Title:
NON-ACIDIC CYCLOPENTANEHEPTANOIC ACID, 2-CYCLOALKYL OR ARYL ALKYL DERIVATIVE THEREOF AS PHARMACEUTICAL
Document Type and Number:
Japanese Patent JP2011052014
Kind Code:
A
Abstract:
To provide an effective ocular hypotensive agent and a widely applicable smooth muscle relaxant.
A cyclopentaneheptanoic acid, 2-cycloalkyl or arylalkyl derivative substituted with halo, methyl, hydroxy, nitro, amino, amide, azide, oxime, cyano, thiol, ether or thioether group at the 1-site, is provided, e.g. 1-OH-cyclopentaneheptanoic acid, 2-(cycloalkyl or arylalkyl) derivative. The derivative is an effective ocular hypotensive agent, being suitable for treating glaucoma in particular. Further, the derivative is a smooth muscle relaxant widely applicable to systemic hypertensive and pulmonary diseases, also being applicable to gastrointestinal diseases, reproduction, fertility, incontinence, shock, etc.
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Inventors:
WOODWARD DAVID F
ANDREWS STEVEN W
BURK ROBERT M
GARST MICHAEL E
ANDREWS STEVEN W
BURK ROBERT M
GARST MICHAEL E
Application Number:
JP2010269407A
Publication Date:
March 17, 2011
Filing Date:
December 02, 2010
Export Citation:
Assignee:
ALLERGAN INC
International Classes:
C07C405/00; A61K31/045; A61K31/075; A61K31/13; A61K31/16; A61K31/275; A61K31/381; A61K31/557; A61K31/5575; A61K31/5585; A61K31/655; A61P1/00; A61P1/04; A61P1/16; A61P9/00; A61P9/10; A61P9/12; A61P11/00; A61P13/00; A61P13/02; A61P15/00; A61P27/02; A61P27/06; A61P27/14; A61P37/08; A61P43/00; C07C35/21; C07C35/50; C07C69/732; C07C69/734; C07C205/17; C07C215/42; C07C235/34; C07C247/10; C07C255/36
Domestic Patent References:
| JP3681068B2 | 2005-08-10 |
Attorney, Agent or Firm:
Sadao Kumakura
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Satsuki Ichikawa
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Satsuki Ichikawa