Title:
SYNTHESIS METHOD FOR SPIRO HYDROXYINDOLE CYCLOPENTANE β-INTRA-ESTER COMPOUND
Document Type and Number:
WIPO Patent Application WO/2018/176350
Kind Code:
A1
Abstract:
Disclosed in the present invention is a synthesis method for a spiro hydroxyindole cyclopentane β-intra-ester compound. Specifically, reactions are carried out by using phenyl-unsaturated aldehyde and unsaturated keto ester as reactants and using heterocyclic carbene as a catalyst, so as to obtain the spiro hydroxyindole cyclopentane β-intra-ester compound. In the method disclosed in the present invention, raw materials are easy to obtain, the reaction conditions are moderate, the aftertreatment is simple and convenient, the scope of applicable substrates is wide, the yield rate is high, the diastereoselectivity and enantioselectivity are high, and a synthesized product can be used as an intermediate for synthesizing drugs and pesticides.
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Inventors:
WANG XINGWANG (CN)
ZHANG JUNQI (CN)
ZHANG JUNQI (CN)
Application Number:
PCT/CN2017/078894
Publication Date:
October 04, 2018
Filing Date:
March 31, 2017
Export Citation:
Assignee:
ZHANGJIAGANG INST IND TECH SOOCHOW UNIV (CN)
International Classes:
C07D491/107; A61P31/00; B01J31/02
Foreign References:
| CN107056795A | 2017-08-18 |
Other References:
ZHANG JUNQI: "Chiral N-Heterocyclic Carbene-Catalyzed Asymmetric Mi- chael-Intramolecular Aldol-Lactonization Cascade for Enantioselective Const- ruction of beta -Propiolactone-Fused Spiro[cyclopentane-oxindoles", ADVANCED SYNTHESIS & CATALYSIS, vol. 359, no. 9, 20 March 2017 (2017-03-20), pages 1541 - 1551, XP055539796, DOI: 10.1002/adsc.201601259
Attorney, Agent or Firm:
SUZHOU CREATOR PATENT AND TRADEMARK AGENCY, LTD. (CN)
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