Title:
A medicine constituent and its use
Document Type and Number:
Japanese Patent JP6222749
Kind Code:
B2
Abstract:
Process for the identification of compounds for treating cancer. The invention relates to a method for identifying candidate compounds for use as therapeutic agents for the treatment of cancer, among those who are able to activate the MDA-5 protein or increase NOXA protein levels and to trigger autophagy. It is based on the fact that activation of dsRNA sensor MDA-5 is able to trigger the destruction of cancer cells by activation both autophagy and apoptosis, autonomously and selectively in tumor cells, without provoking the stabilization of the natural antagonist NOXA, MCL-1. The invention also relates to the use of double-stranded RNAs of the same or similar nature such as polyinosinic-polycytidylic acid (pIC), complexed with carriers such as polyethylenimine polycation (PEI), for the manufacture of medicines for the treatment of cancer.
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Inventors:
Soengus Gonzalez, Maria Soledad
Tormo Garulla, Damia
Tormo Garulla, Damia
Application Number:
JP2015238154A
Publication Date:
November 01, 2017
Filing Date:
December 07, 2015
Export Citation:
Assignee:
FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III
International Classes:
A61K31/713; A61K47/34; A61K47/59; A61P35/00; A61P35/02; A61P35/04; A61P37/02
Domestic Patent References:
| JP2006506433A |
Attorney, Agent or Firm:
Kazuhiro Kiyohara