METHOD FOR PRODUCING ACTIVE CONSTITUENT OF PHARMACEUTICAL OR DIAGNOSTIC AGENT IN MDCK CELL SUSPENSION CULTURE

Japanese Patent JP2008289499

A

To provide a method for producing an active constituent of a pharmaceutical or a diagnostic agent.

The invention relates to the method for producing the active constituent of a pharmaceutical or a diagnostic agent, whereby (a) MDCK cells are infected with a virus, and (b) the MDCK cells are cultivated in a suspension culture on a commercial scale and under conditions which enable viruses to proliferate, the cultivation being carried out in a volume of at least 30 L. The invention also relates to methods for producing a pharmaceutical or a diagnostic agent, whereby an active constituent is produced according to one of the methods and is mixed with a suitable adjuvant, auxiliary agent, buffer solution, diluting agent or pharmaceutical carrier.

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VORLOP JUERGEN
FRECH CHRISTIAN
LUEBBEN HOLGER
GREGERSEN JENS-PETER

JP2008204890A

December 04, 2008

August 07, 2008

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NOVARTIS VACCINES & DIAGNOSTIC

C12N7/00; C12P21/02; A61K39/12; A61K39/15; A61K39/155; A61K39/205; A61K39/235; A61K39/245; A61K39/39; A61K48/00; A61P31/12; A61P31/14; A61P31/16; A61P31/22; C12N5/06; C12N5/10; C12N7/02; C12N7/04; C12N15/867; A61K39/00

Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita

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