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Matches 1 - 50 out of 164,617

Document Document Title
WO/2018/011101A1
Method to perform a PCR assay that comprises the following steps: a. Obtaining a nucleic acid sample; b. Hybridizing that nucleic acid sample to one or more pair of primers where at least one primer consists of a single stranded DNA poly...  
WO/2018/013837A1
Provided are methods of producing nucleic acid libraries. In certain aspects, the methods include combining target nucleic acids (e.g., 5' phosphorylated nucleic acids) and an oligonucleotide pool. Oligonucleotides of the oligonucleotide...  
WO/2018/011075A1
The application concerns melon plants (Cucumis melo) resistant to infection with tomato leaf curl New Dehli virus (ToLCNDV). The resistant melon plants have a genomic introgression fragment on chromosome 5 which confers tolerance to ToLC...  
WO/2018/013851A1
A bioreactor is provided that permits engineering of multiple different tissues. The bioreactor has a series of flow paths that permit application of tissue-specific media while simultaneously innervating the various different tissues wi...  
WO/2018/013542A1
Described herein are in vitro cancer metastasis models that recapitulate biological facets of organ specificity as indicated by the behavior of human colorectal cancer cells when on substrata of liver and lung biomatrix scaffolds, organ-...  
WO/2018/014005A1
The disclosure provides for multiple-reporter systems that are capable of rapidly and indirectly screening cells for a certain cell type and/or cell function.  
WO/2018/013942A1
Provided herein are chromatin protection therapeutics (CPTs) and methods of targeting chromatin heterogeneity for the treatment of cancer therewith. In particular compositions and methods are provided that target physical variations in c...  
WO/2018/013243A1
System and methods for analyzing single molecules and performing nucleic acid sequencing. An integrated device may include multiple pixels with sample wells configured to receive a sample, which when excited, emits radiation. The integra...  
WO/2018/011412A1
A nucleotide-based nanoswitch system for detecting one or more targets in a sample, the system comprising a set of two or more oligonucleotide probes configured to provide a target binding-induced structural change of one or more of the ...  
WO/2018/013332A1
Methods and compositions to genotype microspores and/or pollen grains are provided. Methods provided include using meiotically-related products to non- destructively determine the genotype of one of the meiotically-related products such ...  
WO/2018/013531A1
Compositions and methods relating to a panel of antigen biomarkers for the early detection of ovarian cancer. The compositions and methods encompass antigen biomarkers coupled to a substrate, with the biomarkers being selected from the g...  
WO/2018/013466A2
The present invention is based on the identification of novel biomarkers predictive of endocrine resistance in breast cancer.  
WO/2018/011398A1
Disclosed is a method of identifying the contents of individual droplets in a droplet stream each droplet containing fluorophores in an initial non-fluorescing state characterised by the steps of introducing the droplets one-by-one into ...  
WO/2018/012606A1
Provided is a compound that accelerates an enzymic reaction catalyzed by a peroxidase. Disclosed are a peroxidase reaction accelerator comprising a compound represented by formula (I), and a hydrogen peroxide measurement method employing...  
WO/2018/012692A1
Disclosed is a biosensor. The biosensor comprises: an electrode; and a polymer structure disposed on the electrode and formed of poly-5,2':5',2"-terthiophene-3'-carboxylic acid (pTTCA), wherein an enzyme is present in a state of covalent...  
WO/2018/012341A1
A blood flow measurement device is provided with: a storage unit for storing the relationship between the state of an autonomic nerve and blood flow; a blood flow measurement unit for measuring blood flow; and a control unit for calculat...  
WO/2018/013710A1
Improved methods and compositions are provided herein for primer extension target enrichment of target polynucleotides and affinity capture. The first extension product is enriched by affinity capture using a primer or nucleotides labell...  
WO/2018/013558A1
Provided are methods, compositions, reagents, kits that are useful for detecting a specific nucleic acid region in genome with high efficiency and high sensitivity.  
WO/2018/010075A1
OsACBP5 can be used to enhance tolerance to fungal necrotrophs in genetically modified plants. OsACBP5-overexpressing transgenic Arabidopsis were conferred enhanced tolerance to fungal necrotrophs such as root-infecting necrotroph Rhizoc...  
WO/2018/013426A2
Methods and devices for detecting a low concentration analyte in a sample are provided herein. The methods include flowing a sample through a porous membrane coated with a capture matrix to capture the low concentration analyte. The meth...  
WO/2018/012963A1
The invention relates generally to the field of nanopores and the use thereof in various applications, such as analysis of biopolymer s and macromolecules, typically by making electrical measurements during translocation through a nanopo...  
WO/2018/013250A1
The present invention generally relates to improved methods of assembly of two or more DNA fragments, methods of rapid ligation-independent cloning, and kits for rapid ligation-independent cloning and their uses.  
WO/2018/013509A1
The present invention relates to compositions and methods for diagnosing and treating arrhythmias. In particular, the present invention provides IL-18 markers and uses thereof.  
WO/2018/013534A1
The present invention relates to methods for treating PTEN deficient epithelial cancers using a combination of anti-PI3Kbeta and anti-immune checkpoint agents.  
WO/2018/011316A1
A method of identifying a subject having a bacterial infection, which includes discriminating said subject from a subject having a viral infection or an inflammatory disease. Also provided is a gene signature employed in the method and t...  
