracy. Methods and systems provided herein may enable sequences that may have low-accuracy reads, suc...
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WO/2019/153851A1 |
A fusion protein, a kit and a CHIP-seq detection method. The fusion protein comprises a Tn5 transposase and an Fc binding protein. The kit comprises said fusion protein and other auxiliary detection reagents. Said method uses said fusion...
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WO/2019/157424A1 |
The disclosure provides a nanopore system assembled with non-membrane proteins for detecting analytes. Also disclosed are the methods, kits, and detection devices employing the disclosed nanopore system. The nanopore system has a wide va...
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WO/2019/156248A1 |
The present invention pertains to an immunochromatographic analysis device for detecting the chikungunya virus, the device comprising a sample loading part, a labeling substance holding part, a chromatography medium part having a detecti...
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WO/2019/156054A1 |
In one embodiment, the present invention provides a new marker, method, kit, etc., with which it is possible to determine an MLH1 methylation group at high accuracy. In one embodiment, the present invention relates to a marker for mutL h...
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WO/2019/153675A1 |
Provided in the present application is a novel colorimetric sensing method for a dual pathogen, comprising an in vitro nucleic acid amplification and a detection method, where the in vitro nucleic acid amplification uses a primer consist...
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WO/2019/156910A1 |
A method of characterizing a nucleic acid that includes steps of (a) contacting a primer-template nucleic acid hybrid with a polymerase and a mixture of nucleotides to produce an extended primer hybrid and to form a stabilized ternary co...
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WO/2019/155387A1 |
Compositions and methods are provided for modifying the expression or activity of CXorf67 in order to reduce the activity of PRC2. Increased expression of CXorf67 was identified in certain cancers, including PFA ependymomas. Thus, provid...
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WO/2019/154884A1 |
A method for determining the prognosis for survival of a patient having cancer is disclosed, said cancer being altered (i.e. highly activated or alternatively inactive/inhibited) in the NMDAR signalling pathway, said method comprising de...
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WO/2019/155366A2 |
The subject of the present invention is the sensor for the impedance measurements of the biological or chemical factor sample in the potentiostat system comprising the reference electrode RE and counting electrode CE with the electric co...
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WO/2019/153656A1 |
Provided is a use of piRNA-54265 in the diagnosis, treatment and prognostic evaluation of colorectal cancer. The p iRNA-54265 can be used as a diagnostic marker for colorectal cancer, specifically indicating the chemosensitivity and prog...
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WO/2019/156395A1 |
The present invention relates to a lateral fluid separation-based DNA extraction device. A DNA extraction device according to an embodiment of the present invention may comprise: a sample pad for receiving a sample from which DNA is to b...
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WO/2019/157318A1 |
The present disclosure provides methods and compositions for tracking nucleic acid fragment origin by target-specific barcode tagging when original nucleic acid targets break into small fragments. Nucleic acid targets are captured in vit...
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WO/2019/154414A1 |
Disclosed is the use of a substance or a vector thereof for inhibiting or eliminating TRABD in the preparation of a reagent and/or a drug for detecting or eliminating HIV-infected cells, a method for detecting or eliminating HIV-infected...
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WO/2019/156257A1 |
A method for determining a hyperexcitability in a subject comprising detecting a repeat expansion of TTTCA, TTTTA, or a complementary sequence thereof in a nucleic acid sample from the subject.
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WO/2019/157445A1 |
The present invention relates to, among other things, probes, compositions, methods, and kits for simultaneous, multiplexed detection and quantification of protein and/or nucleic acid expression in a user-defined region of a tissue, user...
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WO/2019/156957A1 |
The invention encompasses hydrogels, monomer precursors of the hydrogels, methods for the preparation thereof, and methods of use therefor. The linking of monomers can take place using non-radical, bioorthogonal reactions such as copper-...
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WO/2019/154783A1 |
The invention relates to a method for detecting infections in joints and to a device for carrying out said method.
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WO/2019/153677A1 |
Provided is a visual quantitative method for heavy metals, comprising an in vitro nucleic acid amplification and detection method, wherein during in vitro nucleic acid amplification, an ultra-fast PCR reaction is carried out by using pri...
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WO/2019/156325A1 |
The present invention relates to a method for diagnosing irritable bowel syndrome via bacterial metagenomic analysis and, more particularly, to a method for diagnosing irritable bowel syndrome by performing bacterial metagenomic analysis...
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WO/2019/157447A1 |
Methods and kits are provided for inhibiting inflammasome activation in cells of a subject or an inflammation- affected eye in a subject by administering to the subject a composition including a nucleotide sequence encoding a membrane in...
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WO/2019/153061A1 |
The present invention provides a LAMP assay device comprising a heating chamber (5) designed to receive a holding rack (2) for at least one sample, the holding rack (2) being inserted therein by means of a sample insertion opening (1), t...
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WO/2019/156251A1 |
The present invention provides a combination of: (1) a composition containing a living bacterium of Bacteroides vulgatus isolated from nature; and (2) a composition containing a living bacterium of Bacteroides dorei isolated from nature.
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WO/2019/154373A1 |
An insect-resistant herbicide-tolerant corn transformation event, and a related creation method, detection method, and application. Using the corn inbred line Xiang 249 as a receptor, by means of agrobacterium-mediated genetic transforma...
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WO/2019/153294A1 |
Provided is an application for 16 SNP loci in a yak whole genome in yak phenotypic trait or molecular breeding analysis, the nucleotide sequences of the 16 SNP loci being shown in SEQ ID No. 1-16.
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WO/2019/157283A1 |
Methods and kits are provided for identifying subjects at increased risk for IgE mediated systemic inflammatory disorders, particularly asthma.
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WO/2019/157279A1 |
This disclosure relates to the production and use of an isolated, purified and/or recombinant T cell receptor (TCR) that specifically binds to a mutant IDH1 protein, or a fragment thereof, wherein the mutant IDH1 protein or fragment ther...
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WO/2019/156626A1 |
There is provided a system and method for on-site detection of pathogens in a liquid sample. The system comprising: a filtration module comprising a mixture of dead-end filtration elements and cross-flow filtration elements configured to...
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