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WO/2024/064761A2 |
Provided herein are methods for screening edited genomic sequences for their effect on expression of a target gene, and for designing a target sequence edit for introducing to a target sequence of a nucleic acid molecule. Also provided a...
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WO/2024/061799A1 |
The invention relates to deformable polymers comprising immobilised primers, particularly for use in nucleic acid sequencing, such as concurrent sequencing.
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WO/2024/060327A1 |
Provided is a tertiary lymphoid structure component marker for predicting the prognosis of nasopharyngeal cancer, which comprises one or more of a germinal center B cell component marker, a follicle-assisted CD4+ T cell component marker,...
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WO/2024/064675A1 |
Methods for determining a functional status of a variant are described. The methods may comprise, for example, receiving sequence read data associated with a plurality of samples; determining one or more feature attributes based on the s...
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WO/2024/061978A1 |
The invention relates to a method for the diagnosis of ulcerative colitis in a subject by detecting a nucleic acid target region and to oligonucleotides, oligonucleotide probes and kits to be used in this method.
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WO/2024/063449A1 |
The present invention relates to a curved plasmonic metal nanostructure based on biomolecules and a nanoplasmonic biosensor using same.
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WO/2024/063484A1 |
The present invention relates to a pharmaceutical composition containing Cbfβ (Core-binding factor subunit beta) expressing vascular smooth muscle cells or a culture fluid thereof as an active ingredient for the prevention or treatment ...
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WO/2024/063938A1 |
This document relates to methods and materials for assessing and/or treating mammals (e.g., humans) having prostate cancer. For example, methods and materials that can be used to determine whether or not a prostate cancer (e.g., a castra...
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WO/2024/060534A1 |
Provided is a method for regulating the number of maize tassel branches, comprising: constructing an miR529 overexpression vector with two tandem repeating hairpin structures by utilizing T-DNA insertion transgenic technology; transferri...
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WO/2024/062603A1 |
Provided is a point mutation rate detection method capable of conducting quantitative examination. The point mutation rate detection method according to the present invention is used for multiplex ligation-dependent probe amplification (...
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WO/2024/064679A1 |
Embodiments of the present disclosure provide systems and methods for determining a functional status of a genomic variant. For example, methods according to the present disclosure comprise receiving sequence read data for a plurality of...
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WO/2024/064962A2 |
The present disclosure relates to polymer beads comprising (i) biomarkers and (ii) nucleic acids comprising: (a) a primer binding site; and (b) a unique molecular identifier; wherein the nucleic acids are bound to the biomarker; and wher...
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WO/2024/064255A2 |
Disclosed are methods for identifying and treating a subject having obstructive sleep apnea.
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WO/2024/064913A1 |
The present disclosure provides gene therapy vectors, such as recombinant adeno-associated virus (rAAV) for expressing a human micro-dystrophin gene. The present disclosure also provides compositions and methods of using these rAAV to tr...
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WO/2023/234965A9 |
A method and system is for receiving data representing gene clusters, the gene clusters including one or more genes configured to encode one or more polypeptides or other small molecules; accessing a machine learning model, the machine l...
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WO/2024/064639A1 |
In some examples, novel nanogel particles are described having dual functionality, temperature responsiveness and pH responsiveness. For nucleic acid sequencing, amplification primers are grafted to nanogel particles to form primer-graft...
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WO/2024/061634A1 |
The invention relates to a method of predicting an outcome of a bladder cancer subject, comprising determining or receiving the result of a determination of a gene expression profile comprising gene expression levels, wherein the gene ex...
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WO/2024/059946A1 |
Multivalent trident aptamers comprising the general formula [A-SA]2 or 3-L-[SB-B] in which a central branched linker molecule (L) possesses 2 or 3 variable arms ([A-SA]2 or 3), and a root ([SB-B]), connected by a central carbon atom, to ...
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WO/2024/059947A1 |
The present disclosure relates to molecular recognition elements (MREs) and, in particular, to aptamers for recognizing and binding to a microorganism, a virus, and/or a molecule present on a microorganism or virus, such as spike protein...
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WO/2024/063731A1 |
This invention relates to an anthocyanin-based antibiotic resistance test, which is developed for detecting antibiotic resistant microorganisms and is based on color change.
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WO/2024/063523A1 |
In the present invention, differential expression of 23 genes has been identified, which are GATA3, FOXA1, RASSF5, PTPN6, TRNP1, APOBEC3D, APOBEC3G, ABL1, ABL2, CACNA2D1, JUN, GNG4, NGF, MYC, MAP4K4, STC1, FOXD1, FOXC2, TGFB1, TGFB3, NOG...
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WO/2024/064915A2 |
The invention provides methods for enriching nucleic acid target sequences from a sample, for example, from a biological sample or from a nucleic acid library.
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WO/2024/064736A1 |
This disclosure provides synthetic nucleic acid oligonucleotides and related methods for analysis of immune repertoires. A disclosed synthetic oligonucleotide contains (a) one or more tags with a sequence that is not contained in a eukar...
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WO/2024/062116A1 |
The present invention relates to improvements in the use of padlock probes whereby the ligation of the padlock probe may be controlled, and in particular to a method of detecting a target nucleic acid in a sample which comprises the use ...
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WO/2024/062102A1 |
The present invention provides a method for detecting two target molecules in a sample, both as individual molecules and in proximity, or interaction with one another. The method involves performing three separate assay reactions to dete...
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WO/2024/061369A1 |
Provided is a mammalian derived cell model which can be used in anti-aging drugs. The mammalian-derived extracembryonic trophoblast cell model is an early mammalian-derived extracembryonic stage. The change model of differentiation of ce...
