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Matches 1 - 50 out of 175,205

Document Document Title
WO/2019/212238A1
The present invention provides a method for providing a target nucleic acid sequence data set of a target nucleic acid molecule. The larger number of synonyms are retrieved from reliable sources than that of synonyms extracted by user ex...  
WO/2019/191429A3
The present invention provides methods of diagnosing and prognosing disease by analyzing the methylation status of exosomal DNA. In particular, exosomal DNA, in particular exosomal DNA isolated from exosomes that originated from a diseas...  
WO/2019/178288A9
Hepatitis E virus (HEV)-based virus like particles (VLP) made with a modified capsid protein containing at least a portion of open reading frame 2 (ORF2) protein and encapsulated insulin protein or insulin encoding nucleic acid are provi...  
WO/2019/213374A1
Provided herein are compositions and methods for production of proteins in microbial systems. In particular, provided herein are compositions and methods for expressing exogenous genes from specific chromosomal locations of E. coli. Spec...  
WO/2019/213348A1
Disclosed are compositions and methods for single-step PCR of a sample containing a complex target gene pool that can simultaneously amplify a wide variety of variant target gene sequences common to the sample while maintaining the origi...  
WO/2019/213321A1
The present disclosure relates to methods for predicting the risk of recurrence and/or metastasis in primary cutaneous squamous cell carcinoma (cSCC).  
WO/2019/213237A1
Disclosed herein include systems, methods, compositions, and kits for molecular barcoding on the 5'-end of a nucleic acid target. After barcoding a nucleic acid target using an oligonucleotide barcode comprising a target binding region a...  
WO/2019/213119A1
Compounds that may inhibit Oplophorus-derived luciferases are disclosed as well as compositions and kits comprising the compounds and methods of using the compounds.  
WO/2019/213504A1
The present invention is directed to the filed of gene therapy. In particular, compositions and methods are disclosed that repair gene microduplication mutations by reversion to a wild type sequence. For example, the creation of a double...  
WO/2019/212899A1
Described herein are methods and systems for identifying subjects suitable for treatment with an inhibitor of CD30L activity or expression, such as an anti-CD30L antibody. Methods and systems disclosed herein identify subjects suitable f...  
WO/2019/210873A1
Various applications can use fragmentation patterns related of cell-free DNA, e.g., plasma DNA and serum DNA. For example, the end positions of DNA fragments can be used for various applications. The fragmentation patterns of short and l...  
WO/2019/213619A1
Provided herein are compositions, systems, and methods for assessing and monitory disease stage and phases, predicting likelihood of disease progression, and predicting and monitoring responses to disease therapies (e.g., in HBV infection).  
WO/2019/213096A1
Devices for assaying a biomolecule from a sample, including: a cartridge assembly structured to accept and secure a magnetofluidic cartridge to be used for the assaying, and a magnetic particle manipulation assembly arranged proximate th...  
WO/2019/213478A1
The present disclosure relates to methods using gene expression measurements to identify mismatch repair deficiency, microsatellite instability and hypermutation in a subject.  
WO/2019/211469A1
The invention provides compositions, processes and kits for determining the metabolic properties of cells of interest in vitro.  
WO/2019/212922A1
The present disclosure relates to using spectrophotometry to estimate genome copies and full/empty ratios adeno-associated virus particles.  
WO/2019/190930A3
RNA molecules comprising a guide sequence portion having 17-20 nucleotides in the sequence of 17-20 contiguous nucleotides set forth in any one of SEQ ID NOs: 1-1313 and compositions, methods, and uses thereof.  
WO/2019/210405A1
In an aspect, there is provided a computer-implemented method for approximating product production in a bioreactor. The method comprises: providing a bioreactor containing live cells in a substrate, the bioreactor for cultivating, over a...  
WO/2019/190927A3
The present disclosure provides methods and compositions for the treatment of cancer. In some aspects, the present disclosure provides splice-switching oligonucleotides that downregulate AR expression and methods of using these splice-sw...  
WO/2019/161139A3
Disclosed are probes based on papilloma virus and modified SV40 that can be used for detecting circulating tumor cells (CTCs) in the blood stream, methods for manufacturing such probes, and methods for using such probes.  
WO/2019/213489A1
Disclosed herein is an assay for determining the concentration of p-aminophenol present in a sample. More particularly, the present invention relates to an improvement of an enzyme-based assay for determining the concentration of acetami...  
WO/2019/211348A1
The present invention relates to an electrode system for measuring the concentration of an analyte under in-vivo conditions, comprising an electrode 5 with immobilized enzyme molecules and a diffusion barrier that controls diffusion of t...  
WO/2019/211418A1
The invention is a method of predicting recurrence of lung cancer in a patient following surgery, the method comprising analysis of circulating tumor DNA from a patient's sample.  
WO/2019/210764A1
Provided is an application of ATPase ATP13A2 in the preparation of biological markers for behavioural and motor abnormalities, the behavioural and motor abnormalities being caused by neural impulse control disorder and dyskinesia, and th...  
WO/2019/213437A1
The disclosure provides a novel system of storing information using a charged polymer, e.g., DNA, the monomers of which correspond to a machine-readable code, e.g., a binary code, and which can be synthesized and/or read using a novel na...  
WO/2019/212158A1
The present invention provides a method for detecting multiple nucleic acids by using a single fluorescence channel gene amplification apparatus (PCR machine) using a TaqMan probe and a PNA probe. A PNA probe designed to have low melting...  
