Title:
PYRIDONE COMPOUND HAVING INTEGRASE INHIBITORY ACTIVITY AND PHARMACEUTICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/253294
Kind Code:
A1
Abstract:
The present disclosure provides a pyridone compound having integrase inhibitory activity and a pharmaceutical use thereof. Specifically, the present disclosure provides a compound having a structure shown as formula I or a pharmaceutically acceptable salt thereof, which can be used to treat human immunodeficiency (HIV) infection.
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Inventors:
ZHU LINGJIAN (CN)
HONG MIN (CN)
TAO WEIFENG (CN)
WU DAIZE (CN)
PAN XIAOYU (CN)
GAO LU (CN)
HUANG JIAN (CN)
HONG MIN (CN)
TAO WEIFENG (CN)
WU DAIZE (CN)
PAN XIAOYU (CN)
GAO LU (CN)
HUANG JIAN (CN)
Application Number:
PCT/CN2022/096750
Publication Date:
December 08, 2022
Filing Date:
June 02, 2022
Export Citation:
Assignee:
JIANGSU HENGRUI PHARMACEUTICALS CO LTD (CN)
SHANGHAI SENHUI MEDICINE CO LTD (CN)
RETROLEAD SHANGHAI BIOPHARMA CO LTD (CN)
SHANGHAI SENHUI MEDICINE CO LTD (CN)
RETROLEAD SHANGHAI BIOPHARMA CO LTD (CN)
International Classes:
C07D471/00; A61K31/495; A61K31/50; A61P31/18; C07D239/00; C07D241/36; C07D487/00; C07D495/00; C07D497/00
Domestic Patent References:
| WO2006116764A1 | 2006-11-02 | |||
| WO2013054862A1 | 2013-04-18 | |||
| WO2020167628A1 | 2020-08-20 |
Foreign References:
| CN101212903A | 2008-07-02 | |||
| CN103974957A | 2014-08-06 |
Other References:
KAWASUJI, T. ET AL.: "Carbamoyl Pyridone HIV-1 Integrase Inhibitors. 2. Bi- and Tricyclic Derivatives Result in Superior Antiviral and Pharmacokinetic Profiles", JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, 14 January 2013 (2013-01-14), pages 1124 - 1135, XP055138745, DOI: 10.1021/jm301550c
Attorney, Agent or Firm:
GE CHENG & CO., LTD (CN)
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