Title:
CGRP RECEPTOR ANTAGONISTS
Document Type and Number:
WIPO Patent Application WO2006044504
Kind Code:
A8
Abstract:
Compounds of Formula (I): and Formula (II): (where variables R2, R4, A, B, D, W, X, Y and Z are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
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Inventors:
BURGEY CHRISTOPHER S (US)
PAONE DANIEL V (US)
SHAW ANTHONY W (US)
NGUYEN DIEM N (US)
DENG ZHENGWU J (US)
WILLIAMS THERESA M (US)
VACCA JOSEPH P (US)
SELNICK HAROLD G (US)
POTTEIGER CRAIG M (US)
PAONE DANIEL V (US)
SHAW ANTHONY W (US)
NGUYEN DIEM N (US)
DENG ZHENGWU J (US)
WILLIAMS THERESA M (US)
VACCA JOSEPH P (US)
SELNICK HAROLD G (US)
POTTEIGER CRAIG M (US)
Application Number:
PCT/US2005/036763
Publication Date:
June 08, 2006
Filing Date:
October 12, 2005
Export Citation:
Assignee:
MERCK & CO INC (US)
BURGEY CHRISTOPHER S (US)
PAONE DANIEL V (US)
SHAW ANTHONY W (US)
NGUYEN DIEM N (US)
DENG ZHENGWU J (US)
WILLIAMS THERESA M (US)
VACCA JOSEPH P (US)
SELNICK HAROLD G (US)
POTTEIGER CRAIG M (US)
BURGEY CHRISTOPHER S (US)
PAONE DANIEL V (US)
SHAW ANTHONY W (US)
NGUYEN DIEM N (US)
DENG ZHENGWU J (US)
WILLIAMS THERESA M (US)
VACCA JOSEPH P (US)
SELNICK HAROLD G (US)
POTTEIGER CRAIG M (US)
International Classes:
C07D519/00; A61K31/55; A61P1/08; A61P25/06; C07D487/04
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