WO/2019/213624A1
Methods, compositions and kits for detection of a taxon of pathogenic microorganisms in a sample are provided. Also provided are methods, compositions and kits for detecting taxons of pathogenic microorganisms present in low titers in a ...  
WO/2019/213525A1
Provided herein are methods and compositions for treating a subject in need thereof, such as a subject with deficient LAL protein expression or a subject having Cholesteryl Ester Storage Disease.  
WO/2018/200505A9
The present disclosure relates to somatic ErbB2 mutations in cancer and provides methods of identifying, diagnosing, and prognosing ErbB2-positive cancers. The present disclosure further provides methods of treating cancer, including cer...  
WO/2019/212615A1
Methods of amplifying nucleic acids in a sample are provided. Aspects of the methods include: a) fragmenting nucleic acids in the sample to produce a fragmented nucleic acid sample; b) contacting the fragmented nucleic acid sample with a...  
WO/2019/210696A1
A prunus mume pendulous trait SNP molecular marker and the use thereof, including molecular markers Marker 301243 and/or Marker 311414, the nucleotide sequences thereof being respectively as shown in SEQ ID NO. 1 and SEQ ID NO. 2. Two pr...  
WO/2019/212023A1
The present invention provides an RNA virus processing method that includes: (a) a step in which a sample possibly including an RNA virus is prepared; (b) a step in which a reverse transcription reaction liquid including the sample from ...  
WO/2019/213005A1
The present invention relates to compounds, compositions and methods for treating diseases or conditions mediated by proteins of the SWI/SNF chromatin-remodeling complex, including PB1.  
WO/2019/213254A1
The present disclosure relates to compositions and methods for assessing relative macromolecule abundance (e.g., RNA expression levels) in a spatially-defined manner across a tissue sample, specifically providing deep transcriptomic cove...  
WO/2019/213294A1
Disclosed herein include systems, methods, compositions, and kits for sample analysis, in particular single cell analysis. Nucleic acid fragments comprising a capture sequence (or a complement thereof) can be generated from double-strand...  
WO/2019/212138A1
The present invention relates to a recombinant vector comprising an oligonucleotide for discovering cross-contamination between next generation sequencing samples, and a next generation sequencing method capable of discovering cross-cont...  
WO/2019/207439A1
A method for analyzing cell free DNA (cfDNA) from the bloodstream of a cancer patient is provided. In some embodiments, the method may comprise sequencing at least part of the coding sequences of TP53 and KRAS in a sample of the cfDNA, a...  
WO/2019/210048A1
A vessel includes a memory and a processor operatively coupled to the memory. The memory is configured to store a vessel identifier. The processor is configured to initiate a timer for a shelf life of a solution placed into the vessel. T...  
WO/2019/208696A1
[Problem] To provide a method for separating long-term and short-term hematopoietic stem cells, a method for identifying genes specifically expressed in long-term hematopoietic stem cells, a method for identifying genes involved in long-...  
WO/2019/210203A1
Disclosed herein are methods, kits and compositions for treating a subject for an inflammatory bowel disease. These methods, kits and compositions may be particularly useful for subjects with single nucleotide polymorphisms in a G Protei...  
WO/2019/208671A1
This invention according to one embodiment provides a kit, a device, and a method for detecting bladder cancer. This invention according to one embodiment relates to: a kit or a device that is for detecting bladder cancer and that contai...  
WO/2019/207030A1
The invention relates to the prediction of responder or non-responder to immune checkpoint inhibitor in patient suffering from lung cancer. To study the interplay between malignant cells and their immune microenvironment, the inventors p...  
WO/2019/209942A1
The present disclosure describes methods, devices and systems of diagnosing, prognosing, and treating subjects with moderate to severe forms of Crohn's disease (CD) that is characterized by stricturing and internal penetrating disease ph...  
WO/2019/205132A1
A method for enriching fetal free nucleic acids, comprising performing PCR amplification on a sample containing fetal free nucleic acids to obtain a fetal free nucleic acid-enriched product; PCR amplification comprises first performing f...  
WO/2019/206122A1
Application of CD93 in preparing a cord blood test kit for early warning infantile hemangioma (IH), in preparing a drug for treating or preventing IH, and in preparing a serum marker for preventing hemangioma. The cord blood test kit wit...  
WO/2019/204985A1
The present invention relates to an osteoporosis biomarker and use thereof. The biomarker comprises Bacteroides thetaiotaomicron, Bacteroides uniformis, Bacteroides intestinalis, Bacteroides dorei, Ruminococcus sp., Akkermansia muciniphi...  
WO/2019/208308A1
The present invention addresses the problem of providing: a glucose dehydrogenase; a polynucleotide encoding the enzyme; a method for producing the enzyme; a method for measuring glucose using the enzyme; a measurement reagent compositio...  
WO/2019/208691A1
A method for detecting Candida auris in which nucleic acid amplification is conducted by the LAMP method on a nucleic acid sample obtained from a specimen and the amplification product is detected, wherein the FIP in the primer set in th...  
WO/2019/209946A1
Disclosed are compositions and methods for determining the nucleotide sequence of sequences of interest using paired-end sequencing. Dumbell circular templates can be generated and used in a rolling circle amplification reaction by ligat...  
WO/2019/208542A1
The present invention provides a biomarker for differentiating between Still's disease and septicemia, comprising any of (a) through (d) below: (a) an FGF-2 protein or an FGF-2 transcription product, (b) an IL-18 protein or an IL-18 tran...  

Matches 1 - 50 out of 175,205