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WO/2024/060732A1 |
Provided is a nucleic acid sequence, which comprises one or more of sequences selected from sequences SEQ ID NOs: 1-7 and complementary sequences thereof. The nucleic acid sequence is derived from a plant, seed or cell comprising a trans...
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WO/2024/064803A2 |
This disclosure contemplates tagging cells or vesicles with agents using a tension activated device. In certain embodiments, a solid surface is conjugated to a double stranded nucleic acid complex wherein a first strand is conjugated to ...
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WO/2024/062675A1 |
Provided are: a stratum corneum formation promoter that promotes stratum corneum formation through the activation of olfactory receptors; a skin roughness inhibitor; a moisturizing agent; a skin barrier function improving agent; a melani...
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WO/2024/061281A1 |
A kit for detecting prostate cancer and the use thereof, and a kit for detecting bladder cancer and the use thereof. The kit for detecting prostate cancer comprises sarcosine oxidase, metal nanoparticles, a gold nanomaterial, and a reage...
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WO/2024/064919A2 |
Methods and compositions disclosed herein involve detecting a nucleic acid epitype, which comprises a region of nucleic acid containing one or more methylation sites. For example, detecting a nucleic acid epitype can involve determining ...
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WO/2024/063562A1 |
The present invention provides an analytic method comprising a step for measuring the expression level of a gene encoding at least one deubiquitinating enzyme, selected from the group consisting of USP3, USP9X, USP26, USP34, COPS5, OTUD6...
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WO/2024/064704A1 |
Provided herein is a device for detecting the presence of pathogens in a sample and methods of use thereof. The device and method comprises one or more amplification components, an indicator, and a sensor (e.g., a pH sensitive polymer). ...
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WO/2024/061920A1 |
The present invention refers to the use of specific metabolites for assessing the activity of NNMT, for selecting patients which may benefit from a treatment with NNMT inhibitors, for the prognosis and/or predicting the response of patie...
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WO/2024/063110A1 |
The present invention addresses the problem of providing an evaluation method of a test substance using an M cell model similar to M cells in a living human body. Provided is an evaluation method of a test substance, the method including...
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WO/2024/063202A1 |
The present invention relates to a method for detecting one or more target nucleic acid molecules in a biological sample. By using the method for detecting one or more target nucleic acid molecules in a biological sample, according to an...
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WO/2024/062131A1 |
The invention relates to a PCR test system (1) comprising a PCR test apparatus (2) and a number of microfluidic sample carriers (4). The PCR test apparatus (2) comprises: a receiving device for at least one microfluidic sample carrier (4...
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WO/2024/063109A1 |
The purpose of the present invention is to provide a pharmaceutical composition and a senescent cell remover to be used in the treatment or prevention of NASH. The present invention is: a pharmaceutical composition for the treatment or p...
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WO/2024/064369A1 |
The invention provides methods of amplifying nucleic acids, and, more particularly, methods of distinguishing methylated and non-methylated nucleic acid residues in an amplification reaction.
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WO/2024/061855A1 |
The present invention relates to device for detecting at least one target nucleic acid sequence. The device comprises a surface which carries at least one activatable protein which is activated in the presence of the at least one target ...
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WO/2024/060775A1 |
Provided are a tumor detection marker TAGMe and use thereof. On the basis of analysis and research on a large number of clinical samples, novel DNA methylation tumor markers are obtained by separation. The markers are in a low methylatio...
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WO/2024/062867A1 |
A method for analyzing the possibility of cancer developing in a subject according to an embodiment of the present invention comprises: counting, through comparison with a reference sequence, the number of types of RNA in which sequence ...
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WO/2024/064787A2 |
Provided are ELISA based methods and compositions and kits for use in said methods, for quantitatively detecting the presence of double stranded RNA (dsRNA) in a sample solution, e.g., a sample solution that comprises dsRNA and messenger...
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WO/2024/061857A1 |
The present invention relates to a method for determining CpG methylation of at least one target nucleic acid sequence in a liquid sample, the method comprising a) providing a liquid sample comprising molecules of the at least one target...
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WO/2024/060326A1 |
Provided is an antibody combination for detecting the prognosis of nasopharyngeal cancer. The antibody combination comprises at least one of IGHM, IGHD, IGHA1, IGHA2, IGHG1, IGHG2, IGHG3, and IGHG4. Provided are use of the antibody combi...
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WO/2024/064912A2 |
Described herein are aspects for sequencing three-dimensional samples using flow cell images. An aspect begins by obtaining a plurality of subsets of flow cell images of a sample in a plurality of sequencing cycles from a subset of chann...
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WO/2024/063132A1 |
Provided are an antibacterial composition containing bacteria that exhibit antibacterial properties against bacteria having a positive correlation with a SCORAD value indicating the severity of atopic dermatitis, and a method for determi...
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WO/2024/061826A1 |
The present invention relates to a kit and an in vitro method for detecting and characterizing the degradation of a particular organ or tissue, on the basis of the analysis of the presence of at least one specific methylated cell-free DN...
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WO/2024/063637A1 |
The present invention is directed to a method and kit for amplification and detection of target DNA or cDNA in a PCR reaction mix containing Sybr Green and the reaction is carried out in a conventional thermocycler. Detection of DNA-Sybr...
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WO/2024/059832A1 |
Provided are nucleic acids encoding kinase-modulated bioluminescent indicator (KiMBI) polypeptides. In certain embodiments, a nuclei acid of the present disclosure encodes a KiMBI polypeptide comprising a first bioluminescent enzyme frag...
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