WO/2018/012607A1
Provided is a compound that accelerates an enzymic reaction catalyzed by an oxidase. Disclosed are an oxidase reaction accelerator comprising a compound represented by formula (I), and a method employing the same.  
WO/2018/011320A1
Disclosed herein are improved PNA based monomers, nucleobases, oligomers and probes for use in a variety of different methods of analysing nucleic acids. Further, the disclosure provides methods of preparing the modified and improved PNA...  
WO/2018/013598A1
The present disclosure provides methods, sets of substantially complementary double-stranded adapters, and kits for performing nucleic acid sequencing. The substantial complementary double-stranded adapters comprise fully complementary m...  
WO/2018/011584A1
The invention relates to a kit for amplifying immunoglobulin sequences and methods thereof, and their use and application in methods for the characterisation of a B-cell repertoire.  
WO/2018/013963A1
A method includes obtaining a biological sample from an individual, extracting DNA from cells in the sample, measuring the degree of methylation of the extracted DNA at one or more specified loci, and identifying if at least one locus ex...  
WO/2018/013723A1
Described herein are methods for preparing DNA templates for single-cell transcript sequencing of RNA from a population of cells. The methods entail distributing cells from the population into separate reaction volumes so that a pluralit...  
WO/2018/012011A1
Provided are a method with which it is possible to assess the state of periodontal disease and caries by a simple method, a method with which it is possible to assess the severity of periodontal disease, therapeutic effect, and risk of e...  
WO/2018/012896A1
The present invention relates to a multiplex PCR primer set capable of specifically amplifying a gene specifically existing in a Beijing family of Mycobacterium tuberculosis, and a gene capable of simultaneously diagnosing Mycobacterium ...  
WO/2018/011603A1
A membrane-spanning nanopore is provided that comprises:i. at least one scaffold polynucleotide strand; ii. a plurality of staple polynucleotide strands; and iii. at least one hydrophobically-modified polynucleotide strand, wherein the a...  
WO/2018/011527A1
The present invention relates to reagents for reversibly protecting biological molecules. In particular, it relates to compounds derived from azaisotoic anhydride and the uses of same for protecting biological molecules, particularly enz...  
WO/2018/013323A1
Compositions and methods useful in identifying and selecting maize plants with increased resistance to gray leaf spot are provided herein. The methods use molecular genetic markers within a QTL region located on chromosome 4 to identify ...  
WO/2018/011989A1
Provided is a graft material for treating nerve damage, the graft material including dental pulp cells, wherein properties required of dental pulp cells provided as a graft material for treating nerve damage are identified. The present i...  
WO/2018/013724A1
The present invention provides a method for targeted enrichment of nucleic acids including contacting a nucleic acid including at least one region of interest with a plurality of transposase complexes. Each of the transposase complexes i...  
WO/2018/013726A1
The invention provides a device, method, and system for high throughput detection of nucleic acid expression in individual cells. Cells are encapsulated in aqueous microdroplets which are merged with a biocompatible matrix, allowing on-c...  
WO/2018/011166A2
The present invention relates to methods for quantifying the population of myeloid dendritic cells in a tissue sample. The tumor microenvironment is a complex tissue which contains many distinct cell populations, and whose composition ma...  
WO/2018/014002A1
Systems and methods that facilitate genetic research are described. The systems and methods can utilize (1) fluorescent dyes to sort tetrads from vegetative cells, dyads and dead cells; (2) natural genetic sequences to capture tetrad rel...  
WO/2018/012497A1
The present invention mainly addresses the problem of providing a novel and specific knockout model animal that presents a symptom of a disease accompanied by a synapse abnormality in the brain, a method for producing same, and a therape...  
WO/2018/011835A1
Provided is a method for selectively determining whether or not a test sample contains a phytopathogenic fungus among two types of fungi, namely, phytopathogenic fungi and non-phytopathogenic fungi. The method for determining whether or ...  
WO/2018/011397A1
In a method for detecting target structures (210), nanoparticles (10) with at least one immobilized specific capture molecule, which can interact with the respective target structure, are used. The nanoparticles (10) are brought into con...  
WO/2018/013640A1
Methods and compositions directed to altering a population of sRNAs in a sperm using vesicles isolated from an epididymosome are provided. Methods and compositions directed to altering a population of sRNAs in an oocyte using vesicles is...  
WO/2018/010803A1
The present invention relates to an eggplant plant, in particular a Solanum melongena plant comprising a QTL, which leads to the plant producing seeds that have a novel colour, wherein said QTL is obtainable by introgression from a plant...  
WO/2018/013955A1
This disclosure relates generally to methods and kits useful for preparing samples, extracting nucleic acids from samples (e.g., biological samples), and/or detecting nucleic acids (e.g., pathogen nucleic acids) in samples (e.g., samples...  
WO/2018/011422A1
There is presented a method for plating cells and for picking corresponding colonies, said method comprising for each predetermined position (xi, yi) in a plurality of spatially distributed predetermined positions (X, Y) on a surface (34...  
WO/2018/011765A1
The twin-to-twin transfusion syndrome (TTTS) is a condition that can occur in 10 to 15% (approximately 150, 000 cases/year worldwide) of monochorionic twin pregnancies. Thus, the present application provides a new molecular based method,...  
WO/2018/011804A1
A composition comprising a cell population wherein the population is suitable for transplantation into a subject in need thereof, and characterized by differences of expression levels of a plurality of genes. Further, methods and kits fo...  

Matches 1 - 50 out of 164,617